Abstract：
:The effects of bis(2-ethylhexyl) phthalate (DEHP), γ-hexachlorocyclohexane (γ-HCH), and 17β-estradiol (E2) on the fry stage of medaka were investigated. The medaka fry were exposed to different concentrations (0.01, 0.1, 1, and 10μg/L) of these chemicals for 3 weeks after hatching. Then, mortality, body weight, sex ratio, and gonadosomatic index (GSI) of the matured fish (after 5 months) were measured. Mortality was increased significantly in the 10μg/L E2 group. Distortion of sex ratio was found in 1 and 10μg/L E2 groups. DEHP treated groups showed the GSI reduction only in male fish. All the γ-HCH and parts of the E2 treated groups showed the GSI reduction in both sexes. Exposure of DEHP, γ-HCH, and E2 during the fry stage affected normal maturation of medaka at the concentrations which had no impact on mortality or sex ratio.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Chikae M,Ikeda R,Hatano Y,Hasan Q,Morita Y,Tamiya Edoi
10.1016/j.etap.2004.04.004subject
Has Abstractpub_date
2004-09-01 00:00:00pages
9-12issue
1eissn
1382-6689issn
1872-7077pii
S1382-6689(04)00070-5journal_volume
18pub_type
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