当前位置： SCI文献检索 > ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY期刊下所有文献 > Evaluation of the acute toxicity of perfluorinated carboxylic acids using eukaryotic cell lines, bacteria and enzymatic assays.

Evaluation of the acute toxicity of perfluorinated carboxylic acids using eukaryotic cell lines, bacteria and enzymatic assays.

Abstract：

:The acute biological activity of a homologous series of perfluorinated carboxylic acids - perfluorohexanoic acid (PFHxA), perfluoroheptanoic acid (PFHpA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA) - was studied. To analyze the potential risk of the perfluorinated acids to humans and the environment, different in vitro toxicity test systems were employed. The cytotoxicity of the chemicals towards two different types of mammalian cell lines and one marine bacteria was investigated. The viability of cells from the promyelocytic leukemia rat cell line (IPC-81) and the rat glioma cell line (C6) was assayed calorimetrically with WST-1 reagent. The evaluation was combined with the Vibrio fischeri acute bioluminescence inhibition assay. The biological activity of the compounds was also determined at the molecular level with acetylcholinesterase and glutathione reductase inhibition assays. This is the first report of the effects of perfluorinated acids on the activity of purified enzymes. The results show these compounds have a very low acute biological activity. The observed effective concentrations lie in the millimole range, which is well above probable intracellular concentrations. A relationship was found between the toxicity of the perfluorinated carboxylic acids and the perfluorocarbon chain length: in every test system applied, the longer the perfluorocarbon chain, the more toxic was the acid. The lowest effective concentrations were thus recorded for perfluorononanoic and perfluorodecanoic acids.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Mulkiewicz E,Jastorff B,Składanowski AC,Kleszczyński K,Stepnowski P

doi

10.1016/j.etap.2006.11.002

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

279-85

issue

3

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(06)00153-0

journal_volume

23

pub_type

杂志文章

相关文献

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY文献大全
  • Toxic effects of sub-chronic exposure of male albino rats to emamectin benzoate and possible ameliorative role of Foeniculum vulgare essential oil.

    abstract：:Emamectin benzoate (EB) is an avermectin insecticide used extensively in pest control on vegetable and field crops. Few studies have been done for evaluating adverse effects of EB. In the current study, we evaluated the toxic effects of EB on male rats and the possible ameliorative role of fennel essential oil (FEO). ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.04.008

    authors： El-Sheikh el-SA,Galal AA

    更新日期：2015-05-01 00:00:00

  • 18β-Glycyrrhetinic acid mitigates radiation-induced skin damage via NADPH oxidase/ROS/p38MAPK and NF-κB pathways.

    abstract：:Radiation-induced inflammation plays an important role in radiation-induced tissue injury. 18β-glycyrrhetinic acid (18β-GA) has shown an anti-inflammatory activity. This study aimed to assess the activity of 18β-GA against radiation-induced skin damage, and explore the underlying mechanisms. In vitro assay revealed 18...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2018.04.012

    authors： Su L,Wang Z,Huang F,Lan R,Chen X,Han D,Zhang L,Zhang W,Hong J

    更新日期：2018-06-01 00:00:00

  • Chemo-preventive effect of crocin against experimentally-induced hepatocarcinogenesis via regulation of apoptotic and Nrf2 signaling pathways.

    abstract：:The results of the current study investigated the chemo-preventive effect of crocin against hepatocarcinogenesis in rats with particular focus on the evaluation of the modulatory impact of crocin on apoptotic and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways. Thioacetamide (TAA) (200 mg/kg, I.P...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2020.103494

    authors： Elsherbiny NM,Eisa NH,El-Sherbiny M,Said E

    更新日期：2020-11-01 00:00:00

  • Changes in fetal brain aromatase activity following in utero 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in rats.

    abstract：:Aromatase catalyzes intraneuronal conversion of androgens to estrogens in the hypothalamus-preoptic area at a specific time during development. This local estrogen formation has a central role in sexual differentiation. To investigate the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on sexual differentiation,...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(01)00094-1

    authors： Ikeda M,Inukai N,Mitsui T,Sone H,Yonemoto J,Tohyama C,Tomita T

    更新日期：2002-01-01 00:00:00

  • Lactate dehydrogenase isoenzyme patterns upon chronic exposure to cigarette smoke: Protective effect of bacoside A.

    abstract：:Despite a strong association between cigarette smoking and alarming increase in mortality rate from smoking-related diseases, around 35-40% of the world's population continues to smoke and many more are being exposed to environmental tobacco smoke. Since the role of free radicals and oxidative damage in the pathogenes...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2005.03.006

    authors： Anbarasi K,Sabitha KE,Devi CS

    更新日期：2005-09-01 00:00:00

  • Antiangiogenic effects of marine sponge derived compounds on cancer.

