当前位置： SCI文献检索 > ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY期刊下所有文献 > Production of M2000 (β-d-mannuronic acid) and its therapeutic effect on experimental nephritis.

Production of M2000 (β-d-mannuronic acid) and its therapeutic effect on experimental nephritis.

Abstract：

UNLABELLED:The present research introduces the method of Production of M2000 (β-d-mannuronic acid) and its therapeutic effect on experimental model of nephritis. M2000 was produced using enzymatic and chemical procedure on prepared alginate from Pseudomonas fluorescens. The experimental glomerulonephritis was induced in rats by a subcutaneous immunization and daily intravenous administration of bovine serum albumin (BSA). M2000 solution (30mg/kg) was administered intraperitoneally at regular 48-h intervals for 4 weeks. Onset of treatment was day 56. Urinary protein was measured weekly and serum anti-BSA antibody was assessed by ELISA method at different intervals. Animals were killed on day 84 and blood samples and kidney specimens were obtained. Serum (creatinine, BUN, cholesterol, and triglyceride) and urine (protein, urea, and creatinine) determinants were measured at the time of sacrifice. Kidney specimens were processed for light and immunofluorescent microscopic examination. The fibrosarcoma cell line was used for assaying tolerability and matrix metalloproteinase type 2 (MMP-2) activity. MMP-2 activity was assessed using zymography. Our data showed that M2000 therapy could significantly reduce the urinary protein excretion in treated rats versus non-treated controls. Anti-BSA antibody titer was lower in treated rats than in controls at the 12th experimental week. PMN infiltration and glomerular immune complex deposition was less intense in treated rats than in controls. Cytotoxicity analysis of M2000 showed a much higher tolerability compared with other tested drugs (diclofenac, piroxicam and dexamethasone). The inhibitory effect of M2000 in MMP-2 activity was significantly greater than that of dexsamethasone and of piroxicam at a concentration of 200μg/ml. Moreover, the toxicological study revealed that M2000 had no influence on serum (BUN, creatinine, triglyceride and cholesterol) determinants, urinary protein excretion and glomerular histology in healthy group receiving drug. CONCLUSIONS:In this research, for the first time we introduced the procedure of production of M2000 (β-d-mannuronic acid) and our data suggest that treatment with M2000, as a novel anti-inflammatory drug can reduce proteinuria, diminish antibody production and suppress the progression of disease in experimental model of glomerulonephritis.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Mirshafiey A,Rehm B,Abhari RS,Borzooy Z,Sotoude M,Razavi A

doi

10.1016/j.etap.2007.02.002

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

60-6

issue

1

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(07)00027-0

journal_volume

24

pub_type

杂志文章

相关文献

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY文献大全
  • Genotoxicity of glyphosate assessed by the comet assay and cytogenetic tests.

    abstract：:It was evaluated the genotoxicity of glyphosate which up to now has heterogeneous results. The comet assay was performed in Hep-2 cells. The level of DNA damage in the control group (5.42±1.83 arbitrary units) for tail moment (TM) measurements has shown a significant increase (p<0.01) with glyphosate at a range concen...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2009.02.001

    authors： Mañas F,Peralta L,Raviolo J,Ovando HG,Weyers A,Ugnia L,Cid MG,Larripa I,Gorla N

    更新日期：2009-07-01 00:00:00

  • Zizyphus jujuba and Origanum majorana extracts protect against hydroquinone-induced clastogenicity.

    abstract：:Hydroquinone (HQ) is a myelotoxin that is found in many foods and formed through the metabolism of benzene. HQ is genotoxic in several in vitro and in vivo test systems, inducing micronuclei (MN), sister-chromatid exchange (SCE), and chromosomal aberrations. The aim of the current study was to explore the protective e...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2007.07.002

    authors： Ghaly IS,Said A,Abdel-Wahhab MA

    更新日期：2008-01-01 00:00:00

  • Oxidative and nitrosative stress in experimental rat liver fibrosis: Protective effect of taurine.

