Abstract:
:Recent studies in our laboratory indicated that arsenite at 20μM significantly induces the apoptosis of HUVECs. In this study we analyzed miRNAs expression profiles upon arsenic exposure of these cells to explore the molecular mechanisms of arsenic-induced vascular toxicity. The expression of miRNAs was examined by Exiqon miRCURY™ LNA microRNA chips. We found that 85 miRNAs were up-regulated and 52 were down-regulated by arsenic treatment as compared to the control group. The expression of altered miRNAs was validated by quantitative reverse-transcription PCR (qRT-PCR). A number of DNA motifs were identified in the promoters of the perturbed miRNAs by promoter analysis using MEME software. Analysis of cellular functions by using DAVID Bioinformatics Resources revealed that phosphoproteins and genes involved in alternative splicing are among the top categories targeted by both up- and down-regulated miRNAs. In conclusion, the results show that the alteration of miRNAs expression might play crucial roles in arsenic-induced vascular injury.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Li X,Shi Y,Wei Y,Ma X,Li Y,Li Rdoi
10.1016/j.etap.2012.05.003subject
Has Abstractpub_date
2012-09-01 00:00:00pages
381-387issue
2eissn
1382-6689issn
1872-7077pii
S1382-6689(12)00074-9journal_volume
34pub_type
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