Integrating molecular genetics analyses into clinical research.

Abstract:

:The integration of molecular genetics approaches into the study of complex health phenomena is an increasingly important and available strategy for researchers across the health science disciplines. Pain sensation and response to painful stimuli are examples of complex health phenomena that are particularly amenable to molecular genetics approaches. Both human and animal model research suggests that differences in these responses may be related, in part, to variation in the genes that modulate sensation and behavior. The authors are currently managing a large cross-disciplinary research effort to identify child characteristics, including genotypes, that predict the degree of distress displayed by children following a painful medical procedure (i.e., IV insertion). The purpose of this article is to describe the strategies used to integrate molecular genetics methods into this project. The authors discuss the steps needed to complete this process, including (a) establishing a collaboration with genetics researchers and laboratory facilities, (b) developing and implementing a plan to manage biologic samples, and (c) incorporating genetics into the informed consent process.

journal_name

Biol Res Nurs

authors

Schutte DL,McCarthy AM,Floria-Santos M,Hanrahan K,Murray JC,Kleiber C

doi

10.1177/1099800406289909

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

67-77

issue

1

eissn

1099-8004

issn

1552-4175

pii

8/1/67

journal_volume

8

pub_type

杂志文章,评审
  • Neural-immune interactions: implications for pain management in patients with low-back pain and sciatica.

    abstract::Bidirectional communication between the immune system and the brain and the implications of this communication are emerging concepts in pain research. Although representing a small portion of the disc degeneration syndromes, lumbar herniated discs can cause significant symptoms that may persist even after surgical int...

    journal_title:Biological research for nursing

    pub_type: 杂志文章,评审

    doi:10.1177/1099800404272221

    authors: Starkweather A,Witek-Janusek L,Mathews HL

    更新日期:2005-01-01 00:00:00

  • A genomic profile of the immune response to stroke with implications for stroke recovery.

    abstract:OBJECTIVES:The objectives of this study were to determine the change in gene expression between two time points following stroke and to identify biomarkers of stroke recovery through gene expression profiling and pathway analysis. METHODS:Peripheral blood was collected from 34 ischemic stroke patients (confirmed by ma...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800414546492

    authors: Barr TL,VanGilder R,Rellick S,Brooks SD,Doll DN,Lucke-Wold AN,Chen D,Denvir J,Warach S,Singleton A,Matarin M

    更新日期:2015-05-01 00:00:00

  • A Systematic Review of Taste Differences Among People With Eating Disorders.

    abstract:BACKGROUND:Eating disorders are a significant cause of morbidity and mortality. The etiology and maintenance of eating-disorder symptoms are not well understood. Evidence suggests that there may be gustatory alterations in patients with eating disorders. OBJECTIVE:This article systematically reviews research assessing...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800419872824

    authors: Chao AM,Roy A,Franks AT,Joseph PV

    更新日期:2020-01-01 00:00:00

  • Effects of separation and separation with supplemental stroking in BALb/c infant mice.

    abstract::The purpose of this pilot study was to investigate selected stress, immune, and growth consequences of maternal separation and separation with supplemental stroking in neonatal BALB/c infant mice and their dams. Three groups of 5 litters each (7 pups per litter) were studied. Control litters were undisturbed. Separate...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800402003003002

    authors: Groër MW,Hill J,Wilkinson JE,Stuart A

    更新日期:2002-01-01 00:00:00

  • Effect of Obesity on Cognitive Impairment in Vascular Dementia Rat Model via BDNF-ERK-CREB Pathway.

    abstract::The prevalence of vascular dementia continues to increase with no cure. Thus, it is important identify the aggravating factors of vascular dementia to delay disease progression in patients. Obesity is a well-known risk factor for vascular dementia and causes mild cognitive impairment. In the present study, we evaluate...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800420951633

    authors: Kim Y,Kim YJ

    更新日期:2020-08-26 00:00:00

  • Understanding cytokines. Part II: Implications for nursing research and practice.

    abstract::Cytokines are small signaling proteins released from a variety of cells that influence virtually every aspect of growth and development and every host response to infection, injury, and inflammation. Because of their widespread and potent effects across the life span, cytokines without a doubt influence nursing resear...

    journal_title:Biological research for nursing

    pub_type: 杂志文章,评审

    doi:10.1177/109980040000200105

    authors: Corwin EJ

    更新日期:2000-07-01 00:00:00

  • Degree of Agreement Between Infant Serum and Salivary Concentration of Leptin and Adiponectin and Its Association With Infants' Feeding.

