Abstract：
:Sleep disturbance is a common and disturbing symptom in military personnel, with many individuals progressing to the development of insomnia, which is characterized by increased arousals, wakefulness after sleep onset, and distorted sleep architecture. The molecular mechanisms underlying insomnia remain elusive, limiting future therapeutic development to address this critical issue. We examined whole gene expression profiles associated with insomnia. We compared subjects with insomnia (n = 25) to controls (n = 13) without insomnia using microarray gene expression profiles obtained from peripheral samples of whole blood obtained from military personnel. Compared to controls, participants with insomnia had differential expression of 44 transcripts from 43 identified genes. Among the identified genes, urotensin 2 was downregulated by more than 6 times in insomnia participants, and the fold-change remained significant after controlling for depression, posttraumatic stress disorder, and medication use. Urotensin 2 is involved in regulation of orexin A and B activity and rapid eye movement during sleep. These findings suggest that differential expression of these sleep-regulating genes contributes to symptoms of insomnia and, specifically, that switching between rapid eye movement and nonrapid eye movement sleep stages underlies insomnia symptoms. Future work to identify therapeutic agents that are able to regulate these pathways may provide novel treatments for insomnia.
journal_name
Biol Res Nursjournal_title
Biological research for nursingauthors
Gill JM,Lee H,Baxter T,Reddy SY,Barr T,Kim HS,Wang D,Mysliwiec Vdoi
10.1177/1099800415575343subject
Has Abstractpub_date
2015-07-01 00:00:00pages
384-92issue
4eissn
1099-8004issn
1552-4175pii
1099800415575343journal_volume
17pub_type
杂志文章abstract：:Depression increases the risk of adverse cardiac events. Cardiovascular reactivity is defined as the pattern of cardiovascular responses to mental stress. An altered pattern of cardiovascular reactivity is an indicator of subsequent cardiovascular disease. Because depression and adverse cardiac events may have a dose-...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800415596227
更新日期：2016-03-01 00:00:00
abstract：:The prevalence of vascular dementia continues to increase with no cure. Thus, it is important identify the aggravating factors of vascular dementia to delay disease progression in patients. Obesity is a well-known risk factor for vascular dementia and causes mild cognitive impairment. In the present study, we evaluate...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800420951633
更新日期：2020-08-26 00:00:00
abstract：:Approximately half of the Canadian adults have sedentary lifestyles that increase their risk of developing cardiovascular disease (CVD). Women are 10 times more likely to die from CVD than from any other disease. Their risk almost doubles with the onset of menopause, which may result in increased body iron burden and ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800413501717
更新日期：2014-01-01 00:00:00
abstract：:The aim of this study was to investigate the effects of a resistance training program (RTP) in older overweight women (OOW) using two different types of elastic devices. METHODS:This study was a randomized controlled trial with pre- and postintervention measures. Participants included OOW, aged 60-85 years, with no m...
journal_title：Biological research for nursing
pub_type： 杂志文章,随机对照试验
doi：10.1177/1099800418757676
更新日期：2018-05-01 00:00:00
abstract：:The integration of molecular genetics approaches into the study of complex health phenomena is an increasingly important and available strategy for researchers across the health science disciplines. Pain sensation and response to painful stimuli are examples of complex health phenomena that are particularly amenable t...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800406289909
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVE:To investigate the prevalence and patterns of and factors associated with hyperphagic behavior in Taiwanese patients with dementia living at home. METHODS:A cross-sectional and correlational design was used. A total of 104 patients with dementia and their primary caregivers were recruited from the geriatric,...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800414562025
更新日期：2015-10-01 00:00:00
abstract：:This article explores ethical concerns and emerging dilemmas associated with the proliferation of information resulting from the extraordinary advances in molecular genetics. It provides an overview of the ethical and legal challenges associated with predictive testing for inherited disease currently being addressed i...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/109980040100300104
更新日期：2001-07-01 00:00:00
abstract：PURPOSE:In recent years, researchers have noted an "obesity paradox," where individuals with obesity survive sepsis at higher rates than their nonobese counterparts. This systematic review summarizes the literature on studies examining the association between obesity and 1-year mortality among patients admitted with se...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800419876070
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Incidence rates of both type 1 and type 2 diabetes mellitus (DM) are increasing in youth and may eventually contribute to premature heart disease in early adulthood. This investigation explored the influence of type of diabetes, gender, body mass index (BMI), metabolic control (HbA1c), exercise beliefs and p...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800405275202
更新日期：2005-07-01 00:00:00
abstract：:Survivors of aneurysmal subarachnoid hemorrhage (aSAH) often experience unfavorable functional outcomes that result in a reduced ability to independently perform activities of daily living. The apolipoprotein E gene ( APOE) encodes for a protein known to facilitate lipid transport and aid in neuronal repair within the...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800417746504
更新日期：2018-03-01 00:00:00
abstract：:The American Academy of Pediatrics recently removed nicotine from the list of drugs contraindicated during breastfeeding. The objective of this study was to evaluate the feasibility of determining the effect of a smoking hygiene intervention on infants of breastfeeding mothers who smoke cigarettes. An experimental des...
