当前位置： SCI文献检索 > ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY期刊下所有文献 > Toxicological effects of short-term dietary acrylamide exposure in male F344 rats.

Toxicological effects of short-term dietary acrylamide exposure in male F344 rats.

Abstract：

:We recently reported that acrylamide, a known rodent and probable human carcinogen, does not increase the risk of azoxymethane (AOM)-induced rat colon precancerous lesions when administered through the diet. Here, we present toxicological data from non-AOM-injected rats. Briefly, male F344 rats were randomized into four dietary groups and received experimental diets based on AIN-93G formulation and containing acrylamide at 0 (control), 5, 10 or 50mg/kg diet (wt/wt) ad libitum for 10 weeks, after which they were killed and their blood collected for hematological and biochemical markers. Acrylamide at the higher doses (10 and 50mg/kg diet) significantly lowered (p<0.05) serum total high density lipoprotein and total testosterone and increased serum lipase in comparison to the control. Blood hematocrit values and lymphocyte counts were significantly lower (p<0.05) in the high dose acrylamide (50mg/kg diet) group compared to control, with a concomitant decrease in hemoglobin level, mean corpuscular volume and mean corpuscular hemoglobin. These results provide additional hazard characterization data and strengthen the notion that at high doses, acrylamide may involve systemic toxicity potentiating tumorigenesis in experimental animals. Further studies are required to understand the health effects of food-borne acrylamide, especially at the lower exposures typified by human diets.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Raju J,Roberts J,Taylor M,Patry D,Chomyshyn E,Caldwell D,Cooke G,Mehta R

doi

10.1016/j.etap.2014.11.009

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

85-92

issue

1

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(14)00267-1

journal_volume

39

pub_type

杂志文章

相关文献

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY文献大全
  • Differential gene expression profiles of human leukemia cell lines exposed to benzene and its metabolites.

    abstract：:Benzene is a well-known environmental pollutant that can induce hematotoxicity, aplastic anemia, acute myelogenous leukemia, and lymphoma. Benzene toxicity is likely mediated through metabolites induced by means of multiple pathways. Although benzene metabolites are known to induce oxidative stress and disrupt the cel...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.06.001

    authors： Sarma SN,Kim YJ,Ryu JC

    更新日期：2011-09-01 00:00:00

  • Preliminary in vitro toxicological evaluation of a series of 2-pyridylcarboxamidrazone candidate anti-tuberculosis compounds.

    abstract：:We have investigated the toxicity of a series of 2-pyridylcarboxamidrazones in vitro using a rat liver metabolism system as well as human erythrocytes and mononuclear leucocytes (MNL) as target cells. Of the seven derivatives and four precursors tested, only minimal (<2.3%) metabolism-mediated methaemoglobin was forme...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(98)00055-6

    authors： Coleman MD,Rathbone DL,Abberley L,Lambert PA,Billington DC

    更新日期：1999-03-01 00:00:00

  • Aluminum-induced suppression of testosterone through nitric oxide production in male mice.

    abstract：:Excessive nitric oxide (NO) production in mice serum and testis due to aluminum (Al) exposure has been shown in previous studies. The aim of this study was to further investigate the role of NO on aluminum-suppressed testosterone level in male CD-1 mice. Each animal in six groups, was given intraperitoneal injections ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2004.02.009

    authors： Guo CH,Lin CY,Yeh MS,Hsu GS

    更新日期：2005-01-01 00:00:00

  • Appraisal of anti-inflammatory and free radical scavenging activities of ethanol extract of Ilex ficoidea Hemsl and Ilex centrochinensis S.Y. Hu.

