当前位置： SCI文献检索 > ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY期刊下所有文献 > Altered p53 response and enhanced transgenerational transmission of carcinogenic risk upon exposure of mice to betel nut.

Altered p53 response and enhanced transgenerational transmission of carcinogenic risk upon exposure of mice to betel nut.

Abstract：

:Alteration of p53 protein level, and possible mutation of the p53 gene during carcinogenesis in mice exposed chronically (P) and transgenerationally to 2mg/ml aqueous extract of betel nut (AEBN) in drinking water, were studied. Exons 5 and 7 of the p53 gene were not mutated under both chronic and transgenerational exposure, but, p53 protein response was altered. In P mice, p53 protein was initially upregulated in comparison to age-matched controls, reaching 2.5 folds in the liver after 6 weeks of exposure. Subsequently, p53 protein declined to control level after 16 weeks, with concomitant preneoplastic nodulation of the liver. After 24 weeks, p53 protein was below control level, and preneoplastic nodules were well-developed. The level of p53 protein in transgenerationally exposed mice remained invariant in comparison to age-matched controls. Liver nodulation was significantly advanced, developing in F1 mice after 8 weeks, F2 mice after 6 weeks and F3 mice after 4 weeks of exposure. Anomalies not observed in P mice, developed in transgenerationally exposed mice, albeit, non-significantly. Thus, AEBN exposure enhanced transgeneration transmission of carcinogenic risk.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Choudhury Y,Sharan RN

doi

10.1016/j.etap.2008.09.003

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

127-38

issue

1

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(08)00137-3

journal_volume

27

pub_type

杂志文章

相关文献

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY文献大全
  • The adverse effects of selenomethionine on skeletal muscle, liver, and brain in the steelhead trout (Oncorhynchus mykiss).

    abstract：:Juvenile Oncorhynchus mykiss (average weight: 22.3 g) were fed one of five selenomethionine diets (1.09, 8.79, 15.37, 30.79, or 61.58 mg Se/kg diet). After 4 weeks, hepatic catalase activity over 15.37 mg Se/kg diets was significantly decreased, and the glutathione peroxidase activity over 30.79 mg Se/kg diets was ele...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2020.103451

    authors： Lee JW,Deng DF,Lee J,Kim K,Jung HJ,Choe Y,Park SH,Yoon M

    更新日期：2020-11-01 00:00:00

  • Bisphenol A and its analogs: Do their metabolites have endocrine activity?

    abstract：:Structural analogs of bisphenol A are commonly used as its alternatives in industrial and commercial applications. Nevertheless, the question arises whether the use of other bisphenols is justified as replacements for bisphenol A in mass production of plastic materials. To evaluate the influence of metabolic reactions...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.etap.2016.09.014

    authors： Gramec Skledar D,Peterlin Mašič L

    更新日期：2016-10-01 00:00:00

  • Pharmacokinetics of thiamine in female Baltic salmon (Salmo salar L.) broodfish.

    abstract：:A thiamine deficiency disease termed M74 syndrome affects the yolk-sac fry of wild and feral Baltic salmon. However, very little is known about the pharmacokinetics of thiamine in salmon. This study examined the pharmacokinetics of thiamine hydrochloride injected intraperitoneally into feral and farmed Baltic salmon f...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2004.06.001

    authors： Koski P,Bäckman C,Pelkonen O

    更新日期：2005-01-01 00:00:00

  • Oxidative stress, protein carbonylation and heat shock proteins in the black tiger shrimp, Penaeus monodon, following exposure to endosulfan and deltamethrin.

    abstract：:The impact of commonly used pesticides, endosulfan and deltamethrin, on the molecular stress level in black tiger shrimp Penaeus monodon, was assessed using classical oxidative stress biomarkers, protein carbonylation profiles, and levels of heat shock proteins. Results showed that 4 days exposure to 0.1 μg L(-1) delt...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2009.05.006

    authors： Dorts J,Silvestre F,Tu HT,Tyberghein AE,Phuong NT,Kestemont P

    更新日期：2009-09-01 00:00:00

  • Identification of the rat liver cytochrome P450 enzymes involved in the metabolism of the calcium channel blocker dipfluzine hydrochloride.

    abstract：:This study aimed to identify the specific cytochrome P450 (CYP450) enzymes involved in the metabolism of dipfluzine hydrochloride using the combination of a chemical inhibition study, a correlation analysis and a panel of recombinant rat CYP450 enzymes. The incubation of Dip with rat liver microsomes yielded four meta...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.08.019

    authors： Guo W,Shi X,Wang W,Zhang W,Li J

    更新日期：2014-11-01 00:00:00

  • Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity.

