Abstract:
:Coutarea hexandra is a species commonly known in Brazil as quina, and its bark is used in folk medicine. In this study, we assess the mutagenic and DNA-damaging effects of ethanol extracts from C. hexandra stem bark (SCH) and leaves (LCH) by employing the Ames test on the TA98 and TA100 strains of Salmonella typhimurium in addition to a plasmid treatment test. Furthermore, we performed a phytochemical analysis by TLC and HPLC, a quantification of the phenolic constituents and an assessment of the antioxidative activity. SCH and LCH showed mutagenic action in the Ames test for TA98 strains after metabolic activation. LCH also showed mutagenicity for the TA100 strain after metabolic activation. The findings from the plasmid treatment test did not indicate any DNA-damaging activity for either of the extracts with the tested dosages. SCH showed greater flavonoid content and greater antioxidative potential in relation to LCH. This study suggests that caution is advisable in the use of this plant. However, in vivo studies should be conducted to confirm these data.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Nunes LG,Gontijo DC,Souza CJ,Fietto LG,Carvalho AF,Leite JPdoi
10.1016/j.etap.2011.12.003subject
Has Abstractpub_date
2012-03-01 00:00:00pages
297-303issue
2eissn
1382-6689issn
1872-7077pii
S1382-6689(11)00180-3journal_volume
33pub_type
杂志文章abstract::The dominant lethal assay was utilized to assess the reproductive performance in male mice, possible genetic hazards, and persistent damage of aluminum (Al). Al chloride, AlCl(3), was administered subcutaneously to CD-1 adult male mice at dosages of 0, 7, or 13mg Al/kg body weight/day for 2 weeks of pre-mating periods...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2004.11.007
更新日期:2005-07-01 00:00:00
abstract::Effects of two widely found chemical pollutants, bis(2-ethylhexyl) phthalate (DEHP) and benzo[a]pyrene (BaP), on the embryos of Japanese medaka were investigated. The embryos were exposed to different concentrations (0.01, 0.1, 1, and 10μg/l) of DEHP and BaP. The following were investigated: (1) hatching time and hatc...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2003.11.007
更新日期:2004-04-01 00:00:00
abstract::Antiretroviral drugs (ARVs) are hazardous therapeutic pharmaceuticals present in South African surface water. Efavirenz is an ARV commonly used in human immunodeficiency virus (HIV) treatment in South Africa. Although little is known about the toxic effects of efavirenz on fish health, threats of toxicity to the aquat...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2017.09.017
更新日期:2017-12-01 00:00:00
abstract::Tinospora cordifolia (Guduchi) has been used for centuries for treating various ailments including cancer in Ayurvedic system of medicine. In this study, we report the mechanism of cell death exhibited by the hexane extract fraction of T. cordifolia (TcHf) against Ehrlich ascites tumor (EAT) in mice. Treatment of EAT ...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2006.10.004
更新日期:2007-03-01 00:00:00
abstract::A physiologically based pharmacokinetic (PBPK) model has been developed for trichloroethylene (1,1,2-trichloroethene, TRI) for rat and humans, based on in vitro metabolic parameters. These were obtained using individual cytochrome P450 and glutathione S-transferase enzymes. The main enzymes involved both for rats and ...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/s1382-6689(02)00019-4
更新日期:2002-07-01 00:00:00
abstract::A thiamine deficiency disease termed M74 syndrome affects the yolk-sac fry of wild and feral Baltic salmon. However, very little is known about the pharmacokinetics of thiamine in salmon. This study examined the pharmacokinetics of thiamine hydrochloride injected intraperitoneally into feral and farmed Baltic salmon f...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2004.06.001
更新日期:2005-01-01 00:00:00
abstract::The effects of oral administration of tamoxifen, 17α-ethynylestradiol (EE2), flutamide, and methyltestosterone (MT), on plasma vitellogenin levels of male and female medaka were investigated. Medaka were fed diets containing different concentrations of these chemicals for 7 days, and these plasma vitellogenin levels w...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2004.02.002
更新日期:2004-05-01 00:00:00
abstract::To investigate the effect of infrasound on the hippocampus-dependent spatial learning and memory as well as its underlying mechanisms, we measured the changes of cognitive abilities, brain-derived neurotrophic factor (BDNF)-tyrosine kinase receptor B (TrkB) signal transduction pathway and neurogenesis in the hippocamp...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2009.04.011
