Inhibition effects of quinones on aldose reductase: Antidiabetic properties.

Abstract:

:Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts glucose to sorbitol. It plays a vital role as a glucose reducing agent and is involved in the pathophysiology of diabetic complications. In this study, we purified AR from sheep kidney with a specific activity of 2.00 EU/mg protein and 133.33- fold purification After the purification of the AR enzyme, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) was performed and the molecular weight of the enzyme was found approximately as 38 kDa. The inhibition effects of eight quinones were studied against AR. The quinones were potent inhibitors of AR with Ki values in the range of 0.07-20.04 μM. Anthraquinone showed the best potential inhibitory effects against AR. All compounds exhibited noncompetitive inhibition against AR. These compounds may be selective inhibitors of this enzyme. AR inhibition is an essential strategy for the attenuation and prevention of diabetic complications.

authors

Demir Y,Özaslan MS,Duran HE,Küfrevioğlu Öİ,Beydemir Ş

doi

10.1016/j.etap.2019.103195

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

103195

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(19)30062-6

journal_volume

70

pub_type

杂志文章
  • Mitochondria protection of baicalein against oxidative damage via induction of manganese superoxide dismutase.

    abstract::This study investigated the cytoprotective effect of baicalein (5,6,7-trihydroxyflavone) against oxidative stress-induced mitochondrial dysfunction. Electron spin resonance (ESR) spectrometry revealed that baicalein showed significant scavenging effects on superoxide radicals and hydroxyl radicals. When H(2)O(2) treat...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2010.11.002

    authors: Lee IK,Kang KA,Zhang R,Kim BJ,Kang SS,Hyun JW

    更新日期:2011-01-01 00:00:00

  • Induction of mitochondria-mediated apoptosis by methanol fraction of Ulmus davidiana Planch (Ulmaceae) in U87 glioblastoma cells.

    abstract::Mitochondria play a pivotal role in apoptosis of mammalian cells by releasing apoptogenic proteins such as cytochrome c into the cytoplasm. Mitochondrial membrane permeability during apoptosis is regulated directly by the Bcl-2 family of proteins. In glioma cells, there are no specific features of apoptosis compared w...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2006.01.005

    authors: Jin UH,Lee DY,Kim DS,Lee IS,Kim CH

    更新日期:2006-09-01 00:00:00

  • Mutagenicity of 3-methylcholanthrene, pcb3, and 4-oh-pcb3 in the lung of transgenic bigblue rats.

    abstract::Recent findings of high levels of predominantly lower chlorinated biphenyls in indoor and outdoor air open the question of possible health consequences. Lower chlorinated biphenyls are more readily metabolized to reactive and potentially harmful intermediates, acting as mutagens and cancer initiators. The goal of this...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2007.10.021

    authors: Maddox C,Wang B,Kirby PA,Wang K,Ludewig G

    更新日期:2008-03-01 00:00:00

  • Evaluation of dose-response curve analysis in delineating shared or different molecular sites of action for osteolathyrogens.

    abstract::Single-chemical and mixture concentration-response curves generated using a frog embryo model were examined for value in assessing whether chemicals exert toxic effects at the same or at different molecular sites of action. Toxicity tests were conducted on a series of osteolathyrogens, i.e. chemicals that inhibit cros...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2003.08.002

    authors: Dawson DA,Scott BD,Ellenberger MJ,Pöch G,Rinaldi AC

    更新日期:2004-03-01 00:00:00

  • In situ assessment of Karaj River genotoxic impact with the alkaline comet assay and micronucleus test, on feral brown trout (Salmo trutta fario).

    abstract::The in situ evaluation of the genotoxic impact of the Karaj River was performed using the comet and micronucleus (MN) assays in erythrocytes, liver, gill and kidney of indigenous brown trout, Salmo trutta fario from three different stations, including Varangerud, Asara and Purkan. The results showed that DNA damage si...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2017.12.024

    authors: Hariri M,Mirvaghefi A,Farahmand H,Taghavi L,Shahabinia AR

    更新日期:2018-03-01 00:00:00

  • Mutagenic and genotoxic assessment of atrazine-based herbicide to freshwater fish Channa punctatus (Bloch) using micronucleus test and single cell gel electrophoresis.

    abstract::The mutagenic and genotoxic effect of 'Rasayanzine', an atrazine herbicide, was carried out in fish Channa punctatus using micronucleus and single cell gel electrophoresis (SCGE) assays. Three sub-lethal concentrations of the test material viz., SL-I (1/5th LC(50)=∼8.48 mgL(-1)), SL-II (1/8th LC(50)=∼5.30 mgL(-1)) and...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2010.12.001

    authors: Nwani CD,Nagpure NS,Kumar R,Kushwaha B,Kumar P,Lakra WS

    更新日期:2011-03-01 00:00:00

  • Differential gene expression profiles of human leukemia cell lines exposed to benzene and its metabolites.