    abstract：:Lead (Pb) is recognized as a potent inducer of synaptic toxicity generally associated with reduced synaptic transmission and increased neuronal fiber excitability, becoming an environmental risk for neurodegenerative processes. Despite numerous toxicological studies on Pb have been directed to the developing brain, at...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2020.103350

    authors： Wu Z,Bai L,Tu R,Zhang L,Ba Y,Zhang H,Li X,Cheng X,Li W,Huang H

    更新日期：2020-05-01 00:00:00

  • Pesticides and their binary combinations as P-glycoprotein inhibitors in NIH 3T3/MDR1 cells.

    abstract：:The purpose of the present study was to assess do selected pesticides as well as their binary combinations act as inhibitors of P-glycoprotein (P-gp) activity of NIH 3T3 mouse fibroblasts stably transfected with human MDR1 gene (NIH 3T3/MDR1). As a result of P-gp inhibition, the increase of intracellular accumulation ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2006.04.002

    authors： Pivčević B,Zaja R

    更新日期：2006-11-01 00:00:00

  • Magnesium lithospermate B acts against dextran sodiumsulfate-induced ulcerative colitis by inhibiting activation of the NRLP3/ASC/Caspase-1 pathway.

    abstract：:This study aimed to observe the therapeutic effects of magnesium lithospermate B on acute and chronic colitis induced by dextran sodiumsulfate (DSS) and the role of inflammasome complex (NOD-like receptor protein, NLRP; apoptosis-associated speck-like protein containing, ASC; caspase-1). Establishment of acute and chr...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.10.009

    authors： Jiang X,Zhong L,Sun D,Rong L

    更新日期：2016-01-01 00:00:00

  • Oxidative stress responses of rats exposed to Roundup and its active ingredient glyphosate.

    abstract：:Glyphosate is the active ingredient and polyoxyethyleneamine, the major component, is the surfactant present in the herbicide Roundup formulation. The objective of this study was to analyze potential cytotoxicity of the Roundup and its fundamental substance (glyphosate). Albino male rats were intraperitoneally treated...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2009.06.001

    authors： El-Shenawy NS

    更新日期：2009-11-01 00:00:00

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses apoptosis and leads to hyperphosphorylation of p53 in rat hepatocytes.

    abstract：:Inhibition of apoptosis of preneoplastic cells is thought to represent a major mechanism of action of tumor promoters. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent promoter of liver carcinogenesis in rodents, suppressed apoptosis in rat hepatocytes pretreated in vitro with an apoptogenic dose of UV ligh...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(98)00040-4

    authors： Wörner W,Schrenk D

    更新日期：1998-12-01 00:00:00

  • Intestinal uptake of genistein and its glycoside in the rat using various isolated perfused gut segments.

    abstract：:Genistein receives much attention because of its potential to prevent hormone-related cancer and cardiovascular diseases. Limited information is available on the pharmacokinetics of this compound like, for instance, their intestinal uptake by humans and systematic bioavailability. In this study, the fate of the absorp...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2004.03.008

    authors： Steensma A,Bienenmann-Ploum ME,Noteborn HP

    更新日期：2004-06-01 00:00:00

  • Impact of long term Fe³⁺ toxicity on expression of glutathione system in rat liver.

    abstract：:The free radicals within the body, produced by metabolic activities or derived from environmental sources are relatively related to hepatoxicity. Since heavy metals including iron have the ability to produce free radicals, the liver glutathione system neutralizes them to protect cells against any damage. The objective...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2013.12.007

    authors： Budak H,Gonul N,Ceylan H,Kocpinar EF

    更新日期：2014-01-01 00:00:00

  • Effects of acute exposure to WIFI signals (2.45GHz) on heart variability and blood pressure in Albinos rabbit.

    abstract：:Electrocardiogram and arterial pressure measurements were studied under acute exposures to WIFI (2.45GHz) during one hour in adult male rabbits. Antennas of WIFI were placed at 25cm at the right side near the heart. Acute exposure of rabbits to WIFI increased heart frequency (+22%) and arterial blood pressure (+14%). ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.08.015

    authors： Saili L,Hanini A,Smirani C,Azzouz I,Azzouz A,Sakly M,Abdelmelek H,Bouslama Z

    更新日期：2015-09-01 00:00:00

  • Preliminary in vitro toxicological evaluation of a series of 2-pyridylcarboxamidrazone candidate anti-tuberculosis compounds.

