Abstract:
:Depression is the leading cause of disability worldwide, and its prevalence is 2 times higher in women than in men. There is, however, a lack of data on sex-specific pathophysiology of this disorder. The purpose of this systematic review is to identify the biological sex differences found in major depressive disorder (MDD) in studies published in the last 10 years. We conducted a literature search using the Medline, PsycInfo, PubMed, and Web of Science databases, selecting English-language studies that included physiological measures compared by sex in addition to MDD. We identified 20 relevant studies, which consisted primarily of mixed methodology and samples. The reported physiological measures comprised a variety of serum biomarkers, gene mRNA expression, and brain activity. Findings suggest different biological patterns in those with MDD depending on sex. Specifically, women presented higher levels of inflammatory, neurotrophic, and serotonergic markers and a stronger correlation between levels of some inflammatory and neurotrophic factors and the severity of symptoms. This review provides information about possible different biological patterns for women and men with depressive disorder and may have important implications for treatment. Future research should include homogeneous samples; make comparisons based on sex, control sex hormone fluctuations and pharmacological treatment; and use consistent criteria for evaluating psychobiological changes in MDD.
journal_name
Biol Res Nursjournal_title
Biological research for nursingauthors
Labaka A,Goñi-Balentziaga O,Lebeña A,Pérez-Tejada Jdoi
10.1177/1099800418776082subject
Has Abstractpub_date
2018-07-01 00:00:00pages
383-392issue
4eissn
1099-8004issn
1552-4175journal_volume
20pub_type
杂志文章abstract::Postpartum depression (PPD) is a serious mood disorder that may carry life-long consequences for a woman and her family. Multiple risk factors for PPD have been identified, including psychosocial, situational, and biological stimuli, several of which are experienced by most, if not all, postpartum women. Given the com...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800410362112
更新日期:2010-07-01 00:00:00
abstract::The focus on a cure for childhood leukemia over the last three decades has resulted in survival rates of more than 80%. However, efforts to manage leukemia-treatment symptoms have not kept pace with new therapies. Symptom toxicity during treatment can result in complications, treatment delays, and therapy dose reducti...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800418772907
更新日期:2018-07-01 00:00:00
abstract::Stress during pregnancy has been associated with a number of adverse outcomes. This study compared and correlated neuroendocrine parameters in women (n=8) who self-reported battering during their pregnancy to those in women who did not (n=8). Women who identified themselves as having a violent relationship with an int...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800405283182
更新日期:2006-01-01 00:00:00
abstract::Current medical technology permits the early detection of risk factors for coronary artery disease (CAD) in adults, and interventions are available to prevent CAD-related morbidity and mortality. The goal of this study was to determine the effectiveness of a Qigong exercise intervention in improving biomarker levels a...
journal_title:Biological research for nursing
pub_type: 杂志文章,随机对照试验
doi:10.1177/1099800415617017
更新日期:2016-05-01 00:00:00
abstract::Bidirectional communication between the immune system and the brain and the implications of this communication are emerging concepts in pain research. Although representing a small portion of the disc degeneration syndromes, lumbar herniated discs can cause significant symptoms that may persist even after surgical int...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800404272221
更新日期:2005-01-01 00:00:00
abstract::The purpose of this study was to examine whether the hepatitis B seroconversion rates in a small sample of subjects reflected that of the published rates, regardless of HIV status, after a hepatitis B vaccination series was completed while following strict vaccine protocols. The study, which had a nonexperimental, cor...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800414524619
更新日期:2015-01-01 00:00:00
abstract::Cytokines such as angiogenin (ANG) and interleukin (IL-8) have been shown to be related to depressive symptoms and inflammatory diseases like coronary heart disease. They may thus be used as stress biomarkers to identify and prevent health problems. To investigate the relationship between cytokines and nurses' job-rel...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800408323219
更新日期:2008-10-01 00:00:00
abstract::Maternal posturing, in which a pregnant or laboring woman assumes specific postures with the intention of altering the position and/or presentation of the fetus within the uterus, is a safe alternative to operative procedures recommended in cases of fetal malpositions and malpresentations. Clinicians and researchers a...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800404268318
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:To investigate associations between components of cumulative risk (CR) and physiological stress responses in African American adolescents and evaluate emotion regulation as a mediator and sex as a moderator of these associations. METHODS:Cortisol and salivary alpha amylase (sAA) were collected in adolescents...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417702742
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Incidence rates of both type 1 and type 2 diabetes mellitus (DM) are increasing in youth and may eventually contribute to premature heart disease in early adulthood. This investigation explored the influence of type of diabetes, gender, body mass index (BMI), metabolic control (HbA1c), exercise beliefs and p...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800405275202
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Many chronic conditions, including heart disease, cancer, and rheumatoid arthritis, are associated with underlying chronic inflammatory processes. Literature reviews have analyzed a variety of integrative therapies and their relationships with chronic inflammation. This systematic review is unique in reporti...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800418820162
更新日期:2019-03-01 00:00:00
abstract::Since the completion of the Human Genome Project, much has been uncovered about inheritance of various illnesses and disorders. There are two main types of inheritance: Mendelian and non-Mendelian. Mendelian inheritance includes autosomal dominant, autosomal recessive, X-linked, and Y-linked inheritance. Non-Mendelian...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417708616
更新日期:2017-07-01 00:00:00
abstract::Scientists and clinicians frequently use immunological methods (IMs) to investigate complex biological phenomena. Commonly used IMs include immunocytochemistry (IC), enzyme-linked immunosorbent assays (ELISA) and flow cytometry. Each of these methodologies exploits a common principle in IMs -the binding of an antibody...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800411402494