    abstract：:Taurine (TAU) has protective effects on experimental liver fibrosis. The present study investigates whether benefits of TAU are mediated through attenuation of oxidative and nitrosative stresses. Liver fibrosis was induced in male Wistar rats by simultaneous administration of iron (0.5%, w/w) and ethanol (6g/kg/day) f...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2009.11.005

    authors： Devi SL,Anuradha CV

    更新日期：2010-03-01 00:00:00

  • Oxidative stress, protein carbonylation and heat shock proteins in the black tiger shrimp, Penaeus monodon, following exposure to endosulfan and deltamethrin.

    abstract：:The impact of commonly used pesticides, endosulfan and deltamethrin, on the molecular stress level in black tiger shrimp Penaeus monodon, was assessed using classical oxidative stress biomarkers, protein carbonylation profiles, and levels of heat shock proteins. Results showed that 4 days exposure to 0.1 μg L(-1) delt...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2009.05.006

    authors： Dorts J,Silvestre F,Tu HT,Tyberghein AE,Phuong NT,Kestemont P

    更新日期：2009-09-01 00:00:00

  • The influence of aripiprazole and olanzapine on neurotransmitters level in frontal cortex of prenatally stressed rats.

    abstract：OBJECTIVES:The study aims to verify whether alterations in the level of neurotransmitters have occurred in prenatally stressed rats (animal model of schizophrenia), and whether aripiprazole (ARI) and olanzapine (OLA) modify this level. METHODS:The effects of ARI (1.5mg/kg) and OLA (0.5mg/kg) were studied by means of m...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2016.07.007

    authors： Ratajczak P,Kus K,Gołembiowska K,Noworyta-Sokołowska K,Woźniak A,Zaprutko T,Nowakowska E

    更新日期：2016-09-01 00:00:00

  • Modulation of rifampicin toxicity by 6 MFA, an interferon inducer obtained from fungus Aspergillus ochraceus.

    abstract：:The effect of 6 MFA (Sixth mycelial fraction of acetone), an interferon inducer obtained from fungus Aspergillus ochraceus, on rifampicin toxicity was studied in rats. Chronic oral administration of rifampicin (1 g/kg per day) for 30 days produced thrombocytopenia, hemolytic anaemia, transient leukopenia and increased...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(98)00006-4

    authors： Dhuley JN,Naik SR

    更新日期：1998-06-02 00:00:00

  • Pharmacokinetics of thiamine in female Baltic salmon (Salmo salar L.) broodfish.

    abstract：:A thiamine deficiency disease termed M74 syndrome affects the yolk-sac fry of wild and feral Baltic salmon. However, very little is known about the pharmacokinetics of thiamine in salmon. This study examined the pharmacokinetics of thiamine hydrochloride injected intraperitoneally into feral and farmed Baltic salmon f...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2004.06.001

    authors： Koski P,Bäckman C,Pelkonen O

    更新日期：2005-01-01 00:00:00

  • Up-regulation of hypoxia-inducible factor-1 alpha by cobalt chloride prevents hearing loss in noise-exposed mice.

    abstract：:Since hypoxia-inducible factor-1α (HIF-1α) is the key transcription factor that enables cells to survive in hypoxia, we have investigated whether an upregulation of HIF-1α prevents the noise-induced hearing loss in BALB/c hybrid mice, which were intraperitoneally injected with CoCl(2) (a HIF-1α inducer) and exposed to...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2010.10.002

    authors： Chung JW,Shin JE,Han KW,Ahn JH,Kim YJ,Park JW,So HS

    更新日期：2011-01-01 00:00:00

  • The analysis of the possibility of using biological tests for assessment of toxicity of leachate from an active municipal landfill.

    abstract：:One of the consequence of municipal waste deposition is the production of landfill leachate. Its volume and composition is determined by numerous factors, including waste composition, landfill age and the volume of precipitation. Leachate may contain a number of mineral and organic compounds, the volume of which must ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.01.013

    authors： Przydatek G

    更新日期：2019-04-01 00:00:00

  • Dietary overload lithium decreases the adipogenesis in abdominal adipose tissue of broiler chickens.

