A novel mouse model of atopic dermatitis that is T helper 2 (Th2)-polarized by an epicutaneous allergen.

abstract：:The in situ evaluation of the genotoxic impact of the Karaj River was performed using the comet and micronucleus (MN) assays in erythrocytes, liver, gill and kidney of indigenous brown trout, Salmo trutta fario from three different stations, including Varangerud, Asara and Purkan. The results showed that DNA damage si...

journal_title：Environmental toxicology and pharmacology

authors： Hariri M,Mirvaghefi A,Farahmand H,Taghavi L,Shahabinia AR

更新日期：2018-03-01 00:00:00

abstract：:Palladium (Pd) is known to be released into the environment in the fine and ultrafine (at the nanoscale) airborne particle fractions mainly from automobile catalytic converters leading to an increase human exposure to this noble metal. It was reported that Pd can induce allergic reactions in individuals exposed to it ...

journal_title：Environmental toxicology and pharmacology

authors： Chhay P,Murphy-Marion M,Samson Y,Girard D

更新日期：2018-01-01 00:00:00

abstract：:We recently reported that acrylamide, a known rodent and probable human carcinogen, does not increase the risk of azoxymethane (AOM)-induced rat colon precancerous lesions when administered through the diet. Here, we present toxicological data from non-AOM-injected rats. Briefly, male F344 rats were randomized into fo...

journal_title：Environmental toxicology and pharmacology

authors： Raju J,Roberts J,Taylor M,Patry D,Chomyshyn E,Caldwell D,Cooke G,Mehta R

更新日期：2015-01-01 00:00:00

abstract：:Chronic exposure to combined fluoride and arsenic continues to be a major public health problem worldwide, affecting thousands of people. In recent years, more and more researchers began to focus on the interaction between the fluorine and the arsenic. In this study, the selected investigation site was located in Chin...

journal_title：Environmental toxicology and pharmacology

authors： Zeng QB,Xu YY,Yu X,Yang J,Hong F,Zhang AH

更新日期：2014-01-01 00:00:00

abstract：:Electrocardiogram and arterial pressure measurements were studied under acute exposures to WIFI (2.45GHz) during one hour in adult male rabbits. Antennas of WIFI were placed at 25cm at the right side near the heart. Acute exposure of rabbits to WIFI increased heart frequency (+22%) and arterial blood pressure (+14%). ...

journal_title：Environmental toxicology and pharmacology

authors： Saili L,Hanini A,Smirani C,Azzouz I,Azzouz A,Sakly M,Abdelmelek H,Bouslama Z

更新日期：2015-09-01 00:00:00

abstract：:To investigate the effect of infrasound on the hippocampus-dependent spatial learning and memory as well as its underlying mechanisms, we measured the changes of cognitive abilities, brain-derived neurotrophic factor (BDNF)-tyrosine kinase receptor B (TrkB) signal transduction pathway and neurogenesis in the hippocamp...

journal_title：Environmental toxicology and pharmacology

authors： Yuan H,Long H,Liu J,Qu L,Chen J,Mou X

更新日期：2009-09-01 00:00:00

abstract：:To elucidate the potential thyroid disrupting effects of refuse leachate on females, female goldfish (Carassius auratus) were exposed to 0.5% diluted leachates from each step of a leachate treatment process (i.e. raw leachate before treatment, after membrane bioreactor treatment, and the final treated leachate) for 21...

journal_title：Environmental toxicology and pharmacology

authors： Gong Y,Tian H,Zhang X,Dong Y,Wang W,Ru S

更新日期：2016-12-01 00:00:00

abstract：:Mitochondrial damage can trigger mitophagy and eventually suppress proliferation. However, the effect of mitophagy on proliferation remains unclear. In this study, HepG2 cells were used to assess mitophagy and proliferation arrest in response to As2O3 exposure. The stimulatory effect of As2O3 on mitophagy was investig...

journal_title：Environmental toxicology and pharmacology

authors： Niu Z,Zhang W,Gu X,Zhang X,Qi Y,Zhang Y

更新日期：2016-07-01 00:00:00

abstract：:We generated germ line-transgenic Xenopus laevis that monitors environmental heavy metal ions. Sperm nuclei were transduced with cDNA of enhanced green fluorescent protein (EGFP) driven by murine metallothionein-1 gene promoters and were microinjected into unfertilized eggs. The eggs developed to sexually matured adul...

journal_title：Environmental toxicology and pharmacology

authors： Oofusa K,Tooi O,Kashiwagi A,Kashiwagi K,Kondo Y,Obara M,Yoshizato K

更新日期：2003-04-01 00:00:00

abstract：:This symposium on susceptibility and risk was the third in a series designed to bring together experts from diverse disciplines to discuss contemporary issues in risk assessment. The topic in 1996 was especially challenging since susceptibility is influenced by a myriad of factors including environmental, genetic, soc...

