当前位置： SCI文献检索 > ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY期刊下所有文献 > Differential tissue regulation of peroxisome proliferator-activated receptor α (PPARα) and cannabinoid receptor 1 (CB1) gene transcription pathways by diethylene glycol dibenzoate (DEGB): preliminary observations in a seabream (Sparus aurata) in vivo mode

Differential tissue regulation of peroxisome proliferator-activated receptor α (PPARα) and cannabinoid receptor 1 (CB1) gene transcription pathways by diethylene glycol dibenzoate (DEGB): preliminary observations in a seabream (Sparus aurata) in vivo mode

Abstract：

:Today a variety of endocrine disrupting chemicals (EDCs) are recognized in the group of metabolic disruptors, a wide range of environmental contaminants that alter energy balance regulation by affecting the peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor (RXR) pathway. Herein, we investigated the effect of diethylene glycol dibenzoate (DEGB), a dibenzoate-based plasticizer used as alternative to phthalates, on the expression of key genes involved in lipid metabolism and energy balance by using Sparus aurata juveniles as models. We also evaluated the correlation between cannabinoid receptor 1 (CB1) and PPARα transcriptional patterns in both liver and brain tissues. Exposure to the highest DEGB concentration differentially modulated PPARα/CB1 transcriptional pathways in liver/brain tissues of seabream. We hypothesize that, at peripheral level (i.e. liver), DEGB acts as PPARα agonist resulting in a potential stimulation of key lipolytic genes and a concomitant down-regulation of endocannabinoid metabolic enzyme genes.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Cocci P,Mozzicafreddo M,Angeletti M,Mosconi G,Palermo FA

doi

10.1016/j.etap.2017.08.015

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

87-93

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(17)30235-1

journal_volume

55

pub_type

杂志文章

相关文献

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY文献大全
  • Chemical composition, anti-inflammatory activity and cytotoxic activity of the liposoluble constituents from different parts of Acanthopanax evodiaefolius by the Herbal Blitzkrieg Extractor.

    abstract：:The liposoluble constituents of leaves (LCL) and stem barks (LCSB) from Acanthopanax evodiaefolius Franch were extracted by Herbal Blitzkrieg Extractor (HBE), and their chemical composition was analyzed by GC-MS. 18 compounds were identified, representing 71.98% of LCL, while 35 compounds were identified, accounting f...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.07.005

    authors： Huang WC,Li Z,Li XJ,Gong LM,Liu XQ,Kwon OK,Ye HX,Lee HK

    更新日期：2014-09-01 00:00:00

  • A novel mouse model of atopic dermatitis that is T helper 2 (Th2)-polarized by an epicutaneous allergen.

    abstract：:The pathogenesis of atopic dermatitis (AD) involves T helper 2 (Th2) cells, and effective therapies remain elusive due to the paucity of animal models. We aimed to develop a mouse model of an immune system aberration caused by allergen. Experiments were conducted in two phases. In experiment 1, BALB/c mice were sensit...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.12.025

    authors： Park HJ,Choi WS,Lee WY,Choi Y,Park C,Kim JH,Hong KH,Song H

    更新日期：2018-03-01 00:00:00

  • Haemato-immunological studies in ZnO and TiO2 nanoparticles exposed euryhaline fish, Oreochromis mossambicus.

    abstract：:The present study was aimed to analyze the effect of ZnO and TiO2 nanoparticles (NPs) on Haemato-immunological parameters in adult Tilapia, Oreochromis mossambicus. The nanoparticles size found as 47 nm and 30 nm for ZnO and TiO2 respectively. The acute toxicity (96 h) of ZnO (LC50: 100-110 ppm) and TiO2 (LC50: 80-90 ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2018.12.011

    authors： Suganthi P,Murali M,Athif P,Sadiq Bukhari A,Syed Mohamed HE,Basu H,Singhal RK

    更新日期：2019-02-01 00:00:00

  • Glyphosate induces cardiovascular toxicity in Danio rerio.

    abstract：:Glyphosate is a broad spectrum herbicide used aggressively in agricultural practices as well as home garden care. Although labeled "safe" by the chemical industry, doses tested by industry do not mimic chronic exposures to sublethal doses that organisms in the environment are exposed to over long periods of time. Give...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2016.08.010

    authors： Roy NM,Ochs J,Zambrzycka E,Anderson A

    更新日期：2016-09-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of sulfamethoxazole and trimethoprim in swimming crabs (Portunus trituberculatus) and in vitro antibacterial activity against Vibrio: PK/PD of SMZ-TMP in crabs and antibacterial activity against Vibrio.

