当前位置： SCI文献检索 > ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY期刊下所有文献 > Temporal changes in urinary levels of cadmium, N-acetyl-β-d-glucosaminidase and β2-microglobulin in individuals in a cadmium-contaminated area.

Temporal changes in urinary levels of cadmium, N-acetyl-β-d-glucosaminidase and β2-microglobulin in individuals in a cadmium-contaminated area.

Abstract：

:Cadmium (Cd) is a metal that is toxic to renal tubules. If renal tubules are damaged by Cd, urinary excretion of N-acetyl-β-D-glucosaminidase (NAG) and beta 2-microglobulin (β2-MG) increases. The aim of this study was to describe the changing patterns of urinary Cd, NAG, and β2-MG levels over a 3-year period in individuals living in a Cd-contaminated area. This follow-up study included 191 residents (65.6±9.3 years) who were living in the vicinity of a copper refinery. Urinary levels of Cd, NAG activity, and β2-MG levels were measured, and their determinants and changing patterns were analyzed statistically. The natural logarithm of urinary Cd levels decreased significantly over time. Sex and intake of locally cultivated rice were significant determinants of urinary Cd concentration. Urinary NAG activity decreased over time. Age and urinary Cd concentration were significant determinants of urinary NAG activity in subjects with urinary Cd concentrations >5μg/g creatinine. In subjects whose urinary Cd concentrations were >2μg/g creatinine, diabetes was found to be a significant risk factor for high urinary NAG activity. The slope for temporal changes in urinary β2-MG levels was negative in subjects whose urinary Cd levels were <2μg/g creatinine but was positive in those whose urinary Cd levels were 2-5μg/g creatinine or >5μg/g creatinine. The urinary β2-MG levels found in individuals whose urinary Cd levels were >2μg/g creatinine suggest that previous Cd-induced renal tubular damage had occurred.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Kim YD,Yim DH,Eom SY,Moon SI,Park CH,Kim GB,Yu SD,Choi BS,Park JD,Kim H

doi

10.1016/j.etap.2014.10.016

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

35-41

issue

1

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(14)00252-X

journal_volume

39

pub_type

杂志文章

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