更新日期:2009-09-01 00:00:00
abstract::Cigarette smoke (CS) is a well-known risk factor for carcinogenesis and has been found to be related to the occurrence and development of colon cancer. In this study, the effect of formaldehyde (FA), benzene (Bz), and isoprene (IP), which are included in main components of CS, on cell viability and apoptosis of SW620 ...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2016.05.016
更新日期:2016-07-01 00:00:00
abstract::In this study, we evaluated the anti-photoaging activity of magnolol in UV-irradiated hairless mice, and hypothesized that magnolol would prevent photoaging in these animals. The inhibitory effect of magnolol on wrinkle formation was determined by analyzing the skin replica, histologically examining the epidermal thic...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2014.12.001
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:Present study aimed at determining blood selenium concentration (Se-B) in a selected population of children inhabiting industrial regions. METHODS:The studies were conducted on a group of 267 children inhabiting industrial regions in Upper Silesia (Poland). Determination of Se-B was performed using hydride gen...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2012.06.005
更新日期:2012-09-01 00:00:00
abstract::Milk contain compounds acting through the estrogen receptor signaling. The still open question whether such estrogens pose a risk for human health, encouraged us to measure the overall estrogenic activity of cow's milk in the in vitro yeast reporter bioassay. First, we assessed the ability of the bioassay to detect es...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2015.09.022
更新日期:2015-11-01 00:00:00
abstract::Poisoning by organophosphorus insecticides is a major global public health problem. Although atropine has been widely used to treat organophosphate (OP) poisoning, sometimes atropinization cannot be achieved, even with high doses of atropine. Hence, we aimed to assess the effect of anisodamine for organophosphorus poi...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2013.12.016
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:: Coughing is one of the chronic respiratory symptoms of patients exposed to sulfur mustard (SM) used against Iranian combatants and civilians by Iraq during the Iran-Iraq war, between 1983 and 1989. This study carried out on SM exposed patients who referred to our clinic because of exacerbation of chronic c...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2004.09.006
更新日期:2005-07-01 00:00:00
abstract::The aim of study was to assess the uptake of polycyclic aromatic hydrocarbons (PAH) by children living in a city and its effect on 1-hydroxypyrene (1-OHP) excretion. Two groups of children (n=11 and 13; 3-6 years old) were chosen: (1) a group from a kindergarten situated near a road with a high traffic density ('pollu...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/s1382-6689(00)00032-6
更新日期:2000-01-01 00:00:00
abstract::In Pakistan a huge number of workers is routinely exposed to various types of chemical contaminants but there is a dearth of information as to the impact of these agents, due to a lack of a routine surveillance system and proper reporting. Prolonged and sometimes acute occupational exposures to varied organic chemical...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.etap.2012.02.009
更新日期:2012-07-01 00:00:00
abstract::The dechlorination of PCB, specifically the noncoplanar congener PCB 153, has been observed in the presence of a crude nitrate reductase extract from Medicago sativa leaves. These observations were further confirmed using a commercially available and pure nitrate reductase from Zea mays. The presence of nitrate reduct...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2007.10.009
更新日期:2008-03-01 00:00:00
abstract::One of the consequence of municipal waste deposition is the production of landfill leachate. Its volume and composition is determined by numerous factors, including waste composition, landfill age and the volume of precipitation. Leachate may contain a number of mineral and organic compounds, the volume of which must ...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2019.01.013
更新日期:2019-04-01 00:00:00
abstract::The purpose of the present study was to assess do selected pesticides as well as their binary combinations act as inhibitors of P-glycoprotein (P-gp) activity of NIH 3T3 mouse fibroblasts stably transfected with human MDR1 gene (NIH 3T3/MDR1). As a result of P-gp inhibition, the increase of intracellular accumulation ...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2006.04.002