    abstract：:Serious bacterial pathogens have recently become a major cause of massive mortality in swimming crabs (Portunus trituberculatus). In this study, the antibacterial activity against Vibrio and the pharmacokinetics (PK) of sulfamethoxazole (SMZ)-trimethoprim (TMP) in crabs were estimated to explore the pharmacokinetics/p...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2016.06.029

    authors： Fu G,Peng J,Wang Y,Zhao S,Fang W,Hu K,Shen J,Yao J

    更新日期：2016-09-01 00:00:00

  • Review: Usnic acid-induced hepatotoxicity and cell death.

    abstract：:Increasing prevalence of herbal and dietary supplement-induced hepatotoxicity has been reported worldwide. Usnic acid (UA) is a well-known hepatotoxin derived from lichens. Since 2000, more than 20 incident reports have been received by the US Food and Drug Administration after intake of UA containing dietary suppleme...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.etap.2020.103493

    authors： Kwong SP,Wang C

    更新日期：2020-11-01 00:00:00

  • Genes regulating wing patterning in Drosophila melanogaster show reduced expression under exposure of Daminozide, the fruit ripening retardant.

    abstract：:In our previous study we demonstrated that the fruit ripening retardant Daminozide or Alar causes change in life history traits, distortion of adult wing structure, DNA damage in brain cells and mutagenic effects in fruit fly Drosophila melanogaster. As a continuation of the previous study the present work is designed...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.103322

    authors： Roy SS,Ghosh S

    更新日期：2020-04-01 00:00:00

  • Isoflavones protect against diesel engine exhaust injury in organotypic culture of lung tissue.

    abstract：:The wide range of potential health beneficial effects of isoflavones, including a chemoprentive action, have prompted us to study the potential benefits of genistein and daidzein in an experimental model of environmental pollution impact on lung tissue. A diesel engine placed was used to generate reproducible emission...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(02)00066-2

    authors： Morin JP,Rumigny JF,Bion A,Dionnet F

    更新日期：2002-11-01 00:00:00

  • Effects of N-Butylphthalide on the expressions of Nogo/NgR in rat brain tissue after carbon monoxide poisoning.

    abstract：:Carbon monoxide (CO) intoxication is one of the most common types of poisoning worldwide, and may result in neuropathologic sequelae, yet its pathogenesis is not clear and there is no optimal management strategy for patients with CO poisoning. In this study, the rat model of CO poisoning was established in a hyperbari...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.02.013

    authors： Li Q,Cheng Y,Bi MJ,Kang H,Qu Y,Lin H,Guo Y,Zou Y

    更新日期：2015-03-01 00:00:00

  • Ardipusilloside I induces apoptosis in human glioblastoma cells through a caspase-8-independent FasL/Fas-signaling pathway.

    abstract：:Ardipusilloside I, a triterpenoid saponin isolated from Ardisia pusilla A. DC, suppresses the growth of a variety of cancer cells, and has certain immunomodulative properties. Herein, we investigated its effect on glioblastoma cell line U87MG cells and primary cultured human glioblastoma cells, and examined the underl...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2008.11.008

    authors： Xiong J,Cheng G,Tang H,Zhen HN,Zhang X

    更新日期：2009-03-01 00:00:00

  • Microassay of superoxide anion scavenging activity in vitro.

    abstract：:We have developed a photometric, platereader-based microassay for superoxide anion scavening activity in vitro. Superoxide anions were generated using a xanthine oxidase/hypoxanthine system and detected by following the reduction of ferricytochrome c at 550 nM. Inhibitory activity was assessed for superoxide dismutase...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(96)00143-3

    authors： Laight DW,Andrews TJ,Haj-Yehia AI,Carrier MJ,Anggård EE

    更新日期：1997-02-15 00:00:00

  • Gambogenic acid induced mitochondrial-dependent apoptosis and referred to phospho-Erk1/2 and phospho-p38 MAPK in human hepatoma HepG2 cells.

    abstract：:Gambogenic acid, identified from Gamboge, is responsible for anti-tumor effects, and has been shown to be a potential molecule against human cancers. In this study, the molecular mechanism of gambogenic acid-induced apoptosis in HepG2 cells was investigated. Gambogenic acid significantly inhibited cell proliferation a...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.12.006

    authors： Yan F,Wang M,Li J,Cheng H,Su J,Wang X,Wu H,Xia L,Li X,Chang HC,Li Q

    更新日期：2012-03-01 00:00:00

  • Antiangiogenic effects of marine sponge derived compounds on cancer.

    abstract：:The term "angiogenic switch" refers to a time-restricted event during tumor progression where the balance between pro- and anti-angiogenic factors, resulting in the transition from dormant avascularized hyperplasia to outgrowing vascularized tumor and eventually to malignant tumor progression. Targeting angiogenesis a...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.etap.2013.09.014

    authors： Senthilkumar K,Venkatesan J,Manivasagan P,Kim SK

    更新日期：2013-11-01 00:00:00

  • Environmental epigenomics: Current approaches to assess epigenetic effects of endocrine disrupting compounds (EDC's) on human health.

