Abstract:
:In the past 20 years there have been great advances in our understanding of the molecular genetics of gastrointestinal tumors. In general, cancers develop and proliferate due to: driver mutations or related alterations in the genome resulting in overactivity of oncogenes, underactivity of tumor suppressor genes allowing tumors to grow, and impaired DNA repair mechanisms either from sequential mutations with or without germline mutations predisposing patients to cancer. Infections such as hepatitis B and C, and Human Papilloma Virus (HPV) can lead to hepatocellular cancers and anal cancers, respectively. This genomic knowledge has helped us better define unique subsets within diseases like colon and pancreatic cancer which may benefit from precisely targeted therapies. Alterations in key proteins on tumors and in the tumor microenvironment can be targets for molecular-targeted radiopharmaceutical therapies, immunotherapies and other targeted treatments. Molecular imaging may be deployed more aggressively in high-risk groups for possible detection of tumor occurrence, progression, and response to therapy. This chapter provides a brief summary of the genomics of gastrointestinal tumors, selected examples of targeted therapies, and examples of how current and emerging molecular imaging tools, assessing the tumor phenotype, inform our management of patients with tumors.
journal_name
Semin Nucl Medjournal_title
Seminars in nuclear medicineauthors
Wahl RLdoi
10.1053/j.semnuclmed.2020.06.002subject
Has Abstractpub_date
2020-09-01 00:00:00pages
471-483issue
5eissn
0001-2998issn
1558-4623pii
S0001-2998(20)30068-4journal_volume
50pub_type
杂志文章,评审abstract::More than 7 million stress perfusion studies are performed in the United States annually, 44% with pharmacological vasodilator stress agents. Both adenosine and dipyridamole are nonselective coronary vasodilators that are commonly used for stress perfusion imaging. These agents are safe and provide an effective means ...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2008.12.003
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abstract::Nuclear medicine renal imaging provides important functional data to assist in the diagnosis and management of patients with a variety of renal disorders. Physiologically stable metal chelates like ethylenediaminetetraacetic acid (EDTA) and diethylenetriamine penta-acetate (DTPA) are excreted by glomerular filtration ...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2016.04.002
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
doi:10.1053/j.semnuclmed.2007.01.004
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
doi:10.1016/s0001-2998(82)80015-9
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abstract::The radionuclide bone scan is one of the most commonly performed pediatric nuclear medicine procedures. Bone scintigraphy is used as the diagnostic procedure of choice for diagnosis of bone and soft-tissue infection and can aid in the diagnosis of occult trauma without radiographic findings. There is a complimentary r...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2007.06.001
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2020.07.002
更新日期:2020-11-01 00:00:00
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
doi:10.1016/s0001-2998(75)80010-9
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2014.04.001
更新日期:2014-07-01 00:00:00
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
doi:10.1016/s0001-2998(75)80030-4
更新日期:1975-04-01 00:00:00
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/snuc.2002.29270
更新日期:2002-01-01 00:00:00
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(99)80014-2
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abstract::Positron emission tomography (PET)/computed tomography (CT) is a rapidly expanding imaging modality, thanks to the availability of compact medical cyclotrons and automated chemistry synthesis modules for the production of PET radiopharmaceuticals. Despite the availability of many radiotracers, [(18)F]fluorodeoxyglucos...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2011.02.003
更新日期:2011-07-01 00:00:00
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
doi:10.1053/j.semnuclmed.2007.10.001
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2004.03.004
更新日期:2004-07-01 00:00:00
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(00)80058-6
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,多中心研究,评审
doi:10.1053/j.semnuclmed.2008.06.003
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2013.04.004
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journal_title:Seminars in nuclear medicine
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abstract::A comprehensive review of the effects of exposure to low levels of ionizing radiation, BEIR VII-Phase 2: Health Risks From Exposure to Low Levels of Ionizing Radiation, was published in 2006. The BEIR (Biological Effects of Ionizing Radiation) reports are a series of publications by the National Academy of Sciences. T...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2008.05.006
更新日期:2008-09-01 00:00:00
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2020.02.011
更新日期:2020-05-01 00:00:00
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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更新日期:2018-11-01 00:00:00
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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更新日期:1988-10-01 00:00:00
abstract::The basic principles of the use of radiation dosimetry in nuclear medicine are reviewed. The basic structure of the main mathematical equations are given and formal dosimetry systems are discussed. An extensive overview of the history and current status of anthropomorphic models (phantoms) is given. The sources and ma...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2014.03.008
更新日期:2014-05-01 00:00:00
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
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