Abstract：
:Hepatotoxicity is the most serious adverse effect related to tuberculosis treatment which interrupts the successful completion of tuberculosis treatment. The purpose of this study was to assess therapeutic effect of thymoquinone (TQ) against anti-tuberculosis drugs (ATD) induced liver damage. Rats were treated with ATD for 8 weeks (3 days/week) as given for the treatment of TB. This was followed by therapy of TQ for 8 weeks (3 days/week). Administration of combined ATD induced hepatotoxicity was evident from a significant elevation in the AST, ALT, ALP, bilirubin, albumin, cholesterol, urea, uric acid, creatinine, LPO and decreased activities of enzymes. These altered variables were significantly reversed toward control after treatment with TQ. Histological studies also supported biochemical findings. Results of this study strongly indicated protective effect of TQ and thus, can be expected as promising protective agent in maintenance of normal hepatic function during treatment with ATD.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Jaswal A,Sinha N,Bhadauria M,Shrivastava S,Shukla Sdoi
10.1016/j.etap.2013.07.010subject
Has Abstractpub_date
2013-11-01 00:00:00pages
779-86issue
3eissn
1382-6689issn
1872-7077pii
S1382-6689(13)00157-9journal_volume
36pub_type
杂志文章abstract：:Skin is frequently exposed to a variety of environmental and chemical agents that accelerate ageing. External stress such as UV radiations (UVR) and environmental pollutants majorly deteriorate the skin morphology, by activating certain intrinsic factors such as Reactive Oxygen Species (ROS) which trigger the activati...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章,评审
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章,评审
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2013.05.018
更新日期：2013-09-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章,评审
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2015.08.027
更新日期：2015-11-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2011.12.022
更新日期：2012-03-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2008.08.002
更新日期：2009-01-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2020.103425
更新日期：2020-10-01 00:00:00
abstract：:The pathogenesis of atopic dermatitis (AD) involves T helper 2 (Th2) cells, and effective therapies remain elusive due to the paucity of animal models. We aimed to develop a mouse model of an immune system aberration caused by allergen. Experiments were conducted in two phases. In experiment 1, BALB/c mice were sensit...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2017.12.025
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2006.04.002
更新日期：2006-11-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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更新日期：2020-11-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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更新日期：2008-09-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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更新日期：1998-10-01 00:00:00
abstract：:Safrole is a natural compound categorized as a group 2B carcinogen extracted from betel quid chewing, which is a common practice of psychoactive habits integrated into social and cultural ceremonies among serveral million people, especially in Southern or Southeastern Asia. Safrole is one of the major risk compunds fo...
journal_title：Environmental toxicology and pharmacology
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更新日期：2018-12-01 00:00:00
abstract：:Association of arsenic exposure with smoking, alcohol, and caffeine consumption was investigated. Data from National Health and Nutrition Examination Survey for the years 2005-2010 were used for this investigation. Urinary levels of total arsenic (UAS) and dimethylarsonic acid (UDMA) were evaluated for children aged 6...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2015.01.011
更新日期：2015-03-01 00:00:00
