Abstract:
:A thiamine deficiency disease termed M74 syndrome affects the yolk-sac fry of wild and feral Baltic salmon. However, very little is known about the pharmacokinetics of thiamine in salmon. This study examined the pharmacokinetics of thiamine hydrochloride injected intraperitoneally into feral and farmed Baltic salmon females preparing for spawning. The total thiamine concentrations in the eggs and white muscle of feral females were only half of those in the farmed fish after injection. The relative inefficiency of the incorporation of thiamine into the eggs in feral Baltic salmon may be a predisposition factor for M74 syndrome. The relative bioavailability of intraperitoneally-injected thiamine hydrochloride was shown to be ca. 94% of that administered intra-aortically. A far lower intraperitoneal dose (ca. 20mgkg(-1) fish) than currently used was shown to elevate the total thiamine concentration in the eggs above the critical threshold of M74 syndrome.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Koski P,Bäckman C,Pelkonen Odoi
10.1016/j.etap.2004.06.001subject
Has Abstractpub_date
2005-01-01 00:00:00pages
139-52issue
1eissn
1382-6689issn
1872-7077pii
S1382-6689(04)00105-Xjournal_volume
19pub_type
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journal_title:Environmental toxicology and pharmacology
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更新日期:2016-07-01 00:00:00
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journal_title:Environmental toxicology and pharmacology
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更新日期:2014-11-01 00:00:00
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journal_title:Environmental toxicology and pharmacology
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journal_title:Environmental toxicology and pharmacology
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journal_title:Environmental toxicology and pharmacology
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journal_title:Environmental toxicology and pharmacology
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journal_title:Environmental toxicology and pharmacology
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journal_title:Environmental toxicology and pharmacology
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