Deoxynivalenol induces apoptosis in PC12 cells via the mitochondrial pathway.

abstract：:Deltamethrin, is a commonly used pyrethroid pesticide. Vitamin E is a antioxidant that plays an important role in protecting cells against toxicity by inactivating free radicals generated following pesticides exposure. Therefore, it was evaluated whether deltamethrin induced histopathological changes and nuclear abnor...

journal_title：Environmental toxicology and pharmacology

authors： Kan Y,Cengiz EI,Ugurlu P,Yanar M

更新日期：2012-09-01 00:00:00

abstract：:There are significant challenges in assessing the toxicity of nanoparticles in the environment in which effective methods for detection are crucial. An inexpensive method that uses superhydrophobic well with an evaporating droplet followed by a simple squeeze flow is described here and found to provide practical high ...

journal_title：Environmental toxicology and pharmacology

authors： Cheong BH,Muradoglu M,Liew OW,Ng TW

更新日期：2015-07-01 00:00:00

abstract：:The use of surfactants in the development of a suitable formulation for insecticides should improve the solubility behavior, the permeability and the efficiency against pests meanwhile decrease the toxic risks of insecticides on human health. Cytotoxicity of insecticides including abamectin, chlorfluazuron, hexaflumur...

journal_title：Environmental toxicology and pharmacology

authors： Li D,Wu X,Yu X,Huang Q,Tao L

更新日期：2015-03-01 00:00:00

abstract：:Using the European common frog, Rana temporaria, as a model, we have studied the organ-specific gene expression patterns of thyroid hormone receptor isoforms after exposure to an organochlorine (OC) compound, p,p'-DDE. Four groups of frogs were subcutaneously injected with p,p'-DDE at 0.01, 0.1, 1 and 10mg/kg body wei...

journal_title：Environmental toxicology and pharmacology

authors： Arukwe A,Jenssen BM

更新日期：2005-11-01 00:00:00

abstract：:Drug-induced blood dyscrasias can be either acute and predictable or delayed and unpredictable (idiosyncratic). The predictable toxicity is relatively easy to reproduce with in vitro models, although they may not work for drugs that require bioactivation. It is very unlikely that idiosyncratic blood dyscrasias can be ...

journal_title：Environmental toxicology and pharmacology

authors： Ip J,Uetrecht JP

更新日期：2006-02-01 00:00:00

abstract：:We have identified two most significant biomarker genes, CYP1A1 (69.81 up-regulation) and MT1K (14.66 up-regulation), showing highest overexpression at p-value <0.005. These were selected out of several hundred genes induced in vitro, using PCB exposed human liver (HepG2) cells. Over expression of the CYP1A1 (cytochro...

journal_title：Environmental toxicology and pharmacology

authors： Dutta SK,Ghosh S,De S,Hoffman EP

更新日期：2008-03-01 00:00:00

abstract：:After the administration of 2,2',4,5,5'-pentachlorobiphenyl (2,2',4,5,5'-pentaCB) to intact rats, the concentration of 2,2',4,5,5'-pentaCB in liver gradually decreased, whereas 3-methylsulfonyl (3-MeSO(2))-2,2',4',5,5'-pentaCB appeared in liver and remained detectable in liver for 6 weeks. A single injection of 2,2',4...

journal_title：Environmental toxicology and pharmacology

authors： Kato Y,Haraguchi K,Tomiyasu K,Saito H,Shibahara T,Masuda Y,Kimura R

更新日期：1999-12-01 00:00:00

abstract：:This study is intended to explore effective and sensitive biomarkers for kidney damage after low level arsenic (As) exposure and to provide scientific evidence on cut-off values of arsenic concentrations in drinking water. The levels of α1-MG detected in urine samples were found to have statistically significant diffe...

journal_title：Environmental toxicology and pharmacology

authors： Feng H,Gao Y,Zhao L,Wei Y,Li Y,Wei W,Wu Y,Sun D

更新日期：2013-05-01 00:00:00

abstract：UNLABELLED:The studies aimed at evaluation of cigarette smoke effect on heart rate turbulence (HRT) in patients with arterial hypertension (AH). 223 consecutive individuals were qualified to the studies. The following groups of patients not suffering from other disease which may affect HRT were distinguished: 1--patien...

journal_title：Environmental toxicology and pharmacology

authors： Gać P,Sobieszczańska M

更新日期：2014-03-01 00:00:00

abstract：:Diclofenac has recently been identified as a cause of the widespread vulture decline on the Indian subcontinent. Although the clinical signs and pathology have been described, the pathophysiology of toxicity remains unexplained. In the following study we attempt to validate the domestic fowl as a model, to allow for t...

journal_title：Environmental toxicology and pharmacology

authors： Naidoo V,Duncan N,Bekker L,Swan G

更新日期：2007-11-01 00:00:00

abstract：:Cadmium (Cd) is a toxic heavy metal, and exposure to Cd causes a range of changes within the cell. At high concentrations, Cd causes damage to cells via a range of mechanisms. At low concentrations, Cd can stimulate expression of genes that are part of an adaptive response. In this study, we have used the astrocytoma ...

