An improved in vitro method for screening toxin and medicine targeting CYP2E1.

abstract：:In the present study, two antioxidant components (polysaccharopeptide complex P(1-a) and condensed tannin P(1-b)) from rose (Rosa rugosa) flowers were each incubated with mouse erythrocytes to investigate their effect on erythrocyte superoxide dismutase (SOD), and catalase (CAT) activities. It was found that the activ...

journal_title：Environmental toxicology and pharmacology

authors： Jiang Y,Wong JH,Pi ZF,Ng TB,Wang CR,Hou J,Chen RR,Niu HJ,Liu F

更新日期：2009-05-01 00:00:00

abstract：:A food allergen may be defined as a substance that reacts with IgE antibodies, induces allergic sensitisation or induces allergic reactions. Some allergens only induce allergic sensitisation but do not provoke symptoms, while others bind IgE but do not induce mast cell degranulation. There is no common structure that ...

journal_title：Environmental toxicology and pharmacology

authors： Aalberse RC

更新日期：1997-11-01 00:00:00

abstract：:Hexavalent chromium-mediated oxidative stress causes severe organ damage. The present study was designed to investigate the possible thyroprotective effect and underlying mechanisms of gallic acid using rat model of potassium dichromate-induced thyroid dysfunction. Forty adult male albino rats were divided into 4 grou...

journal_title：Environmental toxicology and pharmacology

authors： Mohamed HM,Abd El-Twab SM

更新日期：2016-12-01 00:00:00

abstract：:Palladium (Pd) is known to be released into the environment in the fine and ultrafine (at the nanoscale) airborne particle fractions mainly from automobile catalytic converters leading to an increase human exposure to this noble metal. It was reported that Pd can induce allergic reactions in individuals exposed to it ...

journal_title：Environmental toxicology and pharmacology

authors： Chhay P,Murphy-Marion M,Samson Y,Girard D

更新日期：2018-01-01 00:00:00

abstract：:The sensitivity of human lymphocytes from different donors to CdCl2 using a complex of methods for determination of cytotoxicity and genotoxicity was studied. As endpoints for cytotoxicity the mitotic index (MI) and apoptosis were evaluated. To indicate genotoxicity chromosome aberrations test (CA) was used. The resul...

journal_title：Environmental toxicology and pharmacology

authors： Gateva S,Jovtchev G,Stergios M

更新日期：2013-07-01 00:00:00

abstract：:Styrene exposure and color vision for 108 workers (21-65 years) was studied at Swedish reinforced plastic plants. Acute exposure was measured at work. Data on past exposures and personal background data were collected by questionnaire. Current exposure varied between 0.3 and 96mg/m(3). Cumulative past exposures varied...

journal_title：Environmental toxicology and pharmacology

authors： Iregren A,Johnson AC,Nylén P

更新日期：2005-05-01 00:00:00

abstract：:To evaluate the genotoxic effects of formaldehyde, acetaldehyde, acrolein and benzene on A549 cells, the in vitro γH2AX assay was used in combination with high content screening (HCS) technology. All aldehydes showed a significant genotoxicity in a dose/time-dependent effect on the induction of γH2AX. Benzene failed t...

journal_title：Environmental toxicology and pharmacology

authors： Zhang S,Chen H,Wang A,Liu Y,Hou H,Hu Q

更新日期：2017-10-01 00:00:00

abstract：:In this study, we report the antioxidant and antitoxic potential of chemically synthesized 4-oxo-2-phenyl-4H-chromene-7,8-diyl bis((1-amino-2-hydroxypropyl)carbamate) (DHF-BAHPC) compound using in vitro and in vivo assays. The DHF-BAHPC was synthesized by linking 7,8-Dihydroxyflavone (DHF) with two molecules of Fmoc-t...

journal_title：Environmental toxicology and pharmacology

authors： Mohankumar T,Lalithamba HS,Manigandan K,Muthaiyan A,Elangovan N

更新日期：2020-10-01 00:00:00

abstract：:This study investigated the cytoprotective effect of baicalein (5,6,7-trihydroxyflavone) against oxidative stress-induced mitochondrial dysfunction. Electron spin resonance (ESR) spectrometry revealed that baicalein showed significant scavenging effects on superoxide radicals and hydroxyl radicals. When H(2)O(2) treat...

journal_title：Environmental toxicology and pharmacology

authors： Lee IK,Kang KA,Zhang R,Kim BJ,Kang SS,Hyun JW

更新日期：2011-01-01 00:00:00

abstract：:A physiologically based pharmacokinetic (PBPK) model has been developed for trichloroethylene (1,1,2-trichloroethene, TRI) for rat and humans, based on in vitro metabolic parameters. These were obtained using individual cytochrome P450 and glutathione S-transferase enzymes. The main enzymes involved both for rats and ...

journal_title：Environmental toxicology and pharmacology

authors： Hissink EM,Bogaards JJ,Freidig AP,Commandeur JN,Vermeulen NP,van Bladeren PJ

