In vitro toxicity of sodium nitroprusside to human endothelial ECV304 cells.

abstract：:The aim of our study was to examine the effect of calorie restriction (CR) on oxidative and nitrosative liver injury in rats, induced by acute ethanol intoxication. Male Wistar rats were divided into groups: (1) control; (2) calorie-restricted groups with intake of 60-70% (CR60-70) and 40-50% of daily energy needs (CR...

journal_title：Environmental toxicology and pharmacology

authors： Mladenović D,Ninković M,Aleksić V,Šljivančanin T,Vučević D,Todorović V,Stanković M,Stanojlović O,Radosavljević T

更新日期：2013-09-01 00:00:00

abstract：:The environmental contaminants pentachlorophenol (PCP) and 4, 4'-dichlorodiphenyltrichloroethane (DDT) are detected in some human blood samples at levels as high as 5 μM (PCP) and 260 nM (DDT). Several cancers are associated with exposures to these contaminants. IL-6 is a pro-inflammatory cytokine that when dysregulat...

journal_title：Environmental toxicology and pharmacology

authors： Martin TJ,Gabure S,Maise J,Snipes S,Peete M,Whalen MM

更新日期：2019-11-01 00:00:00

abstract：:We generated germ line-transgenic Xenopus laevis that monitors environmental heavy metal ions. Sperm nuclei were transduced with cDNA of enhanced green fluorescent protein (EGFP) driven by murine metallothionein-1 gene promoters and were microinjected into unfertilized eggs. The eggs developed to sexually matured adul...

journal_title：Environmental toxicology and pharmacology

authors： Oofusa K,Tooi O,Kashiwagi A,Kashiwagi K,Kondo Y,Obara M,Yoshizato K

更新日期：2003-04-01 00:00:00

abstract：:The cytochrome P450 enzyme 2E1 (CYP2E1) presents in both microsome and mitochondrion, which influences the metabolism of many xenobiotics. The mice active liver homogenate was prepared for the medicinal incubation and mitochondrion was extracted for chemical screening targeting CYP2E1 enzyme. Representative CYP2E1 ind...

journal_title：Environmental toxicology and pharmacology

authors： Wang M,Zhou Z,Wang J,Zhang X

更新日期：2016-10-01 00:00:00

abstract：:The features of organophosphate-induced brain injuries were investigated. Rats were poisoned intraperitoneally with 9 mg/kg (1.8 LD(50)) of diisopropylfluorophosphate. Pyridostigmine bromide (0.1 mg/kg) and atropine methylnitrate (20 mg/kg), which are centrally inactive, were pre-treated intramuscularly to reduce the ...

journal_title：Environmental toxicology and pharmacology

authors： Kim YB,Hur GH,Shin S,Sok DE,Kang JK,Lee YS

更新日期：1999-04-01 00:00:00

abstract：:The use of surfactants in the development of a suitable formulation for insecticides should improve the solubility behavior, the permeability and the efficiency against pests meanwhile decrease the toxic risks of insecticides on human health. Cytotoxicity of insecticides including abamectin, chlorfluazuron, hexaflumur...

journal_title：Environmental toxicology and pharmacology

authors： Li D,Wu X,Yu X,Huang Q,Tao L

更新日期：2015-03-01 00:00:00

abstract：:Present study was designed to compare cytoprotective and antigenotoxic activity of the polyphenolic fraction of Pilea microphylla (PM1) with that of its active polyphenolic constituents against γ-radiation in V79 cells. PM1 was standardized with respect to the polyphenols present by RP-HPLC. It was evaluated for its f...

journal_title：Environmental toxicology and pharmacology

authors： Paul P,Bansal P,Nayak PG,Pannakal ST,Priyadarsini KI,Unnikrishnan MK

更新日期：2012-01-01 00:00:00

abstract：:Emamectin benzoate (EB) is an avermectin insecticide used extensively in pest control on vegetable and field crops. Few studies have been done for evaluating adverse effects of EB. In the current study, we evaluated the toxic effects of EB on male rats and the possible ameliorative role of fennel essential oil (FEO). ...

journal_title：Environmental toxicology and pharmacology

authors： El-Sheikh el-SA,Galal AA

更新日期：2015-05-01 00:00:00

abstract：:This study investigated the cytoprotective effect of baicalein (5,6,7-trihydroxyflavone) against oxidative stress-induced mitochondrial dysfunction. Electron spin resonance (ESR) spectrometry revealed that baicalein showed significant scavenging effects on superoxide radicals and hydroxyl radicals. When H(2)O(2) treat...

journal_title：Environmental toxicology and pharmacology

authors： Lee IK,Kang KA,Zhang R,Kim BJ,Kang SS,Hyun JW

更新日期：2011-01-01 00:00:00

abstract：:The protective effects of lobenzarit disodium against the toxicity of allyl alcohol were investigated in vitro using isolated rat hepatocytes and in vivo using mice. In mice, at i.p doses of 25, 50 and 100 mg/kg lobenzarit significantly decreased the activity of alanine amino transferase (ALT) in serum and the concent...

