Abstract:
OBJECTIVE:This study used a candidate gene approach to examine genomic variation associated with pain, anxiety, and distress in children undergoing a medical procedure. STUDY DESIGN:Children aged 4-10 years having an IV catheter insertion were recruited from three Midwestern children's hospitals. Self-report measures of pain, anxiety, and distress were obtained as well as an observed measure of distress. Samples were collected from children and biological parents for analysis of genomic variation. Genotyped variants had known or suspected association with phenotypes of interest. Analyses included child-only association and family-based transmission disequilibrium tests. RESULTS:Genotype and phenotype data were available from 828 children and 376 family trios. Children were 50% male, had a mean age of 7.2 years, and were 84% White/non-Hispanic. In family-based analysis, one single-nucleotide polymorphism (SNP; rs1143629, interleukin ( IL1B) 1β) was associated with observed child distress at Bonferroni-corrected levels of significance ( p = .00013), while two approached significance for association with high state anxiety (rs6330 Nerve Growth Factor, Beta Subunit, [ NGFB]) and high trait anxiety (rs6265 brain-derived neurotrophic factor [ BDNF]). In the child-only analysis, multiple SNPs showed nominal evidence of relationships with phenotypes of interest. rs6265 BDNF and rs2941026 cholecystokinin B receptor had possible relationships with trait anxiety in child-only and family-based analyses. CONCLUSIONS:Exploring genomic variation furthers our understanding of pain, anxiety, and distress and facilitates genomic screening to identify children at high risk of procedural pain, anxiety, and distress. Combined with clinical observations and knowledge, such explorations could help guide tailoring of interventions to limit procedure-related distress and identify genes and pathways of interest for future genotype-phenotype studies.
journal_name
Biol Res Nursjournal_title
Biological research for nursingauthors
Ersig AL,Schutte DL,Standley J,Leslie E,Zimmerman B,Kleiber C,Hanrahan K,Murray JC,McCarthy AMdoi
10.1177/1099800417692878subject
Has Abstractpub_date
2017-05-01 00:00:00pages
339-349issue
3eissn
1099-8004issn
1552-4175journal_volume
19pub_type
杂志文章abstract::The purpose of this study was to evaluate for differences in variations in pro- and anti-inflammatory cytokine genes between participants who were classified as having low and high levels of morning and evening fatigue and to evaluate for differences in phenotypic characteristics between these two groups. In a sample ...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800414534313
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence and patterns of and factors associated with hyperphagic behavior in Taiwanese patients with dementia living at home. METHODS:A cross-sectional and correlational design was used. A total of 104 patients with dementia and their primary caregivers were recruited from the geriatric,...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800414562025
更新日期:2015-10-01 00:00:00
abstract:AIM:The purpose of this paper is to review the techniques and implications of laser capture microdissection (LCM) to isolate tissue and DNA of interest using breast biopsy tissue as an example. BACKGROUND:Tissues are a heterogeneous mix of different cell types, and molecular alterations are often specific to a single ...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800411402054
更新日期:2011-07-01 00:00:00
abstract:INTRODUCTION:Diabetes is a serious health problem affecting approximately 29.1 million individuals in the United States. Another 86 million have prediabetes. The development and implementation of lifestyle modifications such as physical activity for these persons are among the most effective methods for prevention and ...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800418767572
更新日期:2018-07-01 00:00:00
abstract::Current medical technology permits the early detection of risk factors for coronary artery disease (CAD) in adults, and interventions are available to prevent CAD-related morbidity and mortality. The goal of this study was to determine the effectiveness of a Qigong exercise intervention in improving biomarker levels a...
journal_title:Biological research for nursing
pub_type: 杂志文章,随机对照试验
doi:10.1177/1099800415617017
更新日期:2016-05-01 00:00:00
abstract::Scientists and clinicians frequently use immunological methods (IMs) to investigate complex biological phenomena. Commonly used IMs include immunocytochemistry (IC), enzyme-linked immunosorbent assays (ELISA) and flow cytometry. Each of these methodologies exploits a common principle in IMs -the binding of an antibody...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800411402494
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Many chronic conditions, including heart disease, cancer, and rheumatoid arthritis, are associated with underlying chronic inflammatory processes. Literature reviews have analyzed a variety of integrative therapies and their relationships with chronic inflammation. This systematic review is unique in reporti...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800418820162
更新日期:2019-03-01 00:00:00
abstract::The purpose of this pilot study was to investigate selected stress, immune, and growth consequences of maternal separation and separation with supplemental stroking in neonatal BALB/c infant mice and their dams. Three groups of 5 litters each (7 pups per litter) were studied. Control litters were undisturbed. Separate...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800402003003002
更新日期:2002-01-01 00:00:00
abstract::The psychophysiological phenomenon of pain is of tremendous concern to nurses because of its potential to adversely affect the mental, emotional, and physical health of patients. Increasingly appreciated is the ability of pain to influence immune variables including enumerative and functional measures of leukocyte sub...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800405286071
更新日期:2006-04-01 00:00:00
abstract::Over the last 10 years, interest in the analysis of saliva as a biomarker for a variety of systemic diseases or for potential disease has soared. There are numerous advantages to using saliva as a biological fluid, particularly for nurse researchers working with vulnerable populations, such as frail older adults. Most...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800411404211
更新日期:2011-07-01 00:00:00
abstract::The ability to maintain balance is often taken for granted, yet it is the foundation for mobility and overall functional independence throughout the life span. The purpose of this article is to define balance, review the components of balance, and describe common instruments used to measure balance. Clinical screening...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/109980040000100408
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:The most consistently replicated genetic variants associated with coronary heart disease (CHD) in populations of European descent have been found on chromosome 9p21. Yet there is little known about these associations in ethnic groups of African ancestry. These disease-associated variants are located in a gen...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800411403469
更新日期:2011-07-01 00:00:00
abstract:PURPOSE:In recent years, researchers have noted an "obesity paradox," where individuals with obesity survive sepsis at higher rates than their nonobese counterparts. This systematic review summarizes the literature on studies examining the association between obesity and 1-year mortality among patients admitted with se...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800419876070
更新日期:2020-01-01 00:00:00
abstract::Stress during pregnancy has been associated with a number of adverse outcomes. This study compared and correlated neuroendocrine parameters in women (n=8) who self-reported battering during their pregnancy to those in women who did not (n=8). Women who identified themselves as having a violent relationship with an int...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800405283182
更新日期:2006-01-01 00:00:00
abstract::Paclitaxel (PAC) treatment is associated with persistent, debilitating neuropathic pain that affects the hands and feet. Female sex and biological stress responsivity are risk factors for persistent pain, but it is unclear whether these important biologically based factors confer risk for PAC-induced neuropathic pain....
