Effect of low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats.


:The objective of this study was to compare effects of Western diet (WD) with low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats. Eighteen rats were randomly assigned to three experimental groups and fed for the next 2 months. The experimental diets were: Control (7% of soybean oil, 20% protein), WD (21% of butter, 20% protein), and LCHP (21% of butter and 52.4% protein) diet. The LCHP diet significantly decreased the body weight of the rats. Diet consumption was differentiated among groups, however significant changes were observed since third week of the experiment duration. Rats fed LCHP diet ate significantly less (25.2g/animal/day) than those from Control (30.2g/animal/day) and WD (27.8 g/animal/day) groups. Additionally, food efficiency ratio (FER) tended to decrease in LCHP fed rats. Serum homocysteine concentration significantly decreased in rats fed WD and LCHP diets. Liver weights were significantly higher in rats fed WD and LCHP diets. At the end of the experiment (2 months) the triacylglycerol (TAG) was significantly decreased in animals fed LCHP compared to WD. qRT-PCR showed that SCD-1 and FAS were decreased in LCHP fed rats, but WD diet increased expression of lipid metabolism genes. Rats receiving LCHP diet had two fold higher kidney weight and 54.5% higher creatinin level compared to Control and WD diets. In conclusion, LCHP diet decreased animal's body weight and decreased TAG in rat's serum. However, kidney damage in LCHP rats was observed.


Kostogrys RB,Franczyk-Żarów M,Maślak E,Topolska K




Has Abstract


2015-03-01 00:00:00














  • Phthalates: European regulation, chemistry, pharmacokinetic and related toxicity.

    abstract::Phthalates are chemicals widely used in industry and the consequences for human health caused by exposure to these agents are of significant current interest. Phthalate toxicity targets the reproductive and respiratory systems primarily, but they also may be involved in the processes of carcinogenesis and even in auti...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章,评审


    authors: Ventrice P,Ventrice D,Russo E,De Sarro G

    更新日期:2013-07-01 00:00:00

  • Cytotoxicity of HC Orange NO. 1 to L929 fibroblast cells.

    abstract::HC Orange No. 1 (HCO1, 2-nitro-4'-hydroxydiphenylamine) (CAS No. 54381-08-7) is used as a colorant in commercial hair dyes. The cytotoxicity of HCO1 to L929 mouse connective tissue fibroblast cells was determined by use of a battery of endpoints that included electron transport activity determined by the MTT assay and...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Liu H,Chen J,Jiang J,Giesy JP,Yu H,Wang X

    更新日期:2008-11-01 00:00:00

  • Genetic polymorphisms in promoter and intronic regions of CYP1A2 gene in Roma and Hungarian population samples.

    abstract::The purpose of this study was to determine the interethnic differences of four CYP1A2 drug metabolizing enzyme variants. A total of 404 Roma and 396 Hungarian healthy subjects were genotyped for -163C>A, -729C>T, -2467delT and -3860G>A variants of CYP1A2 by RT-PCR and PCR-RFLP technique. The -3860A and -729T allele we...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Szalai R,Magyari L,Matyas P,Duga B,Banfai Z,Szabo A,Kovesdi E,Melegh B

    更新日期:2014-11-01 00:00:00

  • Deoxynivalenol induces apoptosis in PC12 cells via the mitochondrial pathway.

    abstract::Deoxynivalenol (DON) has broad toxicity in animals and humans. In this study the impact of DON treatment on apoptotic pathways in PC12 cells was determined. The effects of DON were evaluated on (i) typical indicators of apoptosis, including cellular morphology, cell activity, lactate dehydrogenase (LDH) release, and a...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Wang X,Xu W,Fan M,Meng T,Chen X,Jiang Y,Zhu D,Hu W,Gong J,Feng S,Wu J,Li Y

    更新日期:2016-04-01 00:00:00

  • Inhibition of intercellular communication and induction of ethoxyresorufin-O-deethylase activity by polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans in mouse hepa1c1c7 cells.

    abstract::Inhibition of intercellular communication (IC) between hepa1c1c7 cells was used as a possible bioassay to predict tumor promoting potency of polyhalogenated aromatic hydrocarbons (PAHs). Relative potencies with regard to 2,3,7,8-TCDD to inhibit IC and to induce cytochrome P450IA1/2 (EROD) in these hepa1c1c7 cells were...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: De Haan LH,Halfwerk S,Hovens SE,De Roos B,Koeman JH,Brouwer A

