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Acute toxicity of chlorobenzenes in tetrahymena: estimated by microcalorimetry and mechanism.

Abstract：

:The toxicity of chlorobenzenes to Tetrahymena growth metabolism was studied by microcalorimetry. The growth constant (k), peak time (T) and generation times (T(G)) were calculated. IC(50) of chlorobenzenes was obtained through the kinetic parameters. The results suggested that the order of toxicity was 1,2,4-trichlorobenzene>o-dichlorobenzene>p-dichlorobenzene>m-dichlorobenzene>chlorobenzene. ATR-FTIR spectra revealed that amide groups and PO(2)(-) of the phospholipid phospho-diester, both in the hydrophobic end exposed to the outer layer, were the easiest to be damaged. The relationship between IC(50) and chemicals structure parameters (E(LUMO), E(HOMO), logK(OW), ∑Q(R), ΔQ(πR) and ΔE), indicated that the more chlorine atoms were substituted, the greater the toxicity was. Chlorobenzenes have toxicity of non-polar narcosis. Their toxicity is proportional to their concentrations at the site of action, and caused by membrane perturbation.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Zhang T,Li X,Min X,Fang T,Zhang Z,Yang L,Liu P

doi

10.1016/j.etap.2012.01.009

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

377-85

issue

3

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(12)00011-7

journal_volume

33

pub_type

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