journal_title：Environmental toxicology and pharmacology

authors： Zenick H,Costa DL

更新日期：1997-12-01 00:00:00

abstract：:In the present study, two antioxidant components (polysaccharopeptide complex P(1-a) and condensed tannin P(1-b)) from rose (Rosa rugosa) flowers were each incubated with mouse erythrocytes to investigate their effect on erythrocyte superoxide dismutase (SOD), and catalase (CAT) activities. It was found that the activ...

journal_title：Environmental toxicology and pharmacology

authors： Jiang Y,Wong JH,Pi ZF,Ng TB,Wang CR,Hou J,Chen RR,Niu HJ,Liu F

更新日期：2009-05-01 00:00:00

abstract：:The mutagenic and genotoxic effect of 'Rasayanzine', an atrazine herbicide, was carried out in fish Channa punctatus using micronucleus and single cell gel electrophoresis (SCGE) assays. Three sub-lethal concentrations of the test material viz., SL-I (1/5th LC(50)=∼8.48 mgL(-1)), SL-II (1/8th LC(50)=∼5.30 mgL(-1)) and...

journal_title：Environmental toxicology and pharmacology

authors： Nwani CD,Nagpure NS,Kumar R,Kushwaha B,Kumar P,Lakra WS

更新日期：2011-03-01 00:00:00

abstract：:Genistein receives much attention because of its potential to prevent hormone-related cancer and cardiovascular diseases. Limited information is available on the pharmacokinetics of this compound like, for instance, their intestinal uptake by humans and systematic bioavailability. In this study, the fate of the absorp...

journal_title：Environmental toxicology and pharmacology

authors： Steensma A,Bienenmann-Ploum ME,Noteborn HP

更新日期：2004-06-01 00:00:00

abstract：:Diclofenac is a nonsteroidal anti-inflammatory drug widely used in Mexico where it is sold over the counter. It enters water bodies through municipal and industrial discharges, posing a risk to water systems and aquatic organisms. Diclofenac-enriched artificial sediment was used to evaluate the toxicity of this pharma...

journal_title：Environmental toxicology and pharmacology

authors： Oviedo-Gómez DG,Galar-Martínez M,García-Medina S,Razo-Estrada C,Gómez-Oliván LM

更新日期：2010-01-01 00:00:00

abstract：:Pimpinella brachycarpa (Kom.) Nakai (PB) is one of the most favored edible greens grown in Asian regions. In our previously study, we found PB extract had antioxidant effects in vitro. In the present study, an EtOAc soluble extract (PBet) was isolated from PB. Then the antioxidant properties at cellular level, phytoch...

journal_title：Environmental toxicology and pharmacology

authors： Lu J,Qian W,Xu L,Huang G,Cong W,Wang Z,Deng X,Wang D,Guan S

更新日期：2012-09-01 00:00:00

abstract：:This study aims to investigate potential toxic effects of chrysene (CHR) on mature scallop Chlamys farreri during the reproduction period, using indicators of antioxidant defences and oxidative stress. Scallops were exposed to 0.2, 0.8 and 3.2μg/L waterborne CHR for 21 days, at day 10 scallops were induced to spawn. A...

journal_title：Environmental toxicology and pharmacology

authors： Xiu M,Pan L,Jin Q

更新日期：2016-06-01 00:00:00

abstract：:To evaluate an influence of dioxin on a daily variation of insulin sensitivity, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100ng/kg) was given for 3 weeks in mice. Insulin tolerance test and oral glucose tolerance test were performed. TCDD decreased insulin sensitivity at an active period, but not at a rest period. T...

journal_title：Environmental toxicology and pharmacology

authors： Takuma M,Ushijima K,Kumazaki M,Ando H,Fujimura A

更新日期：2015-09-01 00:00:00

abstract：:Air pollution is a topic discussed all over the world and the search for alternatives to reduce it is of great interest to many researchers. The use of alternative energy sources and biofuels seems to be the environmentally safer solution. In this work, the deleterious effects on the respiratory system of mice exposed...

journal_title：Environmental toxicology and pharmacology

authors： Josino JB,Serra DS,Gomes MDM,Araújo RS,de Oliveira MLM,Cavalcante FSÁ

更新日期：2017-12-01 00:00:00

abstract：:To evaluate the genotoxic effects of formaldehyde, acetaldehyde, acrolein and benzene on A549 cells, the in vitro γH2AX assay was used in combination with high content screening (HCS) technology. All aldehydes showed a significant genotoxicity in a dose/time-dependent effect on the induction of γH2AX. Benzene failed t...

journal_title：Environmental toxicology and pharmacology

authors： Zhang S,Chen H,Wang A,Liu Y,Hou H,Hu Q

更新日期：2017-10-01 00:00:00

abstract：:Lithium, like insulin, activates glycogen synthase and stimulates glucose transport in rat adipocytes. To investigate the effect of dietary overload lithium on glucose metabolism in broiler chickens, one-day-old chicks were fed a basal diet supplemented with 0 (control) or 100mg lithium/kg (overload lithium) for 35day...

