Cytotoxicity of HC Orange NO. 1 to L929 fibroblast cells.

abstract：:Glutathione S-transferase isoenzymes (GSTs) play a critical role in detoxification pathways. Here we report the tissue distribution of four antioxidant GSTs gene in common carp, and their expression profiles. We also investigated the GSTs activity in different tissues after exposure to the agricultural chemicals atraz...

journal_title：Environmental toxicology and pharmacology

authors： Xing H,Wang X,Sun G,Gao X,Xu S,Wang X

更新日期：2012-03-01 00:00:00

abstract：:Most Thai orchid farmers heavily used pesticide mixtures, and were shown to have various hematologic/immunologic alterations. The present study investigated the effect of exposure of male Wistar rats to a mixture of three pesticides (chlorpyrifos, cypermethrin and captan) that are most often used by the farmers. Three...

journal_title：Environmental toxicology and pharmacology

authors： Aroonvilairat S,Tangjarukij C,Sornprachum T,Chaisuriya P,Siwadune T,Ratanabanangkoon K

更新日期：2018-04-01 00:00:00

abstract：:In utero exposure of neonates to pesticide residues could be damaging to the reproductive tract. Hence, the present study assessed the circulating concentrations of pesticide residues in buffalo and their neonatal calves as well as in the reproductive tract tissue samples of same calves. Also, histopathological altera...

journal_title：Environmental toxicology and pharmacology

authors： Kaur K,Ghuman SS,Singh O,Bedi JS,Gill JP

更新日期：2015-11-01 00:00:00

abstract：:N-Phenyl benzamides are potent antibacterial agents. They are active against both Gram-positive and Gram-negative bacteria. The Gram-positive bacteria have strong and thick cell wall while the Gram-negative bacterial have thin and permeable cell wall. The DFT based QSAR reveals that molecular weight and total energy s...

journal_title：Environmental toxicology and pharmacology

authors： Pasha FA,Muddassar M,Lee C,Cho SJ

更新日期：2008-09-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are environmental contaminants found in the serum of human populations across the globe. A small set of sentinel PCB congeners (IUPAC# 101, 118, 138, 153, and 180) commonly sought in human serum are often used as markers of exposure. The Chicago Great Lakes cohort of pregnant African A...

journal_title：Environmental toxicology and pharmacology

authors： McGraw JE,Waller DP

更新日期：2009-01-01 00:00:00

abstract：:To elucidate the potential thyroid disrupting effects of refuse leachate on females, female goldfish (Carassius auratus) were exposed to 0.5% diluted leachates from each step of a leachate treatment process (i.e. raw leachate before treatment, after membrane bioreactor treatment, and the final treated leachate) for 21...

journal_title：Environmental toxicology and pharmacology

authors： Gong Y,Tian H,Zhang X,Dong Y,Wang W,Ru S

更新日期：2016-12-01 00:00:00

abstract：:The in situ evaluation of the genotoxic impact of the Karaj River was performed using the comet and micronucleus (MN) assays in erythrocytes, liver, gill and kidney of indigenous brown trout, Salmo trutta fario from three different stations, including Varangerud, Asara and Purkan. The results showed that DNA damage si...

journal_title：Environmental toxicology and pharmacology

authors： Hariri M,Mirvaghefi A,Farahmand H,Taghavi L,Shahabinia AR

更新日期：2018-03-01 00:00:00

abstract：:Hydroquinone (HQ) is a myelotoxin that is found in many foods and formed through the metabolism of benzene. HQ is genotoxic in several in vitro and in vivo test systems, inducing micronuclei (MN), sister-chromatid exchange (SCE), and chromosomal aberrations. The aim of the current study was to explore the protective e...

journal_title：Environmental toxicology and pharmacology

authors： Ghaly IS,Said A,Abdel-Wahhab MA

更新日期：2008-01-01 00:00:00

abstract：:This study aims to investigate potential toxic effects of chrysene (CHR) on mature scallop Chlamys farreri during the reproduction period, using indicators of antioxidant defences and oxidative stress. Scallops were exposed to 0.2, 0.8 and 3.2μg/L waterborne CHR for 21 days, at day 10 scallops were induced to spawn. A...

journal_title：Environmental toxicology and pharmacology

authors： Xiu M,Pan L,Jin Q

更新日期：2016-06-01 00:00:00

abstract：:The protective effects of lobenzarit disodium against the toxicity of allyl alcohol were investigated in vitro using isolated rat hepatocytes and in vivo using mice. In mice, at i.p doses of 25, 50 and 100 mg/kg lobenzarit significantly decreased the activity of alanine amino transferase (ALT) in serum and the concent...