journal_title：Environmental toxicology and pharmacology

authors： Remirez D,Commandeur JN,Groot E,Gonzalez R,Rodriguez S,Ancheta O,Rojas E,Ramos ME,Vermeulen NP

更新日期：1997-06-06 00:00:00

abstract：:Lead (Pb) is recognized as a potent inducer of synaptic toxicity generally associated with reduced synaptic transmission and increased neuronal fiber excitability, becoming an environmental risk for neurodegenerative processes. Despite numerous toxicological studies on Pb have been directed to the developing brain, at...

journal_title：Environmental toxicology and pharmacology

authors： Wu Z,Bai L,Tu R,Zhang L,Ba Y,Zhang H,Li X,Cheng X,Li W,Huang H

更新日期：2020-05-01 00:00:00

abstract：:Cigarette smoke (CS) is a well-known risk factor for carcinogenesis and has been found to be related to the occurrence and development of colon cancer. In this study, the effect of formaldehyde (FA), benzene (Bz), and isoprene (IP), which are included in main components of CS, on cell viability and apoptosis of SW620 ...

journal_title：Environmental toxicology and pharmacology

authors： Lee HM,Kim CW,Hwang KA,Choi DW,Choi KC

更新日期：2016-07-01 00:00:00

abstract：:Four extracts were prepared from the roots and leaves of Moricandia arvensis: root chloroform extract (ChlR), leaf chloroform extract (ChlL), root ethyl acetate extract (EAR) and leaf ethyl acetate extract (EAL). The genotoxic and antigenotoxic properties of these extracts were investigated by assessing the induction ...

journal_title：Environmental toxicology and pharmacology

authors： Skandrani I,Boubaker J,Bouhlel I,Limem I,Ghedira K,Chekir-Ghedira L

更新日期：2010-07-01 00:00:00

abstract：:Inhibition of intercellular communication (IC) between hepa1c1c7 cells was used as a possible bioassay to predict tumor promoting potency of polyhalogenated aromatic hydrocarbons (PAHs). Relative potencies with regard to 2,3,7,8-TCDD to inhibit IC and to induce cytochrome P450IA1/2 (EROD) in these hepa1c1c7 cells were...

journal_title：Environmental toxicology and pharmacology

authors： De Haan LH,Halfwerk S,Hovens SE,De Roos B,Koeman JH,Brouwer A

更新日期：1996-02-15 00:00:00

abstract：:A systematic study on the effects of diuron on the hepatic metabolism was conducted with emphasis on parameters linked to energy metabolism. The experimental system was the isolated perfused rat liver. The results demonstrate that diuron inhibited biosynthesis (gluconeogenesis) and ammonia detoxification, which are de...

journal_title：Environmental toxicology and pharmacology

authors： da Silva Simões M,Bracht L,Parizotto AV,Comar JF,Peralta RM,Bracht A

更新日期：2017-09-01 00:00:00

abstract：:In this study, Al2O3, CuO and TiO2 nanoparticles (NPs) were administered to mature female rats (Rattus norvegicus var. albinos) via oral gavage (0, 0.5, 5, 50mg/kg b.w./day) for 14days to investigate their effects on 14 serum biomarkers and 4 antioxidant enzyme (catalase, superoxide dismutase, glutathione peroxidase, ...

journal_title：Environmental toxicology and pharmacology

authors： Canli EG,Atli G,Canli M

更新日期：2017-03-01 00:00:00

abstract：:The purpose of this study was to investigate the toxic effects induced by benzo[a]pyrene (BaP). In the present study, juvenile white shrimp Litopenaeus vannamei were exposed to BaP for 21 days at four different concentrations as 0, 0.03, 0.3 and 3μg/L. Detoxification system parameters, transcription of metabolism-rela...

journal_title：Environmental toxicology and pharmacology

authors： Ren X,Pan L,Wang L

更新日期：2015-01-01 00:00:00

abstract：:Indole-3-carbinol (I3C) is extracted from cruciferous vegetables and is well known for its anti-cancer, antioxidant and anti-inflammatory effects. This study investigated the protective effect of I3C in hyperlipidemia zebrafish larvae and early life stage toxicity of I3C on zebrafish embryos/larvae. Zebrafish larvae w...

journal_title：Environmental toxicology and pharmacology

authors： Jiang Y,Yang G,Liao Q,Zou Y,Du Y,Huang J

更新日期：2019-08-01 00:00:00

abstract：:We previously observed that nonylphenol (NP) exposure during development resulted in increases in body weight and hyperadrenalism in adult male offspring. The mechanism of hyperadrenalism includes the primary activation of the adrenal gland and the conversion of inactive glucocorticoids to active glucocorticoids by 11...

journal_title：Environmental toxicology and pharmacology

authors： Chang LL,Wun WS,Wang PS

更新日期：2016-06-01 00:00:00

abstract：:In this study with crucian carp (Carassius auratus gibelio), the effect on enrofloxacin (EF) and its metabolite ciprofloxacin (CF) and on the activity of cytochrome P450 1A (CYP1A) and cytochrome P450 3A (CYP3A) was estimated following the oral administration of rifampicin (RIF) (12mg/kg) and β-naphthoflavone (BNF) (1...