    更新日期:1996-02-15 00:00:00

  • Effects of deltamethrin on the antioxidant defense and heat shock protein expression in Chinese mitten crab, Eriocheir sinensis.

    abstract::In the present study, the status of antioxidant response and molecular regulation in Chinese mitten crab, Eriocheir sinensis under the exposure of synthetic pyrethroid deltamethrin were investigated by means of measuring the antioxidative enzyme activity and relative mRNA expression of heat shock proteins (HSPs) in he...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Hong Y,Huang Y,Yan G,Huang Z

    更新日期:2019-02-01 00:00:00

  • Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells.

    abstract::In some areas of China, citreoviridin (CIT) is considered one of the risk factors for development of cardiovascular disease (CVD). Apoptosis of endothelial cell may induce vascular endothelium injury and atherosclerosis, which result in CVD probably. In this study, we investigated the effect of CIT on apoptosis and pr...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Hou H,Zhou R,Li A,Li C,Li Q,Liu J,Jiang B

    更新日期:2014-03-01 00:00:00

  • Fumonisin toxicity in a transgenic mouse model lacking the mdr1a/1b P-glycoprotein genes.

    abstract::The toxicity of fumonisin B(1) (FB(1)) was investigated in male mdr1a/1b double knockout (MDRK) mice, lacking the drug-transporting P-glycoproteins. These transgenic animals are deficient in their blood:brain barrier and accumulate different drugs in brain and other tissues. The MDRK and their wild-type counterparts, ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Sharma RP,Bhandari N,Tsunoda M,Riley RT,Voss KA,Meredith FI

    更新日期:2000-03-01 00:00:00

  • Risk evaluation: criteria arising from legal traditions and experience with quantitative risk assessment in the United States.

    abstract::Making use of quantitative estimates of risk involves sometimes painful choices about risk control options and ethical and social policies for additional control and/or acceptance of remaining risks. Out of the history of these choices in the U.S., we have drawn four broad categories of risk control criteria: The firs...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Hattis D,Minkowitz WS

    更新日期:1996-10-15 00:00:00

  • Susceptibility and risk: an overview.

    abstract::This symposium on susceptibility and risk was the third in a series designed to bring together experts from diverse disciplines to discuss contemporary issues in risk assessment. The topic in 1996 was especially challenging since susceptibility is influenced by a myriad of factors including environmental, genetic, soc...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Zenick H,Costa DL

    更新日期:1997-12-01 00:00:00

  • Modulatory efficacy of rosmarinic acid on premalignant lesions and antioxidant status in 1,2-dimethylhydrazine induced rat colon carcinogenesis.

    abstract::Colorectal cancer is one of the leading causes of cancer related deaths in Western countries and is becoming increasingly common in Asia. Rosmarinic acid (RA), one of the major components of polyphenol possesses attractive remedial features. The purpose of this study is to investigate the possible chemopreventive mech...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Karthikkumar V,Sivagami G,Vinothkumar R,Rajkumar D,Nalini N

    更新日期:2012-11-01 00:00:00

  • Genotoxicity of glyphosate assessed by the comet assay and cytogenetic tests.

    abstract::It was evaluated the genotoxicity of glyphosate which up to now has heterogeneous results. The comet assay was performed in Hep-2 cells. The level of DNA damage in the control group (5.42±1.83 arbitrary units) for tail moment (TM) measurements has shown a significant increase (p<0.01) with glyphosate at a range concen...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Mañas F,Peralta L,Raviolo J,Ovando HG,Weyers A,Ugnia L,Cid MG,Larripa I,Gorla N

    更新日期:2009-07-01 00:00:00

  • The interplay of glutathione-related processes in antioxidant defense.

    abstract::This review summarizes current knowledge on glutathione (GSH) associated cellular processes that play a central role in defense against oxidative stress. GSH itself is a critical factor in maintaining the cellular redox balance and has been demonstrated to be involved in regulation of cell signalling and repair pathwa...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Cnubben NH,Rietjens IM,Wortelboer H,van Zanden J,van Bladeren PJ

    更新日期:2001-09-01 00:00:00

  • The immune responses and expression of metallothionein (MT) gene and heat shock protein 70 (HSP 70) in juvenile rockfish, Sebastes schlegelii, exposed to waterborne arsenic (As3+).

    abstract::Juvenile rockfish, Sebastes schlegelii (mean length 16.4±1.9cm, and mean weight 71.6±6.4g) were exposed for 20days with the different levels of waterborne arsenic concentration (0, 50, 100, 200 and 400μg/L). The plasma cortisol of S. schlegelii was significantly increased by the waterborne arsenit exposure. In the imm...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Kim JH,Kang JC

