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Effects of deltamethrin on the antioxidant defense and heat shock protein expression in Chinese mitten crab, Eriocheir sinensis.

Abstract：

:In the present study, the status of antioxidant response and molecular regulation in Chinese mitten crab, Eriocheir sinensis under the exposure of synthetic pyrethroid deltamethrin were investigated by means of measuring the antioxidative enzyme activity and relative mRNA expression of heat shock proteins (HSPs) in hepatopancreas. The results showed that activity of superoxide dismutase (SOD) and catalase (CAT) decreased remarkably in all treatments except the SOD activity at concentration of 0.073 μg/L. The oxidative stress products malondialdehyde (MDA) and hydrogen peroxide (H2O2) increased significantly at high concentrations while no significant difference was observed at concentrations of 0.073 and 0.146 μg/L throughout the experiment. Meanwhile, the relative mRNA expression of HSP 60, HSP 70 and HSP 90 was significantly up-regulated in all treatments at each time point. All resutls above indicated that deltamethrin has prominent toxic effect on E. sinensis based on antioxidative enzyme inhibition and oxidative products accumulation at environmental related concentrations, and a protective response by up-regulation of HSPs was carried out by animals to mitigate the oxidative stress. In addition, SOD, CAT, MDA, H2O2 and the expression of heat shock proteins, especially HSP 70 in hepatopancreas could be sensitive biomarkers in the assessment of toxic effect of deltamethrin on E.sinensis.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Hong Y,Huang Y,Yan G,Huang Z

doi

10.1016/j.etap.2018.12.012

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

1-6

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(18)30212-6

journal_volume

66

pub_type

杂志文章

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