    abstract：:This study was to appraise the anti-inflammatory and free radical scavenging activities of ethanol extracts of Ilex ficoidea Hemsl (EIFH) and Ilex centrochinensis S.Y. Hu (EICC). Anti-inflammatory activities were evaluated using xylene-induced ear edema and the cotton pellet granuloma tests. Some antioxidants produced...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.04.003

    authors： Li L,Zhang Y,Zhang P,Pi H,Ruan H,Wu J

    更新日期：2011-09-01 00:00:00

  • Effect of cadmium on the extracellular Na⁺, K⁺, and Ca²⁺ in the gill and small intestine of goldfish Carassius auratus.

    abstract：:In this study, the toxic effect of cadmium on extracellular Na(+), K(+), and Ca(2+) in the gill and small intestine of goldfish Carassius auratus was determined with the technique of ion chromatograph. Two-way ANOVA indicated that the two factors (Cd(2+) treatment and time) and the interaction factor had significant e...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.02.002

    authors： Liu D,Guo H,Chen Z,Wang Y

    更新日期：2014-03-01 00:00:00

  • Paraquat and temperature affect nonspecific immune response of Colossoma macropomum.

    abstract：:This study evaluated the effect of paraquat (PQ) and temperature on hematological parameters and nonspecific immune system of fish Colossoma macropomum (Cachama). Juveniles were used for all experiments. Fish were exposed to three temperatures (18, 28, 35°C) and 10mg/L PQ during 21 days (PQ LC(50) 96h was of 48.05mg/L...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2008.11.010

    authors： Salazar-Lugo R,Estrella A,Oliveros A,Rojas-Villarroel E,Villalobos de B L,Lemus M

    更新日期：2009-05-01 00:00:00

  • Blood selenium concentration in a selected population of children inhabiting industrial regions in Upper Silesia (Poland).

    abstract：PURPOSE:Present study aimed at determining blood selenium concentration (Se-B) in a selected population of children inhabiting industrial regions. METHODS:The studies were conducted on a group of 267 children inhabiting industrial regions in Upper Silesia (Poland). Determination of Se-B was performed using hydride gen...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2012.06.005

    authors： Gać P,Pawlas N,Poręba R,Poręba M,Prokopowicz A,Pawlas K

    更新日期：2012-09-01 00:00:00

  • Arsenic may be involved in fluoride-induced bone toxicity through PTH/PKA/AP1 signaling pathway.

    abstract：:Chronic exposure to combined fluoride and arsenic continues to be a major public health problem worldwide, affecting thousands of people. In recent years, more and more researchers began to focus on the interaction between the fluorine and the arsenic. In this study, the selected investigation site was located in Chin...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2013.11.027

    authors： Zeng QB,Xu YY,Yu X,Yang J,Hong F,Zhang AH

    更新日期：2014-01-01 00:00:00

  • In vitro and other alternative approaches to developmental neurotoxicity testing (DNT).

    abstract：:To address the growing need for scientifically valid and humane alternatives to developmental neurotoxicity testing (DNT), we propose that basic research scientists in developmental neurobiology be brought together with mechanistic toxicologists and policy analysts to develop the science and policy for DNT alternative...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2004.12.035

    authors： Lein P,Silbergeld E,Locke P,Goldberg AM

    更新日期：2005-05-01 00:00:00

  • Physiological changes in the hemolymph of juvenile shrimp Litopenaeus vannamei to sublethal nitrite and nitrate stress in low-salinity waters.

    abstract：:Juveniles of the shrimp Litopenaeus vannamei (3.3 ± 0.4 g) were exposed separately to nitrite (0.0, 1.1, 2.6, and 5.3 mg/L nitrogen as nitrite [NO2--N]) and nitrate (0, 90, 225 and 400 mg/L nitrogen as nitrate [NO3--N]) concentrations equivalent to 0, 10, 25, and 50% of the LC50-96 h value of NO2--N and NO3--N in low ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2020.103472

    authors： Valencia-Castañeda G,Frías-Espericueta MG,Vanegas-Pérez RC,Chávez-Sánchez MC,Páez-Osuna F

    更新日期：2020-11-01 00:00:00

  • The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury.