journal_title：Environmental toxicology and pharmacology

authors： Remirez D,Commandeur JN,Groot E,Gonzalez R,Rodriguez S,Ancheta O,Rojas E,Ramos ME,Vermeulen NP

更新日期：1997-06-06 00:00:00

abstract：:The metabolites of oestrogenic substances of plant origin, phyto-oestrogens, have been proposed as cancer-protective agents in Asian and vegetarian populations. The two principle classes of these weak oestrogens are isoflavonoids and mammalian lignans. The former is derived from soya-based foods and the latter from oi...

journal_title：Environmental toxicology and pharmacology

authors： Morton M,Arisaka O,Miyake A,Evans B

更新日期：1999-07-01 00:00:00

abstract：:Using the European common frog, Rana temporaria, as a model, we have studied the organ-specific gene expression patterns of thyroid hormone receptor isoforms after exposure to an organochlorine (OC) compound, p,p'-DDE. Four groups of frogs were subcutaneously injected with p,p'-DDE at 0.01, 0.1, 1 and 10mg/kg body wei...

journal_title：Environmental toxicology and pharmacology

authors： Arukwe A,Jenssen BM

更新日期：2005-11-01 00:00:00

abstract：:Chlorinated derivatives of bisphenol A (ClBPAs) have been detected in wastewater from waste paper recycling plants. BPA and ClBPAs are always exposed to ultraviolet (UV) radiation in the environment and consequently various photoproducts might be produced. Acute cytotoxicity of photoproducts of BPA and ClBPAs are not ...

journal_title：Environmental toxicology and pharmacology

authors： Mutou Y,Ibuki Y,Terao Y,Kojima S,Goto R

更新日期：2006-05-01 00:00:00

abstract：:Arsenic (As) widely studied for its effects as a neurotoxicant. The present study was designed to evaluate the protective effect of calcium, zinc or monoisoamyl dimercaptosuccinic acid (MiADMSA), either individually or in combination on As induced oxidative stress and apoptosis in brain regions (cerebral cortex, hippo...

journal_title：Environmental toxicology and pharmacology

authors： Kadeyala PK,Sannadi S,Gottipolu RR

更新日期：2013-11-01 00:00:00

abstract：:Bisphenol-A (BPA) has been classified as an endocrine disruptor which disrupts normal cell function by acting as an estrogen agonist. Environmentally relevant doses of the Bisphenol-A have profound effects on rat endocrine pancreas, an essential organ involved in glucose homeostasis. Bisphenol-A acts on insulin releas...

journal_title：Environmental toxicology and pharmacology

authors： Jayashree S,Indumathi D,Akilavalli N,Sathish S,Selvaraj J,Balasubramanian K

更新日期：2013-03-01 00:00:00

abstract：:Aromatase catalyzes intraneuronal conversion of androgens to estrogens in the hypothalamus-preoptic area at a specific time during development. This local estrogen formation has a central role in sexual differentiation. To investigate the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on sexual differentiation,...

journal_title：Environmental toxicology and pharmacology

authors： Ikeda M,Inukai N,Mitsui T,Sone H,Yonemoto J,Tohyama C,Tomita T

更新日期：2002-01-01 00:00:00

abstract：:The study investigated the correlation between infarction areas and behavioural deficits in middle cerebral artery occlusion (MCAO) and photothrombosis stroke models. In the MCAO model, a 0.38 mm-diameter silicone-coated thread was introduced through the left external carotid artery and advanced 18 mm via the internal...

journal_title：Environmental toxicology and pharmacology

authors： Choi BI,Park D,Lee SH,Bae DK,Yang G,Yang YH,Kim TK,Choi EK,Lee HJ,Choi KC,Nahm SS,Kim YB

更新日期：2012-01-01 00:00:00

abstract：:Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of N...

journal_title：Environmental toxicology and pharmacology

authors： Zhang J,Zhou X,Wu W,Wang J,Xie H,Wu Z

更新日期：2017-04-01 00:00:00

abstract：:In assessing interindividual variability in metabolic activation, the toxic metabolite is often too unstable for conventional analysis. Possible alternatives include a stable product of the reactive metabolite e.g. cysteinyl derivatives of N-acetyl-4-benzoquinoneimine, the toxic metabolite of paracetamol, adducts with...

journal_title：Environmental toxicology and pharmacology

authors： Boobis AR

更新日期：1996-10-15 00:00:00

abstract：:Safrole is a natural compound categorized as a group 2B carcinogen extracted from betel quid chewing, which is a common practice of psychoactive habits integrated into social and cultural ceremonies among serveral million people, especially in Southern or Southeastern Asia. Safrole is one of the major risk compunds fo...

journal_title：Environmental toxicology and pharmacology

authors： Chien KJ,Yang ML,Tsai PK,Su CH,Chen CH,Horng CT,Yeh CH,Chen WY,Lin ML,Chen CJ,Chian CY,Kuan YH

