Abstract：
:Vaccination is one of our most powerful antiviral strategies. Despite the emergence of deadly viruses such as Ebola virus, vaccination efforts have focused mainly on childhood communicable diseases. Although Ebola virus was once believed to be limited to isolated outbreaks in distant lands, forces of globalization potentiate outbreaks anywhere in the world through incidental transmission. Moreover, since this virus has already been transformed into weapon-grade material, the potential exists for it to be used as a biological weapon with catastrophic consequences for any population vulnerable to attack. Ebola hemorrhagic fever (EHF) is a syndrome that can rapidly lead to death within days of symptom onset. The disease directly affects the immune system and vascular bed, with correspondingly high mortality rates. Patients with severe disease produce dangerously high levels of inflammatory cytokines, which destroy normal tissue and microcirculation, leading to profound capillary leakage, renal failure, and disseminated intravascular coagulation. Vaccine development has been fraught with obstacles, primarily of a biosafety nature. Case reports of acutely ill patients with EHF showing improvement with the transfusion of convalescent plasma are at odds with animal studies demonstrating further viral replication with the same treatment. Using mRNA extracted from bone marrow of Ebola survivors, human monoclonal antibodies against Ebola virus surface protein have been experimentally produced and now raise the hope for the development of a safe vaccine.
journal_name
Biol Res Nursjournal_title
Biological research for nursingauthors
Nyamathi AM,Fahey JL,Sands H,Casillas AMdoi
10.1177/1099800403252574subject
Has Abstractpub_date
2003-04-01 00:00:00pages
276-81issue
4eissn
1099-8004issn
1552-4175journal_volume
4pub_type
杂志文章,评审abstract：OBJECTIVE:The sacral skin of bedridden older patients often develops a dysbiotic condition. To clarify whether the condition changes or is sustained over time, we analyzed the skin microbiome and the skin physiological functions of the sacral skin in patients who completed our 2017 study. METHODS:In 2019, we collected...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800420941151
更新日期：2021-01-01 00:00:00
abstract：:Stress during pregnancy has been associated with a number of adverse outcomes. This study compared and correlated neuroendocrine parameters in women (n=8) who self-reported battering during their pregnancy to those in women who did not (n=8). Women who identified themselves as having a violent relationship with an int...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800405283182
更新日期：2006-01-01 00:00:00
abstract：:The American Academy of Pediatrics recently removed nicotine from the list of drugs contraindicated during breastfeeding. The objective of this study was to evaluate the feasibility of determining the effect of a smoking hygiene intervention on infants of breastfeeding mothers who smoke cigarettes. An experimental des...
journal_title：Biological research for nursing
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1177/1099800406290643
更新日期：2006-10-01 00:00:00
abstract：:Benefits of daily physical activity are well known, but there are limited data to describe physical activity in heart failure patients who receive cardiac resynchronization therapy devices. The purpose of this pilot study was to evaluate changes in physical activity (PA) levels before and 3 months after Cardiac Resync...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800413481619
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Our program of research focuses on thermal and circulatory stability in extremely premature infants. In prior studies, we found that infants have long periods of time in which foot temperature (FT) is higher than central temperature. We thus wanted to determine whether blood flow in the foot is increased whe...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800416656914
更新日期：2017-01-01 00:00:00
abstract：:Survivors of aneurysmal subarachnoid hemorrhage (aSAH) often experience unfavorable functional outcomes that result in a reduced ability to independently perform activities of daily living. The apolipoprotein E gene ( APOE) encodes for a protein known to facilitate lipid transport and aid in neuronal repair within the...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800417746504
更新日期：2018-03-01 00:00:00
abstract：:Central nervous system (CNS)-directed treatment for acute lymphoblastic leukemia, used to prevent disease recurrence in the brain, is essential for survival. Systemic and intrathecal methotrexate, commonly used for CNS-directed treatment, have been associated with cognitive problems during and after treatment. The cor...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800416644780
更新日期：2016-10-01 00:00:00
abstract：:The integration of molecular genetics approaches into the study of complex health phenomena is an increasingly important and available strategy for researchers across the health science disciplines. Pain sensation and response to painful stimuli are examples of complex health phenomena that are particularly amenable t...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800406289909
更新日期：2006-07-01 00:00:00
abstract：:Night-shift workers are prone to sleep deprivation, misalignment of circadian rhythms, and subsequent sleepiness and sleep-related performance deficits. The purpose of this narrative systematic review is to critically review and synthesize the scientific literature regarding improvements in sleepiness and sleep-relate...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800413476571
更新日期：2014-04-01 00:00:00
abstract：RESULTS:hs-CRP correlated significantly with SLEDAI-2K (p = .036), SDI (p = .00), anti-dsDNA titers (p = .034), diabetes (p = .005), and obesity (p = .027). hs-CRP and Hcy correlated with triglyceride (TG) levels (p = .032 and p < .001, respectively), TG/high-density lipoprotein cholesterol index (p = .020 and p = .001...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800419889192
更新日期：2020-04-01 00:00:00
abstract：:Despite high efficacy rates, significant costs and logistical challenges associated with procuring stool from healthy donors for fecal microbiota transplantation (FMT) have presented barriers to broader institutional adoption and limited the availability of this life-saving treatment. Published outcomes for donor scre...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800420941185
更新日期：2021-01-01 00:00:00
abstract：:Interpretation of changes in health and health care utilization patterns across the life span depends on an understanding of the effects of age, period, and cohort. The purpose of this article is to illustrate differences among three generations of women in demographic factors, health risk factors, and health status i...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800410373804
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND:Application of a thermal stimulus is a common procedure used to promote venodilation for peripheral intravenous cannulation (PIVC); however, the effects of thermal stimulation on the duration of venodilation and skin temperature of the forearm are unclear. AIM:To investigate the duration of venodilation ind...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800416651145
