Effect on enzymes and histopathology in earthworm (Eisenia foetida) induced by triazole fungicides.


:Earthworms are an ideal biological model in toxicity assays and environment monitoring studies, especially for the toxicity of pesticides on soil ecosystem. However, There are very little data on the toxicity of triazoles on earthworms despite the fact that such data are critical in assessing their fate and potential toxic effects in soil organisms. To address this issue, earthworms were exposed to triazoles (triadimefon, triadimenol, difenoconazole and propiconazole) to study biochemical and histopathological examination. The results showed protein content significantly increased in treatment of difenoconazole compared to control. There were no significant differences between controls and triadimefon treated groups, while the glutathione peroxidase (GSH-Px) activity is significantly lower than control. Other triazoles also had an inhibitory effect on GSH-Px activity at higher concentration. The histopathological examination showed the epidermis and the epidermis cell of earthworm was ruined at lower triazoles concentration. The arrangement of smooth muscle layer disordered, and some cell disintegrated with concentration increasing of pesticides. Cell pyknosis, cytoplasm deep stained, nucleus concentrations were observed in the treated group with propiconazole.


Gao M,Song W,Zhang J,Guo J




Has Abstract


2013-05-01 00:00:00














  • Changes in fetal brain aromatase activity following in utero 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in rats.

    abstract::Aromatase catalyzes intraneuronal conversion of androgens to estrogens in the hypothalamus-preoptic area at a specific time during development. This local estrogen formation has a central role in sexual differentiation. To investigate the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on sexual differentiation,...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Ikeda M,Inukai N,Mitsui T,Sone H,Yonemoto J,Tohyama C,Tomita T

    更新日期:2002-01-01 00:00:00

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses apoptosis and leads to hyperphosphorylation of p53 in rat hepatocytes.

    abstract::Inhibition of apoptosis of preneoplastic cells is thought to represent a major mechanism of action of tumor promoters. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent promoter of liver carcinogenesis in rodents, suppressed apoptosis in rat hepatocytes pretreated in vitro with an apoptogenic dose of UV ligh...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Wörner W,Schrenk D

    更新日期:1998-12-01 00:00:00

  • Oxidative stress responses of rats exposed to Roundup and its active ingredient glyphosate.

    abstract::Glyphosate is the active ingredient and polyoxyethyleneamine, the major component, is the surfactant present in the herbicide Roundup formulation. The objective of this study was to analyze potential cytotoxicity of the Roundup and its fundamental substance (glyphosate). Albino male rats were intraperitoneally treated...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: El-Shenawy NS

    更新日期:2009-11-01 00:00:00

  • Circulating miRNA-126, -145 and -155 levels in Mexican women exposed to inorganic arsenic via drinking water.

    abstract::The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 ± 14.0 μg/g creatinine was found after urine samples were anal...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Ruíz-Vera T,Ochoa-Martínez ÁC,Zarazúa S,Carrizales-Yáñez L,Pérez-Maldonado IN

    更新日期:2019-04-01 00:00:00

  • Cytotoxic and clastogenic activity of CdCl2 in human lymphocytes from different donors.

    abstract::The sensitivity of human lymphocytes from different donors to CdCl2 using a complex of methods for determination of cytotoxicity and genotoxicity was studied. As endpoints for cytotoxicity the mitotic index (MI) and apoptosis were evaluated. To indicate genotoxicity chromosome aberrations test (CA) was used. The resul...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Gateva S,Jovtchev G,Stergios M

    更新日期:2013-07-01 00:00:00

  • Effects of bis(2-ethylhexyl) phthalate, γ-hexachlorocyclohexane, and 17β-estradiol on the fry stage of medaka (Oryzias latipes).

    abstract::The effects of bis(2-ethylhexyl) phthalate (DEHP), γ-hexachlorocyclohexane (γ-HCH), and 17β-estradiol (E2) on the fry stage of medaka were investigated. The medaka fry were exposed to different concentrations (0.01, 0.1, 1, and 10μg/L) of these chemicals for 3 weeks after hatching. Then, mortality, body weight, sex ra...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Chikae M,Ikeda R,Hatano Y,Hasan Q,Morita Y,Tamiya E

    更新日期:2004-09-01 00:00:00

  • hOGG1 promoter methylation, hOGG1 genetic variants and their interactions for risk of coal-borne arsenicosis: A case-control study.

    abstract::To identify the effect of hOGG1 methylation, Ser326Cys polymorphism and their interactions on the risk of coal-borne arsenicosis, 113 coal-borne arsenicosis subjects and 55 reference subjects were recruited. Urinary arsenic contents were analyzed with ICP-MS. hOGG1 methylation and Ser326Cys polymorphism was measured b...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Ma L,Liang B,Yang Y,Chen L,Liu Q,Zhang A

    更新日期:2020-04-01 00:00:00

  • Assessment of genotoxicity of four volatile pollutants from cigarette smoke based on the in vitro γH2AX assay using high content screening.

