Abstract：
:Long non-coding RNAs (LncRNAs) are a category of non-coding RNAs (ncRNAs) with a length of 200nt-100kb lacking a significant open reading frame. The study of lncRNAs is a newly established field, due in part to their capability to act as the novel biomarkers in disease. A growing body of research shows that lncRNAs may not only useful as biomarkers for the diagnosis and clinical typing and prognosis of cancers, but also as potential targets for novel therapies. Differential expression of lncRNAs has been found in leukemia in the last two years, however, the majority of the lncRNAs described here are transcripts of unknown function and their role in leukemogenesis is still unclear. Here, we summarize the lncRNAs associated with leukemia in order to find a potential classification tool for leukemia, and a new field of research is being explored.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Chen S,Liang H,Yang H,Zhou K,Xu L,Liu J,Lai B,Song L,Luo H,Peng J,Liu Z,Xiao Y,Chen W,Tang Hdoi
10.1016/j.etap.2017.08.014subject
Has Abstractpub_date
2017-10-01 00:00:00pages
81-86eissn
1382-6689issn
1872-7077pii
S1382-6689(17)30234-Xjournal_volume
55pub_type
杂志文章,评审abstract：:Susceptibility is well-recognized as a potentially important aspect of health risk assessment, particularly for groups such as pregnant women and their fetuses, infants, children, the elderly, and the infirm, that are known or suspected to be more vulnerable to environmental insults. More recently, it has become appar...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(97)10020-5
更新日期：1997-12-01 00:00:00
abstract：:A green fluorescent protein (GFP)-reporter vector regulated by an estrogen response element (ERE) was constructed and transfected into human breast carcinoma MCF7 cells. Stable transfectants were selected and their GFP fluorescence intensity was measured using a quantitative fluorescent imaging system. 17β-estradiol (...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(02)00011-x
更新日期：2002-08-01 00:00:00
abstract：:We have shown previously that prenatal exposure of rats to 0.5 mg/kg/day of methylmercury (MeHg) produces gender-dependent changes in motor activity in adulthood. In the present study we have investigated whether changes in motor activity could also be found during early ontogeny of the offspring. Pregnant rats were t...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(00)00060-0
更新日期：2001-01-01 00:00:00
abstract：:Ozonation and chlorination of 17β-estradiol (E2), 17α-ethynylestradiol (EE2), bisphenol A (BPA), and nonylphenol (NP) were performed to evaluate the estrogenic activity of the by-products of these endocrine disrupting chemicals (EDCs). After 15min oxidation, samples were extracted using solid phase extraction (SPE) ca...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2005.01.008
更新日期：2005-09-01 00:00:00
abstract：:Quantitative structure - activity relationships (QSARs) which are obtained with a representation of the molecular architecture via simplified molecular input-line entry system (SMILES) are applied to build up predictive models of acute toxicity of pesticides towards Daphnia magna. The acute toxicity towards Daphnia ma...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2020.103459
更新日期：2020-11-01 00:00:00
abstract：:Serious bacterial pathogens have recently become a major cause of massive mortality in swimming crabs (Portunus trituberculatus). In this study, the antibacterial activity against Vibrio and the pharmacokinetics (PK) of sulfamethoxazole (SMZ)-trimethoprim (TMP) in crabs were estimated to explore the pharmacokinetics/p...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2016.06.029
更新日期：2016-09-01 00:00:00
abstract：:Effects of aluminum (Al) on membrane properties of excitable cells are not fully understood. Several reports have identified cellular membranes as sensitive targets for Al intoxication. In the present study, we tested the hypothesis that treatment with Al would alter membrane fluidity and potential and these changes w...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2004.05.011
更新日期：2005-02-01 00:00:00
abstract：:Inhibition of intercellular communication (IC) between hepa1c1c7 cells was used as a possible bioassay to predict tumor promoting potency of polyhalogenated aromatic hydrocarbons (PAHs). Relative potencies with regard to 2,3,7,8-TCDD to inhibit IC and to induce cytochrome P450IA1/2 (EROD) in these hepa1c1c7 cells were...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/1382-6689(95)00006-2
更新日期：1996-02-15 00:00:00