    abstract：:Environmental Epigenomics is a developing field to study the epigenetic effect on human health from exposure to environmental factors. Endocrine disrupting chemicals have been detected primarily in pharmaceutical drugs, personal care products, food additives, and food containers. Exposure to endocrine-disrupting chemi...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.etap.2017.02.004

    authors： Tapia-Orozco N,Santiago-Toledo G,Barrón V,Espinosa-García AM,García-García JA,García-Arrazola R

    更新日期：2017-04-01 00:00:00

  • The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene.

    abstract：:A physiologically based pharmacokinetic (PBPK) model has been developed for trichloroethylene (1,1,2-trichloroethene, TRI) for rat and humans, based on in vitro metabolic parameters. These were obtained using individual cytochrome P450 and glutathione S-transferase enzymes. The main enzymes involved both for rats and ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(02)00019-4

    authors： Hissink EM,Bogaards JJ,Freidig AP,Commandeur JN,Vermeulen NP,van Bladeren PJ

    更新日期：2002-07-01 00:00:00

  • Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis.

    abstract：:Organophosphate flame retardants (OPFRs) are increasingly produced and used as alternatives of brominated flame-retardants (BFRs) and have become emerging marine environmental contaminants. So far, however, little is known regarding the biological effects of OPFRs in marine organisms. In this study, the biological eff...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2018.05.022

    authors： Wu H,Zhong M,Lu Z,Shan X,Li F,Ji C,Cong M

    更新日期：2018-07-01 00:00:00

  • Influence of dioxin on the daily variation of insulin sensitivity in mice.

    abstract：:To evaluate an influence of dioxin on a daily variation of insulin sensitivity, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100ng/kg) was given for 3 weeks in mice. Insulin tolerance test and oral glucose tolerance test were performed. TCDD decreased insulin sensitivity at an active period, but not at a rest period. T...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.07.008

    authors： Takuma M,Ushijima K,Kumazaki M,Ando H,Fujimura A

    更新日期：2015-09-01 00:00:00

  • In utero exposure of neonatal buffalo calves to pesticide residues and the alterations within their reproductive tract.

    abstract：:In utero exposure of neonates to pesticide residues could be damaging to the reproductive tract. Hence, the present study assessed the circulating concentrations of pesticide residues in buffalo and their neonatal calves as well as in the reproductive tract tissue samples of same calves. Also, histopathological altera...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.08.031

    authors： Kaur K,Ghuman SS,Singh O,Bedi JS,Gill JP

    更新日期：2015-11-01 00:00:00

  • Effects of inducers of cytochrome P450s on enrofloxacin N-deethylation in crucian carp Carassius auratus gibelio.

    abstract：:In this study with crucian carp (Carassius auratus gibelio), the effect on enrofloxacin (EF) and its metabolite ciprofloxacin (CF) and on the activity of cytochrome P450 1A (CYP1A) and cytochrome P450 3A (CYP3A) was estimated following the oral administration of rifampicin (RIF) (12mg/kg) and β-naphthoflavone (BNF) (1...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2016.07.015

    authors： Fu G,Zhou C,Wang Y,Fang W,Zhou J,Zhao S,Ma L

    更新日期：2016-09-01 00:00:00

  • Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity.

    abstract：:Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of N...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.02.022

    authors： Zhang J,Zhou X,Wu W,Wang J,Xie H,Wu Z

    更新日期：2017-04-01 00:00:00

  • Induction of mitochondria-mediated apoptosis by methanol fraction of Ulmus davidiana Planch (Ulmaceae) in U87 glioblastoma cells.

    abstract：:Mitochondria play a pivotal role in apoptosis of mammalian cells by releasing apoptogenic proteins such as cytochrome c into the cytoplasm. Mitochondrial membrane permeability during apoptosis is regulated directly by the Bcl-2 family of proteins. In glioma cells, there are no specific features of apoptosis compared w...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2006.01.005

    authors： Jin UH,Lee DY,Kim DS,Lee IS,Kim CH

    更新日期：2006-09-01 00:00:00

  • Latent role of in vitro Pb exposure in blocking Aβ clearance and triggering epigenetic modifications.

    abstract：:Both β-amyloid (Aβ) catabolism and epigenetic regulation play critical roles in the onset of neurodegeneration. The latter also contribute to Pb neurotoxicity. The present study explored the role of epigenetic modifiers and Aβ degradation enzymes in Pb-induced latent effects on Aβ overproduction in vitro. Our results ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2018.12.015

    authors： Wang Y,Hu Y,Wu Z,Su Y,Ba Y,Zhang H,Li X,Cheng X,Li W,Huang H

    更新日期：2019-02-01 00:00:00

  • Aluminum trichloride inhibits osteoblastic differentiation through inactivation of Wnt/β-catenin signaling pathway in rat osteoblasts.

