Newer methods of labeling diagnostic agents with Tc-99m.

Abstract:

:The past several years have seen marked advances in technetium/rhenium chemistry applicable to the preparation of new 99mTc-labeled radiopharmaceuticals. This article focuses on recent developments in technetium chemistry, including the preparation of "3 + 1" complexes, the preparation and use of (99mTc[CO]3)+ complexes for labeling biomolecules, the preparation of rhenium steroid inclusion complexes, improvements in both hydrazinonicotinamide labeling chemistry and in the preformed 99mTc complex method of labeling biomolecules, and new solid-phase separation techniques that may allow the isolation of high specific-activity radiopharmaceuticals in a clinical setting.

journal_name

Semin Nucl Med

authors

Mease RC,Lambert C

doi

10.1053/snuc.2001.26182

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

278-85

issue

4

eissn

0001-2998

issn

1558-4623

pii

S0001-2998(01)80007-6

journal_volume

31

pub_type

杂志文章,评审
  • Role and evaluation of mammography and other imaging methods for breast cancer detection, diagnosis, and staging.

    abstract::Mammographic screening of women age 40 and older can reduce breast cancer deaths by at least 30% to 40%. However, not all cancers are detected by mammography. Although a new supplementary modality for screening could, in theory, fill in this detection gap, such utilization must be based on rigorous demonstration of it...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(99)80026-9

    authors: Feig SA

    更新日期:1999-01-01 00:00:00

  • SPECT Ventilation Imaging in Asthma.

    abstract::Uneven distribution of ventilation, or ventilation heterogeneity, has been observed in asthma for over 60 years using multiple breath nitrogen washout (MBNW) studies. Ventilation heterogeneity has been known to predict airway hyperresponsiveness (the ability of the airways to constrict too easily and by too much) in a...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2018.10.007

    authors: Farrow C,King G

    更新日期:2019-01-01 00:00:00

  • Three years' experience with an all-digital nuclear medicine department.

    abstract::We describe our all-digital, filmless, department of nuclear medicine, which has been fully operational for 3 years. The approach to the design and implementation of a nuclear medicine picture archiving and communication system (PACS) is discussed, as well as enhancements found to be necessary or desirable during our ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章

    doi:10.1016/s0001-2998(05)80031-5

    authors: Cohen AM,Parker JA,Donohoe K,Jansons D,Kolodny GM

    更新日期:1990-07-01 00:00:00

  • Radionuclide imaging of parathyroid tumors: historical perspectives and newer techniques.

    abstract::The increasing use of automated blood chemistry screens for serum calcium levels along with improved methods in measuring parathyroid hormone (PTH) levels have made the diagnosis of parathyroid disease a common clinical problem. Parathyroid adenomas account for the majority of primary hyperparathyroidism with diffuse ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(85)80024-6

    authors: Winzelberg GG,Hydovitz JD

    更新日期:1985-04-01 00:00:00

  • Effects of low level radiation-what's new?

    abstract::A comprehensive review of the effects of exposure to low levels of ionizing radiation, BEIR VII-Phase 2: Health Risks From Exposure to Low Levels of Ionizing Radiation, was published in 2006. The BEIR (Biological Effects of Ionizing Radiation) reports are a series of publications by the National Academy of Sciences. T...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2008.05.006

    authors: Royal HD

    更新日期:2008-09-01 00:00:00

  • Renal nuclear medicine.

    abstract::The measurement of renal function has been a major field of interest in nuclear medicine. Many studies in the literature are still dedicated to this subject, with the aim of replacing the traditional urinary clearance methods with simpler and easier techniques. Simplified plasma clearance methods appear of sufficient ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(95)80025-5

    authors: Fommei E,Volterrani D

    更新日期:1995-04-01 00:00:00

  • Positron emission tomography in lung cancer.

