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Chemical composition, anti-inflammatory activity and cytotoxic activity of the liposoluble constituents from different parts of Acanthopanax evodiaefolius by the Herbal Blitzkrieg Extractor.

Abstract：

:The liposoluble constituents of leaves (LCL) and stem barks (LCSB) from Acanthopanax evodiaefolius Franch were extracted by Herbal Blitzkrieg Extractor (HBE), and their chemical composition was analyzed by GC-MS. 18 compounds were identified, representing 71.98% of LCL, while 35 compounds were identified, accounting for 98.28% of the LCSB. Their cytotoxic activity and inhibitory effect on nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells were tested and the LCL showed significant NO, IL-6 and TNF-α inhibition activity. These results provide the scientific basis for looking for new natural anti-inflammatory substances and exploiting and developing resources of A. evodiaefolius Franch.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Huang WC,Li Z,Li XJ,Gong LM,Liu XQ,Kwon OK,Ye HX,Lee HK

doi

10.1016/j.etap.2014.07.005

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

406-11

issue

2

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(14)00159-8

journal_volume

38

pub_type

杂志文章

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