    abstract:BACKGROUND:Leptin and adiponectin, two adipokines involved in glucose and lipid metabolism, have been linked to regulation of growth in early infancy, energy balance, and metabolic disorders in childhood. The aim of this study was to determine if concentrations of leptin and adiponectin could be measured reliably in in...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800420973366

    authors: Linares AM,Rayens MK,Moylan JS,Miller CS

    更新日期:2020-11-28 00:00:00

  • Blunted affect is associated with hypothalamic--pituitary--adrenal axis (HPA) hypoactivity and elevated CSF-interleukin-1 beta (IL-1β) in response to lumbar puncture.

    abstract:OBJECTIVE:Proinflammatory activity has been suggested as one of the psychophysiological mechanisms responsible for the health risks associated with stress and mood disorders. There have been limited studies evaluating central immune and hypothalamic- pituitary-adrenal (HPA) axis responses to experimental stress in heal...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800410383558

    authors: Fitzgerald L

    更新日期:2011-04-01 00:00:00

  • Defining and measuring balance in adults.

    abstract::The ability to maintain balance is often taken for granted, yet it is the foundation for mobility and overall functional independence throughout the life span. The purpose of this article is to define balance, review the components of balance, and describe common instruments used to measure balance. Clinical screening...

    journal_title:Biological research for nursing

    pub_type: 杂志文章,评审

    doi:10.1177/109980040000100408

    authors: Yim-Chiplis PK,Talbot LA

    更新日期:2000-04-01 00:00:00

  • Comparison of autonomic nervous system indices based on abdominal pain reports in women with irritable bowel syndrome.

    abstract::Abdominal pain is an important symptom in irritable bowel syndrome (IBS), but patients report typical pain intensities ranging from mild to very severe. In a sample of women, the authors sought to determine whether measures of systemic autonomic activity are related to self-reported pain intensity and the occurrence o...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/109980040000200203

    authors: Burr RL,Heitkemper M,Jarrett M,Cain KC

    更新日期:2000-10-01 00:00:00

  • Tridimensional personalities and polymorphism of dopamine D2 receptor among heroin addicts.

    abstract:BACKGROUND:Drug addiction is a multifactorial disorder. Researchers have posited that an individual's inherited behavioral propensity or temperament contributes to the disorder by shaping a personality strongly linked with the risk of drug abuse. Further, they hypothesize that the polymorphism of dopamine D2 receptor i...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800411405030

    authors: Teh LK,Izuddin AF,M H FH,Zakaria ZA,Salleh MZ

    更新日期:2012-04-01 00:00:00

  • A Hyperresponsive HPA Axis May Confer Resilience Against Persistent Paclitaxel-Induced Mechanical Hypersensitivity.

    abstract::Paclitaxel (PAC) treatment is associated with persistent, debilitating neuropathic pain that affects the hands and feet. Female sex and biological stress responsivity are risk factors for persistent pain, but it is unclear whether these important biologically based factors confer risk for PAC-induced neuropathic pain....

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800415609418

    authors: Kozachik SL,Page GG

    更新日期:2016-05-01 00:00:00

  • Patient Position Affects Venodilation for Peripheral Intravenous Cannulation.

    abstract:BACKGROUND:Larger veins are associated with a higher rate of success of peripheral intravenous cannulation. Although patient position affects venodilation during central venous cannulation, the association between patient position and vein size for peripheral intravenous cannulation remains unclear. PURPOSE:We examine...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800419893027

    authors: Yamagami Y,Inoue T

    更新日期:2020-04-01 00:00:00

  • Biomarkers and perceived emotional stress in early-stage pregnant taiwanese women with nausea and vomiting.

    abstract::The purpose of this study was to compare physiological and psychological reactions among Taiwanese women with different degrees of severity of nausea and vomiting (NV) during pregnancy. Based on their scores on the Index of Nausea, Vomiting, and Retching (INVR), 59 pregnant women ≥ 18 years of age, with single gestati...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800410388506

    authors: Chou FH,Chan TF,Chin CC,Chen YL,Shen CJ,Kuo SH

    更新日期:2011-10-01 00:00:00

  • Social determinants and heat shock protein-70 among African American and non-Hispanic white women with atherosclerosis: a pilot study.