    abstract::Carcinoma of the lung is one of the most frequent malignancies and a major cause of mortality. The use of positron emission tomography (PET) has been extensively investigated in patients with carcinoma of the lung and has established clinical utility and cost-effectiveness in characterization of solitary pulmonary nod...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/snuc.2002.126059

    authors: Shon IH,O'doherty MJ,Maisey MN

    更新日期:2002-10-01 00:00:00

  • Quantitative planar thallium-201 stress scintigraphy: a critical evaluation of the method.

    abstract::The results of quantitative analysis of planar thallium-201 stress scintigraphy are superior to those of visual analysis. The increased sensitivity for detection of coronary artery disease is associated with maintenance of specificity. Consequently, we believe that quantitative analysis is the state-of-the-art for pla...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章

    doi:10.1016/s0001-2998(85)80043-x

    authors: Wackers FJ,Fetterman RC,Mattera JA,Clements JP

    更新日期:1985-01-01 00:00:00

  • The role of parmacologic manipulation in adrenal cortical scintigraphy.

    abstract::Adrenal scintigraphy is a unique nuclear medicine procedure that provides noninvasive, functional information concerning the status of the adrenal cortex. The uptake of iodocholesterol, in addition to localizing adrenal cortical abnormalities, can be manipulate to focus on adrenal cortical dysfunction in either the al...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章

    doi:10.1016/s0001-2998(81)80042-6

    authors: Gross MD,Valk TW,Swanson DP,Thrall JH,Grekin RJ,Beirewaltes WH

    更新日期:1981-04-01 00:00:00

  • Myocardial viability: it is still alive.

    abstract::Heart failure presents a significant problem in industrialized countries, with a high prevalence, morbidity, and mortality, where it is most frequently caused by coronary artery disease. Revascularization in patients with symptomatic heart failure has been associated with improved cardiovascular outcomes. Predictors o...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2014.07.003

    authors: Lim SP,Mc Ardle BA,Beanlands RS,Hessian RC

    更新日期:2014-09-01 00:00:00

  • SPECT/CT in the Postoperative Painful Knee.

    abstract::This review summarizes the role of SPECT/CT in patients with a painful postoperative knee and describes typical diagnostic criteria in these patients. Pain after knee surgery is common and is influenced by the underlying pathology, the type of surgery, and the patient. Knee joint-preserving surgery includes osteotomy,...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2018.05.003

    authors: van der Bruggen W,Hirschmann MT,Strobel K,Kampen WU,Kuwert T,Gnanasegaran G,Van den Wyngaert T,Paycha F

    更新日期:2018-09-01 00:00:00

  • An overview of the contribution of regional cerebral blood flow studies in cerebrovascular disease: is there a role for single photon emission computed tomography?

    abstract::Regional cerebral blood flow (rCBF) findings and their application to cerebrovascular disease are reviewed. Although the coupling of cerebral blood flow and metabolism are best studied with positron emission tomography, single-photon emission computed tomography measurements of rCBF can contribute to patient managemen...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(05)80236-3

    authors: Hellman RS,Tikofsky RS

    更新日期:1990-10-01 00:00:00

  • A multiscintigraphic approach to imaging of lymphedema and other causes of the congenitally enlarged extremity.

    abstract::Nuclear imaging in the definition of the components of the congenitally enlarged extremity is important in the design of a successful therapeutic regimen. In our series of 32 patients evaluated for primary lymphedema, 85% were determined to have abnormalities that were not purely lymphatic in origin. The multiscintigr...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(05)80112-6

    authors: Mandell GA,Alexander MA,Harcke HT

    更新日期:1993-10-01 00:00:00

  • PET/MRI in Infection and Inflammation.

    abstract::Hybrid positron emission tomography/magnetic resonance imaging (PET/MR) systems are now more and more available for clinical use. PET/MR combines the unique features of MR including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as we...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2018.02.003

    authors: Sollini M,Berchiolli R,Kirienko M,Rossi A,Glaudemans AWJM,Slart R,Erba PA

