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The interplay of glutathione-related processes in antioxidant defense.

Abstract：

:This review summarizes current knowledge on glutathione (GSH) associated cellular processes that play a central role in defense against oxidative stress. GSH itself is a critical factor in maintaining the cellular redox balance and has been demonstrated to be involved in regulation of cell signalling and repair pathways. Enhanced expression of various enzymes involved in GSH metabolism, including glutathione peroxidases, γ-glutamyl cysteinyl synthetase (γ-GCS), glutathione S-transferases (GST) and membrane proteins belonging to the ATP-binding cassette family, such as the multidrug resistance associated protein, have all been demonstrated to play a prominent role in cellular resistance towards oxidative stress. This review stresses the fact that aco-ordinateinterplay between these systems is essential for efficient protection against oxidative stress.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Cnubben NH,Rietjens IM,Wortelboer H,van Zanden J,van Bladeren PJ

doi

10.1016/s1382-6689(01)00077-1

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

141-52

issue

4

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(01)00077-1

journal_volume

10

pub_type

杂志文章

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