    abstract::African American (AA) women are nearly twice as likely as non-Hispanic White (NHW) women to develop atherosclerosis associated with cardiovascular disease. Compelling evidence demonstrates that stress-related biomarkers, such as heat shock protein-70 (HSP70), are associated with increased atherosclerosis risk. Yet lit...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800413491422

    authors: Saban KL,Hoppensteadt D,Bryant FB,DeVon HA

    更新日期:2014-07-01 00:00:00

  • Structural Brain Changes in Delirium: An Integrative Review.

    abstract::Delirium is a serious complication of acute illness. Little is known, however, regarding the neurobiology of delirium, largely due to challenges in studying the complex inpatient population. Neuroimaging is one noninvasive method that can be used to study structural and functional brain abnormalities associated with d...

    journal_title:Biological research for nursing

    pub_type: 杂志文章,评审

    doi:10.1177/1099800419849489

    authors: Kalvas LB,Monroe TB

    更新日期:2019-07-01 00:00:00

  • A longitudinal description of heart rate variability in 28--34-week-old preterm infants.

    abstract::The purpose of this study was to longitudinally describe changes in heart rate variability (HRV) from 28 to 34 weeks postmenstrual age (PMA). A convenience sample of 31 low-risk preterm infants participated. HRV was quantified using a spectral analysis of heart periods and recorded during seven weekly test sessions fr...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800409341175

    authors: Krueger C,van Oostrom JH,Shuster J

    更新日期:2010-01-01 00:00:00

  • Integrated review of cytokines in maternal, cord, and newborn blood: part I--associations with preterm birth.

    abstract::Preterm birth (PTB; spontaneous delivery prior to 37 weeks gestation) affects one out of eight infants born in the United States and is the most common cause of neonatal morbidity and mortality. Although the pathogenesis of PTB is multifactorial, a growing body of literature supports the hypothesis that one cause of P...

    journal_title:Biological research for nursing

    pub_type: 杂志文章,评审

    doi:10.1177/1099800409344620

    authors: Lyon D,Cheng CY,Howland L,Rattican D,Jallo N,Pickler R,Brown L,McGrath J

    更新日期:2010-04-01 00:00:00

  • Ethical aspects of genetic testing.

    abstract::This article explores ethical concerns and emerging dilemmas associated with the proliferation of information resulting from the extraordinary advances in molecular genetics. It provides an overview of the ethical and legal challenges associated with predictive testing for inherited disease currently being addressed i...

    journal_title:Biological research for nursing

    pub_type: 杂志文章,评审

    doi:10.1177/109980040100300104

    authors: Carter MA

    更新日期:2001-07-01 00:00:00

  • Immunological methods for nursing research: from cells to systems.

    abstract::Scientists and clinicians frequently use immunological methods (IMs) to investigate complex biological phenomena. Commonly used IMs include immunocytochemistry (IC), enzyme-linked immunosorbent assays (ELISA) and flow cytometry. Each of these methodologies exploits a common principle in IMs -the binding of an antibody...

    journal_title:Biological research for nursing

    pub_type: 杂志文章,评审

    doi:10.1177/1099800411402494

    authors: Morrison HW,Downs CA

    更新日期:2011-07-01 00:00:00

  • A Diagnosis of Insomnia Is Associated With Differential Expression of Sleep-Regulating Genes in Military Personnel.

    abstract::Sleep disturbance is a common and disturbing symptom in military personnel, with many individuals progressing to the development of insomnia, which is characterized by increased arousals, wakefulness after sleep onset, and distorted sleep architecture. The molecular mechanisms underlying insomnia remain elusive, limit...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800415575343

    authors: Gill JM,Lee H,Baxter T,Reddy SY,Barr T,Kim HS,Wang D,Mysliwiec V

    更新日期:2015-07-01 00:00:00

  • Effect of self-management intervention on cortisol and daily stress levels in irritable bowel syndrome.

    abstract::Self-management programs that include cognitive behavioral strategies have been shown to improve gastrointestinal (GI) symptoms, psychological distress, and quality of life (QoL) in persons with irritable bowel syndrome (IBS). However, less is known about the physiological impact of such a change. As part of a randomi...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800411414047

    authors: Deechakawan W,Cain KC,Jarrett ME,Burr RL,Heitkemper MM

    更新日期:2013-01-01 00:00:00

  • Laser capture microdissection: understanding the techniques and implications for molecular biology in nursing research through analysis of breast cancer tumor samples.