更新日期:2011-07-01 00:00:00
abstract::Survivors of aneurysmal subarachnoid hemorrhage (aSAH) often experience unfavorable functional outcomes that result in a reduced ability to independently perform activities of daily living. The apolipoprotein E gene ( APOE) encodes for a protein known to facilitate lipid transport and aid in neuronal repair within the...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417746504
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence and patterns of and factors associated with hyperphagic behavior in Taiwanese patients with dementia living at home. METHODS:A cross-sectional and correlational design was used. A total of 104 patients with dementia and their primary caregivers were recruited from the geriatric,...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800414562025
更新日期:2015-10-01 00:00:00
abstract::The purpose of this pilot study was to investigate selected stress, immune, and growth consequences of maternal separation and separation with supplemental stroking in neonatal BALB/c infant mice and their dams. Three groups of 5 litters each (7 pups per litter) were studied. Control litters were undisturbed. Separate...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800402003003002
更新日期:2002-01-01 00:00:00
abstract::Military personnel experience posttraumatic stress disorder (PTSD), which is associated with differential DNA methylation across the whole genome. However, the relationship between these DNA methylation patterns and clinically relevant increases in PTSD severity is not yet clearly understood. The purpose of this study...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800418758951
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:This study examined adherence to a personalized, community-based exercise intervention by sedentary adolescents with type 1 or type 2 diabetes or those with obesity. RESEARCH DESIGN AND METHODS:We conducted a pretest-posttest investigation to explore the application of an individualized exercise prescription...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800413500064
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Proinflammatory activity has been suggested as one of the psychophysiological mechanisms responsible for the health risks associated with stress and mood disorders. There have been limited studies evaluating central immune and hypothalamic- pituitary-adrenal (HPA) axis responses to experimental stress in heal...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800410383558
更新日期:2011-04-01 00:00:00
abstract:AIM:The purpose of this paper is to review the techniques and implications of laser capture microdissection (LCM) to isolate tissue and DNA of interest using breast biopsy tissue as an example. BACKGROUND:Tissues are a heterogeneous mix of different cell types, and molecular alterations are often specific to a single ...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800411402054
更新日期:2011-07-01 00:00:00
abstract::Caring, a core tenet of nursing practice, grew out of a holistic approach. Nurse theorists often note the establishment of a therapeutic relationship as the beginning point of caring, with subsequent nursing interventions reliant upon this relationship for effectiveness. Relational exchange serves as a source of eithe...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800412450505
更新日期:2012-10-01 00:00:00
abstract::Over the last 10 years, interest in the analysis of saliva as a biomarker for a variety of systemic diseases or for potential disease has soared. There are numerous advantages to using saliva as a biological fluid, particularly for nurse researchers working with vulnerable populations, such as frail older adults. Most...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800411404211
更新日期:2011-07-01 00:00:00
abstract::The integration of molecular genetics approaches into the study of complex health phenomena is an increasingly important and available strategy for researchers across the health science disciplines. Pain sensation and response to painful stimuli are examples of complex health phenomena that are particularly amenable t...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800406289909
更新日期:2006-07-01 00:00:00
abstract::The theoretical constructs of allostasis and allostatic load (AL) have contributed to our understanding of how constantly changing social and environmental factors impact physiological functioning and shape health and aging disparities, particularly along socioeconomic, gendered, racial, and ethnic lines. AL represent...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800412455688
更新日期:2012-10-01 00:00:00
abstract::Paclitaxel (PAC) treatment is associated with persistent, debilitating neuropathic pain that affects the hands and feet. Female sex and biological stress responsivity are risk factors for persistent pain, but it is unclear whether these important biologically based factors confer risk for PAC-induced neuropathic pain....
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800415609418
更新日期:2016-05-01 00:00:00
abstract:INTRODUCTION:Plasma concentrations of lipids (i.e., total cholesterol, high-density cholesterol, low-density cholesterol, and triglycerides) are amenable to therapeutic intervention and remain important factors for assessing risk of cardiovascular diseases. Some of the observed variability in serum lipid concentrations...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417752246
更新日期:2018-03-01 00:00:00
abstract::People with schizophrenia have a higher prevalence of obesity than the general population. Many people with this illness struggle with weight gain, due, in part, to medications and other factors that act as obstacles to exercise and healthy eating. Several studies have shown the benefits of behavioral weight loss prog...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800410393272
更新日期:2011-10-01 00:00:00
abstract::The purposes of this quasi-experimental pilot study were to determine adherence to a 12-week group-based moderate-intensity walking program for sedentary adult outpatients with serious and persistent mental illness and to examine change from baseline to after the walking program in health status (mental and physical h...
journal_title:Biological research for nursing
pub_type: 临床试验,杂志文章
doi:10.1177/1099800405278116
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:There are documented associations between elevated maternal corticotropin-releasing hormone (CRH) levels and adverse pregnancy outcomes. However, reports of these findings often lack sufficient detail and rationale regarding the bioassay methodology. This shortcoming can be problematic for researchers who do...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800408320970
更新日期:2008-07-01 00:00:00
abstract::This article explores ethical concerns and emerging dilemmas associated with the proliferation of information resulting from the extraordinary advances in molecular genetics. It provides an overview of the ethical and legal challenges associated with predictive testing for inherited disease currently being addressed i...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/109980040100300104
更新日期:2001-07-01 00:00:00