Radiopharmaceuticals for thrombus detection.


:Most of the components of the thrombotic and fibrinolytic systems have at some time been evaluated as a means of carrying a radiolabel specifically to thrombi, although very few have been promising enough to emerge from investigational status to routine clinical use. New approaches are being explored, including improved methods of labeling platelets, chemically modified forms of previously tested plasma proteins, and new biomolecules, including monoclonal antibodies specific for fibrin and platelets. The current goal is to find one or more radiotracers that bind specifically and rapidly to thrombi, and that also have a rapid blood disappearance rate, permitting a clear diagnosis within a few hours after injection. Because this test may be needed to assess the course of therapy in an anticoagulated patient, the ideal radiopharmaceutical should be able to locate thrombi without interference by anticoagulants. Until a suitable thrombus-specific radiopharmaceutical becomes generally available, many hospitals will continue to attempt to make a diagnosis with nonspecific radiopharmaceuticals that can at best provide blood pool images to indicate filling defects. Several of the new approaches seem likely to provide the radiopharmaceutical sought, although clinical trials are at an early stage.


Semin Nucl Med


Knight LC




Has Abstract


1990-01-01 00:00:00














  • 15O-Water PET MPI: Current Status and Future Perspectives.

    abstract::Myocardial perfusion imaging with 15O-water positron emission tomography (PET) is a validated tool for quantitative measurement of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Current scanner and software technology enable quantification of global and regional MBF in clinical PET myocardial perfusion...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Maaniitty T,Knuuti J,Saraste A

    更新日期:2020-05-01 00:00:00

  • FDG-PET in prosthetic graft infections.

    abstract::Graft infection following prosthetic vascular reconstruction is an uncommon but severe complication. The clinical presentation is often subtle and nonspecific and may occur long after surgery. Although defining a prosthetic vascular graft infection can be difficult, early diagnosis and treatment are essential for the ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Keidar Z,Nitecki S

    更新日期:2013-09-01 00:00:00

  • SPECT Ventilation Imaging in Asthma.

    abstract::Uneven distribution of ventilation, or ventilation heterogeneity, has been observed in asthma for over 60 years using multiple breath nitrogen washout (MBNW) studies. Ventilation heterogeneity has been known to predict airway hyperresponsiveness (the ability of the airways to constrict too easily and by too much) in a...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Farrow C,King G

    更新日期:2019-01-01 00:00:00

  • Functional renal imaging: new trends in radiology and nuclear medicine.

    abstract::The objective of this work is to compare the characteristics of various techniques for functional renal imaging, with a focus on nuclear medicine and magnetic resonance imaging. Even with low spatial resolution and rather poor signal-to-noise ratio, classical nuclear medicine has the advantage of linearity and good se...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Durand E,Chaumet-Riffaud P,Grenier N

    更新日期:2011-01-01 00:00:00

  • Complimentary roles of cardiac ultrasound and cardiovascular nuclear medicine.

    abstract::This review is directed at the clinically useful highlights of ultrasound and radionuclide testing in adults with coronary and valvular heart disease, intracardiac shunts, and hypertrophic and congestive cardiomyopathies. As a clinical toto, the radionuclide procedures are currently more useful than ultrasound examina...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章


    authors: Horowitz SF,Goldsmith SJ,Meller J,Patterson RE,Teichholz LE

    更新日期:1980-01-01 00:00:00

  • The Interaction of Genomics, Molecular Imaging, and Therapy in Gastrointestinal Tumors.

    abstract::In the past 20 years there have been great advances in our understanding of the molecular genetics of gastrointestinal tumors. In general, cancers develop and proliferate due to: driver mutations or related alterations in the genome resulting in overactivity of oncogenes, underactivity of tumor suppressor genes allowi...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Wahl RL

    更新日期:2020-09-01 00:00:00

  • Dose Estimation in Pediatric Nuclear Medicine.

    abstract::The practice of nuclear medicine in children is well established for imaging practically all physiologic systems but particularly in the fields of oncology, neurology, urology, and orthopedics. Pediatric nuclear medicine yields images of physiologic and molecular processes that can provide essential diagnostic informa...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Fahey FH,Goodkind AB,Plyku D,Khamwan K,O'Reilly SE,Cao X,Frey EC,Li Y,Bolch WE,Sgouros G,Treves ST

    更新日期:2017-03-01 00:00:00

  • PET/CT Imaging in Soft Tissue Infection and Inflammation-An Update.

    abstract::Nuclear medicine procedures, including Ga-67 and labeled leucocyte SPECT/CT as well as PET/CT using 18F-FDG and recently Ga-68 tracers, have found extensive applications in the assessment of infectious and inflammatory processes in general and in soft tissues in particular. Recent published data focus on summarizing t...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Arnon-Sheleg E,Israel O,Keidar Z

    更新日期:2020-01-01 00:00:00

  • An overview of the contribution of regional cerebral blood flow studies in cerebrovascular disease: is there a role for single photon emission computed tomography?