    abstract：:The term "angiogenic switch" refers to a time-restricted event during tumor progression where the balance between pro- and anti-angiogenic factors, resulting in the transition from dormant avascularized hyperplasia to outgrowing vascularized tumor and eventually to malignant tumor progression. Targeting angiogenesis a...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.etap.2013.09.014

    authors： Senthilkumar K,Venkatesan J,Manivasagan P,Kim SK

    更新日期：2013-11-01 00:00:00

  • Evaluation of antioxidant and antiulcerogenic activities of Opuntia ficus indica f. inermis flowers extract in rats.

    abstract：:The Opuntia ficus indica f. inermis methanolic flowers extract (OMFE) was phytochemical studied, in vitro tested for their potential antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power, linoleic acid peroxidation assays and in vivo evaluated for its ability to prevent ethanol-induced gastri...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.08.007

    authors： Alimi H,Hfaiedh N,Bouoni Z,Sakly M,Ben Rhouma K

    更新日期：2011-11-01 00:00:00

  • The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene.

    abstract：:A physiologically based pharmacokinetic (PBPK) model has been developed for trichloroethylene (1,1,2-trichloroethene, TRI) for rat and humans, based on in vitro metabolic parameters. These were obtained using individual cytochrome P450 and glutathione S-transferase enzymes. The main enzymes involved both for rats and ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(02)00019-4

    authors： Hissink EM,Bogaards JJ,Freidig AP,Commandeur JN,Vermeulen NP,van Bladeren PJ

    更新日期：2002-07-01 00:00:00

  • hOGG1 promoter methylation, hOGG1 genetic variants and their interactions for risk of coal-borne arsenicosis: A case-control study.

    abstract：:To identify the effect of hOGG1 methylation, Ser326Cys polymorphism and their interactions on the risk of coal-borne arsenicosis, 113 coal-borne arsenicosis subjects and 55 reference subjects were recruited. Urinary arsenic contents were analyzed with ICP-MS. hOGG1 methylation and Ser326Cys polymorphism was measured b...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2020.103330

    authors： Ma L,Liang B,Yang Y,Chen L,Liu Q,Zhang A

    更新日期：2020-04-01 00:00:00

  • Evaluation of chronic cough in chemical chronic bronchitis patients.

    abstract：BACKGROUND:: Coughing is one of the chronic respiratory symptoms of patients exposed to sulfur mustard (SM) used against Iranian combatants and civilians by Iraq during the Iran-Iraq war, between 1983 and 1989. This study carried out on SM exposed patients who referred to our clinic because of exacerbation of chronic c...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2004.09.006

    authors： Ghanei M,Hosseini AR,Arabbaferani Z,Shahkarami E

    更新日期：2005-07-01 00:00:00

  • Effects of inducers of cytochrome P450s on enrofloxacin N-deethylation in crucian carp Carassius auratus gibelio.

    abstract：:In this study with crucian carp (Carassius auratus gibelio), the effect on enrofloxacin (EF) and its metabolite ciprofloxacin (CF) and on the activity of cytochrome P450 1A (CYP1A) and cytochrome P450 3A (CYP3A) was estimated following the oral administration of rifampicin (RIF) (12mg/kg) and β-naphthoflavone (BNF) (1...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2016.07.015

    authors： Fu G,Zhou C,Wang Y,Fang W,Zhou J,Zhao S,Ma L

    更新日期：2016-09-01 00:00:00

  • The role of african american ethnicity and metabolism in sentinel polychlorinated biphenyl congener serum levels.

    abstract：:Polychlorinated biphenyls (PCBs) are environmental contaminants found in the serum of human populations across the globe. A small set of sentinel PCB congeners (IUPAC# 101, 118, 138, 153, and 180) commonly sought in human serum are often used as markers of exposure. The Chicago Great Lakes cohort of pregnant African A...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2008.08.008

    authors： McGraw JE,Waller DP

    更新日期：2009-01-01 00:00:00

  • Glycosylated-imidazole aldoximes as reactivators of pesticides inhibited AChE: Synthesis and in-vitro reactivation study.

    abstract：:The present armamentarium of commercially available antidotes provides limited protection against the neurological effects of organophosphate exposure. Hence, there is an urgent need to design and develop molecules that can protect and reactivate inhibited-AChE in the central nervous system. Some natural compounds lik...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2020.103454

    authors： Sharma R,Upadhyaya K,Gupta B,Ghosh KK,Tripathi RP,Musilek K,Kuca K

    更新日期：2020-11-01 00:00:00

  • DNA methylation in the rat livers induced by low dosage isoniazid treatment.