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    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Zhang S,Chen H,Wang A,Liu Y,Hou H,Hu Q

    更新日期:2017-10-01 00:00:00

  • Determination of fluoroquinolones in chicken feces - a new liquid-liquid extraction method combined with LC-MS/MS.

    abstract::The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate environmental loads and for a proper risk assessment it is necessary to determine the antibiotic concentration in feces. Ther...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Janusch F,Scherz G,Mohring SA,Hamscher G

    更新日期:2014-11-01 00:00:00

  • Novel screening test to assess the potential environmental toxicity of waste water samples.

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    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Fuerhacker M,Lemmens-Gruber R,Studenik CR

    更新日期:2005-02-01 00:00:00

  • Trace elements in scalp hair from potentially exposed individuals in the vicinity of the Bayan Obo mine in Baotou, China.

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    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Pan Y,Li H

    更新日期:2015-11-01 00:00:00

  • Differential organ expression patterns of thyroid hormone receptor isoform genes in p,p'-DDE-treated adult male common frog, Rana temporaria.

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    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Arukwe A,Jenssen BM

    更新日期:2005-11-01 00:00:00

  • The teratogenic effects of polychlorinated naphthalenes (PCNs) on early development of the zebrafish (Danio rerio).

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    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Sişman T,Geyikoğlu F

    更新日期:2008-01-01 00:00:00

  • Diclofenac-enriched artificial sediment induces oxidative stress in Hyalella azteca.

    abstract::Diclofenac is a nonsteroidal anti-inflammatory drug widely used in Mexico where it is sold over the counter. It enters water bodies through municipal and industrial discharges, posing a risk to water systems and aquatic organisms. Diclofenac-enriched artificial sediment was used to evaluate the toxicity of this pharma...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Oviedo-Gómez DG,Galar-Martínez M,García-Medina S,Razo-Estrada C,Gómez-Oliván LM

    更新日期:2010-01-01 00:00:00

  • The influence of aluminum exposure on male reproduction and offspring in mice.

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    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Guo CH,Lu YF,Hsu GS

    更新日期:2005-07-01 00:00:00

  • Effects of deltamethrin on the antioxidant defense and heat shock protein expression in Chinese mitten crab, Eriocheir sinensis.

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    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Hong Y,Huang Y,Yan G,Huang Z

    更新日期:2019-02-01 00:00:00

  • A focus on the human lens in vitro.

    abstract::The lens is a unique organ in that it is avascular and non-innervated, obtaining all nutrients from the aqueous and vitreous humours that bathe the lens. All lenses attempt to achieve the same goal, namely to maintain transparency and focus light on to the retina. However, the mechanisms by which these processes are m...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Wormstone IM,Collison DJ,Hansom SP,Duncan G

    更新日期:2006-02-01 00:00:00

  • Chemical change of chlorinated bisphenol A by ultraviolet irradiation and cytotoxicity of their products on Jurkat cells.

    abstract::Chlorinated derivatives of bisphenol A (ClBPAs) have been detected in wastewater from waste paper recycling plants. BPA and ClBPAs are always exposed to ultraviolet (UV) radiation in the environment and consequently various photoproducts might be produced. Acute cytotoxicity of photoproducts of BPA and ClBPAs are not ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Mutou Y,Ibuki Y,Terao Y,Kojima S,Goto R

    更新日期:2006-05-01 00:00:00

  • Pesticides and their binary combinations as P-glycoprotein inhibitors in NIH 3T3/MDR1 cells.

    abstract::The purpose of the present study was to assess do selected pesticides as well as their binary combinations act as inhibitors of P-glycoprotein (P-gp) activity of NIH 3T3 mouse fibroblasts stably transfected with human MDR1 gene (NIH 3T3/MDR1). As a result of P-gp inhibition, the increase of intracellular accumulation ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Pivčević B,Zaja R

    更新日期:2006-11-01 00:00:00

  • Oxidative stress, protein carbonylation and heat shock proteins in the black tiger shrimp, Penaeus monodon, following exposure to endosulfan and deltamethrin.

    abstract::The impact of commonly used pesticides, endosulfan and deltamethrin, on the molecular stress level in black tiger shrimp Penaeus monodon, was assessed using classical oxidative stress biomarkers, protein carbonylation profiles, and levels of heat shock proteins. Results showed that 4 days exposure to 0.1 μg L(-1) delt...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Dorts J,Silvestre F,Tu HT,Tyberghein AE,Phuong NT,Kestemont P

    更新日期:2009-09-01 00:00:00

  • Characterization of phase-II conjugation reaction of polycyclic aromatic hydrocarbons in fish species: unique pyrene metabolism and species specificity observed in fish species.

    abstract::Metabolic activity, particularly conjugation, was examined in fish by analyzing pyrene (a four-ring, polycyclic aromatic hydrocarbon) metabolites using high-performance liquid chromatography (HPLC) with fluorescence detector (FD), a mass spectrometry (MS) system, and kinetic analysis of conjugation enzymes. Fourteen f...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Ikenaka Y,Oguri M,Saengtienchai A,Nakayama SMM,Ijiri S,Ishizuka M