    abstract：:We have investigated the toxicity of a series of 2-pyridylcarboxamidrazones in vitro using a rat liver metabolism system as well as human erythrocytes and mononuclear leucocytes (MNL) as target cells. Of the seven derivatives and four precursors tested, only minimal (<2.3%) metabolism-mediated methaemoglobin was forme...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(98)00055-6

    authors： Coleman MD,Rathbone DL,Abberley L,Lambert PA,Billington DC

    更新日期：1999-03-01 00:00:00

  • Polyphenolic fraction of Pilea microphylla (L.) protects Chinese hamster lung fibroblasts against γ-radiation-induced cytotoxicity and genotoxicity.

    abstract：:Present study was designed to compare cytoprotective and antigenotoxic activity of the polyphenolic fraction of Pilea microphylla (PM1) with that of its active polyphenolic constituents against γ-radiation in V79 cells. PM1 was standardized with respect to the polyphenols present by RP-HPLC. It was evaluated for its f...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.09.007

    authors： Paul P,Bansal P,Nayak PG,Pannakal ST,Priyadarsini KI,Unnikrishnan MK

    更新日期：2012-01-01 00:00:00

  • The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene.

    abstract：:A physiologically based pharmacokinetic (PBPK) model has been developed for trichloroethylene (1,1,2-trichloroethene, TRI) for rat and humans, based on in vitro metabolic parameters. These were obtained using individual cytochrome P450 and glutathione S-transferase enzymes. The main enzymes involved both for rats and ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(02)00019-4

    authors： Hissink EM,Bogaards JJ,Freidig AP,Commandeur JN,Vermeulen NP,van Bladeren PJ

    更新日期：2002-07-01 00:00:00

  • Pharmacokinetic profile of cefquinome after oral subchronic flubendiamide exposure and in vitro plasma protein binding in buffalo calves.

    abstract：:The disposition kinetics study of cefquinome was conducted following single intravenous (IV) administration of 2mg/kg bodyweight in buffalo calves after oral subchronic exposure to flubendiamide and to determine the in vitro plasma protein binding of cefquinome. Plasma concentrations of cefquinome were analyzed using ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.12.004

    authors： Venkatachalam D,Dumka VK

    更新日期：2015-01-01 00:00:00

  • Betaine treatment decreased oxidative stress, inflammation, and stellate cell activation in rats with alcoholic liver fibrosis.

    abstract：:The aim of this study was to investigate the effect of betaine (BET) on alcoholic liver fibrosis in rats. Fibrosis was experimentally generated with ethanol plus carbon tetrachloride (ETH+CCl4) treatment. Rats were treated with ETH (5% v/v in drinking water) for 14 weeks. CCl4 was administered intraperitoneally (i.p.)...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2016.05.033

    authors： Bingül İ,Başaran-Küçükgergin C,Aydın AF,Çoban J,Doğan-Ekici I,Doğru-Abbasoğlu S,Uysal M

    更新日期：2016-07-01 00:00:00

  • Inhibition of intercellular communication and induction of ethoxyresorufin-O-deethylase activity by polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans in mouse hepa1c1c7 cells.

    abstract：:Inhibition of intercellular communication (IC) between hepa1c1c7 cells was used as a possible bioassay to predict tumor promoting potency of polyhalogenated aromatic hydrocarbons (PAHs). Relative potencies with regard to 2,3,7,8-TCDD to inhibit IC and to induce cytochrome P450IA1/2 (EROD) in these hepa1c1c7 cells were...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/1382-6689(95)00006-2

    authors： De Haan LH,Halfwerk S,Hovens SE,De Roos B,Koeman JH,Brouwer A

    更新日期：1996-02-15 00:00:00

  • Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells.

    abstract：:In some areas of China, citreoviridin (CIT) is considered one of the risk factors for development of cardiovascular disease (CVD). Apoptosis of endothelial cell may induce vascular endothelium injury and atherosclerosis, which result in CVD probably. In this study, we investigated the effect of CIT on apoptosis and pr...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.02.016

    authors： Hou H,Zhou R,Li A,Li C,Li Q,Liu J,Jiang B

    更新日期：2014-03-01 00:00:00

  • Common differentially expressed proteins were found in mouse cleft palate models induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoic acid.

    abstract：:Cleft palate(CP) is a widely studied congenital malformation. However, its etiology and pathogenesis still remain unclear. Proteins are fundamental molecules that participate in every biological process within cells. In this study, we established CP mouse models induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) an...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.103270

    authors： Wang C,Zhai SN,Yuan XG,Zhang DW,Jiang H,Qiu L,Fu YX

    更新日期：2019-11-01 00:00:00

  • Determination of fluoroquinolones in chicken feces - a new liquid-liquid extraction method combined with LC-MS/MS.

