Copper effect on the biomarker state of the Mizuhopecten yessoensis tissues in the prespawning period.

abstract：:Exposure to aluminum (Al) suppresses bone formation. Osteoblastic differentiation plays a key role in the process of bone formation. However, the effect of Al on osteoblastic differentiation is still controversial, and the mechanism remains unclear. To investigate the effect of Al on osteoblastic differentiation and w...

journal_title：Environmental toxicology and pharmacology

authors： Cao Z,Fu Y,Sun X,Zhang Q,Xu F,Li Y

更新日期：2016-03-01 00:00:00

abstract：:Cleft palate(CP) is a widely studied congenital malformation. However, its etiology and pathogenesis still remain unclear. Proteins are fundamental molecules that participate in every biological process within cells. In this study, we established CP mouse models induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) an...

journal_title：Environmental toxicology and pharmacology

authors： Wang C,Zhai SN,Yuan XG,Zhang DW,Jiang H,Qiu L,Fu YX

更新日期：2019-11-01 00:00:00

abstract：:We recently reported that acrylamide, a known rodent and probable human carcinogen, does not increase the risk of azoxymethane (AOM)-induced rat colon precancerous lesions when administered through the diet. Here, we present toxicological data from non-AOM-injected rats. Briefly, male F344 rats were randomized into fo...

journal_title：Environmental toxicology and pharmacology

authors： Raju J,Roberts J,Taylor M,Patry D,Chomyshyn E,Caldwell D,Cooke G,Mehta R

更新日期：2015-01-01 00:00:00

abstract：:In this study, the hepatoprotective effect of dieckol on carbon tetrachloride (CCl4) induced hepatic damages in ICR mice liver was investigated. Mice were randomly divided into 4 groups such as saline treated (negative control), CCl4 treated (positive control), CCl4+dieckol (5mg/kg mouse) and CCl4+dieckol (25mg/kg mou...

journal_title：Environmental toxicology and pharmacology

authors： Kang MC,Kang SM,Ahn G,Kim KN,Kang N,Samarakoon KW,Oh MC,Lee JS,Jeon YJ

更新日期：2013-05-01 00:00:00

abstract：:Gambogenic acid, identified from Gamboge, is responsible for anti-tumor effects, and has been shown to be a potential molecule against human cancers. In this study, the molecular mechanism of gambogenic acid-induced apoptosis in HepG2 cells was investigated. Gambogenic acid significantly inhibited cell proliferation a...

journal_title：Environmental toxicology and pharmacology

authors： Yan F,Wang M,Li J,Cheng H,Su J,Wang X,Wu H,Xia L,Li X,Chang HC,Li Q

更新日期：2012-03-01 00:00:00

abstract：:This study was to appraise the anti-inflammatory and free radical scavenging activities of ethanol extracts of Ilex ficoidea Hemsl (EIFH) and Ilex centrochinensis S.Y. Hu (EICC). Anti-inflammatory activities were evaluated using xylene-induced ear edema and the cotton pellet granuloma tests. Some antioxidants produced...

journal_title：Environmental toxicology and pharmacology

authors： Li L,Zhang Y,Zhang P,Pi H,Ruan H,Wu J

更新日期：2011-09-01 00:00:00

abstract：:In an attempt to assess the intensity of environmental pollution in industrial zones of Kvarnerian Bay in Northern Adriatic Sea and the reactivity of Mytilus galloprovincialis to these changes, in this study we estimated the concentration of heavy metals at four locations in both sea-sediment and in the mussels. Furth...

journal_title：Environmental toxicology and pharmacology

authors： Mićović V,Bulog A,Kučić N,Jakovac H,Radošević-Stašić B

更新日期：2009-11-01 00:00:00

abstract：:The toxicity of chlorobenzenes to Tetrahymena growth metabolism was studied by microcalorimetry. The growth constant (k), peak time (T) and generation times (T(G)) were calculated. IC(50) of chlorobenzenes was obtained through the kinetic parameters. The results suggested that the order of toxicity was 1,2,4-trichloro...

journal_title：Environmental toxicology and pharmacology

authors： Zhang T,Li X,Min X,Fang T,Zhang Z,Yang L,Liu P

更新日期：2012-05-01 00:00:00

abstract：:The goal of this study was to investigate the mechanisms of nanocopper-induced nephrotoxicity by analyzing renal gene expression profiles phenotypically anchored to conventional toxicological outcomes. Male Wistar rats were given nanocopper (50, 100, 200 mg/kg) and microcopper (200 mg/kg) at different doses for 5 days...

journal_title：Environmental toxicology and pharmacology

authors： Liao M,Liu H

更新日期：2012-07-01 00:00:00

abstract：:The aim of our study was to examine the effect of calorie restriction (CR) on oxidative and nitrosative liver injury in rats, induced by acute ethanol intoxication. Male Wistar rats were divided into groups: (1) control; (2) calorie-restricted groups with intake of 60-70% (CR60-70) and 40-50% of daily energy needs (CR...