    更新日期:2016-10-01 00:00:00

  • Acute toxicity of chlorobenzenes in tetrahymena: estimated by microcalorimetry and mechanism.

    abstract::The toxicity of chlorobenzenes to Tetrahymena growth metabolism was studied by microcalorimetry. The growth constant (k), peak time (T) and generation times (T(G)) were calculated. IC(50) of chlorobenzenes was obtained through the kinetic parameters. The results suggested that the order of toxicity was 1,2,4-trichloro...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Zhang T,Li X,Min X,Fang T,Zhang Z,Yang L,Liu P

    更新日期:2012-05-01 00:00:00

  • Effect of α-lipoic acid on spatial memory and structural integrity of developing hippocampal neurons in rats subjected to sodium arsenite exposure.

    abstract:BACKGROUND:Exposure to arsenic has been reported to affect the nervous system in a number of ways. Various epidemiological studies suggest cognitive impairment in subjects following exposure to environmental arsenic. The goal of the present study was to determine if supplementation of exogenous α-lipoic acid (ALA) coul...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Dixit S,Mehra RD,Dhar P

    更新日期:2020-04-01 00:00:00

  • Intestinal uptake of genistein and its glycoside in the rat using various isolated perfused gut segments.

    abstract::Genistein receives much attention because of its potential to prevent hormone-related cancer and cardiovascular diseases. Limited information is available on the pharmacokinetics of this compound like, for instance, their intestinal uptake by humans and systematic bioavailability. In this study, the fate of the absorp...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Steensma A,Bienenmann-Ploum ME,Noteborn HP

    更新日期:2004-06-01 00:00:00

  • Altered expression profiles of microRNAs upon arsenic exposure of human umbilical vein endothelial cells.

    abstract::Recent studies in our laboratory indicated that arsenite at 20μM significantly induces the apoptosis of HUVECs. In this study we analyzed miRNAs expression profiles upon arsenic exposure of these cells to explore the molecular mechanisms of arsenic-induced vascular toxicity. The expression of miRNAs was examined by Ex...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Li X,Shi Y,Wei Y,Ma X,Li Y,Li R

    更新日期:2012-09-01 00:00:00

  • Paraquat and temperature affect nonspecific immune response of Colossoma macropomum.

    abstract::This study evaluated the effect of paraquat (PQ) and temperature on hematological parameters and nonspecific immune system of fish Colossoma macropomum (Cachama). Juveniles were used for all experiments. Fish were exposed to three temperatures (18, 28, 35°C) and 10mg/L PQ during 21 days (PQ LC(50) 96h was of 48.05mg/L...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Salazar-Lugo R,Estrella A,Oliveros A,Rojas-Villarroel E,Villalobos de B L,Lemus M

    更新日期:2009-05-01 00:00:00

  • Effect of Bisphenol-A on insulin signal transduction and glucose oxidation in liver of adult male albino rat.

    abstract::Bisphenol-A (BPA) has been classified as an endocrine disruptor which disrupts normal cell function by acting as an estrogen agonist. Environmentally relevant doses of the Bisphenol-A have profound effects on rat endocrine pancreas, an essential organ involved in glucose homeostasis. Bisphenol-A acts on insulin releas...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Jayashree S,Indumathi D,Akilavalli N,Sathish S,Selvaraj J,Balasubramanian K

    更新日期:2013-03-01 00:00:00

  • Grape-seed proanthocyanidins inhibit the lipopolysaccharide-induced inflammatory mediator expression in RAW264.7 macrophages by suppressing MAPK and NF-κb signal pathways.

    abstract::Grape-seed proanthocyanidins (GSPs) have been shown to function as an anti-oxidant and anti-inflammatory agent with little toxicity in vivo and in vitro. However, little is known about their anti-inflammatory properties and mechanisms of action. The specific focus being its effects on the MAP kinases and nuclear facto...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Chu H,Tang Q,Huang H,Hao W,Wei X

    更新日期:2016-01-01 00:00:00

  • Lactate dehydrogenase isoenzyme patterns upon chronic exposure to cigarette smoke: Protective effect of bacoside A.

    abstract::Despite a strong association between cigarette smoking and alarming increase in mortality rate from smoking-related diseases, around 35-40% of the world's population continues to smoke and many more are being exposed to environmental tobacco smoke. Since the role of free radicals and oxidative damage in the pathogenes...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Anbarasi K,Sabitha KE,Devi CS

