Abstract：
:Sleep disturbance is a common and disturbing symptom in military personnel, with many individuals progressing to the development of insomnia, which is characterized by increased arousals, wakefulness after sleep onset, and distorted sleep architecture. The molecular mechanisms underlying insomnia remain elusive, limiting future therapeutic development to address this critical issue. We examined whole gene expression profiles associated with insomnia. We compared subjects with insomnia (n = 25) to controls (n = 13) without insomnia using microarray gene expression profiles obtained from peripheral samples of whole blood obtained from military personnel. Compared to controls, participants with insomnia had differential expression of 44 transcripts from 43 identified genes. Among the identified genes, urotensin 2 was downregulated by more than 6 times in insomnia participants, and the fold-change remained significant after controlling for depression, posttraumatic stress disorder, and medication use. Urotensin 2 is involved in regulation of orexin A and B activity and rapid eye movement during sleep. These findings suggest that differential expression of these sleep-regulating genes contributes to symptoms of insomnia and, specifically, that switching between rapid eye movement and nonrapid eye movement sleep stages underlies insomnia symptoms. Future work to identify therapeutic agents that are able to regulate these pathways may provide novel treatments for insomnia.
journal_name
Biol Res Nursjournal_title
Biological research for nursingauthors
Gill JM,Lee H,Baxter T,Reddy SY,Barr T,Kim HS,Wang D,Mysliwiec Vdoi
10.1177/1099800415575343subject
Has Abstractpub_date
2015-07-01 00:00:00pages
384-92issue
4eissn
1099-8004issn
1552-4175pii
1099800415575343journal_volume
17pub_type
杂志文章abstract：:MicroRNAs (miRs) are epigenetic regulators of messenger RNAs' (mRNA) expression of polypeptides. As such, miRs represent an intriguing mechanism by which gene-environment interactions are hypothesized to occur on the level of epigenetic control over gene expression. In addition to promising findings from in vitro stud...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800411430380
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Insulin resistance plays a determinant role in the development of metabolic syndrome in adolescents. The objective of the present study was to determine the influence of factors commonly associated with insulin resistance in a sample of adolescents. METHODS:This cross-sectional study included 976 adolescent...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800416648207
更新日期：2016-10-01 00:00:00
abstract：:The aim of this study was to investigate the effects of a resistance training program (RTP) in older overweight women (OOW) using two different types of elastic devices. METHODS:This study was a randomized controlled trial with pre- and postintervention measures. Participants included OOW, aged 60-85 years, with no m...
journal_title：Biological research for nursing
pub_type： 杂志文章,随机对照试验
doi：10.1177/1099800418757676
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:The most consistently replicated genetic variants associated with coronary heart disease (CHD) in populations of European descent have been found on chromosome 9p21. Yet there is little known about these associations in ethnic groups of African ancestry. These disease-associated variants are located in a gen...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800411403469
更新日期：2011-07-01 00:00:00
abstract：:African American (AA) women are nearly twice as likely as non-Hispanic White (NHW) women to develop atherosclerosis associated with cardiovascular disease. Compelling evidence demonstrates that stress-related biomarkers, such as heat shock protein-70 (HSP70), are associated with increased atherosclerosis risk. Yet lit...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800413491422
更新日期：2014-07-01 00:00:00
abstract：:Research that uses a psychoneuroimmunology (PNI) framework seeks to determine whether valid associations exist among stress, immune function, and health. These associations are difficult to conclusively determine due to the fact that PNI research is fraught with methodological difficulties. These difficulties arise fr...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/10900402003004002
更新日期：2002-04-01 00:00:00
abstract：:People with schizophrenia have a higher prevalence of obesity than the general population. Many people with this illness struggle with weight gain, due, in part, to medications and other factors that act as obstacles to exercise and healthy eating. Several studies have shown the benefits of behavioral weight loss prog...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800410393272
更新日期：2011-10-01 00:00:00
abstract：:Preterm birth (PTB; spontaneous delivery prior to 37 weeks gestation) affects one out of eight infants born in the United States and is the most common cause of neonatal morbidity and mortality. Although the pathogenesis of PTB is multifactorial, a growing body of literature supports the hypothesis that one cause of P...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800409344620
更新日期：2010-04-01 00:00:00
abstract：:To examine the effects of exercise and vitamin E supplementation on oxidative stress in older adults, 59 participants, age 76.3 +/- 4.2 years, were randomly assigned to 1 of 4 groups: an exercise group taking placebos (EGP) or vitamin E (EGE) or a sedentary group taking placebos (SGP) or vitamin E (SGE). Measures incl...