journal_title：Environmental toxicology and pharmacology

authors： Mladenović D,Ninković M,Aleksić V,Šljivančanin T,Vučević D,Todorović V,Stanković M,Stanojlović O,Radosavljević T

更新日期：2013-09-01 00:00:00

abstract：:To evaluate an influence of dioxin on a daily variation of insulin sensitivity, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100ng/kg) was given for 3 weeks in mice. Insulin tolerance test and oral glucose tolerance test were performed. TCDD decreased insulin sensitivity at an active period, but not at a rest period. T...

journal_title：Environmental toxicology and pharmacology

authors： Takuma M,Ushijima K,Kumazaki M,Ando H,Fujimura A

更新日期：2015-09-01 00:00:00

abstract：:The effects of obesity and smoking in the coronavirus disease 2019 (COVID-19) pandemic remain controversial. Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin system (RAS), is the human cell receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVI...

journal_title：Environmental toxicology and pharmacology

authors： Engin AB,Engin ED,Engin A

更新日期：2020-08-01 00:00:00

abstract：:This symposium on susceptibility and risk was the third in a series designed to bring together experts from diverse disciplines to discuss contemporary issues in risk assessment. The topic in 1996 was especially challenging since susceptibility is influenced by a myriad of factors including environmental, genetic, soc...

journal_title：Environmental toxicology and pharmacology

authors： Zenick H,Costa DL

更新日期：1997-12-01 00:00:00

abstract：:Juveniles of the shrimp Litopenaeus vannamei (3.3 ± 0.4 g) were exposed separately to nitrite (0.0, 1.1, 2.6, and 5.3 mg/L nitrogen as nitrite [NO2--N]) and nitrate (0, 90, 225 and 400 mg/L nitrogen as nitrate [NO3--N]) concentrations equivalent to 0, 10, 25, and 50% of the LC50-96 h value of NO2--N and NO3--N in low ...

journal_title：Environmental toxicology and pharmacology

authors： Valencia-Castañeda G,Frías-Espericueta MG,Vanegas-Pérez RC,Chávez-Sánchez MC,Páez-Osuna F

更新日期：2020-11-01 00:00:00

abstract：:We examined the genotoxicity of diaveridine and trimethoprim in the bacterial umu test, the bacterial reverse mutation test, the in vitro chromosome aberration test, the in vivo rodent bone marrow micronucleus test in two species, and the in vivo comet assay in five mouse organs. Both compounds were negative in the um...

journal_title：Environmental toxicology and pharmacology

authors： Ono T,Sekiya T,Takahashi Y,Sasaki YF,Izumiyama F,Nishidate E,Tsuda S,Ohta T

更新日期：1997-09-01 00:00:00

abstract：:Genistein receives much attention because of its potential to prevent hormone-related cancer and cardiovascular diseases. Limited information is available on the pharmacokinetics of this compound like, for instance, their intestinal uptake by humans and systematic bioavailability. In this study, the fate of the absorp...

journal_title：Environmental toxicology and pharmacology

authors： Steensma A,Bienenmann-Ploum ME,Noteborn HP

更新日期：2004-06-01 00:00:00

abstract：:Ozonation and chlorination of 17β-estradiol (E2), 17α-ethynylestradiol (EE2), bisphenol A (BPA), and nonylphenol (NP) were performed to evaluate the estrogenic activity of the by-products of these endocrine disrupting chemicals (EDCs). After 15min oxidation, samples were extracted using solid phase extraction (SPE) ca...

journal_title：Environmental toxicology and pharmacology

authors： Liu J,Carr S,Rinaldi K,Chandler W

更新日期：2005-09-01 00:00:00

abstract：:The aim of this work was to evaluate the induction of protoporphyrins IX (PpIX) activity and superoxide anions (SO) in human leukocytes exposed to anthracene (ANT) and benzo(a)pyrene (B(a)P). The leukocyte LC(50)s for both hydrocarbons and the PpIX accumulation and SO overproduction were measured. The LC(50)s were 0.3...

journal_title：Environmental toxicology and pharmacology

authors： Uribe-Hernández R,Pérez-Zapata AJ,Vega-Barrita ML,Ramón-Gallegos E,Amezcua-Allieri MA

更新日期：2008-09-01 00:00:00

abstract：:The features of organophosphate-induced brain injuries were investigated. Rats were poisoned intraperitoneally with 9 mg/kg (1.8 LD(50)) of diisopropylfluorophosphate. Pyridostigmine bromide (0.1 mg/kg) and atropine methylnitrate (20 mg/kg), which are centrally inactive, were pre-treated intramuscularly to reduce the ...

journal_title：Environmental toxicology and pharmacology

authors： Kim YB,Hur GH,Shin S,Sok DE,Kang JK,Lee YS

更新日期：1999-04-01 00:00:00

abstract：:Endosulfan, a chlorinated cyclodiene insecticide, is known to cause a significant enhancement of altered hepatic foci in rats and to be a potent inhibitor of gap-junctional intercellular communication in vitro. Both of these features are common to many tumor promoters. However, long-term studies in rodents provide no ...