journal_title：Biological research for nursing
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1177/1099800406290643
更新日期：2006-10-01 00:00:00
abstract：:The purpose of this study was to describe the sleep patterns and fatigue of both mothers and fathers before and after childbirth. The authors used wrist actigraphy and questionnaires to estimate sleep and fatigue in 72 couples during their last month of pregnancy and 1st month postpartum. Both parents experienced more...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800403262142
更新日期：2004-04-01 00:00:00
abstract：OBJECTIVE:This study used a candidate gene approach to examine genomic variation associated with pain, anxiety, and distress in children undergoing a medical procedure. STUDY DESIGN:Children aged 4-10 years having an IV catheter insertion were recruited from three Midwestern children's hospitals. Self-report measures ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800417692878
更新日期：2017-05-01 00:00:00
abstract：:The primary purpose of this exploratory study was to compare percentages of natural killer (NK) cells and activated NK and T cells, and both cytotoxic and in vitro cytokine production activity in women with and without symptomatic irritable bowel syndrome (IBS). A secondary purpose was to examine the relationships of ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800402004001005
更新日期：2002-07-01 00:00:00
abstract：:Fatigue is the most frequently reported symptom by cancer patients. Many of these patients perceive fatigue as the most distressing symptom associated with their illness because it imposes limitations on their physical activity level. Skeletal muscle wasting, which occurs as part of cancer cachexia, is one of the mech...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/109980040100200304
更新日期：2001-01-01 00:00:00
abstract：:Caring, a core tenet of nursing practice, grew out of a holistic approach. Nurse theorists often note the establishment of a therapeutic relationship as the beginning point of caring, with subsequent nursing interventions reliant upon this relationship for effectiveness. Relational exchange serves as a source of eithe...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800412450505
更新日期：2012-10-01 00:00:00
abstract：:Maternal posturing, in which a pregnant or laboring woman assumes specific postures with the intention of altering the position and/or presentation of the fetus within the uterus, is a safe alternative to operative procedures recommended in cases of fetal malpositions and malpresentations. Clinicians and researchers a...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800404268318
更新日期：2004-10-01 00:00:00
abstract：:The effects of a 12-week low-intensity exercise conditioning program (walking) on blood pressure (BP), heart rate (HR), rate-pressure product (RPP), and cardiac autonomic function were measured in 40 sedentary women with hypertension. Women were assigned to either an exercise group (n = 20) or a control group (n = 20)...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800412461562
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Drug addiction is a multifactorial disorder. Researchers have posited that an individual's inherited behavioral propensity or temperament contributes to the disorder by shaping a personality strongly linked with the risk of drug abuse. Further, they hypothesize that the polymorphism of dopamine D2 receptor i...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800411405030
更新日期：2012-04-01 00:00:00
abstract：:Shift work schedules, intensive physical exercise late in the day, psychological stress, or a busy lifestyle might induce disorders of the circadian structure, which can affect health on both the physiological and neurobehavioral levels. Rest-activity rhythm is strongly connected with an organism's circadian structure...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800411416224
更新日期：2013-01-01 00:00:00
abstract：:The purpose of this study was to longitudinally describe changes in heart rate variability (HRV) from 28 to 34 weeks postmenstrual age (PMA). A convenience sample of 31 low-risk preterm infants participated. HRV was quantified using a spectral analysis of heart periods and recorded during seven weekly test sessions fr...
journal_title：Biological research for nursing
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Depression and inflammation are concomitantly elevated in patients with lung cancer and may have collective survival implications. However, the longitudinal relationship between depression and inflammation in patients with metastatic lung cancer is not fully appreciated. We hypothesized that longitudinal cha...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800420959721
更新日期：2020-09-22 00:00:00
abstract：:Abdominal pain is an important symptom in irritable bowel syndrome (IBS), but patients report typical pain intensities ranging from mild to very severe. In a sample of women, the authors sought to determine whether measures of systemic autonomic activity are related to self-reported pain intensity and the occurrence o...
journal_title：Biological research for nursing
pub_type： 杂志文章
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更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:The most consistently replicated genetic variants associated with coronary heart disease (CHD) in populations of European descent have been found on chromosome 9p21. Yet there is little known about these associations in ethnic groups of African ancestry. These disease-associated variants are located in a gen...
journal_title：Biological research for nursing
pub_type： 杂志文章
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更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:To investigate associations between components of cumulative risk (CR) and physiological stress responses in African American adolescents and evaluate emotion regulation as a mediator and sex as a moderator of these associations. METHODS:Cortisol and salivary alpha amylase (sAA) were collected in adolescents...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800417702742
更新日期：2017-07-01 00:00:00
abstract：:Preterm birth (PTB; spontaneous delivery prior to 37 weeks gestation) affects one out of eight infants born in the United States and is the most common cause of neonatal morbidity and mortality. Although the pathogenesis of PTB is multifactorial, a growing body of literature supports the hypothesis that one cause of P...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
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更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Persistent organic pollutants (POPs), dispersed in all environmental compartments, are associated with increased adipogenesis and body weight. These lipophilic toxicants bioaccumulate in the human body and get transferred from mothers to their offspring via the placental circulation and breast milk. The curr...
journal_title：Biological research for nursing
pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
abstract：INTRODUCTION:Diabetes is a serious health problem affecting approximately 29.1 million individuals in the United States. Another 86 million have prediabetes. The development and implementation of lifestyle modifications such as physical activity for these persons are among the most effective methods for prevention and ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800418767572
更新日期：2018-07-01 00:00:00
abstract：:MicroRNAs (miRs) are epigenetic regulators of messenger RNAs' (mRNA) expression of polypeptides. As such, miRs represent an intriguing mechanism by which gene-environment interactions are hypothesized to occur on the level of epigenetic control over gene expression. In addition to promising findings from in vitro stud...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
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更新日期：2013-04-01 00:00:00
abstract：:People with schizophrenia have a higher prevalence of obesity than the general population. Many people with this illness struggle with weight gain, due, in part, to medications and other factors that act as obstacles to exercise and healthy eating. Several studies have shown the benefits of behavioral weight loss prog...
journal_title：Biological research for nursing
pub_type： 杂志文章
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更新日期：2011-10-01 00:00:00
