Abstract:
:Positron emission tomography (PET)/computed tomography (CT) is a rapidly expanding imaging modality, thanks to the availability of compact medical cyclotrons and automated chemistry synthesis modules for the production of PET radiopharmaceuticals. Despite the availability of many radiotracers, [(18)F]fluorodeoxyglucose (FDG) is currently the most widely used radiopharmaceutical in PET, and the field of molecular imaging is anxiously awaiting the introduction of new PET radiopharmaceuticals for routine clinical use. During the last five years, several proprietary PET radiopharmaceuticals have been developed by major companies, and these new agents are in different stages of clinical evaluation. These new PET drugs are designed for imaging brain beta amyloid, myocardial perfusion, amino acid transport, angiogenesis, and tumor antigen expression. In addition, the National Cancer Institute, Society of Nuclear Medicine Clinical Trials Network, and the American College of Radiology Imaging Network have been conducting multicenter clinical trials with several nonproprietary PET drugs such as sodium [(18)F]fluoride, [(18)F]fluorothymidine, [(18)F]fluoromisonidazole, and (64)Cu-labeled diacetyl-bis (N(4)-methylthiosemicarbazone. All new PET radiopharmaceuticals, like any other drugs, must be manufactured under current good manufacturing practices as required by the Food and Drug Administration before clinical evaluation (phases I, II, and III) and submission of new drug application. This review briefly describes the chemistry, mechanisms(s) of localization, and clinical application of both proprietary and nonproprietary new PET drugs under multicenter clinical evaluation.
journal_name
Semin Nucl Medjournal_title
Seminars in nuclear medicineauthors
Vallabhajosula S,Solnes L,Vallabhajosula Bdoi
10.1053/j.semnuclmed.2011.02.003subject
Has Abstractpub_date
2011-07-01 00:00:00pages
246-64issue
4eissn
0001-2998issn
1558-4623pii
S0001-2998(11)00032-8journal_volume
41pub_type
杂志文章,评审abstract::Although planar radionuclide techniques provide accurate, noninvasive measurements of myocardial perfusion and function that are of proven clinical value in the evaluation of the cardiac patient, they are limited by poor object contrast and superimposition of surrounding structures. Due to incomplete angular sampling ...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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abstract::When serious infections are suspected, patients are often treated empirically with broad-spectrum antibiotics while awaiting results that provide information on the bacterial class and species causing the infection, as well as drug susceptibilities. For deep-seated infections, these traditional diagnostic techniques o...
journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
pub_type: 历史文章,杂志文章
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abstract::Nuclear medicine renal imaging provides important functional data to assist in the diagnosis and management of patients with a variety of renal disorders. Physiologically stable metal chelates like ethylenediaminetetraacetic acid (EDTA) and diethylenetriamine penta-acetate (DTPA) are excreted by glomerular filtration ...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in nuclear medicine
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abstract::Graft infection following prosthetic vascular reconstruction is an uncommon but severe complication. The clinical presentation is often subtle and nonspecific and may occur long after surgery. Although defining a prosthetic vascular graft infection can be difficult, early diagnosis and treatment are essential for the ...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(05)80176-x
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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更新日期:2020-09-01 00:00:00
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2017.02.005
更新日期:2017-07-01 00:00:00
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
doi:10.1016/s0001-2998(81)80042-6
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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更新日期:1984-04-01 00:00:00
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/snuc.2002.29270
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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更新日期:1990-10-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2010.08.003
更新日期:2011-01-01 00:00:00
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2014.07.006
更新日期:2015-01-01 00:00:00
abstract::Consolidating personal computers (PCs) with nuclear medicine technology can create high computational power comparable with that produced by vendor-specific computer equipment, and at more affordable prices. The integration of a standard platform and operating system with a large installed base has enabled our departm...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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