    abstract：:To investigate the toxic effects of dietary overload lithium on the adipogenesis in adipose tissue of chicken and the role of hypothalamic neuropeptide Y (NPY) in this process, one-day-old male chicks were fed with the basal diet added with 0 (control) or 100mg lithium/kg diet from lithium chloride (overload lithium) ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2016.12.012

    authors： Bai S,Pan S,Zhang K,Ding X,Wang J,Zeng Q,Xuan Y,Su Z

    更新日期：2017-01-01 00:00:00

  • Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine.

    abstract：:Triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) is a chlorinated phenolic antibacterial compound found as an active ingredient in many personal care and household products. The structural similarity of triclosan to thyroid hormones and recent studies demonstrating activation of the human pregnane X receptor (PXR) a...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2007.04.008

    authors： Crofton KM,Paul KB,Devito MJ,Hedge JM

    更新日期：2007-09-01 00:00:00

  • Tumor promoters induce inhibition of gap junctional intercellular communication in mouse epidermal cells by affecting the localization of connexin43 and E-cadherin.

    abstract：:The molecular and histological effects of tumor promoters on gap junctional intercellular communication (GJIC) were studied in three mouse epidermal cell types, representing different stages of tumor formation. GJIC was inhibited by most of the studied compounds (l-ethionine, d-limonene, o-anisidine, clofibrate, Arocl...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/1382-6689(96)00005-1

    authors： Jansen L,Mesnil M,Koeman J,Jongen W

    更新日期：1996-05-15 00:00:00

  • Differences in binding of epidermal growth factor to liver membranes of TCDD-resistant and TCDD-sensitive rats after a single dose of TCDD.

    abstract：:Epidermal growth factor (EGF) receptor has been implied as having a role in certain actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). After a single dose of TCDD, the receptor has been shown to be downregulated in several tissues including the liver. Two rat substrains, the Han/Wistar (Kuopio; H/W) rat and the Lo...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/1382-6689(95)00016-x

    authors： Tuomisto J,Sewall CH,Unkila M,Pohjanvirta R,Clark GC,Viluksela M,Rozman K,Lucier GW

    更新日期：1996-04-15 00:00:00

  • Disposition kinetics of selenium in healthy volunteers following therapeutic shampoo treatment.

    abstract：:This study was aimed at documenting the kinetic time courses of selenium (Se) in accessible biological matrices of volunteers following controlled applications of therapeutic shampoo containing Se, to better elucidate the mechanisms by which shampoo-Se accumulates in hair and hence estimate the contribution of this so...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2010.02.001

    authors： Noisel N,Bouchard M,Carrier G

    更新日期：2010-05-01 00:00:00

  • Activation of apoptotic pathway in normal, cancer ovarian cells by epothilone B.

    abstract：:The epothilones, a new class of microtubule-targeting agents, seem to be a very promising alternative to the current strategy of cancer treatment. We have analyzed the aspects of epothilone B (Epo B) on cellular metabolism of tumor (OV-90) and normal (MM 14) ovarian cells. The observed effects were compared with those...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2013.06.003

    authors： Rogalska A,Szula E,Gajek A,Marczak A,Jóźwiak Z

    更新日期：2013-09-01 00:00:00

  • Copper effect on the biomarker state of the Mizuhopecten yessoensis tissues in the prespawning period.

    abstract：:The aim of this study was to investigate the sensitivity of the marine scallop Mizuhopecten yessoensis to different copper concentrations (10 and 30 μgl-1) in the prespawning period. Reaction of the scallop to this effect was evaluated by a set of biomarkers, including general metabolism enzymes (acid and alkaline pho...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.04.010

    authors： Istomina A,Chelomin V,Kukla S,Zvyagintsev A,Karpenko A,Slinko E,Dovzhenko N,Slobodskova V,Kolosova L

    更新日期：2019-08-01 00:00:00

  • Effect on enzymes and histopathology in earthworm (Eisenia foetida) induced by triazole fungicides.