    abstract：:As a first-line anti-tuberculosis drug, isoniazid has a serious adverse side effect: hepatotoxicity. Therefore, the assessment and monitoring of hepatotoxicity from isoniazid to prevent liver injury are great concerns. In this experiment, we compared the levels of ALT in plasma and DNA methylation. 30 male SD rats wer...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.07.001

    authors： Zhang B,Sun S,Shen L,Zu X,Chen Y,Hao J,Huang X,Feng F

    更新日期：2011-11-01 00:00:00

  • Diclofenac-enriched artificial sediment induces oxidative stress in Hyalella azteca.

    abstract：:Diclofenac is a nonsteroidal anti-inflammatory drug widely used in Mexico where it is sold over the counter. It enters water bodies through municipal and industrial discharges, posing a risk to water systems and aquatic organisms. Diclofenac-enriched artificial sediment was used to evaluate the toxicity of this pharma...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2009.09.004

    authors： Oviedo-Gómez DG,Galar-Martínez M,García-Medina S,Razo-Estrada C,Gómez-Oliván LM

    更新日期：2010-01-01 00:00:00

  • A focus on the human lens in vitro.

    abstract：:The lens is a unique organ in that it is avascular and non-innervated, obtaining all nutrients from the aqueous and vitreous humours that bathe the lens. All lenses attempt to achieve the same goal, namely to maintain transparency and focus light on to the retina. However, the mechanisms by which these processes are m...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2005.07.012

    authors： Wormstone IM,Collison DJ,Hansom SP,Duncan G

    更新日期：2006-02-01 00:00:00

  • The effects of zeta cypermethrin on the gills of common guppy Lebistes reticulatus.

    abstract：:Effects of lethal and sublethal concentrations 15, 20, 26 and 35 μg/l of zeta cypermethrin on the gills of common guppies (L. reticulatus) were examined by light microscopy during 96 h exposure. The most common changes at all doses of zeta cypermethrin are the lifting of epithelial layer from gill lamellae and some ne...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/S1382-6689(03)00046-2

    authors： Caliskan M,Erkmen B,Yerli SV

    更新日期：2003-09-01 00:00:00

  • An improved in vitro method for screening toxin and medicine targeting CYP2E1.

    abstract：:The cytochrome P450 enzyme 2E1 (CYP2E1) presents in both microsome and mitochondrion, which influences the metabolism of many xenobiotics. The mice active liver homogenate was prepared for the medicinal incubation and mitochondrion was extracted for chemical screening targeting CYP2E1 enzyme. Representative CYP2E1 ind...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2016.09.006

    authors： Wang M,Zhou Z,Wang J,Zhang X

    更新日期：2016-10-01 00:00:00

  • Common differentially expressed proteins were found in mouse cleft palate models induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoic acid.

    abstract：:Cleft palate(CP) is a widely studied congenital malformation. However, its etiology and pathogenesis still remain unclear. Proteins are fundamental molecules that participate in every biological process within cells. In this study, we established CP mouse models induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) an...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.103270

    authors： Wang C,Zhai SN,Yuan XG,Zhang DW,Jiang H,Qiu L,Fu YX

    更新日期：2019-11-01 00:00:00

  • In vitro and other alternative approaches to developmental neurotoxicity testing (DNT).

    abstract：:To address the growing need for scientifically valid and humane alternatives to developmental neurotoxicity testing (DNT), we propose that basic research scientists in developmental neurobiology be brought together with mechanistic toxicologists and policy analysts to develop the science and policy for DNT alternative...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2004.12.035

    authors： Lein P,Silbergeld E,Locke P,Goldberg AM

    更新日期：2005-05-01 00:00:00

  • A new index to assess chemicals increasing the greenhouse effect based on their toxicity to algae.

    abstract：:CO2, as the typical greenhouse gas causing the greenhouse effect, is a major global environmental problem and has attracted increasing attention from governments. Using algae to eliminate CO2, which has been proposed as an effective way to reduce the greenhouse effect in the past decades, can be disturbed by a growing...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.08.034

    authors： Wang T,Zhang X,Tian D,Gao Y,Lin Z,Liu Y,Kong L

    更新日期：2015-11-01 00:00:00

  • Quercetin abrogates bisphenol A induced altered neurobehavioral response and oxidative stress in zebrafish by modulating brain antioxidant defence system.

    abstract：:Bisphenol A (BPA), a well-recognized anthropogenic xenoestrogen, has been identified as a causative agent responsible for inducing carcinogenicity, cognitive impairment, neurotoxicity, oxidative stress, etc. However, BPA-induced neurotoxicity and its possible amelioration through natural compound intervention remain e...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2020.103483

    authors： Sahoo PK,Pradhan LK,Aparna S,Agarwal K,Banerjee A,Das SK

    更新日期：2020-11-01 00:00:00

  • The role of 3-methylsulfonyl-2,2',4',5,5'-pentachlorobiphenyl, a metabolite of 2,2',4,5,5'-pentachlorobiphenyl, in the induction of hepatic microsomal drug-metabolizing enzymes by 2,2',4,5,5'-pentachlorobiphenyl in rats.