更新日期：2018-12-01 00:00:00

abstract：:To evaluate an influence of dioxin on a daily variation of insulin sensitivity, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100ng/kg) was given for 3 weeks in mice. Insulin tolerance test and oral glucose tolerance test were performed. TCDD decreased insulin sensitivity at an active period, but not at a rest period. T...

journal_title：Environmental toxicology and pharmacology

authors： Takuma M,Ushijima K,Kumazaki M,Ando H,Fujimura A

更新日期：2015-09-01 00:00:00

abstract：:The effect of 6 MFA (Sixth mycelial fraction of acetone), an interferon inducer obtained from fungus Aspergillus ochraceus, on rifampicin toxicity was studied in rats. Chronic oral administration of rifampicin (1 g/kg per day) for 30 days produced thrombocytopenia, hemolytic anaemia, transient leukopenia and increased...

journal_title：Environmental toxicology and pharmacology

authors： Dhuley JN,Naik SR

更新日期：1998-06-02 00:00:00

abstract：:This study aimed to observe the therapeutic effects of magnesium lithospermate B on acute and chronic colitis induced by dextran sodiumsulfate (DSS) and the role of inflammasome complex (NOD-like receptor protein, NLRP; apoptosis-associated speck-like protein containing, ASC; caspase-1). Establishment of acute and chr...

journal_title：Environmental toxicology and pharmacology

authors： Jiang X,Zhong L,Sun D,Rong L

更新日期：2016-01-01 00:00:00

abstract：:Radiation-induced inflammation plays an important role in radiation-induced tissue injury. 18β-glycyrrhetinic acid (18β-GA) has shown an anti-inflammatory activity. This study aimed to assess the activity of 18β-GA against radiation-induced skin damage, and explore the underlying mechanisms. In vitro assay revealed 18...

journal_title：Environmental toxicology and pharmacology

authors： Su L,Wang Z,Huang F,Lan R,Chen X,Han D,Zhang L,Zhang W,Hong J

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:: Coughing is one of the chronic respiratory symptoms of patients exposed to sulfur mustard (SM) used against Iranian combatants and civilians by Iraq during the Iran-Iraq war, between 1983 and 1989. This study carried out on SM exposed patients who referred to our clinic because of exacerbation of chronic c...

journal_title：Environmental toxicology and pharmacology

authors： Ghanei M,Hosseini AR,Arabbaferani Z,Shahkarami E

更新日期：2005-07-01 00:00:00

abstract：:Cigarette smoke (CS) is a well-known risk factor for carcinogenesis and has been found to be related to the occurrence and development of colon cancer. In this study, the effect of formaldehyde (FA), benzene (Bz), and isoprene (IP), which are included in main components of CS, on cell viability and apoptosis of SW620 ...

journal_title：Environmental toxicology and pharmacology

authors： Lee HM,Kim CW,Hwang KA,Choi DW,Choi KC

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND AIMS:To find new diagnostic markers to monitor isoniazid-induced liver injury. METHODS:SD rats were treated with low dosage of isoniazid and the light microscopic findings of livers were collected. The methylation status of cytochrome p450 2E1 promoter was determined. RESULTS:Cell edema and spotty necr...

journal_title：Environmental toxicology and pharmacology

authors： Shen L,Zhang B,Sun S,Feng F

更新日期：2013-07-01 00:00:00

abstract：:Coniferaldehyde (CA) exerts anti-inflammatory properties by inducing heme oxygenase-1 (HO-1). To define the regulation mechanism by which CA induces a cytoprotective function and HO-1 expression, the up-stream regulations involved in the activation of nuclear transcription factor-erythroid 2-related factor (Nrf)-2/HO-...

journal_title：Environmental toxicology and pharmacology

authors： Kim KM,Heo DR,Kim YA,Lee J,Kim NS,Bang OS

更新日期：2016-12-01 00:00:00

abstract：:The histopathological effects of deltamethrin on the gill and kidney tissues of the common carp, Cyprinus carpio were determined by light microscopy. The fish were exposed to 0.029mgl(-1) (50% of 96h LC(50)) and 0.041mgl(-1) (70% of 96h LC(50)) solutions of deltamethrin for short-term (96h). The most common gill chang...

journal_title：Environmental toxicology and pharmacology

authors： Cengiz EI

更新日期：2006-09-01 00:00:00

abstract：:In order to better inform scientific decision making in the occupational environment, we need a better understanding of the toxicology of mixed exposures. In particular, we need an understanding of the dose-response relationship from the level of individual or population exposure down to the molecular level (and then ...

journal_title：Environmental toxicology and pharmacology

authors： Robinson P,Macdonell M

更新日期：2004-12-01 00:00:00