journal_title：Environmental toxicology and pharmacology

authors： Lawal AO,Ellis EM

更新日期：2011-07-01 00:00:00

abstract：:HC Orange No. 1 (HCO1, 2-nitro-4'-hydroxydiphenylamine) (CAS No. 54381-08-7) is used as a colorant in commercial hair dyes. The cytotoxicity of HCO1 to L929 mouse connective tissue fibroblast cells was determined by use of a battery of endpoints that included electron transport activity determined by the MTT assay and...

journal_title：Environmental toxicology and pharmacology

authors： Liu H,Chen J,Jiang J,Giesy JP,Yu H,Wang X

更新日期：2008-11-01 00:00:00

abstract：:A water extract of the lyophilised fresh-water alga Anabaena flos-aquae enhanced substantially the release of [(3)H]acetylcholine ([(3)H]acetylcholine and [(3)H]choline) from cholinergic nerves of rat bronchi. Parallel experiments performed with the related species Anabaena lemmermannii did not demonstrate this effect...

journal_title：Environmental toxicology and pharmacology

authors： Ruge Holte H,Eriksen S,Skulberg O,Aas P

更新日期：1998-01-01 00:00:00

abstract：:Insulin resistance and risk of type 2 diabetes are the most important complications following exposure to organophosphorous (OPs) pesticides. Regarding the importance of liver on metabolic pathways regulation, in particular blood glucose homeostasis, we focused on liver inflammation and oxidative damages in a subchron...

journal_title：Environmental toxicology and pharmacology

authors： Lasram MM,Dhouib IB,Bouzid K,Lamine AJ,Annabi A,Belhadjhmida N,Ahmed MB,Fazaa SE,Abdelmoula J,Gharbi N

更新日期：2014-09-01 00:00:00

abstract：:Safrole is a natural compound categorized as a group 2B carcinogen extracted from betel quid chewing, which is a common practice of psychoactive habits integrated into social and cultural ceremonies among serveral million people, especially in Southern or Southeastern Asia. Safrole is one of the major risk compunds fo...

journal_title：Environmental toxicology and pharmacology

authors： Chien KJ,Yang ML,Tsai PK,Su CH,Chen CH,Horng CT,Yeh CH,Chen WY,Lin ML,Chen CJ,Chian CY,Kuan YH

更新日期：2018-12-01 00:00:00

abstract：:To explore the effects of microcystin-LR (MC-LR), a hepatotoxin, on the incidence of liver lipid metabolism abnormality, and the potential molecular mechanisms of action, healthy male Balb/c mice were intraperitoneally injected with MC-LR at doses of 0, 5, 10, and 20 μg/kg/d for 14 days. Hepatic histopathology and ser...

journal_title：Environmental toxicology and pharmacology

authors： Qin W,Zhang X,Yang L,Xu L,Zhang Z,Wu J,Wang Y

更新日期：2015-07-01 00:00:00

abstract：:Effects of lethal and sublethal concentrations 15, 20, 26 and 35 μg/l of zeta cypermethrin on the gills of common guppies (L. reticulatus) were examined by light microscopy during 96 h exposure. The most common changes at all doses of zeta cypermethrin are the lifting of epithelial layer from gill lamellae and some ne...

journal_title：Environmental toxicology and pharmacology

authors： Caliskan M,Erkmen B,Yerli SV

更新日期：2003-09-01 00:00:00

abstract：:A series of N(1)-benzylidene pyridine-2-carboxamidrazone anti-tuberculosis compounds has been evaluated for their cytotoxicity using human mononuclear leucocytes (MNL) as target cells. All eight compounds were significantly more toxic than dimethyl sulphoxide control and isoniazid (INH) with the exception of a 4-metho...

journal_title：Environmental toxicology and pharmacology

authors： Coleman MD,Tims KJ,Rathbone DL

更新日期：2003-06-01 00:00:00

abstract：:Although neurotoxicity and hepatotoxicity have long been associated with exposure to polychlorinated biphenyls (PCBs), less is known about the selective toxicity of those hydroxylated PCBs (OH-PCBs) and PCB sulfates that are metabolites derived from exposure to PCBs found in indoor air. We have examined the toxicity o...

journal_title：Environmental toxicology and pharmacology

authors： Rodriguez EA,Vanle BC,Doorn JA,Lehmler HJ,Robertson LW,Duffel MW

更新日期：2018-09-01 00:00:00

abstract：:Cadmium (Cd) is a major pollutant of environment. It can be fatal to human. In spite of bulk of research and literatures, the mechanism of a fatality against human is still not understood completely. Toxic and carcinogenic effects of Cd in rodents and humans are well known. However, effects of Cd on induction of apopt...

