Abstract：
:In this study, the effects of acute and subacute formaldehyde (FA) exposures on spontaneous locomotor activity (SLMA), wet dog shake (WDS) behavior and pentylenetetrazole (PTZ) induced seizures were evaluated in Balb/C mice. SLMA was concentration dependently reduced after acute FA exposures at 1.8, 3.2, 4.5, 6.4, 9.7, and 14.8 ppm. The incidence of WDS behavior was increased only after acute FA exposures at 1.8, 3.2 and 6.4-ppm. PTZ-injections caused more intensive seizures in mice acutely exposed to FA only at 1.8 ppm. Meanwhile, the incidence of PTZ induced seizures was significantly lower after acute FA exposure at 14.8 ppm. SLMA was also reduced after subacute FA exposure at 2.0 ppm for 3 weeks. The inhibitory effects were significant after 1-week exposure at this concentration, but a tolerance developed at the end of the second week. As the concentration increased to 3.2 ppm, SLMA has found to be reduced after 2-week exposure. There was no change either on the incidence of WDS or on the parameters of PTZ-induced seizures, due to the subacute exposures of FA at the respective concentrations. In conclusion, based upon these data, acute and subacute exposures of FA produce a significant behavioral depression on mice. The data also suggest that acute FA exposures at low concentrations (such as 1.8 ppm) may increase the excitability of central nervous system (CNS).
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Usanmaz SE,Akarsu ES,Vural Ndoi
10.1016/s1382-6689(01)00109-0subject
Has Abstractpub_date
2002-03-01 00:00:00pages
93-100issue
2eissn
1382-6689issn
1872-7077pii
S1382-6689(01)00109-0journal_volume
11pub_type
杂志文章abstract：:In an attempt to assess the intensity of environmental pollution in industrial zones of Kvarnerian Bay in Northern Adriatic Sea and the reactivity of Mytilus galloprovincialis to these changes, in this study we estimated the concentration of heavy metals at four locations in both sea-sediment and in the mussels. Furth...
journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章,评审
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journal_title：Environmental toxicology and pharmacology
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更新日期：2017-12-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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