abstract：:Heart transplantation is an effective and life-saving therapy for patients with end-stage heart disease. Cardiac allograft vasculopathy (CAV) is a frequent complication after heart transplantation and a leading cause of graft failure and death. The diffuse involvement of the coronary macro- and microvasculature in CAV...

journal_title：Seminars in nuclear medicine

authors： Chih S,Wiefels CC,Beanlands RSB

更新日期：2021-01-19 00:00:00

abstract：:The definition of tumor involved volumes in patients with head and neck cancer poses great challenges with the increasing use of highly conformal radiotherapy techniques eg, volumetric modulated arc therapy and intensity modulated proton therapy. The risk of underdosing the tumor might increase unless great care is ta...

journal_title：Seminars in nuclear medicine

authors： Jensen K,Al-Farra G,Dejanovic D,Eriksen JG,Loft A,Hansen CR,Pameijer FA,Zukauskaite R,Grau C

更新日期：2021-01-01 00:00:00

abstract：:Molecular imaging has revolutionized clinical oncology by imaging-specific facets of cancer biology. Through noninvasive measurements of tumor physiology, targeted radiotracers can serve as biomarkers for disease characterization, prognosis, response assessment, and predicting long-term response/survival. In turn, the...

journal_title：Seminars in nuclear medicine

authors： Gillman JA,Pantel AR,Mankoff DA,Edmonds CE

更新日期：2020-11-01 00:00:00

abstract：:In the past 20 years there have been great advances in our understanding of the molecular genetics of gastrointestinal tumors. In general, cancers develop and proliferate due to: driver mutations or related alterations in the genome resulting in overactivity of oncogenes, underactivity of tumor suppressor genes allowi...

journal_title：Seminars in nuclear medicine

authors： Wahl RL

更新日期：2020-09-01 00:00:00

abstract：:Autonomic innervation plays an important role in proper functioning of the cardiovascular system. Altered cardiac sympathetic function is present in a variety of diseases, and can be assessed with radionuclide imaging using sympathetic neurotransmitter analogues. The most studied adrenergic radiotracer is cardiac 123I...

journal_title：Seminars in nuclear medicine

authors： Wan N,Travin MI

更新日期：2020-07-01 00:00:00

abstract：:Myocardial perfusion imaging with 15O-water positron emission tomography (PET) is a validated tool for quantitative measurement of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Current scanner and software technology enable quantification of global and regional MBF in clinical PET myocardial perfusion...

journal_title：Seminars in nuclear medicine

authors： Maaniitty T,Knuuti J,Saraste A

更新日期：2020-05-01 00:00:00

abstract：:The short range and high linear energy transfer of α-particles offer the potential for efficient tumor killing while sparing normal bystander cells. Hematologic malignancies are ideally suited to targeted α-particle therapy (TAT) due to easy accessibility of malignant cells in blood, bone marrow, lymph nodes, and sple...

journal_title：Seminars in nuclear medicine

authors： Jurcic JG

更新日期：2020-03-01 00:00:00

abstract：:Nuclear medicine procedures, including Ga-67 and labeled leucocyte SPECT/CT as well as PET/CT using 18F-FDG and recently Ga-68 tracers, have found extensive applications in the assessment of infectious and inflammatory processes in general and in soft tissues in particular. Recent published data focus on summarizing t...

journal_title：Seminars in nuclear medicine

authors： Arnon-Sheleg E,Israel O,Keidar Z

更新日期：2020-01-01 00:00:00

abstract：:FDG-PET/CT has an established role in the initial staging of locally advanced cervical cancers, particularly in evaluation of nodal disease and distant metastases. It is common practice to perform FDG-PET/CT 3 months postcompletion of chemoradiotherapy as it can predict outcome and be used to tailor management, includ...

journal_title：Seminars in nuclear medicine

authors： Gandy N,Arshad MA,Park WE,Rockall AG,Barwick TD

更新日期：2019-11-01 00:00:00

abstract：:This review describes general concepts with regard to radiopharmaceuticals for diagnostic or therapeutic applications that help to understand the specific challenges encountered during the design, (radio)synthesis, in vitro and in vivo evaluation and clinical translation of novel radiopharmaceuticals. The design of a ...