    abstract::Regional cerebral blood flow (rCBF) findings and their application to cerebrovascular disease are reviewed. Although the coupling of cerebral blood flow and metabolism are best studied with positron emission tomography, single-photon emission computed tomography measurements of rCBF can contribute to patient managemen...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Hellman RS,Tikofsky RS

    更新日期:1990-10-01 00:00:00

  • Radionuclide-labeled red blood cells: current status and future prospects.

    abstract::Radiolabeling of red cells and their clinical and research application in nuclear medicine constitute an area of continued interest and steady growth during the past two decades. Significant advances have been made so that at the present time, radiolabels with sufficient in vitro and in vivo stability are available fo...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Srivastava SC,Chervu LR

    更新日期:1984-04-01 00:00:00

  • Clinical Value of FDG-PET/CT for the Evaluation of Rheumatic Diseases: Rheumatoid Arthritis, Polymyalgia Rheumatica, and Relapsing Polychondritis.

    abstract::FDG is a tracer for visualizing glucose metabolism. PET/CT using FDG is widely used for the diagnosis of cancer, because glycolysis is elevated in cancer cells. Similarly, active inflammatory tissue also exhibits elevated glucose metabolism because of glycolysis in activated macrophages and proliferating fibroblasts. ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Kubota K,Yamashita H,Mimori A

    更新日期:2017-07-01 00:00:00

  • Positron emission imaging of head and neck cancer, including thyroid carcinoma.

    abstract::Most positron emission tomography (PET) imaging studies in head and neck cancer are performed using the radiotracer 18-fluorodeoxyglucose ((18)FDG). PET with FDG has become a standard clinical imaging modality in patients with head and neck cancer. It contributes valuable information in localizing a primary tumor in p...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Schöder H,Yeung HW

    更新日期:2004-07-01 00:00:00

  • The problems of the clinical and laboratory diagnosis of pulmonary embolism.

    abstract::Suspecting and diagnosing venous thrombosis and pulmonary embolism remain major clinical problems. For a variety of reasons, including the patient's pre-existing cardiac and pulmonary status and the release of humoral mediators, pulmonary emboli evoke varied responses in different patients. Symptoms and signs of pulmo...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Palevsky HI

    更新日期:1991-10-01 00:00:00

  • The use of personal computers in nuclear medicine.

    abstract::Consolidating personal computers (PCs) with nuclear medicine technology can create high computational power comparable with that produced by vendor-specific computer equipment, and at more affordable prices. The integration of a standard platform and operating system with a large installed base has enabled our departm...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Tello R,Potter JE,Hill TC

    更新日期:1994-01-01 00:00:00

  • Myocardial infarct imaging with technetium-labeled complexes.

    abstract::Detection of acute myocardial infarction as an area of increased activity has intrigued investigators for some time. Initial attempts with 203Hg-chlormerodrin and 203Hg-fluorescein analogues were successful in man. More recently, however, successful imaging of the acute myocardial infarct has been achieved with severa...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Holman BL,Davis MA,Hanson RN

    更新日期:1977-01-01 00:00:00

  • Benign bone tumors.

    abstract::There is little information in the literature concerning the role of bone scanning in benign bone neoplasms except for sporadic reports. Since the advent of 99mTc-polyphosphate, bone imaging has proven feasible and useful in locating the cause of bone pain, such as in osteoid osteomas, which are not always radiologica...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章


    authors: Gilday DL,Ash JM

    更新日期:1976-01-01 00:00:00

  • PET/CT in Lymphoma: Current Overview and Future Directions.

    abstract::Over the past several decades, PET has emerged as critical to accurate staging and restaging of lymphomas. Nonetheless, a number of critical issues regarding its optimal use remain. Whereas risk-adapted strategies appear to improve the outcome of patients with Hodgkin lymphoma, results are less convincing in non-Hodgk...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Cheson BD

    更新日期:2018-01-01 00:00:00

  • Positron emission tomography/computed tomography for target delineation in head and neck cancers.

    abstract::Radiation and concurrent chemoradiation are essential in the treatment of head and neck cancers because they allow a potentially curative organ preservation approach in a manner that greatly affects quality of life. Greater doses of radiation to areas of gross disease have invariably led to greater loco-regional contr...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Ahn PH,Garg MK

    更新日期:2008-03-01 00:00:00

  • Basic principles in the radiation dosimetry of nuclear medicine.

    abstract::The basic principles of the use of radiation dosimetry in nuclear medicine are reviewed. The basic structure of the main mathematical equations are given and formal dosimetry systems are discussed. An extensive overview of the history and current status of anthropomorphic models (phantoms) is given. The sources and ma...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Stabin M,Xu XG

    更新日期:2014-05-01 00:00:00

  • The lung as a metabolic organ.

    abstract::Recently, the lung has received increasing attention as a metabolic organ. In this role, the lung modulates the composition of the arterial blood by several mechanisms: removing active substances from the plasma, releasing substances into the plasma, temporarily holding substances from circulation, and activating or i...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章


    authors: Touya JJ,Rahimian J,Corbus HF,Grubbs DE,Savala KM,Glass EC,Bennett LR

    更新日期:1986-10-01 00:00:00

  • Present assessment of myocardial viability by nuclear imaging.

