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Diclofenac-enriched artificial sediment induces oxidative stress in Hyalella azteca.

Abstract：

:Diclofenac is a nonsteroidal anti-inflammatory drug widely used in Mexico where it is sold over the counter. It enters water bodies through municipal and industrial discharges, posing a risk to water systems and aquatic organisms. Diclofenac-enriched artificial sediment was used to evaluate the toxicity of this pharmaceutical on the sentinel species Hyalella azteca, using oxidative stress biomarkers in order to determine if the set of tests used in this study is a suitable early damage biomarker. The median lethal concentration (72-h LC(50)) was determined and oxidative stress was evaluated using lipid peroxidation, protein carbonyl content to evaluate oxidized protein content, and the activity of superoxide dismutase, catalase, and glutathione peroxidase. All biomarkers were significantly altered. Diclofenac induces oxidative stress in H. azteca and the set of tests used (lipid peroxidation, protein carbonyl content, antioxidant enzyme activities) constitutes an adequate early damage biomarker for evaluating the toxicity of this pharmaceutical group in aquatic species.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Oviedo-Gómez DG,Galar-Martínez M,García-Medina S,Razo-Estrada C,Gómez-Oliván LM

doi

10.1016/j.etap.2009.09.004

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

39-43

issue

1

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(09)00150-1

journal_volume

29

pub_type

杂志文章

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