    更新日期:2005-09-01 00:00:00

  • The adverse effects of selenomethionine on skeletal muscle, liver, and brain in the steelhead trout (Oncorhynchus mykiss).

    abstract::Juvenile Oncorhynchus mykiss (average weight: 22.3 g) were fed one of five selenomethionine diets (1.09, 8.79, 15.37, 30.79, or 61.58 mg Se/kg diet). After 4 weeks, hepatic catalase activity over 15.37 mg Se/kg diets was significantly decreased, and the glutathione peroxidase activity over 30.79 mg Se/kg diets was ele...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Lee JW,Deng DF,Lee J,Kim K,Jung HJ,Choe Y,Park SH,Yoon M

    更新日期:2020-11-01 00:00:00

  • Differential organ expression patterns of thyroid hormone receptor isoform genes in p,p'-DDE-treated adult male common frog, Rana temporaria.

    abstract::Using the European common frog, Rana temporaria, as a model, we have studied the organ-specific gene expression patterns of thyroid hormone receptor isoforms after exposure to an organochlorine (OC) compound, p,p'-DDE. Four groups of frogs were subcutaneously injected with p,p'-DDE at 0.01, 0.1, 1 and 10mg/kg body wei...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Arukwe A,Jenssen BM

    更新日期:2005-11-01 00:00:00

  • Evaluating the human response to chemicals: odor, irritation and non-sensory factors.

    abstract::Although airborne chemicals can directly elicit adverse reactions via stimulation of the olfactory and trigeminal nerves, such as sensory irritation of the mucous membranes of the eyes, nose and throat, an individual's subjective experience is often the result of a complex sequence of events involving those sensory, p...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Smeets MA,Dalton PH

    更新日期:2005-05-01 00:00:00

  • Disposition kinetics of selenium in healthy volunteers following therapeutic shampoo treatment.

    abstract::This study was aimed at documenting the kinetic time courses of selenium (Se) in accessible biological matrices of volunteers following controlled applications of therapeutic shampoo containing Se, to better elucidate the mechanisms by which shampoo-Se accumulates in hair and hence estimate the contribution of this so...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Noisel N,Bouchard M,Carrier G

    更新日期:2010-05-01 00:00:00

  • Effects of perfluorooctane sulfonate on mallard and northern bobwhite quail exposed chronically via the diet.

    abstract::Adult mallard ducks and northern bobwhite quail were exposed to 0, 10, 50, or 150mg perfluorooctane sulfonate (PFOS)/kg in the diet for up to 21 weeks. Adult health, body and liver weight, feed consumption, gross morphology and histology of body organs, and reproduction were examined. Due to mortality, birds exposed t...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Newsted JL,Coady KK,Beach SA,Butenhoff JL,Gallagher S,Giesy JP

    更新日期:2007-01-01 00:00:00

  • Daphnia intoxicated by nerve agent tabun can be treated using human antidotes.

    abstract::Application of human antidotes against nerve agent intoxications to microcrustacean Daphnia magna (Crustacea, Cladocera) intoxicated by a nerve agent tabun (O-ethyl-N,N-dimethylphosphoramidocyanidate) and their efficacy was investigated. It was found that antidotes can be successfully applied to intoxicated daphnids. ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Vesela S,Kuca K,Jun D

    更新日期:2008-05-01 00:00:00

  • Assessment of pulmonary toxicity of gold nanorods following intra-tracheal instillation in rats.

    abstract::The present investigation was aimed to evaluate the pulmonary toxicity of 10 and 25nm gold nanorods (GNRs) following intra-tracheal instillation in rats using bronchoalveolar lavage (BAL) fluid and lung histopathological analysis. The GNRs displayed that the dose-dependent toxicity via elevated lactate dehydrogenase l...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Lingabathula H,Yellu N

    更新日期:2017-06-01 00:00:00

  • Food flavor cinnamaldehyde-induced biochemical and histological changes in the kidney of male albino wistar rat.

    abstract::Rats were given food flavor cinnamaldehyde (CNMA) orally by gavage at the dose of 2.14, 6.96, 22.62 and 73.5mg/kg body weight/day for 10, 30 and 90 days. Only the group of rats treated with CNMA at the dose 73.5mg/kg body weight/day for 90 days showed histological changes in the kidney followed by increased activities...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Gowder SJ,Devaraj H

    更新日期:2008-07-01 00:00:00