Abstract:
:The process of discovering and developing a new pharmaceutical is a long, difficult, and risky process that requires numerous resources. Molecular imaging techniques such as PET have recently become a useful tool for making decisions along a drug candidate's development timeline. PET is a translational, noninvasive imaging technique that provides quantitative information about a potential drug candidate and its target at the molecular level. Using this technique provides decisional information to ensure that the right drug candidate is being chosen, for the right target, at the right dose within the right patient population. This review will focus on small molecule PET tracers and how they are used within the drug discovery process. PET provides key information about a drug candidate's pharmacokinetic and pharmacodynamic properties in both preclinical and clinical studies. PET is being used in all phases of the drug discovery and development process, and the goal of these studies are to accelerate the process in which drugs are developed.
journal_name
Semin Nucl Medjournal_title
Seminars in nuclear medicineauthors
Donnelly DJdoi
10.1053/j.semnuclmed.2017.05.006subject
Has Abstractpub_date
2017-09-01 00:00:00pages
454-460issue
5eissn
0001-2998issn
1558-4623pii
S0001-2998(17)30048-Xjournal_volume
47pub_type
杂志文章,评审abstract::Due to the increasing life expectancy, the diagnosis of malignancy and treatment of elderly patients is becoming more common. Prostate cancer is particularly frequent in this setting. Many different approaches are now available, but some of them imply significant risks or collateral effects. In those patients an accur...
journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
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journal_title:Seminars in nuclear medicine
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