    abstract：:Earthworms are an ideal biological model in toxicity assays and environment monitoring studies, especially for the toxicity of pesticides on soil ecosystem. However, There are very little data on the toxicity of triazoles on earthworms despite the fact that such data are critical in assessing their fate and potential ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2013.02.003

    authors： Gao M,Song W,Zhang J,Guo J

    更新日期：2013-05-01 00:00:00

  • Effect of Bisphenol-A on insulin signal transduction and glucose oxidation in liver of adult male albino rat.

    abstract：:Bisphenol-A (BPA) has been classified as an endocrine disruptor which disrupts normal cell function by acting as an estrogen agonist. Environmentally relevant doses of the Bisphenol-A have profound effects on rat endocrine pancreas, an essential organ involved in glucose homeostasis. Bisphenol-A acts on insulin releas...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2012.12.016

    authors： Jayashree S,Indumathi D,Akilavalli N,Sathish S,Selvaraj J,Balasubramanian K

    更新日期：2013-03-01 00:00:00

  • The protective role of vitamin E on gill and liver tissue histopathology and micronucleus frequencies in peripheral erythrocytes of Oreochromis niloticus exposed to deltamethrin.

    abstract：:Deltamethrin, is a commonly used pyrethroid pesticide. Vitamin E is a antioxidant that plays an important role in protecting cells against toxicity by inactivating free radicals generated following pesticides exposure. Therefore, it was evaluated whether deltamethrin induced histopathological changes and nuclear abnor...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2012.03.009

    authors： Kan Y,Cengiz EI,Ugurlu P,Yanar M

    更新日期：2012-09-01 00:00:00

  • A new index to assess chemicals increasing the greenhouse effect based on their toxicity to algae.

    abstract：:CO2, as the typical greenhouse gas causing the greenhouse effect, is a major global environmental problem and has attracted increasing attention from governments. Using algae to eliminate CO2, which has been proposed as an effective way to reduce the greenhouse effect in the past decades, can be disturbed by a growing...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.08.034

    authors： Wang T,Zhang X,Tian D,Gao Y,Lin Z,Liu Y,Kong L

    更新日期：2015-11-01 00:00:00

  • Effects of zinc oxide nanoparticles on bioaccumulation and oxidative stress in different organs of tilapia (Oreochromis niloticus).

    abstract：:Nano-size zinc oxide particles (ZnO NPs) are used in diverse industrial and commercial fields. However, the information from existing studies is not sufficient in evaluating the potential toxic effects of ZnO NPs. In this study, tilapia fish (Oreochromis niloticus) were exposed to different concentrations of small and...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.10.001

    authors： Kaya H,Aydın F,Gürkan M,Yılmaz S,Ates M,Demir V,Arslan Z

    更新日期：2015-11-01 00:00:00

  • Inhibition of intercellular communication and induction of ethoxyresorufin-O-deethylase activity by polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans in mouse hepa1c1c7 cells.

    abstract：:Inhibition of intercellular communication (IC) between hepa1c1c7 cells was used as a possible bioassay to predict tumor promoting potency of polyhalogenated aromatic hydrocarbons (PAHs). Relative potencies with regard to 2,3,7,8-TCDD to inhibit IC and to induce cytochrome P450IA1/2 (EROD) in these hepa1c1c7 cells were...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/1382-6689(95)00006-2

    authors： De Haan LH,Halfwerk S,Hovens SE,De Roos B,Koeman JH,Brouwer A

    更新日期：1996-02-15 00:00:00

  • Gambogenic acid induced mitochondrial-dependent apoptosis and referred to phospho-Erk1/2 and phospho-p38 MAPK in human hepatoma HepG2 cells.

    abstract：:Gambogenic acid, identified from Gamboge, is responsible for anti-tumor effects, and has been shown to be a potential molecule against human cancers. In this study, the molecular mechanism of gambogenic acid-induced apoptosis in HepG2 cells was investigated. Gambogenic acid significantly inhibited cell proliferation a...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.12.006

    authors： Yan F,Wang M,Li J,Cheng H,Su J,Wang X,Wu H,Xia L,Li X,Chang HC,Li Q

    更新日期：2012-03-01 00:00:00

  • Immunopotentiation and antitumor effects of a ginsenoside Rg₃-fortified red ginseng preparation in mice bearing H460 lung cancer cells.