journal_title：Environmental toxicology and pharmacology

authors： Bai S,Pan S,Zhang K,Ding X,Wang J,Zeng Q,Xuan Y,Su Z

更新日期：2017-09-01 00:00:00

abstract：:The aim of this work was to evaluate the Ascidian Embryo Teratogenicity assay (AET) as new alternative invertebrate model to test the developmental effects of the co-exposure to ethanol and fluconazole. Ciona intestinalis embryos were exposed to the azolic fungicide fluconazole, (FLUCO, 7.8-250μM), to ethanol (Eth, 0....

journal_title：Environmental toxicology and pharmacology

authors： Battistoni M,Mercurio S,Ficetola GF,Metruccio FC,Menegola E,Pennati R

更新日期：2018-01-01 00:00:00

abstract：:Drug-induced blood dyscrasias can be either acute and predictable or delayed and unpredictable (idiosyncratic). The predictable toxicity is relatively easy to reproduce with in vitro models, although they may not work for drugs that require bioactivation. It is very unlikely that idiosyncratic blood dyscrasias can be ...

journal_title：Environmental toxicology and pharmacology

authors： Ip J,Uetrecht JP

更新日期：2006-02-01 00:00:00

abstract：:It is well known that developmental exposure to polychlorinated biphenyls (PCBs) could cause learning and memory deficits, but the underlying mechanisms are not clear. Actin cytoskeleton is directly involved in synaptic plasticity which is considered critical to learning and memory formation by LIM kinase 1 (LIMK-1)/c...

journal_title：Environmental toxicology and pharmacology

authors： Tang F,Yan C,Wu S,Li F,Yu Y,Gao Y,Jin X,Shen X

更新日期：2007-03-01 00:00:00

abstract：:The epothilones, a new class of microtubule-targeting agents, seem to be a very promising alternative to the current strategy of cancer treatment. We have analyzed the aspects of epothilone B (Epo B) on cellular metabolism of tumor (OV-90) and normal (MM 14) ovarian cells. The observed effects were compared with those...

journal_title：Environmental toxicology and pharmacology

authors： Rogalska A,Szula E,Gajek A,Marczak A,Jóźwiak Z

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:The study aims to verify whether alterations in the level of neurotransmitters have occurred in prenatally stressed rats (animal model of schizophrenia), and whether aripiprazole (ARI) and olanzapine (OLA) modify this level. METHODS:The effects of ARI (1.5mg/kg) and OLA (0.5mg/kg) were studied by means of m...

journal_title：Environmental toxicology and pharmacology

authors： Ratajczak P,Kus K,Gołembiowska K,Noworyta-Sokołowska K,Woźniak A,Zaprutko T,Nowakowska E

更新日期：2016-09-01 00:00:00

abstract：:Antiretroviral drugs (ARVs) are hazardous therapeutic pharmaceuticals present in South African surface water. Efavirenz is an ARV commonly used in human immunodeficiency virus (HIV) treatment in South Africa. Although little is known about the toxic effects of efavirenz on fish health, threats of toxicity to the aquat...

journal_title：Environmental toxicology and pharmacology

authors： Robson L,Barnhoorn IEJ,Wagenaar GM

更新日期：2017-12-01 00:00:00

abstract：:The Cd has been recognized as one of the most toxic environmental and industrial pollutants due to its ability to induce disturbances in several organs and tissues following either acute or chronic exposure. This review accounts for the recent evidence on its mechanisms to induce neurotoxicity, the role of the blood-b...

journal_title：Environmental toxicology and pharmacology

authors： Méndez-Armenta M,Ríos C

更新日期：2007-05-01 00:00:00

abstract：:The aim of this study was to evaluate cytogenotoxic effects of bee venom to human lymphocytes and take a look into the mechanisms behind them. Bee venom was tested in concentrations ranging from 0.1μg/ml to 20μg/ml over different lengths of time. Cell viability, type of the cell death, and morphological alterations we...

journal_title：Environmental toxicology and pharmacology

authors： Gajski G,Garaj-Vrhovac V

更新日期：2011-09-01 00:00:00

abstract：:Cadmium (Cd) is a toxic heavy metal, and exposure to Cd causes a range of changes within the cell. At high concentrations, Cd causes damage to cells via a range of mechanisms. At low concentrations, Cd can stimulate expression of genes that are part of an adaptive response. In this study, we have used the astrocytoma ...

journal_title：Environmental toxicology and pharmacology

authors： Lawal AO,Ellis EM

更新日期：2011-07-01 00:00:00

abstract：:A water extract of the lyophilised fresh-water alga Anabaena flos-aquae enhanced substantially the release of [(3)H]acetylcholine ([(3)H]acetylcholine and [(3)H]choline) from cholinergic nerves of rat bronchi. Parallel experiments performed with the related species Anabaena lemmermannii did not demonstrate this effect...

journal_title：Environmental toxicology and pharmacology

authors： Ruge Holte H,Eriksen S,Skulberg O,Aas P

更新日期：1998-01-01 00:00:00