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Species-specific models in toxicology: in vitro epithelial barriers.

Abstract：

:Species-specific in vitro epithelial barriers represent interesting predictive tools for risk assessment evaluation in toxicological studies. Moreover, these models could be applied either as stand-alone methods for the study of absorption, bioavailability, excretion, transport, effects of xenobiotics, or through an Integrated Testing Strategy. The aim of this review is to give a comprehensive overview of in vitro species-specific epithelial barrier models from bovine, dog and swine. Bovine mammary epithelial barrier as a fundamental instrument for the evaluation of the toxicant excretion, the blood brain barrier as a useful first approach in toxicological and pharmacological studies, the porcine intestinal barrier, the canine skin barrier, and finally the pulmonary barrier from bovine and swine species are described in this review.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Bertero A,Augustyniak J,Buzanska L,Caloni F

doi

10.1016/j.etap.2019.103203

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

103203

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(19)30069-9

journal_volume

70

pub_type

杂志文章,评审

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