Abstract：
BACKGROUND:Drug addiction is a multifactorial disorder. Researchers have posited that an individual's inherited behavioral propensity or temperament contributes to the disorder by shaping a personality strongly linked with the risk of drug abuse. Further, they hypothesize that the polymorphism of dopamine D2 receptor increases the susceptibility to and severity of addiction. We, therefore, investigated possible associations between dopamine D2 receptor (DRD2) and personality traits among intravenous heroin addicts. METHODS:We assessed 93 intravenous heroin addicts and controls using Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) and the Tridimensional Personality Questionnaire (TPQ). We confirmed drug-dependence status using a questionnaire based on DSM-IV criteria. We extracted DNA from the subjects' whole blood and genotyped it for DRD2 allelic variants. RESULTS:Genotype analysis showed a significantly higher frequency for the TaqIA polymorphism among the addicts (69.9%) compared to control subjects (42.6%; Fisher's exact χ(2), p < .05). We observed no significant differences for other variants between the addicts and controls. The addicts had higher scores for novelty seeking (NS) and harm avoidance (HA) personality traits but lower scores for reward dependence (RD) when compared to control subjects. LIMITATION:The environmental cues are different for the addicts, and the healthy university students we used as controls. We recommend that researchers employ a gene-environment interaction approach to study factors associated with addictive behaviors in future studies. CONCLUSION:Taq1A may be implicated for an increased vulnerability to addiction. Screening of this marker might be useful for identifying individuals at risk of addiction.
journal_name
Biol Res Nursjournal_title
Biological research for nursingauthors
Teh LK,Izuddin AF,M H FH,Zakaria ZA,Salleh MZdoi
10.1177/1099800411405030subject
Has Abstractpub_date
2012-04-01 00:00:00pages
188-96issue
2eissn
1099-8004issn
1552-4175pii
1099800411405030journal_volume
14pub_type
杂志文章abstract：:The purpose of this study was to compare physiological and psychological reactions among Taiwanese women with different degrees of severity of nausea and vomiting (NV) during pregnancy. Based on their scores on the Index of Nausea, Vomiting, and Retching (INVR), 59 pregnant women ≥ 18 years of age, with single gestati...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800410388506
更新日期：2011-10-01 00:00:00
abstract：:The purpose of this study was to evaluate for differences in variations in pro- and anti-inflammatory cytokine genes between participants who were classified as having low and high levels of morning and evening fatigue and to evaluate for differences in phenotypic characteristics between these two groups. In a sample ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800414534313
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) is considered the gold standard for gastric bypass, displaying better results for metabolic disorders than other surgical procedures over the long term. The aim of this study was to determine the effects of bariatric surgery, in particular the RYGB technique, on metabolic synd...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800416675406
更新日期：2017-03-01 00:00:00
abstract：:To examine the effects of exercise and vitamin E supplementation on oxidative stress in older adults, 59 participants, age 76.3 +/- 4.2 years, were randomly assigned to 1 of 4 groups: an exercise group taking placebos (EGP) or vitamin E (EGE) or a sedentary group taking placebos (SGP) or vitamin E (SGE). Measures incl...
journal_title：Biological research for nursing
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/1099800403005001005
更新日期：2003-07-01 00:00:00
abstract：:The American Academy of Pediatrics recently removed nicotine from the list of drugs contraindicated during breastfeeding. The objective of this study was to evaluate the feasibility of determining the effect of a smoking hygiene intervention on infants of breastfeeding mothers who smoke cigarettes. An experimental des...
