Abstract:
BACKGROUND:The most consistently replicated genetic variants associated with coronary heart disease (CHD) in populations of European descent have been found on chromosome 9p21. Yet there is little known about these associations in ethnic groups of African ancestry. These disease-associated variants are located in a genomic region of unknown function. The purpose of this exploratory study was to examine the allelic frequencies and haplotype structure of single nucleotide polymorphisms (SNPs) for Black and White women with CHD. The authors also sought to explore the relationship between these genetic variants and biomarkers of inflammation. METHODS:Using polymerase chain reaction amplification, the authors genotyped 8 SNPs in a 58-kilobase region of chromosome 9p21 in a cohort of women with CHD (n = 91). The authors examined the interethnic relationship between the SNPs and four inflammatory biomarkers (C-reactive protein, intercellular adhesion molecule-1, interleukin-6, and tumor necrosis factor-alpha) using analysis of variance (ANOVA). RESULTS:We found considerable interethnic allelic and haplotype diversity across the 9p21 locus, with only two SNPs in perfect linkage disequilibrium (LD) in both races. A pair of high- and low-risk haplotypes was most common in White women, while about 41% of Blacks carried the risk alleles for three of the eight SNPs the authors examined. The interethnic associations between the SNP genotypes and inflammatory markers were divergent in both direction and magnitude. CONCLUSIONS:Our results lend support for the importance of ancestry-specific allelic context when examining variants on chromosome 9p21. Additional work is needed to elucidate the genetic contribution to inflammatory biomarkers for diverse racial groups.
journal_name
Biol Res Nursjournal_title
Biological research for nursingauthors
Beckie TM,Beckstead JW,Groer MWdoi
10.1177/1099800411403469subject
Has Abstractpub_date
2011-07-01 00:00:00pages
306-19issue
3eissn
1099-8004issn
1552-4175pii
1099800411403469journal_volume
13pub_type
杂志文章abstract::During the menopausal transition and early postmenopause, participants in the Seattle Midlife Women's Health Study (SMWHS) experienced one of the three symptom severity clusters identified through latent class analysis: severe hot flashes with moderate sleep, mood, cognitive, and pain symptoms (high-severity hot flash...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417753536
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:This study examined adherence to a personalized, community-based exercise intervention by sedentary adolescents with type 1 or type 2 diabetes or those with obesity. RESEARCH DESIGN AND METHODS:We conducted a pretest-posttest investigation to explore the application of an individualized exercise prescription...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800413500064
更新日期:2014-01-01 00:00:00
abstract::The purpose of this study was to describe the sleep patterns and fatigue of both mothers and fathers before and after childbirth. The authors used wrist actigraphy and questionnaires to estimate sleep and fatigue in 72 couples during their last month of pregnancy and 1st month postpartum. Both parents experienced more...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800403262142
更新日期:2004-04-01 00:00:00
abstract:RESULTS:hs-CRP correlated significantly with SLEDAI-2K (p = .036), SDI (p = .00), anti-dsDNA titers (p = .034), diabetes (p = .005), and obesity (p = .027). hs-CRP and Hcy correlated with triglyceride (TG) levels (p = .032 and p < .001, respectively), TG/high-density lipoprotein cholesterol index (p = .020 and p = .001...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800419889192
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:The purpose of this study was to explore gene expression changes in fatigued men with nonmetastatic prostate cancer receiving localized external beam radiation therapy (EBRT). METHODS:Fatigue was measured in 40 men with prostate cancer (20 receiving EBRT and 20 controls on active surveillance) using the Functi...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800415618786
更新日期:2016-05-01 00:00:00
abstract::Vaccination is one of our most powerful antiviral strategies. Despite the emergence of deadly viruses such as Ebola virus, vaccination efforts have focused mainly on childhood communicable diseases. Although Ebola virus was once believed to be limited to isolated outbreaks in distant lands, forces of globalization pot...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800403252574
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Persistent organic pollutants (POPs), dispersed in all environmental compartments, are associated with increased adipogenesis and body weight. These lipophilic toxicants bioaccumulate in the human body and get transferred from mothers to their offspring via the placental circulation and breast milk. The curr...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800420909151
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:Sleep deficit affects neurobehavioral functioning, reduces attention and cognitive function, and negatively impacts occupational safety. This study investigated selective attention levels of nursing staff on different shifts. METHODS:Using a prospective, randomized parallel group study, selective attention was...
journal_title:Biological research for nursing
pub_type: 杂志文章,随机对照试验
doi:10.1177/1099800412445907
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:In recent years, researchers have noted an "obesity paradox," where individuals with obesity survive sepsis at higher rates than their nonobese counterparts. This systematic review summarizes the literature on studies examining the association between obesity and 1-year mortality among patients admitted with se...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800419876070
更新日期:2020-01-01 00:00:00
abstract::Current medical technology permits the early detection of risk factors for coronary artery disease (CAD) in adults, and interventions are available to prevent CAD-related morbidity and mortality. The goal of this study was to determine the effectiveness of a Qigong exercise intervention in improving biomarker levels a...