journal_title：Seminars in nuclear medicine

authors： Vermeulen K,Vandamme M,Bormans G,Cleeren F

更新日期：2019-09-01 00:00:00

abstract：:According to SEER Cancer Statistics Review there are around 165,000 new prostate cancer cases estimated in 2018 accounting for 9.5% of all newly diagnosed cancers. Accurate staging of primary prostate cancer is important for therapy selection (local vs systemic). Recent developments in molecular imaging may significan...

journal_title：Seminars in nuclear medicine

authors： Pomykala KL,Farolfi A,Hadaschik B,Fendler WP,Herrmann K

更新日期：2019-07-01 00:00:00

abstract：:Holmium microspheres have recently become available in the European market as the third type of microspheres for radioembolization of unresectable liver malignancies. Holmium microspheres come with a dedicated administration system, and since these microspheres contain holmium-166 (166Ho) instead of yttrium-90, unique...

journal_title：Seminars in nuclear medicine

authors： Reinders MTM,Smits MLJ,van Roekel C,Braat AJAT

更新日期：2019-05-01 00:00:00

abstract：:In the early 1970s, when Seminars in Nuclear Medicine started publication, little was known about the quality of reporting in biomedical journals. Senior scholars were invited to become scientific editors of journals based on their research credibility and stature. Their knowledge of journalology (publication science)...

journal_title：Seminars in nuclear medicine

authors： Wilson M,Moher D

更新日期：2019-03-01 00:00:00

abstract：:Although electronic imaging was performed in the early 1950s in nuclear medicine, it was the introduction of computed tomography in 1972 that caused a revolution in medical imaging in that it marked the beginning of the inevitable transformation to digital imaging. This transformation is now more or less complete. Whi...

journal_title：Seminars in nuclear medicine

authors： Yaffe MJ

更新日期：2019-03-01 00:00:00

abstract：:Uneven distribution of ventilation, or ventilation heterogeneity, has been observed in asthma for over 60 years using multiple breath nitrogen washout (MBNW) studies. Ventilation heterogeneity has been known to predict airway hyperresponsiveness (the ability of the airways to constrict too easily and by too much) in a...

journal_title：Seminars in nuclear medicine

authors： Farrow C,King G

更新日期：2019-01-01 00:00:00

abstract：:Ventilation/Perfusion (V/Q) positron emission tomography computed tomography (PET/CT) is now possible by substituting Technetium-99m (99mTc) with Gallium-68 (68Ga), using the same carrier molecules as conventional V/Q imaging. Ventilation imaging can be performed with 68Ga-carbon nanoparticles using the same synthesis...

journal_title：Seminars in nuclear medicine

authors： Le Roux PY,Hicks RJ,Siva S,Hofman MS

更新日期：2019-01-01 00:00:00

abstract：:Due to the increasing life expectancy, the diagnosis of malignancy and treatment of elderly patients is becoming more common. Prostate cancer is particularly frequent in this setting. Many different approaches are now available, but some of them imply significant risks or collateral effects. In those patients an accur...

journal_title：Seminars in nuclear medicine

authors： Castellucci P,Nanni C,Ambrosini V

更新日期：2018-11-01 00:00:00

abstract：:This review summarizes the role of SPECT/CT in patients with a painful postoperative knee and describes typical diagnostic criteria in these patients. Pain after knee surgery is common and is influenced by the underlying pathology, the type of surgery, and the patient. Knee joint-preserving surgery includes osteotomy,...

journal_title：Seminars in nuclear medicine

authors： van der Bruggen W,Hirschmann MT,Strobel K,Kampen WU,Kuwert T,Gnanasegaran G,Van den Wyngaert T,Paycha F

更新日期：2018-09-01 00:00:00

abstract：:Hybrid positron emission tomography/magnetic resonance imaging (PET/MR) systems are now more and more available for clinical use. PET/MR combines the unique features of MR including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as we...

journal_title：Seminars in nuclear medicine

authors： Sollini M,Berchiolli R,Kirienko M,Rossi A,Glaudemans AWJM,Slart R,Erba PA

更新日期：2018-05-01 00:00:00

abstract：:When serious infections are suspected, patients are often treated empirically with broad-spectrum antibiotics while awaiting results that provide information on the bacterial class and species causing the infection, as well as drug susceptibilities. For deep-seated infections, these traditional diagnostic techniques o...