    abstract：OBJECTIVES:Acetaminophen (APAP) overdose may cause acute liver injury. Ozone therapy (OT) is shown to reduce inflammation and necrosis in several entities. Thus, we have designed this study to evaluate the efficacy of OT in a rat model of APAP-induced liver injury. METHODS:Twenty-seven Sprague-Dawley rats were divided...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2012.02.006

    authors： Gul H,Uysal B,Cakir E,Yaman H,Macit E,Yildirim AO,Eyi YE,Kaldirim U,Oztas E,Akgul EO,Cayci T,Ozler M,Topal T,Oter S,Korkmaz A,Toygar M,Demirbag S

    更新日期：2012-07-01 00:00:00

  • Toxic effects of chlorpyrifos on antioxidant enzymes and target enzyme acetylcholinesterase interaction in mosquito fish, Gambusia affinis.

    abstract：:The recovery effect of chlorpyrifos (CPF) on antioxidant enzymes, locomotor behaviour and the target enzyme acetylcholinesterase (AChE) interaction were studied after exposure to 297μgL(-1) (LC(50) for 96h) in mosquito fish, Gambusia affinis. Activities of the antioxidant enzymes-superoxide dismutase, catalase, glutat...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2008.03.010

    authors： Kavitha P,Rao JV

    更新日期：2008-09-01 00:00:00

  • Acute toxicity, biochemical toxicity and genotoxicity caused by 1-butyl-3-methylimidazolium chloride and 1-butyl-3-methylimidazolium tetrafluoroborate in zebrafish (Danio rerio) livers.

    abstract：:The present study examined the potential toxicity of 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) and 1-butyl-3- methylimidazolium tetrafluoroborate ([Bmim]BF4) in the liver cells of zebrafish (Danio rerio) with different doses (20-160mg/L) on 7 and 14days. The effects of [Bmim]Cl and [Bmim]BF4 on acute toxicity, r...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.02.018

    authors： Zhang C,Shao Y,Zhu L,Wang J,Wang J,Guo Y

    更新日期：2017-04-01 00:00:00

  • Antiangiogenic effects of marine sponge derived compounds on cancer.

    abstract：:The term "angiogenic switch" refers to a time-restricted event during tumor progression where the balance between pro- and anti-angiogenic factors, resulting in the transition from dormant avascularized hyperplasia to outgrowing vascularized tumor and eventually to malignant tumor progression. Targeting angiogenesis a...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.etap.2013.09.014

    authors： Senthilkumar K,Venkatesan J,Manivasagan P,Kim SK

    更新日期：2013-11-01 00:00:00

  • Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine.

    abstract：:Triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) is a chlorinated phenolic antibacterial compound found as an active ingredient in many personal care and household products. The structural similarity of triclosan to thyroid hormones and recent studies demonstrating activation of the human pregnane X receptor (PXR) a...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2007.04.008

    authors： Crofton KM,Paul KB,Devito MJ,Hedge JM

    更新日期：2007-09-01 00:00:00

  • The metabolic effects of diuron in the rat liver.

    abstract：:A systematic study on the effects of diuron on the hepatic metabolism was conducted with emphasis on parameters linked to energy metabolism. The experimental system was the isolated perfused rat liver. The results demonstrate that diuron inhibited biosynthesis (gluconeogenesis) and ammonia detoxification, which are de...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.06.024

    authors： da Silva Simões M,Bracht L,Parizotto AV,Comar JF,Peralta RM,Bracht A

    更新日期：2017-09-01 00:00:00

  • Modulation of rifampicin toxicity by 6 MFA, an interferon inducer obtained from fungus Aspergillus ochraceus.