    abstract:AIM:The purpose of this paper is to review the techniques and implications of laser capture microdissection (LCM) to isolate tissue and DNA of interest using breast biopsy tissue as an example. BACKGROUND:Tissues are a heterogeneous mix of different cell types, and molecular alterations are often specific to a single ...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800411402054

    authors: Zanni KL,Chan GK

    更新日期:2011-07-01 00:00:00

  • Measurement of MicroRNA: a regulator of gene expression.

    abstract::MicroRNAs (miRs) are epigenetic regulators of messenger RNAs' (mRNA) expression of polypeptides. As such, miRs represent an intriguing mechanism by which gene-environment interactions are hypothesized to occur on the level of epigenetic control over gene expression. In addition to promising findings from in vitro stud...

    journal_title:Biological research for nursing

    pub_type: 杂志文章,评审

    doi:10.1177/1099800411430380

    authors: Flowers E,Froelicher ES,Aouizerat BE

    更新日期:2013-04-01 00:00:00

  • A Longitudinal Analysis of Inflammation and Depression in Patients With Metastatic Lung Cancer: Associations With Survival.

    abstract:BACKGROUND:Depression and inflammation are concomitantly elevated in patients with lung cancer and may have collective survival implications. However, the longitudinal relationship between depression and inflammation in patients with metastatic lung cancer is not fully appreciated. We hypothesized that longitudinal cha...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800420959721

    authors: McFarland DC,Miller AH,Nelson C

    更新日期:2020-09-22 00:00:00

  • Intraoral Vacuum of Breast-Feeding Newborns Within the First 24 Hr: Cesarean Section Versus Vaginal Delivery.

    abstract:OBJECTIVES:To explore whether newborns born via Cesarean section have a weaker intraoral vacuum compared with those born vaginally and to determine whether a weaker intraoral vacuum is related to a delayed onset of lactation. METHODS:For this prospective cohort study, 71 mother-infant dyads were enrolled and divided i...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800416636687

    authors: Zhang F,Xia H,Li X,Qin L,Gu H,Xu X,Shen M

    更新日期:2016-07-01 00:00:00

  • Perfusion Index in Very Low Birth Weight Premature Infants During Their First 2 Weeks of Life.

    abstract:BACKGROUND:Our program of research focuses on thermal and circulatory stability in extremely premature infants. In prior studies, we found that infants have long periods of time in which foot temperature (FT) is higher than central temperature. We thus wanted to determine whether blood flow in the foot is increased whe...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800416656914

    authors: Knobel-Dail RB,Tanaka DT,Holditch-Davis D,White J

    更新日期:2017-01-01 00:00:00

  • Biological Sex Differences in Depression: A Systematic Review.

    abstract::Depression is the leading cause of disability worldwide, and its prevalence is 2 times higher in women than in men. There is, however, a lack of data on sex-specific pathophysiology of this disorder. The purpose of this systematic review is to identify the biological sex differences found in major depressive disorder ...

    journal_title:Biological research for nursing

    pub_type: 杂志文章

    doi:10.1177/1099800418776082

    authors: Labaka A,Goñi-Balentziaga O,Lebeña A,Pérez-Tejada J

    更新日期:2018-07-01 00:00:00

  • Cancer-induced fatigue and skeletal muscle wasting: the role of exercise.

    abstract::Fatigue is the most frequently reported symptom by cancer patients. Many of these patients perceive fatigue as the most distressing symptom associated with their illness because it imposes limitations on their physical activity level. Skeletal muscle wasting, which occurs as part of cancer cachexia, is one of the mech...

    journal_title:Biological research for nursing

    pub_type: 杂志文章,评审

    doi:10.1177/109980040100200304

    authors: al-Majid S,McCarthy DO

    更新日期:2001-01-01 00:00:00

  • A systematic review of allostatic load, health, and health disparities.

    abstract::The theoretical constructs of allostasis and allostatic load (AL) have contributed to our understanding of how constantly changing social and environmental factors impact physiological functioning and shape health and aging disparities, particularly along socioeconomic, gendered, racial, and ethnic lines. AL represent...

    journal_title:Biological research for nursing

    pub_type: 杂志文章,评审

    doi:10.1177/1099800412455688

    authors: Beckie TM

    更新日期:2012-10-01 00:00:00