abstract：:Association of arsenic exposure with smoking, alcohol, and caffeine consumption was investigated. Data from National Health and Nutrition Examination Survey for the years 2005-2010 were used for this investigation. Urinary levels of total arsenic (UAS) and dimethylarsonic acid (UDMA) were evaluated for children aged 6...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2015.01.011
更新日期：2015-03-01 00:00:00
abstract：:We have investigated the toxicity of a series of 2-pyridylcarboxamidrazones in vitro using a rat liver metabolism system as well as human erythrocytes and mononuclear leucocytes (MNL) as target cells. Of the seven derivatives and four precursors tested, only minimal (<2.3%) metabolism-mediated methaemoglobin was forme...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(98)00055-6
更新日期：1999-03-01 00:00:00
abstract：:Acyclovir (ACV) exposure is a common cause of acute kidney injury (AKI). The toxicity mechanism of ACV has always been a matter of debate. The present study investigated into the time-effect relationship and dose-effect relationship of ACV-induced nephrotoxicity in rats using metabonomics. Twenty-four rats were random...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2016.07.018
更新日期：2016-09-01 00:00:00
abstract：:Four extracts were prepared from the roots and leaves of Moricandia arvensis: root chloroform extract (ChlR), leaf chloroform extract (ChlL), root ethyl acetate extract (EAR) and leaf ethyl acetate extract (EAL). The genotoxic and antigenotoxic properties of these extracts were investigated by assessing the induction ...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2010.03.014
更新日期：2010-07-01 00:00:00
abstract：:The present study was aimed to evaluate the effect of morin on blood glucose, insulin level, hepatic glucose regulating enzyme activities and glycogen level in experimental diabetes. Diabetes mellitus was induced by a single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg b.w.). Five days after STZ injecti...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2013.11.017
更新日期：2014-01-01 00:00:00
abstract：:Triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) is a chlorinated phenolic antibacterial compound found as an active ingredient in many personal care and household products. The structural similarity of triclosan to thyroid hormones and recent studies demonstrating activation of the human pregnane X receptor (PXR) a...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2007.04.008
更新日期：2007-09-01 00:00:00
abstract：:Gambogenic acid, identified from Gamboge, is responsible for anti-tumor effects, and has been shown to be a potential molecule against human cancers. In this study, the molecular mechanism of gambogenic acid-induced apoptosis in HepG2 cells was investigated. Gambogenic acid significantly inhibited cell proliferation a...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2011.12.006
更新日期：2012-03-01 00:00:00
abstract：:Epidemiological studies indicate that arsenic exposure induces hypertension. We hypothesized that arsenate exposure modulates the contractility of vascular smooth muscle through the stress response. Intraperitoneal injection of sodium arsenate (15mg/kg) 16h before increased not only the blood pressure of rats but also...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2004.08.002
更新日期：2005-02-01 00:00:00
abstract：:Iran is one of the main suppliers of pistachio for the European market accounting for over 90% of its demands; hence, efficient analytical methods are required for detection of mycotoxins contamination in pistachio kernels before exporting them. In this study, aflatoxin B1 (AFB1) and ochratoxin A (OTA) levels in five ...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2018.05.010
更新日期：2018-07-01 00:00:00
abstract：:Coutarea hexandra is a species commonly known in Brazil as quina, and its bark is used in folk medicine. In this study, we assess the mutagenic and DNA-damaging effects of ethanol extracts from C. hexandra stem bark (SCH) and leaves (LCH) by employing the Ames test on the TA98 and TA100 strains of Salmonella typhimuri...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2011.12.003
更新日期：2012-03-01 00:00:00
abstract：:Environmental Epigenomics is a developing field to study the epigenetic effect on human health from exposure to environmental factors. Endocrine disrupting chemicals have been detected primarily in pharmaceutical drugs, personal care products, food additives, and food containers. Exposure to endocrine-disrupting chemi...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.etap.2017.02.004
更新日期：2017-04-01 00:00:00