journal_title：Environmental toxicology and pharmacology

authors： Dubois M,Pfohl-Leszkowicz A,De Waziers I,Kremers P

更新日期：1996-07-15 00:00:00

abstract：OBJECTIVES:Acetaminophen (APAP) overdose may cause acute liver injury. Ozone therapy (OT) is shown to reduce inflammation and necrosis in several entities. Thus, we have designed this study to evaluate the efficacy of OT in a rat model of APAP-induced liver injury. METHODS:Twenty-seven Sprague-Dawley rats were divided...

journal_title：Environmental toxicology and pharmacology

authors： Gul H,Uysal B,Cakir E,Yaman H,Macit E,Yildirim AO,Eyi YE,Kaldirim U,Oztas E,Akgul EO,Cayci T,Ozler M,Topal T,Oter S,Korkmaz A,Toygar M,Demirbag S

更新日期：2012-07-01 00:00:00

abstract：:The objective of this study was to compare effects of Western diet (WD) with low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats. Eighteen rats were randomly assigned to three experimental groups and fed for the next 2 months. The experimental diets were: Control (7% of soy...

journal_title：Environmental toxicology and pharmacology

authors： Kostogrys RB,Franczyk-Żarów M,Maślak E,Topolska K

更新日期：2015-03-01 00:00:00

abstract：:The hypothesis that temperature variation is able to modify the chronic toxicity of the antibiotic florfenicol (FLO) to Daphnia magna was tested in the present study. Twenty-one day laboratory bioassays were carried out at 20 and 25 °C. FLO concentrations and its potential decay during the assays were checked by spect...

journal_title：Environmental toxicology and pharmacology

authors： Martins A,Guimarães L,Guilhermino L

更新日期：2013-11-01 00:00:00

abstract：:The histopathological effects of deltamethrin on the gill and kidney tissues of the common carp, Cyprinus carpio were determined by light microscopy. The fish were exposed to 0.029mgl(-1) (50% of 96h LC(50)) and 0.041mgl(-1) (70% of 96h LC(50)) solutions of deltamethrin for short-term (96h). The most common gill chang...

journal_title：Environmental toxicology and pharmacology

authors： Cengiz EI

更新日期：2006-09-01 00:00:00

abstract：:Glyphosate is a broad spectrum herbicide used aggressively in agricultural practices as well as home garden care. Although labeled "safe" by the chemical industry, doses tested by industry do not mimic chronic exposures to sublethal doses that organisms in the environment are exposed to over long periods of time. Give...

journal_title：Environmental toxicology and pharmacology

authors： Roy NM,Ochs J,Zambrzycka E,Anderson A

更新日期：2016-09-01 00:00:00

abstract：:Inhibition of apoptosis of preneoplastic cells is thought to represent a major mechanism of action of tumor promoters. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent promoter of liver carcinogenesis in rodents, suppressed apoptosis in rat hepatocytes pretreated in vitro with an apoptogenic dose of UV ligh...

journal_title：Environmental toxicology and pharmacology

authors： Wörner W,Schrenk D

更新日期：1998-12-01 00:00:00

abstract：:Cadmium (Cd) is a metal that is toxic to renal tubules. If renal tubules are damaged by Cd, urinary excretion of N-acetyl-β-D-glucosaminidase (NAG) and beta 2-microglobulin (β2-MG) increases. The aim of this study was to describe the changing patterns of urinary Cd, NAG, and β2-MG levels over a 3-year period in indivi...

journal_title：Environmental toxicology and pharmacology

authors： Kim YD,Yim DH,Eom SY,Moon SI,Park CH,Kim GB,Yu SD,Choi BS,Park JD,Kim H

更新日期：2015-01-01 00:00:00

abstract：:Acetylcholinesterase (AChE) is an important part of cholinergic nerves where it participates in termination of neurotransmission. AChE can be inhibited by e.g. some Alzheimer disease drugs, nerve agents, and secondary metabolites. In this work, metal salts aluminum chloride, calcium chloride, cupric chloride, ferric c...

journal_title：Environmental toxicology and pharmacology

authors： Pohanka M

更新日期：2014-01-01 00:00:00

abstract：:Male F344 rats were exposed to potassium bromate (KBrO₃) in drinking water at concentrations of 0, 5, 20, 100, 200, or 400 mg/L for 2 or 13 weeks. Endpoints evaluated included clinical observations, body weights, serum chemistry, gross pathology, organ weights, and select tissue histopathology (kidney, lung, liver, th...

journal_title：Environmental toxicology and pharmacology

authors： Dodd DE,Layko DK,Cantwell KE,Willson GA,Thomas RS

更新日期：2013-11-01 00:00:00

abstract：:Ardipusilloside I, a triterpenoid saponin isolated from Ardisia pusilla A. DC, suppresses the growth of a variety of cancer cells, and has certain immunomodulative properties. Herein, we investigated its effect on glioblastoma cell line U87MG cells and primary cultured human glioblastoma cells, and examined the underl...

journal_title：Environmental toxicology and pharmacology

authors： Xiong J,Cheng G,Tang H,Zhen HN,Zhang X

更新日期：2009-03-01 00:00:00