    abstract::Benzene is a well-known environmental pollutant that can induce hematotoxicity, aplastic anemia, acute myelogenous leukemia, and lymphoma. Benzene toxicity is likely mediated through metabolites induced by means of multiple pathways. Although benzene metabolites are known to induce oxidative stress and disrupt the cel...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2011.06.001

    authors: Sarma SN,Kim YJ,Ryu JC

    更新日期:2011-09-01 00:00:00

  • Gene expression profiling of nephrotoxicity from copper nanoparticles in rats after repeated oral administration.

    abstract::The goal of this study was to investigate the mechanisms of nanocopper-induced nephrotoxicity by analyzing renal gene expression profiles phenotypically anchored to conventional toxicological outcomes. Male Wistar rats were given nanocopper (50, 100, 200 mg/kg) and microcopper (200 mg/kg) at different doses for 5 days...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2011.05.014

    authors: Liao M,Liu H

    更新日期:2012-07-01 00:00:00

  • Altered expression profiles of microRNAs upon arsenic exposure of human umbilical vein endothelial cells.

    abstract::Recent studies in our laboratory indicated that arsenite at 20μM significantly induces the apoptosis of HUVECs. In this study we analyzed miRNAs expression profiles upon arsenic exposure of these cells to explore the molecular mechanisms of arsenic-induced vascular toxicity. The expression of miRNAs was examined by Ex...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2012.05.003

    authors: Li X,Shi Y,Wei Y,Ma X,Li Y,Li R

    更新日期:2012-09-01 00:00:00

  • Safrole induced cytotoxicity, DNA damage, and apoptosis in macrophages via reactive oxygen species generation and Akt phosphorylation.

    abstract::Safrole is a natural compound categorized as a group 2B carcinogen extracted from betel quid chewing, which is a common practice of psychoactive habits integrated into social and cultural ceremonies among serveral million people, especially in Southern or Southeastern Asia. Safrole is one of the major risk compunds fo...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2018.09.012

    authors: Chien KJ,Yang ML,Tsai PK,Su CH,Chen CH,Horng CT,Yeh CH,Chen WY,Lin ML,Chen CJ,Chian CY,Kuan YH

    更新日期:2018-12-01 00:00:00

  • Application of the yeast-based reporter gene bioassay for the assessment of estrogenic activity in cow's milk from Poland.

    abstract::Milk contain compounds acting through the estrogen receptor signaling. The still open question whether such estrogens pose a risk for human health, encouraged us to measure the overall estrogenic activity of cow's milk in the in vitro yeast reporter bioassay. First, we assessed the ability of the bioassay to detect es...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.09.022

    authors: Stypuła-Trębas S,Minta M,Radko L,Żmudzki J

    更新日期:2015-11-01 00:00:00

  • Association of inflammatory response and oxidative injury in the pathogenesis of liver steatosis and insulin resistance following subchronic exposure to malathion in rats.

    abstract::Insulin resistance and risk of type 2 diabetes are the most important complications following exposure to organophosphorous (OPs) pesticides. Regarding the importance of liver on metabolic pathways regulation, in particular blood glucose homeostasis, we focused on liver inflammation and oxidative damages in a subchron...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.08.007

    authors: Lasram MM,Dhouib IB,Bouzid K,Lamine AJ,Annabi A,Belhadjhmida N,Ahmed MB,Fazaa SE,Abdelmoula J,Gharbi N

    更新日期:2014-09-01 00:00:00

  • Acute and chronic effects of sarin exposure from the Tokyo subway incident.

    abstract::The Tokyo subway sarin attack was the second documented incident of nerve gas poisoning in Japan. The St. Luke's International Hospital received 640 patients on the day of the attack. Reduction in plasma cholinesterase (ChE) activity was generally associated with the severity of acute signs of toxicity. With time and ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2004.12.005

    authors: Okumura T,Hisaoka T,Naito T,Isonuma H,Okumura S,Miura K,Maekawa H,Ishimatsu S,Takasu N,Suzuki K

    更新日期:2005-05-01 00:00:00

  • Immunopotentiation and antitumor effects of a ginsenoside Rg₃-fortified red ginseng preparation in mice bearing H460 lung cancer cells.