    abstract：:The effect of 6 MFA (Sixth mycelial fraction of acetone), an interferon inducer obtained from fungus Aspergillus ochraceus, on rifampicin toxicity was studied in rats. Chronic oral administration of rifampicin (1 g/kg per day) for 30 days produced thrombocytopenia, hemolytic anaemia, transient leukopenia and increased...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(98)00006-4

    authors： Dhuley JN,Naik SR

    更新日期：1998-06-02 00:00:00

  • Diclofenac-enriched artificial sediment induces oxidative stress in Hyalella azteca.

    abstract：:Diclofenac is a nonsteroidal anti-inflammatory drug widely used in Mexico where it is sold over the counter. It enters water bodies through municipal and industrial discharges, posing a risk to water systems and aquatic organisms. Diclofenac-enriched artificial sediment was used to evaluate the toxicity of this pharma...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2009.09.004

    authors： Oviedo-Gómez DG,Galar-Martínez M,García-Medina S,Razo-Estrada C,Gómez-Oliván LM

    更新日期：2010-01-01 00:00:00

  • Review: Usnic acid-induced hepatotoxicity and cell death.

    abstract：:Increasing prevalence of herbal and dietary supplement-induced hepatotoxicity has been reported worldwide. Usnic acid (UA) is a well-known hepatotoxin derived from lichens. Since 2000, more than 20 incident reports have been received by the US Food and Drug Administration after intake of UA containing dietary suppleme...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.etap.2020.103493

    authors： Kwong SP,Wang C

    更新日期：2020-11-01 00:00:00

  • Cytotoxic and clastogenic activity of CdCl2 in human lymphocytes from different donors.

    abstract：:The sensitivity of human lymphocytes from different donors to CdCl2 using a complex of methods for determination of cytotoxicity and genotoxicity was studied. As endpoints for cytotoxicity the mitotic index (MI) and apoptosis were evaluated. To indicate genotoxicity chromosome aberrations test (CA) was used. The resul...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2013.03.021

    authors： Gateva S,Jovtchev G,Stergios M

    更新日期：2013-07-01 00:00:00

  • Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism(s): a critical discussion.

    abstract：:Liver is a primary organ involved in biotransformation of food and drugs. Hepatic diseases are a major worldwide problem. Hepatic disorders are mainly caused by toxic chemicals (alcohol), xenobiotics (carbon tetrachloride, chlorinated hydrocarbons and gases CO₂ and O₂) anticancer (azathioprine, doxorubicin, cisplatin)...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.etap.2013.08.015

    authors： Ingawale DK,Mandlik SK,Naik SR

    更新日期：2014-01-01 00:00:00

  • Validating the domestic fowl as a model to investigate the pathophysiology of diclofenac in Gyps vultures.

    abstract：:Diclofenac has recently been identified as a cause of the widespread vulture decline on the Indian subcontinent. Although the clinical signs and pathology have been described, the pathophysiology of toxicity remains unexplained. In the following study we attempt to validate the domestic fowl as a model, to allow for t...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2007.06.003

    authors： Naidoo V,Duncan N,Bekker L,Swan G

    更新日期：2007-11-01 00:00:00

  • Dietary overload lithium decreases the adipogenesis in abdominal adipose tissue of broiler chickens.

    abstract：:To investigate the toxic effects of dietary overload lithium on the adipogenesis in adipose tissue of chicken and the role of hypothalamic neuropeptide Y (NPY) in this process, one-day-old male chicks were fed with the basal diet added with 0 (control) or 100mg lithium/kg diet from lithium chloride (overload lithium) ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2016.12.012

    authors： Bai S,Pan S,Zhang K,Ding X,Wang J,Zeng Q,Xuan Y,Su Z

    更新日期：2017-01-01 00:00:00

  • Genes regulating wing patterning in Drosophila melanogaster show reduced expression under exposure of Daminozide, the fruit ripening retardant.