journal_title：Seminars in nuclear medicine

authors： Ordonez AA,Jain SK

更新日期：2018-03-01 00:00:00

abstract：:Over the past several decades, PET has emerged as critical to accurate staging and restaging of lymphomas. Nonetheless, a number of critical issues regarding its optimal use remain. Whereas risk-adapted strategies appear to improve the outcome of patients with Hodgkin lymphoma, results are less convincing in non-Hodgk...

journal_title：Seminars in nuclear medicine

authors： Cheson BD

更新日期：2018-01-01 00:00:00

abstract：:Postsurgical bile leaks can be associated with significant morbidity and even mortality, if not identified and treated at an early phase. Hepatobiliary iminodiacetic acid (HIDA) scan is an important test for detection of bile leaks in the postoperative abdomen. However, the lack of anatomical details on planar images ...

journal_title：Seminars in nuclear medicine

authors： Matesan M,Bermo M,Cruite I,Shih CH,Elojeimy S,Behnia F,Lewis D,Vesselle H

更新日期：2017-11-01 00:00:00

abstract：:The process of discovering and developing a new pharmaceutical is a long, difficult, and risky process that requires numerous resources. Molecular imaging techniques such as PET have recently become a useful tool for making decisions along a drug candidate's development timeline. PET is a translational, noninvasive im...

journal_title：Seminars in nuclear medicine

authors： Donnelly DJ

更新日期：2017-09-01 00:00:00

abstract：:FDG is a tracer for visualizing glucose metabolism. PET/CT using FDG is widely used for the diagnosis of cancer, because glycolysis is elevated in cancer cells. Similarly, active inflammatory tissue also exhibits elevated glucose metabolism because of glycolysis in activated macrophages and proliferating fibroblasts. ...

journal_title：Seminars in nuclear medicine

authors： Kubota K,Yamashita H,Mimori A

更新日期：2017-07-01 00:00:00

abstract：:The practice of nuclear medicine in children is well established for imaging practically all physiologic systems but particularly in the fields of oncology, neurology, urology, and orthopedics. Pediatric nuclear medicine yields images of physiologic and molecular processes that can provide essential diagnostic informa...

journal_title：Seminars in nuclear medicine

authors： Fahey FH,Goodkind AB,Plyku D,Khamwan K,O'Reilly SE,Cao X,Frey EC,Li Y,Bolch WE,Sgouros G,Treves ST

更新日期：2017-03-01 00:00:00

abstract：:The introduction of in vivo imaging of Aβ-amyloid (Αβ) pathology more than a decade ago, transformed the assessment of Alzheimer disease (AD) allowing the evaluation of Aβ deposition over time by providing highly accurate, reliable, and reproducible quantitative statements of regional or global Aβ burden in the brain ...

journal_title：Seminars in nuclear medicine

authors： Villemagne VL,Doré V,Bourgeat P,Burnham SC,Laws S,Salvado O,Masters CL,Rowe CC

更新日期：2017-01-01 00:00:00

abstract：:The use of positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in prostate cancer depends on the phase of the disease along the natural history of this prevalent malignancy in men. Incidental high FDG uptake in the prostate gland, although rare, should prompt further investigation with at least a meas...

journal_title：Seminars in nuclear medicine

authors： Jadvar H

更新日期：2016-11-01 00:00:00

abstract：:Nuclear medicine renal imaging provides important functional data to assist in the diagnosis and management of patients with a variety of renal disorders. Physiologically stable metal chelates like ethylenediaminetetraacetic acid (EDTA) and diethylenetriamine penta-acetate (DTPA) are excreted by glomerular filtration ...

journal_title：Seminars in nuclear medicine

authors： Hofman MS,Hicks RJ

更新日期：2016-09-01 00:00:00

abstract：:In epilepsy, a detailed history, blood chemistry, routine electroencephalography, and brain MRI are important for the diagnosis of seizure type or epilepsy syndrome for the decision of appropriate drug treatment. Although antiepileptic drugs are mostly successful for controlling epileptic seizures, 20%-30% patients ar...

journal_title：Seminars in nuclear medicine

authors： Ergün EL,Saygi S,Yalnizoglu D,Oguz KK,Erbas B

更新日期：2016-07-01 00:00:00

abstract：:Much efficacy is gained in clinical practice if a single agent can be used for both diagnosis and therapy, a practice termed theranostics. Metaiodobenzylguanidine (mIBG), a norepinephrine analogue with high sensitivity and specificity for neuroblastoma, is an exemplar of theranostics. The physiologic biodistribution o...