    abstract：:After the administration of 2,2',4,5,5'-pentachlorobiphenyl (2,2',4,5,5'-pentaCB) to intact rats, the concentration of 2,2',4,5,5'-pentaCB in liver gradually decreased, whereas 3-methylsulfonyl (3-MeSO(2))-2,2',4',5,5'-pentaCB appeared in liver and remained detectable in liver for 6 weeks. A single injection of 2,2',4...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(99)00028-9

    authors： Kato Y,Haraguchi K,Tomiyasu K,Saito H,Shibahara T,Masuda Y,Kimura R

    更新日期：1999-12-01 00:00:00

  • Copper effect on the biomarker state of the Mizuhopecten yessoensis tissues in the prespawning period.

    abstract：:The aim of this study was to investigate the sensitivity of the marine scallop Mizuhopecten yessoensis to different copper concentrations (10 and 30 μgl-1) in the prespawning period. Reaction of the scallop to this effect was evaluated by a set of biomarkers, including general metabolism enzymes (acid and alkaline pho...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.04.010

    authors： Istomina A,Chelomin V,Kukla S,Zvyagintsev A,Karpenko A,Slinko E,Dovzhenko N,Slobodskova V,Kolosova L

    更新日期：2019-08-01 00:00:00

  • Identifying adverse outcome pathways (AOP) for Amsterdam city fish by integrated field monitoring.

    abstract：:The European City Fish project aimed to develop a generic methodology for ecological risk assessment for urban rivers. Since traditional methods only consider a small fraction of substances present in the water cycle, biological effect monitoring is required for a more reliable assessment of the pollution status. A ma...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.103301

    authors： van der Oost R,McKenzie DJ,Verweij F,Satumalay C,van der Molen N,Winter MJ,Chipman JK

    更新日期：2020-02-01 00:00:00

  • Activity of the enzymes of the antioxidative system in cadmium-treated Oxya chinensis (Orthoptera Acridoidae).

    abstract：:One purpose in this research was to determine the toxic effects of Cd on antioxidant enzymes of Oxya chinensis (Orthoptera: Acridoidae). Changes in the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and guaiacol peroxidase (GPx) were measured in O. chinensis insects injected with Cd(...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2005.04.001

    authors： Lijun L,Xuemei L,Yaping G,Enbo M

    更新日期：2005-11-01 00:00:00

  • The organochlorine pesticides pentachlorophenol and dichlorodiphenyltrichloroethane increase secretion and production of interleukin 6 by human immune cells.

    abstract：:The environmental contaminants pentachlorophenol (PCP) and 4, 4'-dichlorodiphenyltrichloroethane (DDT) are detected in some human blood samples at levels as high as 5 μM (PCP) and 260 nM (DDT). Several cancers are associated with exposures to these contaminants. IL-6 is a pro-inflammatory cytokine that when dysregulat...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.103263

    authors： Martin TJ,Gabure S,Maise J,Snipes S,Peete M,Whalen MM

    更新日期：2019-11-01 00:00:00

  • Temporal changes in urinary levels of cadmium, N-acetyl-β-d-glucosaminidase and β2-microglobulin in individuals in a cadmium-contaminated area.

    abstract：:Cadmium (Cd) is a metal that is toxic to renal tubules. If renal tubules are damaged by Cd, urinary excretion of N-acetyl-β-D-glucosaminidase (NAG) and beta 2-microglobulin (β2-MG) increases. The aim of this study was to describe the changing patterns of urinary Cd, NAG, and β2-MG levels over a 3-year period in indivi...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.10.016

    authors： Kim YD,Yim DH,Eom SY,Moon SI,Park CH,Kim GB,Yu SD,Choi BS,Park JD,Kim H

    更新日期：2015-01-01 00:00:00

  • Developmental changes of membrane electrical properties of rat skeletal muscle fibers produced by prenatal exposure to carbon monoxide.

    abstract：:The effects of prenatal exposure to 75 and 150 ppm of carbon monoxide (CO) were evaluated in vitro on the electrical parameters of extensor digitorum longus muscle of newborn rats, by means of computerized two intracellular microelectrode technique. Within the first 2 months of postnatal life the muscles from offsprin...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/S1382-6689(96)00058-0

    authors： De Luca A,Pierno S,Tricarico D,Carratù MR,Cagiano R,Cuomo V,Camerino DC

    更新日期：1996-10-15 00:00:00

  • The analysis of the possibility of using biological tests for assessment of toxicity of leachate from an active municipal landfill.

    abstract：:One of the consequence of municipal waste deposition is the production of landfill leachate. Its volume and composition is determined by numerous factors, including waste composition, landfill age and the volume of precipitation. Leachate may contain a number of mineral and organic compounds, the volume of which must ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.01.013

    authors： Przydatek G

    更新日期：2019-04-01 00:00:00