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Erythrocyte antioxidants enzymes imbalance following subcutaneous pyrethroid treatments in rats of different sex.

Abstract：

:Permethrin and deltamethrin are insecticides used all over the world in agriculture to control pests. The aim of this work is to investigate the effects of subcutaneous permethrin and/or deltamethrin treatments on erythrocyte antioxidant enzymes activity in rats of different sex. The results obtained show that permethrin decreases SOD and GPx activity in female rats, while it increases SOD activity in male rats. Deltamethrin treatment reduces GPx activity in male rats, while permethrin has a similar effect but only for short time treatments. A catalase activity decrease was observed in both sexes following pyrethroid treatment but when both the pyrethroids were administrated in male rats, the enzyme activity has increased. In conclusion, this study points out for the first time the importance of rat gender on erythrocyte antioxidant enzymes, which are influenced not only by the length and the type of insecticide treatment but importantly by sex.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Chargui I,Falcioni ML,Cheikh HB,Gabbianelli R

doi

10.1016/j.etap.2010.04.005

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

116-20

issue

2

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(10)00088-8

journal_volume

30

pub_type

杂志文章

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