Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine.

abstract：:Male F344 rats were exposed to potassium bromate (KBrO₃) in drinking water at concentrations of 0, 5, 20, 100, 200, or 400 mg/L for 2 or 13 weeks. Endpoints evaluated included clinical observations, body weights, serum chemistry, gross pathology, organ weights, and select tissue histopathology (kidney, lung, liver, th...

journal_title：Environmental toxicology and pharmacology

authors： Dodd DE,Layko DK,Cantwell KE,Willson GA,Thomas RS

更新日期：2013-11-01 00:00:00

abstract：:Endosulfan, a chlorinated cyclodiene insecticide, is known to cause a significant enhancement of altered hepatic foci in rats and to be a potent inhibitor of gap-junctional intercellular communication in vitro. Both of these features are common to many tumor promoters. However, long-term studies in rodents provide no ...

journal_title：Environmental toxicology and pharmacology

authors： Dubois M,Pfohl-Leszkowicz A,De Waziers I,Kremers P

更新日期：1996-07-15 00:00:00

abstract：:Essential oils from aerial parts of Piper aduncum (Matico) and Piper obliquum (Anis del Oriente) of ecuadorian origin were analyzed by GC-FID, GC-MS, (13)C NMR and their biological and pharmacological activities were assessed. Chemical composition proved to be unusually different from previous reports for safrole-rich...

journal_title：Environmental toxicology and pharmacology

authors： Guerrini A,Sacchetti G,Rossi D,Paganetto G,Muzzoli M,Andreotti E,Tognolini M,Maldonado ME,Bruni R

更新日期：2009-01-01 00:00:00

abstract：:In order to allow an interpretation of in vitro results on the estrogenic potency of 4-nonylphenol (NP) and 4-octylphenol (OP), their distribution and pharmacokinetics were investigated in primary mouse hepatocyte cultures. 10(-5) M NP and 10(-6)M OP were added to the hepatocyte cultures and incubated up to 48 h. The ...

journal_title：Environmental toxicology and pharmacology

authors： Müller S,Schmid P,Schlatter C

更新日期：1998-08-04 00:00:00

abstract：:Antitumor effects of a ginsenoside Rg(3)-fortified red ginseng preparation (Rg(3)-RGP) were investigated in human non-small cell lung carcinoma (H460) cells using in vitro cytotoxicity assay and in vivo nude mouse xenograft model. Immunomodulatory effects of the preparation were also assessed by measuring the facilita...

journal_title：Environmental toxicology and pharmacology

authors： Park D,Bae DK,Jeon JH,Lee J,Oh N,Yang G,Yang YH,Kim TK,Song J,Lee SH,Song BS,Jeon TH,Kang SJ,Joo SS,Kim SU,Kim YB

更新日期：2011-05-01 00:00:00

abstract：:Earthworms are the key soil organisms, contribute to many positive ecological services that could be degraded by pesticides and other soil pollutants such as heavy metals. Chemicals usually occur as mixtures in the environmental systems which can lead synergistic effects. The assessment and characterization of soil po...

journal_title：Environmental toxicology and pharmacology

authors： Uwizeyimana H,Wang M,Chen W,Khan K

更新日期：2017-10-01 00:00:00

abstract：:Effects of aluminum (Al) on membrane properties of excitable cells are not fully understood. Several reports have identified cellular membranes as sensitive targets for Al intoxication. In the present study, we tested the hypothesis that treatment with Al would alter membrane fluidity and potential and these changes w...

journal_title：Environmental toxicology and pharmacology

authors： Johnson VJ,Tsunoda M,Murray TF,Sharma RP

更新日期：2005-02-01 00:00:00

abstract：:Glyphosate is a broad spectrum herbicide used aggressively in agricultural practices as well as home garden care. Although labeled "safe" by the chemical industry, doses tested by industry do not mimic chronic exposures to sublethal doses that organisms in the environment are exposed to over long periods of time. Give...

journal_title：Environmental toxicology and pharmacology

authors： Roy NM,Ochs J,Zambrzycka E,Anderson A

更新日期：2016-09-01 00:00:00

abstract：:CO2, as the typical greenhouse gas causing the greenhouse effect, is a major global environmental problem and has attracted increasing attention from governments. Using algae to eliminate CO2, which has been proposed as an effective way to reduce the greenhouse effect in the past decades, can be disturbed by a growing...

journal_title：Environmental toxicology and pharmacology

authors： Wang T,Zhang X,Tian D,Gao Y,Lin Z,Liu Y,Kong L

更新日期：2015-11-01 00:00:00

abstract：:Ulcerative colitis (UC) is a disease of increased worldwide prevalence. UC progression is associated with serious complications that leave the patient with considerable health burdens. Nifuroxazide is an oral nitrofuran antibiotic used as antidiarrheal medication. The current study places an emphasis on investigating ...

