Structural Brain Changes in Delirium: An Integrative Review.

Abstract:

:Delirium is a serious complication of acute illness. Little is known, however, regarding the neurobiology of delirium, largely due to challenges in studying the complex inpatient population. Neuroimaging is one noninvasive method that can be used to study structural and functional brain abnormalities associated with delirium. The purpose of this integrative literature review was to examine the content and quality of current structural neuroimaging evidence in delirium. After meeting inclusion criteria, 11 articles were included in the review. Commonly noted structural abnormalities were impaired white matter integrity, brain atrophy, ischemic lesions, edema, and inflammation. Findings demonstrated widespread alterations in several brain structures. Limitations of the studies in this review included small sample sizes, inappropriate or questionable delirium measurements, and failure to consider confounding variables. This review provides insight into possible structural changes responsible for the signs and symptoms seen in patients with delirium, but more high-quality studies are needed.

journal_name

Biol Res Nurs

authors

Kalvas LB,Monroe TB

doi

10.1177/1099800419849489

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

355-365

issue

4

eissn

1099-8004

issn

1552-4175

journal_volume

21

pub_type

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