abstract：:Essential oils from aerial parts of Piper aduncum (Matico) and Piper obliquum (Anis del Oriente) of ecuadorian origin were analyzed by GC-FID, GC-MS, (13)C NMR and their biological and pharmacological activities were assessed. Chemical composition proved to be unusually different from previous reports for safrole-rich...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2008.08.002
更新日期：2009-01-01 00:00:00
abstract：:We generated germ line-transgenic Xenopus laevis that monitors environmental heavy metal ions. Sperm nuclei were transduced with cDNA of enhanced green fluorescent protein (EGFP) driven by murine metallothionein-1 gene promoters and were microinjected into unfertilized eggs. The eggs developed to sexually matured adul...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/S1382-6689(03)00003-6
更新日期：2003-04-01 00:00:00
abstract：:The present study was aimed to analyze the effect of ZnO and TiO2 nanoparticles (NPs) on Haemato-immunological parameters in adult Tilapia, Oreochromis mossambicus. The nanoparticles size found as 47 nm and 30 nm for ZnO and TiO2 respectively. The acute toxicity (96 h) of ZnO (LC50: 100-110 ppm) and TiO2 (LC50: 80-90 ...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2018.12.011
更新日期：2019-02-01 00:00:00
abstract：:Metabolic activity, particularly conjugation, was examined in fish by analyzing pyrene (a four-ring, polycyclic aromatic hydrocarbon) metabolites using high-performance liquid chromatography (HPLC) with fluorescence detector (FD), a mass spectrometry (MS) system, and kinetic analysis of conjugation enzymes. Fourteen f...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2013.05.018
更新日期：2013-09-01 00:00:00
abstract：:Combretastatin A-4 exhibits efficient anti-cancer potential in human tumors, including multidrug-resistant tumors. We evaluated the mutagenic, apoptotic and immunomodulatory potential of two diaryl sulfide analogs of combretastatin A-4, 1,2,3-trimethoxy-5-([4-methoxy-3-nitrophenyl]thio)benzene (analog 1) and 1,2,3-tri...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2015.08.028
更新日期：2015-11-01 00:00:00
abstract：:A water extract of the lyophilised fresh-water alga Anabaena flos-aquae enhanced substantially the release of [(3)H]acetylcholine ([(3)H]acetylcholine and [(3)H]choline) from cholinergic nerves of rat bronchi. Parallel experiments performed with the related species Anabaena lemmermannii did not demonstrate this effect...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(97)10007-2
更新日期：1998-01-01 00:00:00
abstract：:The Cd has been recognized as one of the most toxic environmental and industrial pollutants due to its ability to induce disturbances in several organs and tissues following either acute or chronic exposure. This review accounts for the recent evidence on its mechanisms to induce neurotoxicity, the role of the blood-b...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2006.11.009
更新日期：2007-05-01 00:00:00
abstract：BACKGROUND:Sulfur mustard is an alkylating agent which cause to short and long term incapacitations on various organs including lung. There is no definite treatment for lung disorders induced by SM exposure. In the present study, the preventive effect of Zataria multiflora (Z. multiflora) on hematological parameters, o...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.etap.2018.01.006
更新日期：2018-03-01 00:00:00
abstract：:Palladium (Pd) is known to be released into the environment in the fine and ultrafine (at the nanoscale) airborne particle fractions mainly from automobile catalytic converters leading to an increase human exposure to this noble metal. It was reported that Pd can induce allergic reactions in individuals exposed to it ...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2017.12.002
更新日期：2018-01-01 00:00:00
abstract：:The study investigated the correlation between infarction areas and behavioural deficits in middle cerebral artery occlusion (MCAO) and photothrombosis stroke models. In the MCAO model, a 0.38 mm-diameter silicone-coated thread was introduced through the left external carotid artery and advanced 18 mm via the internal...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2011.11.001
更新日期：2012-01-01 00:00:00
abstract：:This study was aimed at documenting the kinetic time courses of selenium (Se) in accessible biological matrices of volunteers following controlled applications of therapeutic shampoo containing Se, to better elucidate the mechanisms by which shampoo-Se accumulates in hair and hence estimate the contribution of this so...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2010.02.001
更新日期：2010-05-01 00:00:00