更新日期：2002-07-01 00:00:00

abstract：:Application of human antidotes against nerve agent intoxications to microcrustacean Daphnia magna (Crustacea, Cladocera) intoxicated by a nerve agent tabun (O-ethyl-N,N-dimethylphosphoramidocyanidate) and their efficacy was investigated. It was found that antidotes can be successfully applied to intoxicated daphnids. ...

journal_title：Environmental toxicology and pharmacology

authors： Vesela S,Kuca K,Jun D

更新日期：2008-05-01 00:00:00

abstract：:In utero exposure of neonates to pesticide residues could be damaging to the reproductive tract. Hence, the present study assessed the circulating concentrations of pesticide residues in buffalo and their neonatal calves as well as in the reproductive tract tissue samples of same calves. Also, histopathological altera...

journal_title：Environmental toxicology and pharmacology

authors： Kaur K,Ghuman SS,Singh O,Bedi JS,Gill JP

更新日期：2015-11-01 00:00:00

abstract：:Epidemiological and experimental studies have demonstrated that cigarette smoking intensifies gastric ulceration. Although nicotine can act as an anxiolytic and antidepressant, its withdrawal may also lead to increased anxiety and depression. In order to associate the toxic actions of nicotine on gastric mucosa with a...

journal_title：Environmental toxicology and pharmacology

authors： Deniz M,Sahin HH,Tekin S,Yeşiller M,Ağaoğlu B,Cetinel S,Yeğen BÇ

更新日期：2009-03-01 00:00:00

abstract：:A series of N(1)-benzylidene pyridine-2-carboxamidrazone anti-tuberculosis compounds has been evaluated for their cytotoxicity using human mononuclear leucocytes (MNL) as target cells. All eight compounds were significantly more toxic than dimethyl sulphoxide control and isoniazid (INH) with the exception of a 4-metho...

journal_title：Environmental toxicology and pharmacology

authors： Coleman MD,Tims KJ,Rathbone DL

更新日期：2003-06-01 00:00:00

abstract：:In this study with crucian carp (Carassius auratus gibelio), the effect on enrofloxacin (EF) and its metabolite ciprofloxacin (CF) and on the activity of cytochrome P450 1A (CYP1A) and cytochrome P450 3A (CYP3A) was estimated following the oral administration of rifampicin (RIF) (12mg/kg) and β-naphthoflavone (BNF) (1...

journal_title：Environmental toxicology and pharmacology

authors： Fu G,Zhou C,Wang Y,Fang W,Zhou J,Zhao S,Ma L

更新日期：2016-09-01 00:00:00

abstract：:In order to allow an interpretation of in vitro results on the estrogenic potency of 4-nonylphenol (NP) and 4-octylphenol (OP), their distribution and pharmacokinetics were investigated in primary mouse hepatocyte cultures. 10(-5) M NP and 10(-6)M OP were added to the hepatocyte cultures and incubated up to 48 h. The ...

journal_title：Environmental toxicology and pharmacology

authors： Müller S,Schmid P,Schlatter C

更新日期：1998-08-04 00:00:00

abstract：:Essential oils from aerial parts of Piper aduncum (Matico) and Piper obliquum (Anis del Oriente) of ecuadorian origin were analyzed by GC-FID, GC-MS, (13)C NMR and their biological and pharmacological activities were assessed. Chemical composition proved to be unusually different from previous reports for safrole-rich...

journal_title：Environmental toxicology and pharmacology

authors： Guerrini A,Sacchetti G,Rossi D,Paganetto G,Muzzoli M,Andreotti E,Tognolini M,Maldonado ME,Bruni R

更新日期：2009-01-01 00:00:00

abstract：:Increasing prevalence of herbal and dietary supplement-induced hepatotoxicity has been reported worldwide. Usnic acid (UA) is a well-known hepatotoxin derived from lichens. Since 2000, more than 20 incident reports have been received by the US Food and Drug Administration after intake of UA containing dietary suppleme...

journal_title：Environmental toxicology and pharmacology

authors： Kwong SP,Wang C

更新日期：2020-11-01 00:00:00

abstract：:Cleft palate(CP) is a widely studied congenital malformation. However, its etiology and pathogenesis still remain unclear. Proteins are fundamental molecules that participate in every biological process within cells. In this study, we established CP mouse models induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) an...

journal_title：Environmental toxicology and pharmacology

authors： Wang C,Zhai SN,Yuan XG,Zhang DW,Jiang H,Qiu L,Fu YX

更新日期：2019-11-01 00:00:00

abstract：:To evaluate an influence of dioxin on a daily variation of insulin sensitivity, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100ng/kg) was given for 3 weeks in mice. Insulin tolerance test and oral glucose tolerance test were performed. TCDD decreased insulin sensitivity at an active period, but not at a rest period. T...