journal_title:Biological research for nursing
pub_type: 杂志文章,随机对照试验
doi:10.1177/1099800415617017
更新日期:2016-05-01 00:00:00
abstract::The purpose of this study was to longitudinally describe changes in heart rate variability (HRV) from 28 to 34 weeks postmenstrual age (PMA). A convenience sample of 31 low-risk preterm infants participated. HRV was quantified using a spectral analysis of heart periods and recorded during seven weekly test sessions fr...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800409341175
更新日期:2010-01-01 00:00:00
abstract::Approximately half of the Canadian adults have sedentary lifestyles that increase their risk of developing cardiovascular disease (CVD). Women are 10 times more likely to die from CVD than from any other disease. Their risk almost doubles with the onset of menopause, which may result in increased body iron burden and ...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800413501717
更新日期:2014-01-01 00:00:00
abstract::Delirium is a serious complication of acute illness. Little is known, however, regarding the neurobiology of delirium, largely due to challenges in studying the complex inpatient population. Neuroimaging is one noninvasive method that can be used to study structural and functional brain abnormalities associated with d...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800419849489
更新日期:2019-07-01 00:00:00
abstract::Military personnel experience posttraumatic stress disorder (PTSD), which is associated with differential DNA methylation across the whole genome. However, the relationship between these DNA methylation patterns and clinically relevant increases in PTSD severity is not yet clearly understood. The purpose of this study...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800418758951
更新日期:2018-05-01 00:00:00
abstract::Scientists and clinicians frequently use immunological methods (IMs) to investigate complex biological phenomena. Commonly used IMs include immunocytochemistry (IC), enzyme-linked immunosorbent assays (ELISA) and flow cytometry. Each of these methodologies exploits a common principle in IMs -the binding of an antibody...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800411402494
更新日期:2011-07-01 00:00:00
abstract::The integration of molecular genetics approaches into the study of complex health phenomena is an increasingly important and available strategy for researchers across the health science disciplines. Pain sensation and response to painful stimuli are examples of complex health phenomena that are particularly amenable t...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800406289909
更新日期:2006-07-01 00:00:00
abstract::Preterm birth (PTB; spontaneous delivery prior to 37 weeks gestation) affects one out of eight infants born in the United States and is the most common cause of neonatal morbidity and mortality. Although the pathogenesis of PTB is multifactorial, a growing body of literature supports the hypothesis that one cause of P...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800409344620
更新日期:2010-04-01 00:00:00
abstract::Survivors of aneurysmal subarachnoid hemorrhage (aSAH) often experience unfavorable functional outcomes that result in a reduced ability to independently perform activities of daily living. The apolipoprotein E gene ( APOE) encodes for a protein known to facilitate lipid transport and aid in neuronal repair within the...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417746504
更新日期:2018-03-01 00:00:00
abstract::The purpose of this study was to examine whether the hepatitis B seroconversion rates in a small sample of subjects reflected that of the published rates, regardless of HIV status, after a hepatitis B vaccination series was completed while following strict vaccine protocols. The study, which had a nonexperimental, cor...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800414524619
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Drug addiction is a multifactorial disorder. Researchers have posited that an individual's inherited behavioral propensity or temperament contributes to the disorder by shaping a personality strongly linked with the risk of drug abuse. Further, they hypothesize that the polymorphism of dopamine D2 receptor i...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800411405030
更新日期:2012-04-01 00:00:00
abstract::Variations in sex hormones influence bone health in men. Aging in men is associated with a decrease in testosterone (T) levels. We examined the relationship between T levels and changes in bone health status as measured by quantitative ultrasound (QUS) at the phalanges and the os calcis and by peripheral bone mineral ...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800414532710
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To investigate associations between components of cumulative risk (CR) and physiological stress responses in African American adolescents and evaluate emotion regulation as a mediator and sex as a moderator of these associations. METHODS:Cortisol and salivary alpha amylase (sAA) were collected in adolescents...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417702742
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:The sacral skin of bedridden older patients often develops a dysbiotic condition. To clarify whether the condition changes or is sustained over time, we analyzed the skin microbiome and the skin physiological functions of the sacral skin in patients who completed our 2017 study. METHODS:In 2019, we collected...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800420941151
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:We examined genomic variation potentially associated with the cortisol stress response in children having a painful medical procedure. DESIGN:Children 4-10 years old having a peripheral intravenous line inserted provided saliva samples for evaluation of the cortisol response as a biological measure of distre...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800419826315
更新日期:2019-03-01 00:00:00
abstract::This article explores ethical concerns and emerging dilemmas associated with the proliferation of information resulting from the extraordinary advances in molecular genetics. It provides an overview of the ethical and legal challenges associated with predictive testing for inherited disease currently being addressed i...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/109980040100300104
更新日期:2001-07-01 00:00:00
abstract::The purpose of this pilot study was to investigate selected stress, immune, and growth consequences of maternal separation and separation with supplemental stroking in neonatal BALB/c infant mice and their dams. Three groups of 5 litters each (7 pups per litter) were studied. Control litters were undisturbed. Separate...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800402003003002
更新日期:2002-01-01 00:00:00
abstract::To examine the effects of exercise and vitamin E supplementation on oxidative stress in older adults, 59 participants, age 76.3 +/- 4.2 years, were randomly assigned to 1 of 4 groups: an exercise group taking placebos (EGP) or vitamin E (EGE) or a sedentary group taking placebos (SGP) or vitamin E (SGE). Measures incl...
journal_title:Biological research for nursing
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/1099800403005001005
更新日期:2003-07-01 00:00:00
abstract::The ability to maintain balance is often taken for granted, yet it is the foundation for mobility and overall functional independence throughout the life span. The purpose of this article is to define balance, review the components of balance, and describe common instruments used to measure balance. Clinical screening...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/109980040000100408
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:There are documented associations between elevated maternal corticotropin-releasing hormone (CRH) levels and adverse pregnancy outcomes. However, reports of these findings often lack sufficient detail and rationale regarding the bioassay methodology. This shortcoming can be problematic for researchers who do...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800408320970
更新日期:2008-07-01 00:00:00
abstract::Abdominal pain is an important symptom in irritable bowel syndrome (IBS), but patients report typical pain intensities ranging from mild to very severe. In a sample of women, the authors sought to determine whether measures of systemic autonomic activity are related to self-reported pain intensity and the occurrence o...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/109980040000200203
更新日期:2000-10-01 00:00:00