journal_title：Environmental toxicology and pharmacology

authors： Fu G,Zhou C,Wang Y,Fang W,Zhou J,Zhao S,Ma L

更新日期：2016-09-01 00:00:00

abstract：:The influence of prenatal alcohol exposure on the serotoninergic system in the brain has been well studied, however its influence on the serotoninergic system in the gastrointestinal system remains unknown. The objective of the study was to use a mouse model of prenatal alcohol exposure to investigate the effects on s...

journal_title：Environmental toxicology and pharmacology

authors： Dylag KA,Fidalgo SVS,Gard PR,Patel BA

更新日期：2018-07-01 00:00:00

abstract：:This study was to investigate the combined toxicity of silica nanoparticles (SiNPs) and methylmercury (MeHg) on cardiovascular system in zebrafish (Danio rerio) embryos. Ultraviolet absorption analysis showed that the co-exposure system had high absorption and stability. The dosages used in this study were based on th...

journal_title：Environmental toxicology and pharmacology

authors： Duan J,Hu H,Li Q,Jiang L,Zou Y,Wang Y,Sun Z

更新日期：2016-06-01 00:00:00

abstract：:Although airborne chemicals can directly elicit adverse reactions via stimulation of the olfactory and trigeminal nerves, such as sensory irritation of the mucous membranes of the eyes, nose and throat, an individual's subjective experience is often the result of a complex sequence of events involving those sensory, p...

journal_title：Environmental toxicology and pharmacology

authors： Smeets MA,Dalton PH

更新日期：2005-05-01 00:00:00

abstract：:There are numerous examples, of both the identical and different effects of animals exposure to toxic agents, which can be compared in both, exposed prenatal/neonatal animals and exposed adults. In some instances, although the chemical and its metabolites are stored for long periods in adipose tissue, adult exposure (...

journal_title：Environmental toxicology and pharmacology

authors： Barnett JB

更新日期：1997-12-01 00:00:00

abstract：:The dominant lethal assay was utilized to assess the reproductive performance in male mice, possible genetic hazards, and persistent damage of aluminum (Al). Al chloride, AlCl(3), was administered subcutaneously to CD-1 adult male mice at dosages of 0, 7, or 13mg Al/kg body weight/day for 2 weeks of pre-mating periods...

journal_title：Environmental toxicology and pharmacology

authors： Guo CH,Lu YF,Hsu GS

更新日期：2005-07-01 00:00:00

abstract：:Chlorinated derivatives of bisphenol A (ClBPAs) have been detected in wastewater from waste paper recycling plants. BPA and ClBPAs are always exposed to ultraviolet (UV) radiation in the environment and consequently various photoproducts might be produced. Acute cytotoxicity of photoproducts of BPA and ClBPAs are not ...

journal_title：Environmental toxicology and pharmacology

authors： Mutou Y,Ibuki Y,Terao Y,Kojima S,Goto R

更新日期：2006-05-01 00:00:00

abstract：:The epothilones, a new class of microtubule-targeting agents, seem to be a very promising alternative to the current strategy of cancer treatment. We have analyzed the aspects of epothilone B (Epo B) on cellular metabolism of tumor (OV-90) and normal (MM 14) ovarian cells. The observed effects were compared with those...

journal_title：Environmental toxicology and pharmacology

authors： Rogalska A,Szula E,Gajek A,Marczak A,Jóźwiak Z

更新日期：2013-09-01 00:00:00

abstract：:We investigated the effect of phytosterol (PS) in regard to liver damage induced by 4-nitrophenol (PNP). Twenty rats were randomly divided into four groups (Control, PS, PNP, and PNP+PS). The PS and PNP+PS groups were pretreated with PS for one week. The PNP and PNP+PS groups were injected subcutaneously with PNP for ...

journal_title：Environmental toxicology and pharmacology

authors： Chen J,Song M,Li Y,Zhang Y,Taya K,Li C

更新日期：2016-01-01 00:00:00

abstract：:We have developed a photometric, platereader-based microassay for superoxide anion scavening activity in vitro. Superoxide anions were generated using a xanthine oxidase/hypoxanthine system and detected by following the reduction of ferricytochrome c at 550 nM. Inhibitory activity was assessed for superoxide dismutase...

journal_title：Environmental toxicology and pharmacology

authors： Laight DW,Andrews TJ,Haj-Yehia AI,Carrier MJ,Anggård EE

更新日期：1997-02-15 00:00:00

abstract：:To investigate the effect of infrasound on the hippocampus-dependent spatial learning and memory as well as its underlying mechanisms, we measured the changes of cognitive abilities, brain-derived neurotrophic factor (BDNF)-tyrosine kinase receptor B (TrkB) signal transduction pathway and neurogenesis in the hippocamp...

journal_title：Environmental toxicology and pharmacology

authors： Yuan H,Long H,Liu J,Qu L,Chen J,Mou X

更新日期：2009-09-01 00:00:00