    更新日期:2018-05-01 00:00:00

  • The Interaction of Genomics, Molecular Imaging, and Therapy in Gastrointestinal Tumors.

    abstract::In the past 20 years there have been great advances in our understanding of the molecular genetics of gastrointestinal tumors. In general, cancers develop and proliferate due to: driver mutations or related alterations in the genome resulting in overactivity of oncogenes, underactivity of tumor suppressor genes allowi...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2020.06.002

    authors: Wahl RL

    更新日期:2020-09-01 00:00:00

  • Software for image registration: algorithms, accuracy, efficacy.

    abstract::Image registration is finding increased clinical use both in aiding diagnosis and guiding therapy. There are numerous algorithms for registration, which all involve maximizing a measure of similarity between a transformed floating image and a fixed reference image. The choice of the similarity measure depends, to some...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/snuc.2003.127309

    authors: Hutton BF,Braun M

    更新日期:2003-07-01 00:00:00

  • Advances in evaluation of primary brain tumors.

    abstract::The evaluation of primary brain tumor is challenging. Neuroimaging plays a significant role. At diagnosis, imaging is needed to establish a differential diagnosis, provide prognostic information, as well as direct biopsy. After the initial treatment, imaging is needed to distinguish recurrent disease from treatment-re...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2008.02.005

    authors: Chen W,Silverman DH

    更新日期:2008-07-01 00:00:00

  • Gallium-67 citrate imaging studies of the lung.

    abstract::In spite of localization of gallium in the lungs in a large variety of inflammatory pulmonary diseases, the chest radiograph is and will continue to be the principal diagnostic tool for evaluation of pulmonary inflammatory disease. The 67Ga-citrate scan, however, serves as a study complementary to chest radiography be...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(80)80007-9

    authors: Bekerman C,Hoffer PB,Bitran JD,Gupta RG

    更新日期:1980-07-01 00:00:00

  • 15O-Water PET MPI: Current Status and Future Perspectives.

    abstract::Myocardial perfusion imaging with 15O-water positron emission tomography (PET) is a validated tool for quantitative measurement of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Current scanner and software technology enable quantification of global and regional MBF in clinical PET myocardial perfusion...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2020.02.011

    authors: Maaniitty T,Knuuti J,Saraste A

    更新日期:2020-05-01 00:00:00

  • A broad overview of positron emission tomography radiopharmaceuticals and clinical applications: what is new?

    abstract::Positron emission tomography (PET)/computed tomography (CT) is a rapidly expanding imaging modality, thanks to the availability of compact medical cyclotrons and automated chemistry synthesis modules for the production of PET radiopharmaceuticals. Despite the availability of many radiotracers, [(18)F]fluorodeoxyglucos...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2011.02.003

    authors: Vallabhajosula S,Solnes L,Vallabhajosula B

    更新日期:2011-07-01 00:00:00

  • Radiopharmaceuticals for thrombus detection.

    abstract::Most of the components of the thrombotic and fibrinolytic systems have at some time been evaluated as a means of carrying a radiolabel specifically to thrombi, although very few have been promising enough to emerge from investigational status to routine clinical use. New approaches are being explored, including improv...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(05)80176-x

    authors: Knight LC

    更新日期:1990-01-01 00:00:00

  • Scintigraphic evaluation of hepatic mass lesions: emphasis on hemangioma detection.

    abstract::Nuclear medicine imaging techniques continue to play a unique role in the evaluation of hepatic masses. Although many useful radiodiagnostic agents are available, the predominant nuclear medicine study used to evaluate hepatic masses in this decade is technetium-labeled red blood cell "blood-pool" scintigraphy. Hepati...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章

    doi:10.1016/s0001-2998(96)80012-2

    authors: Middleton ML

    更新日期:1996-01-01 00:00:00

  • A history of the American Board of Nuclear Medicine.