更新日期:2006-11-01 00:00:00
abstract::The pathogenesis of atopic dermatitis (AD) involves T helper 2 (Th2) cells, and effective therapies remain elusive due to the paucity of animal models. We aimed to develop a mouse model of an immune system aberration caused by allergen. Experiments were conducted in two phases. In experiment 1, BALB/c mice were sensit...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2017.12.025
更新日期:2018-03-01 00:00:00
abstract::The epothilones, a new class of microtubule-targeting agents, seem to be a very promising alternative to the current strategy of cancer treatment. We have analyzed the aspects of epothilone B (Epo B) on cellular metabolism of tumor (OV-90) and normal (MM 14) ovarian cells. The observed effects were compared with those...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2013.06.003
更新日期:2013-09-01 00:00:00
abstract::This study is intended to explore effective and sensitive biomarkers for kidney damage after low level arsenic (As) exposure and to provide scientific evidence on cut-off values of arsenic concentrations in drinking water. The levels of α1-MG detected in urine samples were found to have statistically significant diffe...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2013.02.010
更新日期:2013-05-01 00:00:00
abstract::This study was to investigate the combined toxicity of silica nanoparticles (SiNPs) and methylmercury (MeHg) on cardiovascular system in zebrafish (Danio rerio) embryos. Ultraviolet absorption analysis showed that the co-exposure system had high absorption and stability. The dosages used in this study were based on th...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2016.05.004
更新日期:2016-06-01 00:00:00
abstract::Exposure of HL-60 cells, a human myeloid cell line, to 500μM etomidate for 24h reduced cell viability and increased nitric oxide production and mitochondrial permeability transition pore (mPTP) opening. Preconditioning (1h) with 1μM etomidate 4h before exposure to the 500μM dose of etomidate attenuated those detriment...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2010.02.003
更新日期:2010-05-01 00:00:00
abstract::Coniferaldehyde (CA) exerts anti-inflammatory properties by inducing heme oxygenase-1 (HO-1). To define the regulation mechanism by which CA induces a cytoprotective function and HO-1 expression, the up-stream regulations involved in the activation of nuclear transcription factor-erythroid 2-related factor (Nrf)-2/HO-...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2016.10.016
更新日期:2016-12-01 00:00:00
abstract::The recovery effect of chlorpyrifos (CPF) on antioxidant enzymes, locomotor behaviour and the target enzyme acetylcholinesterase (AChE) interaction were studied after exposure to 297μgL(-1) (LC(50) for 96h) in mosquito fish, Gambusia affinis. Activities of the antioxidant enzymes-superoxide dismutase, catalase, glutat...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2008.03.010
更新日期:2008-09-01 00:00:00
abstract::Genistein receives much attention because of its potential to prevent hormone-related cancer and cardiovascular diseases. Limited information is available on the pharmacokinetics of this compound like, for instance, their intestinal uptake by humans and systematic bioavailability. In this study, the fate of the absorp...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2004.03.008
更新日期:2004-06-01 00:00:00
abstract::Long non-coding RNAs (LncRNAs) are a category of non-coding RNAs (ncRNAs) with a length of 200nt-100kb lacking a significant open reading frame. The study of lncRNAs is a newly established field, due in part to their capability to act as the novel biomarkers in disease. A growing body of research shows that lncRNAs ma...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.etap.2017.08.014
更新日期:2017-10-01 00:00:00
abstract::A water extract of the lyophilised fresh-water alga Anabaena flos-aquae enhanced substantially the release of [(3)H]acetylcholine ([(3)H]acetylcholine and [(3)H]choline) from cholinergic nerves of rat bronchi. Parallel experiments performed with the related species Anabaena lemmermannii did not demonstrate this effect...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/s1382-6689(97)10007-2
更新日期:1998-01-01 00:00:00
abstract::Effects of aluminum (Al) on membrane properties of excitable cells are not fully understood. Several reports have identified cellular membranes as sensitive targets for Al intoxication. In the present study, we tested the hypothesis that treatment with Al would alter membrane fluidity and potential and these changes w...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2004.05.011
更新日期:2005-02-01 00:00:00