journal_title：Environmental toxicology and pharmacology

authors： El-Far YM,Elsherbiny NM,El-Shafey M,Said E

更新日期：2020-10-01 00:00:00

abstract：:Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Plantamajoside (PMS), a major compound of Plantago asiatica (PA), was reported to have the antioxida...

journal_title：Environmental toxicology and pharmacology

authors： Jung HY,Seo DW,Hong CO,Kim JY,Yang SY,Lee KW

更新日期：2015-01-01 00:00:00

abstract：:Butyl benzyl phthalate (BBP) is commonly added during the manufacturing of plastics to increase flexibility and elasticity. However, BBP leaches off of plastic and environment presence has been detected in soil, groundwater and sediment potentially effecting organisms in the environment. Given the widespread uses of B...

journal_title：Environmental toxicology and pharmacology

authors： Roy NM,Zambrzycka E,Santangelo J

更新日期：2017-12-01 00:00:00

abstract：:Benzene is a well-known environmental pollutant that can induce hematotoxicity, aplastic anemia, acute myelogenous leukemia, and lymphoma. Benzene toxicity is likely mediated through metabolites induced by means of multiple pathways. Although benzene metabolites are known to induce oxidative stress and disrupt the cel...

journal_title：Environmental toxicology and pharmacology

authors： Sarma SN,Kim YJ,Ryu JC

更新日期：2011-09-01 00:00:00

abstract：:It is well established that oxidative stress plays a central role in the onset and progression of over a 100 different diseases. Recently, a growing body of evidence has shown that chemicals/agents as diverse as aromatic compounds, UV radiation and redox-active metals also generate oxy-radicals in vivo and lead to cel...

journal_title：Environmental toxicology and pharmacology

authors： Ashraf SS,Galadari S,Patel M

更新日期：2006-07-01 00:00:00

abstract：:Deoxynivalenol (DON) has broad toxicity in animals and humans. In this study the impact of DON treatment on apoptotic pathways in PC12 cells was determined. The effects of DON were evaluated on (i) typical indicators of apoptosis, including cellular morphology, cell activity, lactate dehydrogenase (LDH) release, and a...

journal_title：Environmental toxicology and pharmacology

authors： Wang X,Xu W,Fan M,Meng T,Chen X,Jiang Y,Zhu D,Hu W,Gong J,Feng S,Wu J,Li Y

更新日期：2016-04-01 00:00:00

abstract：:Mitochondria play a pivotal role in apoptosis of mammalian cells by releasing apoptogenic proteins such as cytochrome c into the cytoplasm. Mitochondrial membrane permeability during apoptosis is regulated directly by the Bcl-2 family of proteins. In glioma cells, there are no specific features of apoptosis compared w...

journal_title：Environmental toxicology and pharmacology

authors： Jin UH,Lee DY,Kim DS,Lee IS,Kim CH

更新日期：2006-09-01 00:00:00

abstract：:We have shown previously that prenatal exposure of rats to 0.5 mg/kg/day of methylmercury (MeHg) produces gender-dependent changes in motor activity in adulthood. In the present study we have investigated whether changes in motor activity could also be found during early ontogeny of the offspring. Pregnant rats were t...

journal_title：Environmental toxicology and pharmacology

authors： Giménez-Llort L,Ahlbom E,Daré E,Vahter M,Ögren S,Ceccatelli S

更新日期：2001-01-01 00:00:00

abstract：:Arsenic (As) widely studied for its effects as a neurotoxicant. The present study was designed to evaluate the protective effect of calcium, zinc or monoisoamyl dimercaptosuccinic acid (MiADMSA), either individually or in combination on As induced oxidative stress and apoptosis in brain regions (cerebral cortex, hippo...

journal_title：Environmental toxicology and pharmacology

authors： Kadeyala PK,Sannadi S,Gottipolu RR

更新日期：2013-11-01 00:00:00

abstract：:Indole-3-carbinol (I3C) is extracted from cruciferous vegetables and is well known for its anti-cancer, antioxidant and anti-inflammatory effects. This study investigated the protective effect of I3C in hyperlipidemia zebrafish larvae and early life stage toxicity of I3C on zebrafish embryos/larvae. Zebrafish larvae w...

journal_title：Environmental toxicology and pharmacology

authors： Jiang Y,Yang G,Liao Q,Zou Y,Du Y,Huang J

更新日期：2019-08-01 00:00:00

abstract：:Prednisolone is a synthetic glucocorticoid used clinically for treating allergies, inflammation, and autoimmune diseases. Long-term prednisolone use has been shown to have negative effects on physiology and mood. We aimed to study the pharmacology and toxicology of glucocorticoid-like drugs by investigating behavioral...

journal_title：Environmental toxicology and pharmacology

authors： Xin N,Jiang Y,Liu S,Zhou Y,Cheng Y

更新日期：2020-04-01 00:00:00

abstract：:Most Thai orchid farmers heavily used pesticide mixtures, and were shown to have various hematologic/immunologic alterations. The present study investigated the effect of exposure of male Wistar rats to a mixture of three pesticides (chlorpyrifos, cypermethrin and captan) that are most often used by the farmers. Three...