journal_title：Environmental toxicology and pharmacology

authors： Takuma M,Ushijima K,Kumazaki M,Ando H,Fujimura A

更新日期：2015-09-01 00:00:00

abstract：:The environmental contaminants pentachlorophenol (PCP) and 4, 4'-dichlorodiphenyltrichloroethane (DDT) are detected in some human blood samples at levels as high as 5 μM (PCP) and 260 nM (DDT). Several cancers are associated with exposures to these contaminants. IL-6 is a pro-inflammatory cytokine that when dysregulat...

journal_title：Environmental toxicology and pharmacology

authors： Martin TJ,Gabure S,Maise J,Snipes S,Peete M,Whalen MM

更新日期：2019-11-01 00:00:00

abstract：:The present study was aimed to analyze the effect of ZnO and TiO2 nanoparticles (NPs) on Haemato-immunological parameters in adult Tilapia, Oreochromis mossambicus. The nanoparticles size found as 47 nm and 30 nm for ZnO and TiO2 respectively. The acute toxicity (96 h) of ZnO (LC50: 100-110 ppm) and TiO2 (LC50: 80-90 ...

journal_title：Environmental toxicology and pharmacology

authors： Suganthi P,Murali M,Athif P,Sadiq Bukhari A,Syed Mohamed HE,Basu H,Singhal RK

更新日期：2019-02-01 00:00:00

abstract：:The study investigated the correlation between infarction areas and behavioural deficits in middle cerebral artery occlusion (MCAO) and photothrombosis stroke models. In the MCAO model, a 0.38 mm-diameter silicone-coated thread was introduced through the left external carotid artery and advanced 18 mm via the internal...

journal_title：Environmental toxicology and pharmacology

authors： Choi BI,Park D,Lee SH,Bae DK,Yang G,Yang YH,Kim TK,Choi EK,Lee HJ,Choi KC,Nahm SS,Kim YB

更新日期：2012-01-01 00:00:00

abstract：:The free radicals within the body, produced by metabolic activities or derived from environmental sources are relatively related to hepatoxicity. Since heavy metals including iron have the ability to produce free radicals, the liver glutathione system neutralizes them to protect cells against any damage. The objective...

journal_title：Environmental toxicology and pharmacology

authors： Budak H,Gonul N,Ceylan H,Kocpinar EF

更新日期：2014-01-01 00:00:00

abstract：:The existing hazard of joint mycotoxin exposure of animals/humans and the significance of masked mycotoxins in foods or feeds and their respective contributions to the development of some food born mycotoxicoses is briefly reviewed. The importance of joint mycotoxin interaction in the complex etiology of some foodborn...

journal_title：Environmental toxicology and pharmacology

authors： Stoev SD

更新日期：2015-03-01 00:00:00

abstract：:This study is intended to explore effective and sensitive biomarkers for kidney damage after low level arsenic (As) exposure and to provide scientific evidence on cut-off values of arsenic concentrations in drinking water. The levels of α1-MG detected in urine samples were found to have statistically significant diffe...

journal_title：Environmental toxicology and pharmacology

authors： Feng H,Gao Y,Zhao L,Wei Y,Li Y,Wei W,Wu Y,Sun D

更新日期：2013-05-01 00:00:00

abstract：:In Pakistan a huge number of workers is routinely exposed to various types of chemical contaminants but there is a dearth of information as to the impact of these agents, due to a lack of a routine surveillance system and proper reporting. Prolonged and sometimes acute occupational exposures to varied organic chemical...

journal_title：Environmental toxicology and pharmacology

authors： Kamal A,Malik RN,Fatima N,Rashid A

更新日期：2012-07-01 00:00:00

abstract：:Endothelial nitric oxidase synthase (eNOS) uncoupling plays a causal role in endothelial dysfunction in atherosclerosis. Genistein consumption has been associated with the prevention of atherosclerosis. However, the effect of genistein on eNOS uncoupling has not been reported. A model of oxidized low-density lipoprote...

journal_title：Environmental toxicology and pharmacology

authors： Zhang HP,Zhao JH,Yu HX,Guo DX

更新日期：2016-03-01 00:00:00

abstract：:The aliphatic ether 1,6-dimethoxyhexane (DMH) was previously identified as a testicular toxicant. Testis protein extracts from control and DMH-treated rats were subjected to two-dimensional gel electrophoresis for comparison of protein expression profiles. MALDI-ToF peptide mass fingerprinting of differentially expres...

journal_title：Environmental toxicology and pharmacology

authors： Pelletier G,Masson S,Wang YL,Wade MG,Mohottalage S,Kumarathasan P,Vincent R,Poon R,Chu I

更新日期：2007-09-01 00:00:00

abstract：:The results of the current study investigated the chemo-preventive effect of crocin against hepatocarcinogenesis in rats with particular focus on the evaluation of the modulatory impact of crocin on apoptotic and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways. Thioacetamide (TAA) (200 mg/kg, I.P...

journal_title：Environmental toxicology and pharmacology

authors： Elsherbiny NM,Eisa NH,El-Sherbiny M,Said E

更新日期：2020-11-01 00:00:00