    abstract：:In our previous study we demonstrated that the fruit ripening retardant Daminozide or Alar causes change in life history traits, distortion of adult wing structure, DNA damage in brain cells and mutagenic effects in fruit fly Drosophila melanogaster. As a continuation of the previous study the present work is designed...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.103322

    authors： Roy SS,Ghosh S

    更新日期：2020-04-01 00:00:00

  • Gambogenic acid induced mitochondrial-dependent apoptosis and referred to phospho-Erk1/2 and phospho-p38 MAPK in human hepatoma HepG2 cells.

    abstract：:Gambogenic acid, identified from Gamboge, is responsible for anti-tumor effects, and has been shown to be a potential molecule against human cancers. In this study, the molecular mechanism of gambogenic acid-induced apoptosis in HepG2 cells was investigated. Gambogenic acid significantly inhibited cell proliferation a...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.12.006

    authors： Yan F,Wang M,Li J,Cheng H,Su J,Wang X,Wu H,Xia L,Li X,Chang HC,Li Q

    更新日期：2012-03-01 00:00:00

  • S-allyl-glutathione, a synthetic analogue of glutathione protected liver against carbon tetrachloride toxicity: Focus towards anti-oxidative efficiency.

    abstract：:A simple analogue of well known natural antioxidant glutathione (GSH) called S-allyl-glutathione (SAG) was evaluated against carbon tetrachloride (CCl4)-induced oxidative stress liver injury in rat. Pretreatment of SAG attenuated the CCl4-toxicity induced elevation of liver injury markers such as enzymes (AST, ALT, GG...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.12.006

    authors： Thayumanavan P,Loganathan C,Iruthayaraj A,Poomani K,Nallaiyan S

    更新日期：2018-03-01 00:00:00

  • Evaluation of chronic cough in chemical chronic bronchitis patients.

    abstract：BACKGROUND:: Coughing is one of the chronic respiratory symptoms of patients exposed to sulfur mustard (SM) used against Iranian combatants and civilians by Iraq during the Iran-Iraq war, between 1983 and 1989. This study carried out on SM exposed patients who referred to our clinic because of exacerbation of chronic c...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2004.09.006

    authors： Ghanei M,Hosseini AR,Arabbaferani Z,Shahkarami E

    更新日期：2005-07-01 00:00:00

  • Strain differences in age-associated change in testosterone 6β-hydroxylation in Wistar and Dark Agouti rats.

    abstract：:This study examines strain differences in testosterone (T)-hydroxylations between Wistar and Dark Agouti (DA) rats of both genders. The DA rat, an animal model, is a poor metabolizer of such drugs as debrisoquine, which are metabolized by cytochrome P450 (CYP) 2D. T-16α-, 2α-hydroxylations, which are linked to CYP2C11...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(96)00130-5

    authors： Maeda Y,Morita K,Tasaki T,Kazusaka A,Imaoka S,Funae Y,Fujita S

    更新日期：1997-02-15 00:00:00

  • Effect of active fraction of Eriocaulon sieboldianum on human leukemia K562 cells via proliferation inhibition, cell cycle arrest and apoptosis induction.

    abstract：:Eriocaulon sieboldianum (Sieb. & Zucc. ex Steud.), a genus of Eriocaulon in the Eriocaulaceae family, is an edible and medicinal plant used in traditional Chinese medicine. It was processed into healthcare beverages for expelling wind-heat, protecting eyes, and reducing blood fat. Also, it has been used with other her...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.11.001

    authors： Fan Y,Lu H,An L,Wang C,Zhou Z,Feng F,Ma H,Xu Y,Zhao Q

    更新日期：2016-04-01 00:00:00

  • A comparative study on influences of static electric field and power frequency electric field on cognition in mice.

    abstract：:Recently, electromagnetic fields around ultra-high voltage transmission lines have received considerable attentions for their potential biological effects. This study aimed to investigate the effects of static electric field (SEF) and power frequency electric field (PFEF) on cognition. Mice were exposed to SEF and PFE...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.01.001

    authors： Di G,Kim H,Xu Y,Kim J,Gu X

    更新日期：2019-02-01 00:00:00