    abstract::Antitumor effects of a ginsenoside Rg(3)-fortified red ginseng preparation (Rg(3)-RGP) were investigated in human non-small cell lung carcinoma (H460) cells using in vitro cytotoxicity assay and in vivo nude mouse xenograft model. Immunomodulatory effects of the preparation were also assessed by measuring the facilita...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2011.01.008

    authors: Park D,Bae DK,Jeon JH,Lee J,Oh N,Yang G,Yang YH,Kim TK,Song J,Lee SH,Song BS,Jeon TH,Kang SJ,Joo SS,Kim SU,Kim YB

    更新日期:2011-05-01 00:00:00

  • Dietary overload lithium decreases the adipogenesis in abdominal adipose tissue of broiler chickens.

    abstract::To investigate the toxic effects of dietary overload lithium on the adipogenesis in adipose tissue of chicken and the role of hypothalamic neuropeptide Y (NPY) in this process, one-day-old male chicks were fed with the basal diet added with 0 (control) or 100mg lithium/kg diet from lithium chloride (overload lithium) ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2016.12.012

    authors: Bai S,Pan S,Zhang K,Ding X,Wang J,Zeng Q,Xuan Y,Su Z

    更新日期:2017-01-01 00:00:00

  • The interplay of glutathione-related processes in antioxidant defense.

    abstract::This review summarizes current knowledge on glutathione (GSH) associated cellular processes that play a central role in defense against oxidative stress. GSH itself is a critical factor in maintaining the cellular redox balance and has been demonstrated to be involved in regulation of cell signalling and repair pathwa...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1382-6689(01)00077-1

    authors: Cnubben NH,Rietjens IM,Wortelboer H,van Zanden J,van Bladeren PJ

    更新日期:2001-09-01 00:00:00

  • Efficiency of anisodamine for organophosphorus-poisoned patients when atropinization cannot be achieved with high doses of atropine.

    abstract::Poisoning by organophosphorus insecticides is a major global public health problem. Although atropine has been widely used to treat organophosphate (OP) poisoning, sometimes atropinization cannot be achieved, even with high doses of atropine. Hence, we aimed to assess the effect of anisodamine for organophosphorus poi...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2013.12.016

    authors: Wang W,Chen QF,Li QB,Wu YB,Chen K,Chen B,Wen JM

    更新日期:2014-03-01 00:00:00

  • DNA methylation in the rat livers induced by low dosage isoniazid treatment.

    abstract::As a first-line anti-tuberculosis drug, isoniazid has a serious adverse side effect: hepatotoxicity. Therefore, the assessment and monitoring of hepatotoxicity from isoniazid to prevent liver injury are great concerns. In this experiment, we compared the levels of ALT in plasma and DNA methylation. 30 male SD rats wer...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2011.07.001

    authors: Zhang B,Sun S,Shen L,Zu X,Chen Y,Hao J,Huang X,Feng F

    更新日期:2011-11-01 00:00:00

  • Acute toxicity of cypermethrin to the non target organism Hyalella curvispina.

    abstract::The acute toxicity of cypermethrin to the amphipod Hyalella curvispina was evaluated by means of a toxicity test under laboratory conditions. Cypermethrin is one of the most widely used insecticides in Argentina. H. curvispina is a widely distributed and commonly abundant component of the invertebrate assemblages in s...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2012.11.008

    authors: Mugni H,Paracampo A,Marrochi N,Bonetto C

    更新日期:2013-01-01 00:00:00

  • The potential effects of efavirenz on Oreochromis mossambicus after acute exposure.

    abstract::Antiretroviral drugs (ARVs) are hazardous therapeutic pharmaceuticals present in South African surface water. Efavirenz is an ARV commonly used in human immunodeficiency virus (HIV) treatment in South Africa. Although little is known about the toxic effects of efavirenz on fish health, threats of toxicity to the aquat...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2017.09.017

    authors: Robson L,Barnhoorn IEJ,Wagenaar GM

    更新日期:2017-12-01 00:00:00

  • Activation of apoptotic pathway in normal, cancer ovarian cells by epothilone B.

    abstract::The epothilones, a new class of microtubule-targeting agents, seem to be a very promising alternative to the current strategy of cancer treatment. We have analyzed the aspects of epothilone B (Epo B) on cellular metabolism of tumor (OV-90) and normal (MM 14) ovarian cells. The observed effects were compared with those...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2013.06.003

    authors: Rogalska A,Szula E,Gajek A,Marczak A,Jóźwiak Z

    更新日期:2013-09-01 00:00:00

  • Altered p53 response and enhanced transgenerational transmission of carcinogenic risk upon exposure of mice to betel nut.