journal_title：Biological research for nursing
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1177/1099800406290643
更新日期：2006-10-01 00:00:00
abstract：:Nausea and vomiting are the most common side effects of antineoplastic chemotherapy. However, only a small number of studies have been conducted in Taiwan to determine the efficacy of acupressure in treating these side effects in cancer patients receiving chemotherapy. In this quasi-experimental study, we aimed to exp...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800416683801
更新日期：2017-03-01 00:00:00
abstract：:Stress during pregnancy has been associated with a number of adverse outcomes. This study compared and correlated neuroendocrine parameters in women (n=8) who self-reported battering during their pregnancy to those in women who did not (n=8). Women who identified themselves as having a violent relationship with an int...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800405283182
更新日期：2006-01-01 00:00:00
abstract：:Adolescence is considered a critical period for risk of depressive symptoms, with prevalence ranging from 13% to 34%. Few studies have examined the relationships among perceived stress, bullying, and depressive symptoms accompanied by a biological marker of stress (cortisol). The purpose of this pilot study was to det...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800416656396
更新日期：2017-01-01 00:00:00
abstract：:Paclitaxel (PAC) treatment is associated with persistent, debilitating neuropathic pain that affects the hands and feet. Female sex and biological stress responsivity are risk factors for persistent pain, but it is unclear whether these important biologically based factors confer risk for PAC-induced neuropathic pain....
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800415609418
更新日期：2016-05-01 00:00:00
abstract：:The ability to maintain balance is often taken for granted, yet it is the foundation for mobility and overall functional independence throughout the life span. The purpose of this article is to define balance, review the components of balance, and describe common instruments used to measure balance. Clinical screening...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/109980040000100408
更新日期：2000-04-01 00:00:00
abstract：:Despite high efficacy rates, significant costs and logistical challenges associated with procuring stool from healthy donors for fecal microbiota transplantation (FMT) have presented barriers to broader institutional adoption and limited the availability of this life-saving treatment. Published outcomes for donor scre...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800420941185
更新日期：2021-01-01 00:00:00
abstract：:Central nervous system (CNS)-directed treatment for acute lymphoblastic leukemia, used to prevent disease recurrence in the brain, is essential for survival. Systemic and intrathecal methotrexate, commonly used for CNS-directed treatment, have been associated with cognitive problems during and after treatment. The cor...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800416644780
更新日期：2016-10-01 00:00:00
abstract：:Survivors of aneurysmal subarachnoid hemorrhage (aSAH) often experience unfavorable functional outcomes that result in a reduced ability to independently perform activities of daily living. The apolipoprotein E gene ( APOE) encodes for a protein known to facilitate lipid transport and aid in neuronal repair within the...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800417746504
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:The sacral skin of bedridden older patients often develops a dysbiotic condition. To clarify whether the condition changes or is sustained over time, we analyzed the skin microbiome and the skin physiological functions of the sacral skin in patients who completed our 2017 study. METHODS:In 2019, we collected...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800420941151
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVE:The Finnmarksløpet dogsled race lasts up to 7 days. Helpers, who keep time, coach, and transport equipment, have to be alert though they have little and fragmented sleep. This study investigated disruptions of the rest-activity rhythm among helpers. METHODS:10 helpers were monitored by actigraph a week befor...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800412475077
更新日期：2014-04-01 00:00:00
abstract：:Maternal posturing, in which a pregnant or laboring woman assumes specific postures with the intention of altering the position and/or presentation of the fetus within the uterus, is a safe alternative to operative procedures recommended in cases of fetal malpositions and malpresentations. Clinicians and researchers a...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800404268318
更新日期：2004-10-01 00:00:00
abstract：:The purpose of this study was to describe the sleep patterns and fatigue of both mothers and fathers before and after childbirth. The authors used wrist actigraphy and questionnaires to estimate sleep and fatigue in 72 couples during their last month of pregnancy and 1st month postpartum. Both parents experienced more...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800403262142
更新日期：2004-04-01 00:00:00
abstract：:The purpose of this study was to examine whether the hepatitis B seroconversion rates in a small sample of subjects reflected that of the published rates, regardless of HIV status, after a hepatitis B vaccination series was completed while following strict vaccine protocols. The study, which had a nonexperimental, cor...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800414524619
更新日期：2015-01-01 00:00:00
abstract：:Scientists and clinicians frequently use immunological methods (IMs) to investigate complex biological phenomena. Commonly used IMs include immunocytochemistry (IC), enzyme-linked immunosorbent assays (ELISA) and flow cytometry. Each of these methodologies exploits a common principle in IMs -the binding of an antibody...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800411402494
更新日期：2011-07-01 00:00:00
abstract：:Current medical technology permits the early detection of risk factors for coronary artery disease (CAD) in adults, and interventions are available to prevent CAD-related morbidity and mortality. The goal of this study was to determine the effectiveness of a Qigong exercise intervention in improving biomarker levels a...