journal_title：Environmental toxicology and pharmacology

authors： Aroonvilairat S,Tangjarukij C,Sornprachum T,Chaisuriya P,Siwadune T,Ratanabanangkoon K

更新日期：2018-04-01 00:00:00

abstract：:Impact of smoking on the levels of apolipoprotein B (APOB) was evaluated by analyzing data from National Health and Nutrition Examination Survey for the years 2007-2012 for US adolescents aged 12-19 years and adults aged >=20 years. When adjustments were made for the effects of age, gender, race/ethnicity, body mass i...

journal_title：Environmental toxicology and pharmacology

authors： Jain RB

更新日期：2017-07-01 00:00:00

abstract：:Long non-coding RNAs (LncRNAs) are a category of non-coding RNAs (ncRNAs) with a length of 200nt-100kb lacking a significant open reading frame. The study of lncRNAs is a newly established field, due in part to their capability to act as the novel biomarkers in disease. A growing body of research shows that lncRNAs ma...

journal_title：Environmental toxicology and pharmacology

authors： Chen S,Liang H,Yang H,Zhou K,Xu L,Liu J,Lai B,Song L,Luo H,Peng J,Liu Z,Xiao Y,Chen W,Tang H

更新日期：2017-10-01 00:00:00

abstract：:The present study was aimed to evaluate the effect of morin on blood glucose, insulin level, hepatic glucose regulating enzyme activities and glycogen level in experimental diabetes. Diabetes mellitus was induced by a single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg b.w.). Five days after STZ injecti...

journal_title：Environmental toxicology and pharmacology

authors： Vanitha P,Uma C,Suganya N,Bhakkiyalakshmi E,Suriyanarayanan S,Gunasekaran P,Sivasubramanian S,Ramkumar KM

更新日期：2014-01-01 00:00:00

abstract：:Milk contain compounds acting through the estrogen receptor signaling. The still open question whether such estrogens pose a risk for human health, encouraged us to measure the overall estrogenic activity of cow's milk in the in vitro yeast reporter bioassay. First, we assessed the ability of the bioassay to detect es...

journal_title：Environmental toxicology and pharmacology

authors： Stypuła-Trębas S,Minta M,Radko L,Żmudzki J

更新日期：2015-11-01 00:00:00

abstract：:A thiamine deficiency disease termed M74 syndrome affects the yolk-sac fry of wild and feral Baltic salmon. However, very little is known about the pharmacokinetics of thiamine in salmon. This study examined the pharmacokinetics of thiamine hydrochloride injected intraperitoneally into feral and farmed Baltic salmon f...

journal_title：Environmental toxicology and pharmacology

authors： Koski P,Bäckman C,Pelkonen O

更新日期：2005-01-01 00:00:00

abstract：:The mutagenic and genotoxic effect of 'Rasayanzine', an atrazine herbicide, was carried out in fish Channa punctatus using micronucleus and single cell gel electrophoresis (SCGE) assays. Three sub-lethal concentrations of the test material viz., SL-I (1/5th LC(50)=∼8.48 mgL(-1)), SL-II (1/8th LC(50)=∼5.30 mgL(-1)) and...

journal_title：Environmental toxicology and pharmacology

authors： Nwani CD,Nagpure NS,Kumar R,Kushwaha B,Kumar P,Lakra WS

更新日期：2011-03-01 00:00:00

abstract：:To investigate the effect of infrasound on the hippocampus-dependent spatial learning and memory as well as its underlying mechanisms, we measured the changes of cognitive abilities, brain-derived neurotrophic factor (BDNF)-tyrosine kinase receptor B (TrkB) signal transduction pathway and neurogenesis in the hippocamp...

journal_title：Environmental toxicology and pharmacology

authors： Yuan H,Long H,Liu J,Qu L,Chen J,Mou X

更新日期：2009-09-01 00:00:00

abstract：:Taurine (TAU) has protective effects on experimental liver fibrosis. The present study investigates whether benefits of TAU are mediated through attenuation of oxidative and nitrosative stresses. Liver fibrosis was induced in male Wistar rats by simultaneous administration of iron (0.5%, w/w) and ethanol (6g/kg/day) f...

journal_title：Environmental toxicology and pharmacology

authors： Devi SL,Anuradha CV

更新日期：2010-03-01 00:00:00

abstract：:Trichosanthin (TCS) is a type 1 ribosome inactivating protein extracted from Chinese medicinal herb. It possesses various biological functions such as abortifacient, anti-tumor and anti-viral activities. Clinical trial of this compound against human immunodeficiency virus (HIV) had been conducted. However, its use is ...

journal_title：Environmental toxicology and pharmacology

authors： Chan HM,Tam SC

更新日期：2005-07-01 00:00:00