journal_title：Environmental toxicology and pharmacology

authors： Al-Assaf AH,Alqahtani AM,Alshatwi AA,Syed NA,Shafi G,Hasan TN

更新日期：2013-11-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is known to affect various cellular activities including growth factor signal transduction, hormone responses, and cell differentiation. The purpose of this study was to examine more closely the very early effects of TCDD on protein tyrosine kinase activity, specifically p60(...

journal_title：Environmental toxicology and pharmacology

authors： Blankenship A,Matsumura F

更新日期：1997-07-01 00:00:00

abstract：:Mining activities including mineral excavation and ore transportation produce and release large amounts of pollutants to the surrounding environment, raising concerns regarding the effects of environmental exposure to pollutants on human health. The concentration of elements in hair can be used as a biomarker of expos...

journal_title：Environmental toxicology and pharmacology

authors： Pan Y,Li H

更新日期：2015-11-01 00:00:00

abstract：:In order to allow an interpretation of in vitro results on the estrogenic potency of 4-nonylphenol (NP) and 4-octylphenol (OP), their distribution and pharmacokinetics were investigated in primary mouse hepatocyte cultures. 10(-5) M NP and 10(-6)M OP were added to the hepatocyte cultures and incubated up to 48 h. The ...

journal_title：Environmental toxicology and pharmacology

authors： Müller S,Schmid P,Schlatter C

更新日期：1998-08-04 00:00:00

abstract：:Although airborne chemicals can directly elicit adverse reactions via stimulation of the olfactory and trigeminal nerves, such as sensory irritation of the mucous membranes of the eyes, nose and throat, an individual's subjective experience is often the result of a complex sequence of events involving those sensory, p...

journal_title：Environmental toxicology and pharmacology

authors： Smeets MA,Dalton PH

更新日期：2005-05-01 00:00:00

abstract：:We examined the genotoxicity of diaveridine and trimethoprim in the bacterial umu test, the bacterial reverse mutation test, the in vitro chromosome aberration test, the in vivo rodent bone marrow micronucleus test in two species, and the in vivo comet assay in five mouse organs. Both compounds were negative in the um...

journal_title：Environmental toxicology and pharmacology

authors： Ono T,Sekiya T,Takahashi Y,Sasaki YF,Izumiyama F,Nishidate E,Tsuda S,Ohta T

更新日期：1997-09-01 00:00:00

abstract：:Antitumor effects of a ginsenoside Rg(3)-fortified red ginseng preparation (Rg(3)-RGP) were investigated in human non-small cell lung carcinoma (H460) cells using in vitro cytotoxicity assay and in vivo nude mouse xenograft model. Immunomodulatory effects of the preparation were also assessed by measuring the facilita...

journal_title：Environmental toxicology and pharmacology

authors： Park D,Bae DK,Jeon JH,Lee J,Oh N,Yang G,Yang YH,Kim TK,Song J,Lee SH,Song BS,Jeon TH,Kang SJ,Joo SS,Kim SU,Kim YB

更新日期：2011-05-01 00:00:00

abstract：:Arsenic (As) widely studied for its effects as a neurotoxicant. The present study was designed to evaluate the protective effect of calcium, zinc or monoisoamyl dimercaptosuccinic acid (MiADMSA), either individually or in combination on As induced oxidative stress and apoptosis in brain regions (cerebral cortex, hippo...

journal_title：Environmental toxicology and pharmacology

authors： Kadeyala PK,Sannadi S,Gottipolu RR

更新日期：2013-11-01 00:00:00

abstract：:Since hypoxia-inducible factor-1α (HIF-1α) is the key transcription factor that enables cells to survive in hypoxia, we have investigated whether an upregulation of HIF-1α prevents the noise-induced hearing loss in BALB/c hybrid mice, which were intraperitoneally injected with CoCl(2) (a HIF-1α inducer) and exposed to...

journal_title：Environmental toxicology and pharmacology

authors： Chung JW,Shin JE,Han KW,Ahn JH,Kim YJ,Park JW,So HS

更新日期：2011-01-01 00:00:00

abstract：:Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts glucose to sorbitol. It plays a vital role as a glucose reducing agent and is involved in the pathophysiology of diabetic complications. In this st...

journal_title：Environmental toxicology and pharmacology

authors： Demir Y,Özaslan MS,Duran HE,Küfrevioğlu Öİ,Beydemir Ş

更新日期：2019-08-01 00:00:00

abstract：:We investigated whether treatment with N-acetylcysteine (NAC) reduces oxidative stress intensity and restores the expression and activities of superoxide dismutase (Sod1, SOD), catalase (Cat, CAT) and glutathione peroxidase (Gpx1, GPx) in lead-exposed workers. The exposed population was divided randomly into two group...

journal_title：Environmental toxicology and pharmacology

authors： Kasperczyk S,Dobrakowski M,Kasperczyk A,Machnik G,Birkner E

更新日期：2014-03-01 00:00:00