    更新日期:2013-09-01 00:00:00

  • In vitro and animal models of drug-induced blood dyscrasias.

    abstract::Drug-induced blood dyscrasias can be either acute and predictable or delayed and unpredictable (idiosyncratic). The predictable toxicity is relatively easy to reproduce with in vitro models, although they may not work for drugs that require bioactivation. It is very unlikely that idiosyncratic blood dyscrasias can be ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Ip J,Uetrecht JP

    更新日期:2006-02-01 00:00:00

  • An improved in vitro method for screening toxin and medicine targeting CYP2E1.

    abstract::The cytochrome P450 enzyme 2E1 (CYP2E1) presents in both microsome and mitochondrion, which influences the metabolism of many xenobiotics. The mice active liver homogenate was prepared for the medicinal incubation and mitochondrion was extracted for chemical screening targeting CYP2E1 enzyme. Representative CYP2E1 ind...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Wang M,Zhou Z,Wang J,Zhang X

    更新日期:2016-10-01 00:00:00

  • Anticedants and natural prevention of environmental toxicants induced accelerated aging of skin.

    abstract::Skin is frequently exposed to a variety of environmental and chemical agents that accelerate ageing. External stress such as UV radiations (UVR) and environmental pollutants majorly deteriorate the skin morphology, by activating certain intrinsic factors such as Reactive Oxygen Species (ROS) which trigger the activati...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章,评审


    authors: Tanuja Yadav,Mishra S,Das S,Aggarwal S,Rani V

    更新日期:2015-01-01 00:00:00

  • Effects of β-ODAP and its biosynthetic precursor on the electrophysiological activity of cloned glutamate receptors.

    abstract::3-N-Oxalyl-l-2,3-diaminopropanoic acid (β-ODAP) induces neurolathyrism, a motor neuron disease. To elucidate the pathogenic mechanism of this process, the action of β-ODAP on the excitatory amino acid (EAA) receptor-mediated currents was examined using cloned EAA receptors expressed in Xenopus oocytes. On the voltage-...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Kusama-Eguchi K,Ikegami F,Kusama T,Lambein F,Watanabe K

    更新日期:1996-12-20 00:00:00

  • The effects of zeta cypermethrin on the gills of common guppy Lebistes reticulatus.

    abstract::Effects of lethal and sublethal concentrations 15, 20, 26 and 35 μg/l of zeta cypermethrin on the gills of common guppies (L. reticulatus) were examined by light microscopy during 96 h exposure. The most common changes at all doses of zeta cypermethrin are the lifting of epithelial layer from gill lamellae and some ne...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Caliskan M,Erkmen B,Yerli SV

    更新日期:2003-09-01 00:00:00

  • Chemical composition, anti-inflammatory activity and cytotoxic activity of the liposoluble constituents from different parts of Acanthopanax evodiaefolius by the Herbal Blitzkrieg Extractor.

    abstract::The liposoluble constituents of leaves (LCL) and stem barks (LCSB) from Acanthopanax evodiaefolius Franch were extracted by Herbal Blitzkrieg Extractor (HBE), and their chemical composition was analyzed by GC-MS. 18 compounds were identified, representing 71.98% of LCL, while 35 compounds were identified, accounting f...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Huang WC,Li Z,Li XJ,Gong LM,Liu XQ,Kwon OK,Ye HX,Lee HK

    更新日期:2014-09-01 00:00:00

  • 18β-Glycyrrhetinic acid mitigates radiation-induced skin damage via NADPH oxidase/ROS/p38MAPK and NF-κB pathways.

    abstract::Radiation-induced inflammation plays an important role in radiation-induced tissue injury. 18β-glycyrrhetinic acid (18β-GA) has shown an anti-inflammatory activity. This study aimed to assess the activity of 18β-GA against radiation-induced skin damage, and explore the underlying mechanisms. In vitro assay revealed 18...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Su L,Wang Z,Huang F,Lan R,Chen X,Han D,Zhang L,Zhang W,Hong J

    更新日期:2018-06-01 00:00:00

  • Grape-seed proanthocyanidins inhibit the lipopolysaccharide-induced inflammatory mediator expression in RAW264.7 macrophages by suppressing MAPK and NF-κb signal pathways.

    abstract::Grape-seed proanthocyanidins (GSPs) have been shown to function as an anti-oxidant and anti-inflammatory agent with little toxicity in vivo and in vitro. However, little is known about their anti-inflammatory properties and mechanisms of action. The specific focus being its effects on the MAP kinases and nuclear facto...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Chu H,Tang Q,Huang H,Hao W,Wei X

    更新日期:2016-01-01 00:00:00

  • Nephroprotection of plantamajoside in rats treated with cadmium.

    abstract::Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Plantamajoside (PMS), a major compound of Plantago asiatica (PA), was reported to have the antioxida...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章


    authors: Jung HY,Seo DW,Hong CO,Kim JY,Yang SY,Lee KW

    更新日期:2015-01-01 00:00:00