journal_title：Biological research for nursing
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/1099800403005001005
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND:Persistent organic pollutants (POPs), dispersed in all environmental compartments, are associated with increased adipogenesis and body weight. These lipophilic toxicants bioaccumulate in the human body and get transferred from mothers to their offspring via the placental circulation and breast milk. The curr...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800420909151
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:Activity restriction (AR), one of the most common interventions used in high-risk pregnancies, may exacerbate loss of bone mass. The purpose of this study was to determine changes over time in bone resorption in hospitalized AR women during late pregnancy. METHODS:This was a short-term prospective study conduc...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800412463120
更新日期：2014-01-01 00:00:00
abstract：:Food intake and, subsequently, body weight are influenced by endogenous opioids acting in the central nervous system. Agonists for the opioid receptor increase food intake, whereas antagonists reduce food intake. Body weight, however, is the result of food consumed and energy expended. Although much has been reported ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800406298774
更新日期：2007-04-01 00:00:00
abstract：:Stress during pregnancy has been associated with a number of adverse outcomes. This study compared and correlated neuroendocrine parameters in women (n=8) who self-reported battering during their pregnancy to those in women who did not (n=8). Women who identified themselves as having a violent relationship with an int...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800405283182
更新日期：2006-01-01 00:00:00
abstract：:The purpose of this study was to compare physiological and psychological reactions among Taiwanese women with different degrees of severity of nausea and vomiting (NV) during pregnancy. Based on their scores on the Index of Nausea, Vomiting, and Retching (INVR), 59 pregnant women ≥ 18 years of age, with single gestati...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800410388506
更新日期：2011-10-01 00:00:00
abstract：:Variations in sex hormones influence bone health in men. Aging in men is associated with a decrease in testosterone (T) levels. We examined the relationship between T levels and changes in bone health status as measured by quantitative ultrasound (QUS) at the phalanges and the os calcis and by peripheral bone mineral ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800414532710
更新日期：2015-03-01 00:00:00
abstract：:The current study was performed to evaluate the antinociceptive and antiedematogenic properties of andrographolide isolated from the leaves of Andrographis paniculata using two animal models. Antinociceptive activity was evaluated using the acetic acid- induced writhing and the hot-plate tests, while antiedematogenic ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800409343311
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:To investigate associations between components of cumulative risk (CR) and physiological stress responses in African American adolescents and evaluate emotion regulation as a mediator and sex as a moderator of these associations. METHODS:Cortisol and salivary alpha amylase (sAA) were collected in adolescents...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800417702742
更新日期：2017-07-01 00:00:00
abstract：INTRODUCTION:Diabetes is a serious health problem affecting approximately 29.1 million individuals in the United States. Another 86 million have prediabetes. The development and implementation of lifestyle modifications such as physical activity for these persons are among the most effective methods for prevention and ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800418767572
更新日期：2018-07-01 00:00:00
abstract：:The focus on a cure for childhood leukemia over the last three decades has resulted in survival rates of more than 80%. However, efforts to manage leukemia-treatment symptoms have not kept pace with new therapies. Symptom toxicity during treatment can result in complications, treatment delays, and therapy dose reducti...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800418772907
更新日期：2018-07-01 00:00:00
abstract：:The prevalence of vascular dementia continues to increase with no cure. Thus, it is important identify the aggravating factors of vascular dementia to delay disease progression in patients. Obesity is a well-known risk factor for vascular dementia and causes mild cognitive impairment. In the present study, we evaluate...
journal_title：Biological research for nursing
pub_type： 杂志文章
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更新日期：2020-08-26 00:00:00
abstract：:Fatigue is the most frequently reported symptom by cancer patients. Many of these patients perceive fatigue as the most distressing symptom associated with their illness because it imposes limitations on their physical activity level. Skeletal muscle wasting, which occurs as part of cancer cachexia, is one of the mech...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/109980040100200304
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Incidence rates of both type 1 and type 2 diabetes mellitus (DM) are increasing in youth and may eventually contribute to premature heart disease in early adulthood. This investigation explored the influence of type of diabetes, gender, body mass index (BMI), metabolic control (HbA1c), exercise beliefs and p...
journal_title：Biological research for nursing
pub_type： 杂志文章
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更新日期：2005-07-01 00:00:00
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journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800420973366
更新日期：2020-11-28 00:00:00
abstract：:The purpose of this study was to evaluate for differences in variations in pro- and anti-inflammatory cytokine genes between participants who were classified as having low and high levels of morning and evening fatigue and to evaluate for differences in phenotypic characteristics between these two groups. In a sample ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800414534313
更新日期：2015-03-01 00:00:00
abstract：:Military personnel experience posttraumatic stress disorder (PTSD), which is associated with differential DNA methylation across the whole genome. However, the relationship between these DNA methylation patterns and clinically relevant increases in PTSD severity is not yet clearly understood. The purpose of this study...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800418758951
更新日期：2018-05-01 00:00:00
abstract：:Approximately half of the Canadian adults have sedentary lifestyles that increase their risk of developing cardiovascular disease (CVD). Women are 10 times more likely to die from CVD than from any other disease. Their risk almost doubles with the onset of menopause, which may result in increased body iron burden and ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800413501717
更新日期：2014-01-01 00:00:00
abstract：:The prevalence of obesity and obesity-related illnesses is higher among Hispanics (Latinos) than other racial and ethnic groups, and rates increase exponentially with the number of years living in the United States. Mounting evidence suggests that the origins of many chronic illnesses among disadvantaged minority grou...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800412457017
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Eating disorders are a significant cause of morbidity and mortality. The etiology and maintenance of eating-disorder symptoms are not well understood. Evidence suggests that there may be gustatory alterations in patients with eating disorders. OBJECTIVE:This article systematically reviews research assessing...
journal_title：Biological research for nursing
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
abstract：:The ability to maintain balance is often taken for granted, yet it is the foundation for mobility and overall functional independence throughout the life span. The purpose of this article is to define balance, review the components of balance, and describe common instruments used to measure balance. Clinical screening...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
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更新日期：2000-04-01 00:00:00
abstract：:The purpose of this study was to examine whether the hepatitis B seroconversion rates in a small sample of subjects reflected that of the published rates, regardless of HIV status, after a hepatitis B vaccination series was completed while following strict vaccine protocols. The study, which had a nonexperimental, cor...
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更新日期：2015-01-01 00:00:00