    abstract::The American Board of Nuclear Medicine gave its first certifying examination in 1972 to 1,096 candidates. It was established with the support of the Society of Nuclear Medicine amid considerable conflict involving the American Board of Radiology, the American Board of Internal Medicine, and the American Board of Patho...

    journal_title:Seminars in nuclear medicine

    pub_type: 历史文章,杂志文章

    doi:10.1016/s0001-2998(96)80024-9

    authors: Ross JF

    更新日期:1996-07-01 00:00:00

  • Clinical studies with spleen-specific radiolabeled agents.

    abstract::While 99mTc sulfur colloid imaging, because of its availability and convenience, remains the initial procedure of choice for spleen imaging, selective spleen scanning with damaged 99mTc-labeled RBCs can provide additional information in some cases. These cases include overlapping left hepatic lobe and suspected spleni...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(85)80004-0

    authors: Armas RR

    更新日期:1985-07-01 00:00:00

  • Musculoskeletal imaging using fluoride PET.

    abstract::The convenience of (18)F-fluoride imaging is undeniable both because of its favorable tracer and because of its technical characteristics, including high image quality and short examination times leading to increased patient comfort. Depending on the activity administered, the radiation dose to patients is about compa...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2013.06.004

    authors: Fischer DR

    更新日期:2013-11-01 00:00:00

  • Thematic planning: the role of the International Atomic Energy Agency in promoting education, medical research, and technology transfer among nuclear medicine communities of developing countries.

    abstract::One of the major mechanisms of implementing the International Atomic Energy Agency's (IAEA) programs in nuclear medicine has been through coordinated research projects (CRPs). In recent years, the IAEA has initiated a new type of CRP, called Doctoral CRP, in an attempt to further improve the effectiveness of its progr...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章

    doi:10.1053/j.semnuclmed.2007.10.001

    authors: Padhy AK,Dondi M

    更新日期:2008-03-01 00:00:00

  • The use of monoclonal antibodies and antibody fragments in the imaging of infectious lesions.

    abstract::The advantage of immunoscintigraphy over autologous leukocyte techniques in the imaging of infection is the simplicity of its use compared with techniques that require the isolation of autologous white blood cells. The advantage over 99mTc- or 111In-labeled nonspecific human immunoglobulin is the excellent target-to-b...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章

    doi:10.1016/s0001-2998(05)80228-4

    authors: Becker W,Goldenberg DM,Wolf F

    更新日期:1994-04-01 00:00:00

  • Pathophysiologic considerations and clinicopathological correlates of technetium-99m stannous pyrophosphate myocardial scintigraphy.

    abstract::99mTc-PYP myocardial scintigrams represent a means to detect and localize acute myocardial necrosis. These scintigrams are expected to be abnormal with acute myocardial infarcts of at least 3 grams in weight if serial imaging is utilized and proper attention to technique is provided. Any etiology of myocardial necrosi...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(80)80029-8

    authors: Willerson JT,Parkey RW,Bonte FJ,Lewis SE,Corbett J,Buja LM

    更新日期:1980-01-01 00:00:00

  • Monoclonal antibodies and neuroblastoma.

    abstract::Several antineuroblastoma monoclonal antibodies (MoAbs) have been described and two have been used in radioimmunoimaging and radioimmunotherapy in patients. MoAb 3F8 is a murine IgG3 antibody specific for the ganglioside GD2. Radioiodine-labeled 3F8 has been shown to specifically target human neuroblastoma in patients...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(89)80021-2

    authors: Miraldi F

    更新日期:1989-10-01 00:00:00

  • Positron emission tomography/computed tomography for target delineation in head and neck cancers.

    abstract::Radiation and concurrent chemoradiation are essential in the treatment of head and neck cancers because they allow a potentially curative organ preservation approach in a manner that greatly affects quality of life. Greater doses of radiation to areas of gross disease have invariably led to greater loco-regional contr...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2007.11.002

    authors: Ahn PH,Garg MK

    更新日期:2008-03-01 00:00:00