    abstract：:The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate environmental loads and for a proper risk assessment it is necessary to determine the antibiotic concentration in feces. Ther...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.09.011

    authors： Janusch F,Scherz G,Mohring SA,Hamscher G

    更新日期：2014-11-01 00:00:00

  • A focus on the human lens in vitro.

    abstract：:The lens is a unique organ in that it is avascular and non-innervated, obtaining all nutrients from the aqueous and vitreous humours that bathe the lens. All lenses attempt to achieve the same goal, namely to maintain transparency and focus light on to the retina. However, the mechanisms by which these processes are m...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2005.07.012

    authors： Wormstone IM,Collison DJ,Hansom SP,Duncan G

    更新日期：2006-02-01 00:00:00

  • Mechanism of cadmium induced apoptosis in human peripheral blood lymphocytes: the role of p53, Fas and Caspase-3.

    abstract：:Cadmium (Cd) is a major pollutant of environment. It can be fatal to human. In spite of bulk of research and literatures, the mechanism of a fatality against human is still not understood completely. Toxic and carcinogenic effects of Cd in rodents and humans are well known. However, effects of Cd on induction of apopt...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2013.09.006

    authors： Al-Assaf AH,Alqahtani AM,Alshatwi AA,Syed NA,Shafi G,Hasan TN

    更新日期：2013-11-01 00:00:00

  • A new index to assess chemicals increasing the greenhouse effect based on their toxicity to algae.

    abstract：:CO2, as the typical greenhouse gas causing the greenhouse effect, is a major global environmental problem and has attracted increasing attention from governments. Using algae to eliminate CO2, which has been proposed as an effective way to reduce the greenhouse effect in the past decades, can be disturbed by a growing...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.08.034

    authors： Wang T,Zhang X,Tian D,Gao Y,Lin Z,Liu Y,Kong L

    更新日期：2015-11-01 00:00:00

  • Chemo-preventive effect of crocin against experimentally-induced hepatocarcinogenesis via regulation of apoptotic and Nrf2 signaling pathways.

    abstract：:The results of the current study investigated the chemo-preventive effect of crocin against hepatocarcinogenesis in rats with particular focus on the evaluation of the modulatory impact of crocin on apoptotic and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways. Thioacetamide (TAA) (200 mg/kg, I.P...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2020.103494

    authors： Elsherbiny NM,Eisa NH,El-Sherbiny M,Said E

    更新日期：2020-11-01 00:00:00

  • Interindividual variability in metabolic activation in humans in vivo.

    abstract：:In assessing interindividual variability in metabolic activation, the toxic metabolite is often too unstable for conventional analysis. Possible alternatives include a stable product of the reactive metabolite e.g. cysteinyl derivatives of N-acetyl-4-benzoquinoneimine, the toxic metabolite of paracetamol, adducts with...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/S1382-6689(96)00048-8

    authors： Boobis AR

    更新日期：1996-10-15 00:00:00

  • A comparative study on influences of static electric field and power frequency electric field on cognition in mice.

    abstract：:Recently, electromagnetic fields around ultra-high voltage transmission lines have received considerable attentions for their potential biological effects. This study aimed to investigate the effects of static electric field (SEF) and power frequency electric field (PFEF) on cognition. Mice were exposed to SEF and PFE...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.01.001

    authors： Di G,Kim H,Xu Y,Kim J,Gu X

    更新日期：2019-02-01 00:00:00

  • Fumonisin toxicity in a transgenic mouse model lacking the mdr1a/1b P-glycoprotein genes.

    abstract：:The toxicity of fumonisin B(1) (FB(1)) was investigated in male mdr1a/1b double knockout (MDRK) mice, lacking the drug-transporting P-glycoproteins. These transgenic animals are deficient in their blood:brain barrier and accumulate different drugs in brain and other tissues. The MDRK and their wild-type counterparts, ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(00)00038-7

    authors： Sharma RP,Bhandari N,Tsunoda M,Riley RT,Voss KA,Meredith FI

    更新日期：2000-03-01 00:00:00

  • Protection of Flos Lonicerae against acetaminophen-induced liver injury and its mechanism.

    abstract：:This study aims to observe the protective action of Flos Lonicerae (FL) aqueous extract against acetaminophen (AP)-induced liver injury and its mechanism. Results show that FL decreases AP-increased serum alanine/aspartate transaminases (ALT/AST) activity, as well as total bilirubin (TB) amount, in mice. Histological ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.10.019

    authors： Jiang P,Sheng YC,Chen YH,Ji LL,Wang ZT

    更新日期：2014-11-01 00:00:00