    abstract::Prospective delineation of viable from nonviable myocardium in patients with coronary artery disease in an important factor in deciding whether a patient should be revascularized or treated medically. Two common techniques--single-photon emission computed tomography (SPECT) and positron-emission computed tomography (P...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Saha GB,MacIntyre WJ,Brunken RC,Go RT,Raja S,Wong CO,Chen EQ

    更新日期:1996-10-01 00:00:00

  • Gallium-67 citrate imaging studies of the lung.

    abstract::In spite of localization of gallium in the lungs in a large variety of inflammatory pulmonary diseases, the chest radiograph is and will continue to be the principal diagnostic tool for evaluation of pulmonary inflammatory disease. The 67Ga-citrate scan, however, serves as a study complementary to chest radiography be...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Bekerman C,Hoffer PB,Bitran JD,Gupta RG

    更新日期:1980-07-01 00:00:00

  • ¹³¹I-Metaiodobenzylguanidine Theranostics in Neuroblastoma: Historical Perspectives; Practical Applications.

    abstract::Much efficacy is gained in clinical practice if a single agent can be used for both diagnosis and therapy, a practice termed theranostics. Metaiodobenzylguanidine (mIBG), a norepinephrine analogue with high sensitivity and specificity for neuroblastoma, is an exemplar of theranostics. The physiologic biodistribution o...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Parisi MT,Eslamy H,Park JR,Shulkin BL,Yanik GA

    更新日期:2016-05-01 00:00:00

  • Gallium-68 EDTA PET/CT for Renal Imaging.

    abstract::Nuclear medicine renal imaging provides important functional data to assist in the diagnosis and management of patients with a variety of renal disorders. Physiologically stable metal chelates like ethylenediaminetetraacetic acid (EDTA) and diethylenetriamine penta-acetate (DTPA) are excreted by glomerular filtration ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Hofman MS,Hicks RJ

    更新日期:2016-09-01 00:00:00

  • FLT: measuring tumor cell proliferation in vivo with positron emission tomography and 3'-deoxy-3'-[18F]fluorothymidine.

    abstract::Positron emission tomography (PET) using the radiotracer 3'-deoxy-3'-[(18)F]fluorothymidine (FLT) can image cellular proliferation in human cancers in vivo. FLT uptake has been shown to correlate with pathology-based proliferation measurements, including the Ki-67 score, in a variety of human cancers. Unlike pathology...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Salskov A,Tammisetti VS,Grierson J,Vesselle H

    更新日期:2007-11-01 00:00:00

  • PET/CT Lung Ventilation and Perfusion Scanning using Galligas and Gallium-68-MAA.

    abstract::Ventilation/Perfusion (V/Q) positron emission tomography computed tomography (PET/CT) is now possible by substituting Technetium-99m (99mTc) with Gallium-68 (68Ga), using the same carrier molecules as conventional V/Q imaging. Ventilation imaging can be performed with 68Ga-carbon nanoparticles using the same synthesis...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Le Roux PY,Hicks RJ,Siva S,Hofman MS

    更新日期:2019-01-01 00:00:00

  • Bone and marrow imaging in sickle cell disease: diagnosis of infarction.

    abstract::Sickling of erythrocytes in patients with S-hemoglobin causes marrow and bone infarction. The former can be demonstrated as a lack of 99mTc-sulfur colloid uptake on marrow imaging examination. These defects may resolve or persist long after the acute episode. If the bone is involved in the acute episode, imaging withi...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Lutzker LG,Alavi A

    更新日期:1976-01-01 00:00:00

  • Radionuclide imaging of parathyroid tumors: historical perspectives and newer techniques.

    abstract::The increasing use of automated blood chemistry screens for serum calcium levels along with improved methods in measuring parathyroid hormone (PTH) levels have made the diagnosis of parathyroid disease a common clinical problem. Parathyroid adenomas account for the majority of primary hyperparathyroidism with diffuse ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Winzelberg GG,Hydovitz JD

    更新日期:1985-04-01 00:00:00

  • Transition from planar to SPECT V/Q scintigraphy: rationale, practicalities, and challenges.

    abstract::Compared with planar imaging, ventilation/perfusion scintigraphy performed with single-photon emission computed tomography (SPECT) has a greater sensitivity and specificity, greater accuracy, improved reproducibility, and a lower number of inconclusive reports in the detection of pulmonary embolism. Despite these impr...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Roach PJ,Bailey DL,Schembri GP,Thomas PA

    更新日期:2010-11-01 00:00:00

  • FDG-PET Imaging in Cervical Cancer.

    abstract::FDG-PET/CT has an established role in the initial staging of locally advanced cervical cancers, particularly in evaluation of nodal disease and distant metastases. It is common practice to perform FDG-PET/CT 3 months postcompletion of chemoradiotherapy as it can predict outcome and be used to tailor management, includ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Gandy N,Arshad MA,Park WE,Rockall AG,Barwick TD

    更新日期:2019-11-01 00:00:00