    abstract：:Exposure to aluminum (Al) suppresses bone formation. Osteoblastic differentiation plays a key role in the process of bone formation. However, the effect of Al on osteoblastic differentiation is still controversial, and the mechanism remains unclear. To investigate the effect of Al on osteoblastic differentiation and w...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.11.023

    authors： Cao Z,Fu Y,Sun X,Zhang Q,Xu F,Li Y

    更新日期：2016-03-01 00:00:00

  • The interplay of glutathione-related processes in antioxidant defense.

    abstract：:This review summarizes current knowledge on glutathione (GSH) associated cellular processes that play a central role in defense against oxidative stress. GSH itself is a critical factor in maintaining the cellular redox balance and has been demonstrated to be involved in regulation of cell signalling and repair pathwa...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(01)00077-1

    authors： Cnubben NH,Rietjens IM,Wortelboer H,van Zanden J,van Bladeren PJ

    更新日期：2001-09-01 00:00:00

  • Acute toxicity, biochemical toxicity and genotoxicity caused by 1-butyl-3-methylimidazolium chloride and 1-butyl-3-methylimidazolium tetrafluoroborate in zebrafish (Danio rerio) livers.

    abstract：:The present study examined the potential toxicity of 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) and 1-butyl-3- methylimidazolium tetrafluoroborate ([Bmim]BF4) in the liver cells of zebrafish (Danio rerio) with different doses (20-160mg/L) on 7 and 14days. The effects of [Bmim]Cl and [Bmim]BF4 on acute toxicity, r...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.02.018

    authors： Zhang C,Shao Y,Zhu L,Wang J,Wang J,Guo Y

    更新日期：2017-04-01 00:00:00

  • Investigation of chronic toxicity of (14)C-fenitrothion and its degradation products on stored soybeans.

    abstract：:Grains of soybeans were treated with the recommended dose of fenitrothion insecticide, 5mg/kg, and double that dose, before storage for 30 weeks under ambient local conditions. During the storage period, the penetration and distribution of insecticide residues were studied. The amount of surface residues on stored soy...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 信件

    doi：10.1016/j.etap.2008.08.005

    authors： Farghaly M,El-Maghraby S

    更新日期：2009-01-01 00:00:00

  • Assessment of the cytotoxic and anti-viral potential of aqueous extracts from different parts of Acacia nilotica (Linn) Delile against Peste des petits ruminants virus.

    abstract：:Peste des petits ruminants virus (PPRV); a negative sense single stranded RNA enveloped virus that causes Peste des petits ruminants (PPR), is dramatically affecting the health status of ruminants all around the world resulting in extensive economical losses in livestock sector. Acacia nilotica (Linn) Delile; a tannin...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2012.11.005

    authors： Raheel R,Ashraf M,Ejaz S,Javeed A,Altaf I

    更新日期：2013-01-01 00:00:00

  • Assessment of pulmonary toxicity of gold nanorods following intra-tracheal instillation in rats.

    abstract：:The present investigation was aimed to evaluate the pulmonary toxicity of 10 and 25nm gold nanorods (GNRs) following intra-tracheal instillation in rats using bronchoalveolar lavage (BAL) fluid and lung histopathological analysis. The GNRs displayed that the dose-dependent toxicity via elevated lactate dehydrogenase l...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.04.015

    authors： Lingabathula H,Yellu N

    更新日期：2017-06-01 00:00:00

  • Mitochondria protection of baicalein against oxidative damage via induction of manganese superoxide dismutase.

    abstract：:This study investigated the cytoprotective effect of baicalein (5,6,7-trihydroxyflavone) against oxidative stress-induced mitochondrial dysfunction. Electron spin resonance (ESR) spectrometry revealed that baicalein showed significant scavenging effects on superoxide radicals and hydroxyl radicals. When H(2)O(2) treat...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2010.11.002

    authors： Lee IK,Kang KA,Zhang R,Kim BJ,Kang SS,Hyun JW

    更新日期：2011-01-01 00:00:00

  • Low-level styrene exposure and color vision in Swedish styrene workers.

    abstract：:Styrene exposure and color vision for 108 workers (21-65 years) was studied at Swedish reinforced plastic plants. Acute exposure was measured at work. Data on past exposures and personal background data were collected by questionnaire. Current exposure varied between 0.3 and 96mg/m(3). Cumulative past exposures varied...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2004.12.057

    authors： Iregren A,Johnson AC,Nylén P

    更新日期：2005-05-01 00:00:00