更新日期：2017-03-01 00:00:00
abstract：:Approximately half of the Canadian adults have sedentary lifestyles that increase their risk of developing cardiovascular disease (CVD). Women are 10 times more likely to die from CVD than from any other disease. Their risk almost doubles with the onset of menopause, which may result in increased body iron burden and ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800413501717
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:The Finnmarksløpet dogsled race lasts up to 7 days. Helpers, who keep time, coach, and transport equipment, have to be alert though they have little and fragmented sleep. This study investigated disruptions of the rest-activity rhythm among helpers. METHODS:10 helpers were monitored by actigraph a week befor...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800412475077
更新日期：2014-04-01 00:00:00
abstract：:Maternal posturing, in which a pregnant or laboring woman assumes specific postures with the intention of altering the position and/or presentation of the fetus within the uterus, is a safe alternative to operative procedures recommended in cases of fetal malpositions and malpresentations. Clinicians and researchers a...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800404268318
更新日期：2004-10-01 00:00:00
abstract：OBJECTIVE:To investigate the prevalence and patterns of and factors associated with hyperphagic behavior in Taiwanese patients with dementia living at home. METHODS:A cross-sectional and correlational design was used. A total of 104 patients with dementia and their primary caregivers were recruited from the geriatric,...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800414562025
更新日期：2015-10-01 00:00:00
abstract：:The effects of a 12-week low-intensity exercise conditioning program (walking) on blood pressure (BP), heart rate (HR), rate-pressure product (RPP), and cardiac autonomic function were measured in 40 sedentary women with hypertension. Women were assigned to either an exercise group (n = 20) or a control group (n = 20)...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800412461562
更新日期：2013-10-01 00:00:00
abstract：:To examine the effects of exercise and vitamin E supplementation on oxidative stress in older adults, 59 participants, age 76.3 +/- 4.2 years, were randomly assigned to 1 of 4 groups: an exercise group taking placebos (EGP) or vitamin E (EGE) or a sedentary group taking placebos (SGP) or vitamin E (SGE). Measures incl...
journal_title：Biological research for nursing
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/1099800403005001005
更新日期：2003-07-01 00:00:00
abstract：:Age-related changes in skeletal muscle, in combination with bed rest, may result in a poorer rehabilitation potential for an elderly patient. The purpose of this study was to determine the effects of non-weight bearing (hind limb unweighting [HU]) on the soleus and extensor digitorum longus (EDL) in older rats. Two no...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800403260693
更新日期：2004-01-01 00:00:00
abstract：PURPOSE:The purpose of this study was to explore gene expression changes in fatigued men with nonmetastatic prostate cancer receiving localized external beam radiation therapy (EBRT). METHODS:Fatigue was measured in 40 men with prostate cancer (20 receiving EBRT and 20 controls on active surveillance) using the Functi...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800415618786
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:Proinflammatory activity has been suggested as one of the psychophysiological mechanisms responsible for the health risks associated with stress and mood disorders. There have been limited studies evaluating central immune and hypothalamic- pituitary-adrenal (HPA) axis responses to experimental stress in heal...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800410383558
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Drug addiction is a multifactorial disorder. Researchers have posited that an individual's inherited behavioral propensity or temperament contributes to the disorder by shaping a personality strongly linked with the risk of drug abuse. Further, they hypothesize that the polymorphism of dopamine D2 receptor i...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800411405030
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Depression and inflammation are concomitantly elevated in patients with lung cancer and may have collective survival implications. However, the longitudinal relationship between depression and inflammation in patients with metastatic lung cancer is not fully appreciated. We hypothesized that longitudinal cha...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800420959721
更新日期：2020-09-22 00:00:00
abstract：:The primary purpose of this exploratory study was to compare percentages of natural killer (NK) cells and activated NK and T cells, and both cytotoxic and in vitro cytokine production activity in women with and without symptomatic irritable bowel syndrome (IBS). A secondary purpose was to examine the relationships of ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800402004001005
更新日期：2002-07-01 00:00:00
abstract：:MicroRNAs (miRs) are epigenetic regulators of messenger RNAs' (mRNA) expression of polypeptides. As such, miRs represent an intriguing mechanism by which gene-environment interactions are hypothesized to occur on the level of epigenetic control over gene expression. In addition to promising findings from in vitro stud...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800411430380
更新日期：2013-04-01 00:00:00
abstract：:Caring, a core tenet of nursing practice, grew out of a holistic approach. Nurse theorists often note the establishment of a therapeutic relationship as the beginning point of caring, with subsequent nursing interventions reliant upon this relationship for effectiveness. Relational exchange serves as a source of eithe...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800412450505
更新日期：2012-10-01 00:00:00
abstract：:Shift work schedules, intensive physical exercise late in the day, psychological stress, or a busy lifestyle might induce disorders of the circadian structure, which can affect health on both the physiological and neurobehavioral levels. Rest-activity rhythm is strongly connected with an organism's circadian structure...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800411416224
更新日期：2013-01-01 00:00:00
abstract：:The aim of this study was to investigate the effects of a resistance training program (RTP) in older overweight women (OOW) using two different types of elastic devices. METHODS:This study was a randomized controlled trial with pre- and postintervention measures. Participants included OOW, aged 60-85 years, with no m...
journal_title：Biological research for nursing
pub_type： 杂志文章,随机对照试验
doi：10.1177/1099800418757676
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) is considered the gold standard for gastric bypass, displaying better results for metabolic disorders than other surgical procedures over the long term. The aim of this study was to determine the effects of bariatric surgery, in particular the RYGB technique, on metabolic synd...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800416675406
更新日期：2017-03-01 00:00:00
