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Magnolol reduces UVB-induced photodamage by regulating matrix metalloproteinase activity.

Abstract：

:In this study, we evaluated the anti-photoaging activity of magnolol in UV-irradiated hairless mice, and hypothesized that magnolol would prevent photoaging in these animals. The inhibitory effect of magnolol on wrinkle formation was determined by analyzing the skin replica, histologically examining the epidermal thickness, and identifying damage to the collagen fibers. The protective effects of magnolol on UVB-induced skin photoaging were examined by determining the level of MMPs and mitogen-activated protein kinases (MAPKs). Exposure to UVB radiation significantly increased skin thickness and wrinkle grade, but magnolol treatment significantly reduced the average length and depth of wrinkles, and this was correlated with the inhibition of collagen fiber loss. The magnolol-treated group had remarkably decreased activity levels of MMP-1, -9, and -13 compared to the corresponding levels in the vehicle-treated UVB-irradiated group. These results indicate that magnolol prevents skin photoaging in UVB-irradiated hairless mice.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Im AR,Song JH,Lee MY,Chae S

doi

10.1016/j.etap.2014.12.001

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

417-23

issue

1

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(14)00303-2

journal_volume

39

pub_type

杂志文章

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