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Influence of dioxin on the daily variation of insulin sensitivity in mice.

Abstract：

:To evaluate an influence of dioxin on a daily variation of insulin sensitivity, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100ng/kg) was given for 3 weeks in mice. Insulin tolerance test and oral glucose tolerance test were performed. TCDD decreased insulin sensitivity at an active period, but not at a rest period. TCDD elevated plasma TNF-α, and the value was significantly higher during an active period than during a rest period. These data suggest that TCDD blunts insulin sensitivity, mainly during an active period. Higher elevation in plasma TNF-α during an active period might be involved in this phenomenon.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Takuma M,Ushijima K,Kumazaki M,Ando H,Fujimura A

doi

10.1016/j.etap.2015.07.008

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

349-51

issue

2

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(15)30034-X

journal_volume

40

pub_type

杂志文章

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