journal_title：Seminars in nuclear medicine

authors： Parisi MT,Eslamy H,Park JR,Shulkin BL,Yanik GA

更新日期：2016-05-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most common cancers in men and is the second leading cause of cancer-related deaths in the USA. In the United States, it is the second most frequently diagnosed cancer after skin cancer, and in Europe it is number one. According to the American Cancer Society, approximately 221,000 ...

journal_title：Seminars in nuclear medicine

authors： Evans-Axelsson S,Timmermand OV,Bjartell A,Strand SE,Elgqvist J

更新日期：2016-03-01 00:00:00

abstract：:The radionuclide (99m)Tc-MDP bone scan is one of the most commonly performed nuclear medicine studies and helps in the diagnosis of different pathologies relating to the musculoskeletal system. With its increasing utility in clinical practice, it becomes more important to be aware of various limitations of this imagin...

journal_title：Seminars in nuclear medicine

authors： Agrawal K,Marafi F,Gnanasegaran G,Van der Wall H,Fogelman I

更新日期：2015-09-01 00:00:00

abstract：:The advent of simultaneous PET/MRI brought a large amount of possibilities in research and clinical applications into hybrid imaging. Unlike in PET/CT protocols, the MR component provides an almost unlimited number of pulse sequences and possibilities of different protocols in PET/MRI. Nevertheless, there is an impera...

journal_title：Seminars in nuclear medicine

authors： Barbosa Fde G,von Schulthess G,Veit-Haibach P

更新日期：2015-07-01 00:00:00

abstract：:Bone metastases are associated with increased morbidity and poor prognosis in castration-resistant prostate cancer. Since 2010, 5 systemic therapies for metastatic castration-resistant prostate cancer have been approved by the US Food and Drug Administration based on an improvement in overall survival, offering altern...

journal_title：Seminars in nuclear medicine

authors： Abi-Ghanem AS,McGrath MA,Jacene HA

更新日期：2015-01-01 00:00:00

abstract：:Heart failure presents a significant problem in industrialized countries, with a high prevalence, morbidity, and mortality, where it is most frequently caused by coronary artery disease. Revascularization in patients with symptomatic heart failure has been associated with improved cardiovascular outcomes. Predictors o...

journal_title：Seminars in nuclear medicine

authors： Lim SP,Mc Ardle BA,Beanlands RS,Hessian RC

更新日期：2014-09-01 00:00:00

abstract：:New software methods that incorporate iterative reconstruction, resolution recovery, and noise compensation now provide the ability to maintain or improve myocardial perfusion SPECT image quality with conventional sodium iodide cameras. Despite lower image counting statistics associated with significantly decreased in...

journal_title：Seminars in nuclear medicine

authors： Gordon DePuey E 3rd

更新日期：2014-07-01 00:00:00

abstract：:The basic principles of the use of radiation dosimetry in nuclear medicine are reviewed. The basic structure of the main mathematical equations are given and formal dosimetry systems are discussed. An extensive overview of the history and current status of anthropomorphic models (phantoms) is given. The sources and ma...

journal_title：Seminars in nuclear medicine

authors： Stabin M,Xu XG

更新日期：2014-05-01 00:00:00

abstract：:The best option for the treatment of end-stage renal disease is kidney transplantation. Prompt diagnosis and management of early posttransplantation complications is of utmost importance for graft survival. Biochemical markers, allograft biopsies, and imaging modalities are used for the timely recognition and manageme...

journal_title：Seminars in nuclear medicine

authors： Aktaş A

更新日期：2014-03-01 00:00:00

abstract：:The convenience of (18)F-fluoride imaging is undeniable both because of its favorable tracer and because of its technical characteristics, including high image quality and short examination times leading to increased patient comfort. Depending on the activity administered, the radiation dose to patients is about compa...

journal_title：Seminars in nuclear medicine

authors： Fischer DR

更新日期：2013-11-01 00:00:00

abstract：:Graft infection following prosthetic vascular reconstruction is an uncommon but severe complication. The clinical presentation is often subtle and nonspecific and may occur long after surgery. Although defining a prosthetic vascular graft infection can be difficult, early diagnosis and treatment are essential for the ...

journal_title：Seminars in nuclear medicine

authors： Keidar Z,Nitecki S

更新日期：2013-09-01 00:00:00