    abstract::Alteration of p53 protein level, and possible mutation of the p53 gene during carcinogenesis in mice exposed chronically (P) and transgenerationally to 2mg/ml aqueous extract of betel nut (AEBN) in drinking water, were studied. Exons 5 and 7 of the p53 gene were not mutated under both chronic and transgenerational exp...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2008.09.003

    authors: Choudhury Y,Sharan RN

    更新日期:2009-01-01 00:00:00

  • Susceptibility and risk: an overview.

    abstract::This symposium on susceptibility and risk was the third in a series designed to bring together experts from diverse disciplines to discuss contemporary issues in risk assessment. The topic in 1996 was especially challenging since susceptibility is influenced by a myriad of factors including environmental, genetic, soc...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1382-6689(97)10010-2

    authors: Zenick H,Costa DL

    更新日期:1997-12-01 00:00:00

  • Chronic toxicity of the veterinary antibiotic florfenicol to Daphnia magna assessed at two temperatures.

    abstract::The hypothesis that temperature variation is able to modify the chronic toxicity of the antibiotic florfenicol (FLO) to Daphnia magna was tested in the present study. Twenty-one day laboratory bioassays were carried out at 20 and 25 °C. FLO concentrations and its potential decay during the assays were checked by spect...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2013.09.001

    authors: Martins A,Guimarães L,Guilhermino L

    更新日期:2013-11-01 00:00:00

  • Study of the relationship between the lifestyle of residents residing in fluorosis endemic areas and adult skeletal fluorosis.

    abstract::The relationship between fluorosis and the lifestyle of adult residents of areas in which fluorosis is endemic was evaluated. A cross-sectional and case-control analysis was performed to study 289 villagers living in fluorosis endemic areas who drank the local water. Subjects were divided into skeletal fluorosis and n...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.06.022

    authors: Liu G,Ye Q,Chen W,Zhao Z,Li L,Lin P

    更新日期:2015-07-01 00:00:00

  • Review: Usnic acid-induced hepatotoxicity and cell death.

    abstract::Increasing prevalence of herbal and dietary supplement-induced hepatotoxicity has been reported worldwide. Usnic acid (UA) is a well-known hepatotoxin derived from lichens. Since 2000, more than 20 incident reports have been received by the US Food and Drug Administration after intake of UA containing dietary suppleme...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.etap.2020.103493

    authors: Kwong SP,Wang C

    更新日期:2020-11-01 00:00:00

  • Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-α/PGC-1α signaling mediated energy biosynthesis.

    abstract::We previously reported that Astragalus polysaccharide (APS) extracted from Chinese medicine Astragalus membranaceus (Fisch.) Bge, attenuates hypertrophy of neonatal rat ventricular myocytes (NRVMs) induced by isoproterenol (Iso). The present study was designed to investigate the effects and the possible mechanism of A...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.03.014

    authors: Luan A,Tang F,Yang Y,Lu M,Wang H,Zhang Y

    更新日期:2015-05-01 00:00:00

  • Impact of smoking on the observed levels of apolipoprotein B: Data from NHANES 2007-2012.

    abstract::Impact of smoking on the levels of apolipoprotein B (APOB) was evaluated by analyzing data from National Health and Nutrition Examination Survey for the years 2007-2012 for US adolescents aged 12-19 years and adults aged >=20 years. When adjustments were made for the effects of age, gender, race/ethnicity, body mass i...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2017.06.006

    authors: Jain RB

    更新日期:2017-07-01 00:00:00

  • Magnesium lithospermate B acts against dextran sodiumsulfate-induced ulcerative colitis by inhibiting activation of the NRLP3/ASC/Caspase-1 pathway.

    abstract::This study aimed to observe the therapeutic effects of magnesium lithospermate B on acute and chronic colitis induced by dextran sodiumsulfate (DSS) and the role of inflammasome complex (NOD-like receptor protein, NLRP; apoptosis-associated speck-like protein containing, ASC; caspase-1). Establishment of acute and chr...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.10.009

    authors: Jiang X,Zhong L,Sun D,Rong L

    更新日期:2016-01-01 00:00:00

  • Enhanced contractility of vascular smooth muscle after brief exposure to arsenate.

    abstract::Epidemiological studies indicate that arsenic exposure induces hypertension. We hypothesized that arsenate exposure modulates the contractility of vascular smooth muscle through the stress response. Intraperitoneal injection of sodium arsenate (15mg/kg) 16h before increased not only the blood pressure of rats but also...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2004.08.002

    authors: Park TG,Seong Y,Suk K,Ha JH,Kim I

    更新日期:2005-02-01 00:00:00