    abstract：:Antitumor effects of a ginsenoside Rg(3)-fortified red ginseng preparation (Rg(3)-RGP) were investigated in human non-small cell lung carcinoma (H460) cells using in vitro cytotoxicity assay and in vivo nude mouse xenograft model. Immunomodulatory effects of the preparation were also assessed by measuring the facilita...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.01.008

    authors： Park D,Bae DK,Jeon JH,Lee J,Oh N,Yang G,Yang YH,Kim TK,Song J,Lee SH,Song BS,Jeon TH,Kang SJ,Joo SS,Kim SU,Kim YB

    更新日期：2011-05-01 00:00:00

  • Influence of dioxin on the daily variation of insulin sensitivity in mice.

    abstract：:To evaluate an influence of dioxin on a daily variation of insulin sensitivity, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100ng/kg) was given for 3 weeks in mice. Insulin tolerance test and oral glucose tolerance test were performed. TCDD decreased insulin sensitivity at an active period, but not at a rest period. T...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.07.008

    authors： Takuma M,Ushijima K,Kumazaki M,Ando H,Fujimura A

    更新日期：2015-09-01 00:00:00

  • Comparative cardioprotective effects and mechanisms of vitamin E and lisinopril against ischemic reperfusion induced cardiac toxicity.

    abstract：:The present study was undertaken to scientifically evaluate, validate and compare the cardioprotective effects of lisinopril (Lsp), an angiotensin converting enzyme (ACE) inhibitor and vitamin E (Vit E), an antioxidant in the setting of ischemia and reperfusion (I-R) injury. An open chest left anterior descending coro...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2012.12.003

    authors： Mohanty IR,Arya DS,Dinda A,Gupta SK

    更新日期：2013-03-01 00:00:00

  • Selective induction of the CYP3A family by endosulfan and DNA-adduct formation in different hepatic and hepatoma cells.

    abstract：:Endosulfan, a chlorinated cyclodiene insecticide, is known to cause a significant enhancement of altered hepatic foci in rats and to be a potent inhibitor of gap-junctional intercellular communication in vitro. Both of these features are common to many tumor promoters. However, long-term studies in rodents provide no ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/1382-6689(96)00018-X

    authors： Dubois M,Pfohl-Leszkowicz A,De Waziers I,Kremers P

    更新日期：1996-07-15 00:00:00

  • Effect of low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats.

    abstract：:The objective of this study was to compare effects of Western diet (WD) with low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats. Eighteen rats were randomly assigned to three experimental groups and fed for the next 2 months. The experimental diets were: Control (7% of soy...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.01.008

    authors： Kostogrys RB,Franczyk-Żarów M,Maślak E,Topolska K

    更新日期：2015-03-01 00:00:00

  • Age-related susceptibility to immunotoxicants: animal data and human parallels.

    abstract：:There are numerous examples, of both the identical and different effects of animals exposure to toxic agents, which can be compared in both, exposed prenatal/neonatal animals and exposed adults. In some instances, although the chemical and its metabolites are stored for long periods in adipose tissue, adult exposure (...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(97)10030-8

    authors： Barnett JB

    更新日期：1997-12-01 00:00:00

  • Decreased membrane fluidity and hyperpolarization in aluminum-treated PC-12 cells correlates with increased production of cellular oxidants.

    abstract：:Effects of aluminum (Al) on membrane properties of excitable cells are not fully understood. Several reports have identified cellular membranes as sensitive targets for Al intoxication. In the present study, we tested the hypothesis that treatment with Al would alter membrane fluidity and potential and these changes w...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2004.05.011

    authors： Johnson VJ,Tsunoda M,Murray TF,Sharma RP

    更新日期：2005-02-01 00:00:00