journal_title：Biological research for nursing
pub_type： 杂志文章,随机对照试验
doi：10.1177/1099800415617017
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:Proinflammatory activity has been suggested as one of the psychophysiological mechanisms responsible for the health risks associated with stress and mood disorders. There have been limited studies evaluating central immune and hypothalamic- pituitary-adrenal (HPA) axis responses to experimental stress in heal...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800410383558
更新日期：2011-04-01 00:00:00
abstract：:Age-related changes in skeletal muscle, in combination with bed rest, may result in a poorer rehabilitation potential for an elderly patient. The purpose of this study was to determine the effects of non-weight bearing (hind limb unweighting [HU]) on the soleus and extensor digitorum longus (EDL) in older rats. Two no...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800403260693
更新日期：2004-01-01 00:00:00
abstract：:The purpose of this pilot study was to investigate selected stress, immune, and growth consequences of maternal separation and separation with supplemental stroking in neonatal BALB/c infant mice and their dams. Three groups of 5 litters each (7 pups per litter) were studied. Control litters were undisturbed. Separate...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800402003003002
更新日期：2002-01-01 00:00:00
abstract：:For precision health care to be successful, an in-depth understanding of the biological mechanisms for symptom development and severity is essential. Omics-based research approaches facilitate identification of the biological underpinnings of symptoms. We reviewed literature for omics-based approaches and exemplar sym...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800417751069
更新日期：2018-03-01 00:00:00
abstract：:Bidirectional communication between the immune system and the brain and the implications of this communication are emerging concepts in pain research. Although representing a small portion of the disc degeneration syndromes, lumbar herniated discs can cause significant symptoms that may persist even after surgical int...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800404272221
更新日期：2005-01-01 00:00:00
abstract：:The primary purpose of this exploratory study was to compare percentages of natural killer (NK) cells and activated NK and T cells, and both cytotoxic and in vitro cytokine production activity in women with and without symptomatic irritable bowel syndrome (IBS). A secondary purpose was to examine the relationships of ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800402004001005
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND:Leptin and adiponectin, two adipokines involved in glucose and lipid metabolism, have been linked to regulation of growth in early infancy, energy balance, and metabolic disorders in childhood. The aim of this study was to determine if concentrations of leptin and adiponectin could be measured reliably in in...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800420973366
更新日期：2020-11-28 00:00:00
abstract：:The aim of this study was to investigate the effects of a resistance training program (RTP) in older overweight women (OOW) using two different types of elastic devices. METHODS:This study was a randomized controlled trial with pre- and postintervention measures. Participants included OOW, aged 60-85 years, with no m...
journal_title：Biological research for nursing
pub_type： 杂志文章,随机对照试验
doi：10.1177/1099800418757676
更新日期：2018-05-01 00:00:00
abstract：:Society has a rapidly growing accumulative sleep debt due to employment obligations and lifestyle choices that limit sleep opportunities. The degree to which poor sleep may set the stage for adverse symptom outcomes among more than 1.7 million persons who will be diagnosed with cancer is not entirely understood. Pacli...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800414539385
更新日期：2015-03-01 00:00:00
abstract：:People with schizophrenia have a higher prevalence of obesity than the general population. Many people with this illness struggle with weight gain, due, in part, to medications and other factors that act as obstacles to exercise and healthy eating. Several studies have shown the benefits of behavioral weight loss prog...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800410393272
更新日期：2011-10-01 00:00:00