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800415609418
更新日期:2016-05-01 00:00:00
abstract::Postpartum depression (PPD) affects at least 10% to 15% of postpartum women, including more than 600,000 American mothers in 2003 alone. Dramatic changes in the hypothalamic-pituitary-adrenal (HPA) system in the transition from pregnancy to postpartum coupled with research on the psychobiology of depression provided t...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800406294598
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to determine the change in gene expression between two time points following stroke and to identify biomarkers of stroke recovery through gene expression profiling and pathway analysis. METHODS:Peripheral blood was collected from 34 ischemic stroke patients (confirmed by ma...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800414546492
更新日期:2015-05-01 00:00:00
abstract::The American Academy of Pediatrics recently removed nicotine from the list of drugs contraindicated during breastfeeding. The objective of this study was to evaluate the feasibility of determining the effect of a smoking hygiene intervention on infants of breastfeeding mothers who smoke cigarettes. An experimental des...
journal_title:Biological research for nursing
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/1099800406290643
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Incidence rates of both type 1 and type 2 diabetes mellitus (DM) are increasing in youth and may eventually contribute to premature heart disease in early adulthood. This investigation explored the influence of type of diabetes, gender, body mass index (BMI), metabolic control (HbA1c), exercise beliefs and p...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800405275202
更新日期:2005-07-01 00:00:00
abstract::Military personnel experience posttraumatic stress disorder (PTSD), which is associated with differential DNA methylation across the whole genome. However, the relationship between these DNA methylation patterns and clinically relevant increases in PTSD severity is not yet clearly understood. The purpose of this study...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800418758951
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:To investigate associations between components of cumulative risk (CR) and physiological stress responses in African American adolescents and evaluate emotion regulation as a mediator and sex as a moderator of these associations. METHODS:Cortisol and salivary alpha amylase (sAA) were collected in adolescents...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417702742
更新日期:2017-07-01 00:00:00
abstract::Delirium is a serious complication of acute illness. Little is known, however, regarding the neurobiology of delirium, largely due to challenges in studying the complex inpatient population. Neuroimaging is one noninvasive method that can be used to study structural and functional brain abnormalities associated with d...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800419849489
更新日期:2019-07-01 00:00:00
abstract::Despite high efficacy rates, significant costs and logistical challenges associated with procuring stool from healthy donors for fecal microbiota transplantation (FMT) have presented barriers to broader institutional adoption and limited the availability of this life-saving treatment. Published outcomes for donor scre...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800420941185
更新日期:2021-01-01 00:00:00
abstract::Cytokines are small signaling proteins released from a variety of cells that influence virtually every aspect of growth and development and every host response to infection, injury, and inflammation. Because of their widespread and potent effects across the life span, cytokines without a doubt influence nursing resear...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/109980040000200105
更新日期:2000-07-01 00:00:00
abstract::Listening to soothing music has been used as a complementary therapy to improve sleep quality. However, there is no empirical evidence for the effects of music videos (MVs) on sleep quality in adults with insomnia as assessed by polysomnography (PSG). In this randomized crossover controlled trial, we compared the effe...
journal_title:Biological research for nursing
pub_type: 杂志文章,随机对照试验
doi:10.1177/1099800414549237
更新日期:2015-05-01 00:00:00
abstract::Food intake and, subsequently, body weight are influenced by endogenous opioids acting in the central nervous system. Agonists for the opioid receptor increase food intake, whereas antagonists reduce food intake. Body weight, however, is the result of food consumed and energy expended. Although much has been reported ...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800406298774
更新日期:2007-04-01 00:00:00
abstract::Shift work schedules, intensive physical exercise late in the day, psychological stress, or a busy lifestyle might induce disorders of the circadian structure, which can affect health on both the physiological and neurobehavioral levels. Rest-activity rhythm is strongly connected with an organism's circadian structure...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800411416224
更新日期:2013-01-01 00:00:00
abstract::Interpretation of changes in health and health care utilization patterns across the life span depends on an understanding of the effects of age, period, and cohort. The purpose of this article is to illustrate differences among three generations of women in demographic factors, health risk factors, and health status i...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800410373804
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:We examined genomic variation potentially associated with the cortisol stress response in children having a painful medical procedure. DESIGN:Children 4-10 years old having a peripheral intravenous line inserted provided saliva samples for evaluation of the cortisol response as a biological measure of distre...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800419826315
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:Sleep deficit affects neurobehavioral functioning, reduces attention and cognitive function, and negatively impacts occupational safety. This study investigated selective attention levels of nursing staff on different shifts. METHODS:Using a prospective, randomized parallel group study, selective attention was...
journal_title:Biological research for nursing
pub_type: 杂志文章,随机对照试验
doi:10.1177/1099800412445907
更新日期:2013-10-01 00:00:00