Radiopharmaceuticals for thrombus detection.


:Most of the components of the thrombotic and fibrinolytic systems have at some time been evaluated as a means of carrying a radiolabel specifically to thrombi, although very few have been promising enough to emerge from investigational status to routine clinical use. New approaches are being explored, including improved methods of labeling platelets, chemically modified forms of previously tested plasma proteins, and new biomolecules, including monoclonal antibodies specific for fibrin and platelets. The current goal is to find one or more radiotracers that bind specifically and rapidly to thrombi, and that also have a rapid blood disappearance rate, permitting a clear diagnosis within a few hours after injection. Because this test may be needed to assess the course of therapy in an anticoagulated patient, the ideal radiopharmaceutical should be able to locate thrombi without interference by anticoagulants. Until a suitable thrombus-specific radiopharmaceutical becomes generally available, many hospitals will continue to attempt to make a diagnosis with nonspecific radiopharmaceuticals that can at best provide blood pool images to indicate filling defects. Several of the new approaches seem likely to provide the radiopharmaceutical sought, although clinical trials are at an early stage.


Semin Nucl Med


Knight LC




Has Abstract


1990-01-01 00:00:00














  • Vital dyes in sentinel node localization.

    abstract::Vital blue dyes were used to show the feasibility and accuracy of intraoperative lymphatic mapping of the sentinel node (SN) in patients with melanoma, breast cancer, and other solid tumors. Surgeons who have successfully completed an adequate number of cases of intraoperative mapping and sentinel lymph node dissectio...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Bostick PJ,Giuliano AE

    更新日期:2000-01-01 00:00:00

  • Functional renal imaging: new trends in radiology and nuclear medicine.

    abstract::The objective of this work is to compare the characteristics of various techniques for functional renal imaging, with a focus on nuclear medicine and magnetic resonance imaging. Even with low spatial resolution and rather poor signal-to-noise ratio, classical nuclear medicine has the advantage of linearity and good se...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Durand E,Chaumet-Riffaud P,Grenier N

    更新日期:2011-01-01 00:00:00

  • Radioimmunotherapy of lymphoma: Bexxar and Zevalin.

    abstract::Radioimmunotherapy is a form of targeted radionuclide therapy that uses a monoclonal antibody to deliver localized radiation. It is most appropriate for treatment of multiple tumor sites that cannot be readily excised surgically or irradiated using external beam radiation or brachytherapy. At present, 2 products, Bexx...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Goldsmith SJ

    更新日期:2010-03-01 00:00:00

  • Role and evaluation of mammography and other imaging methods for breast cancer detection, diagnosis, and staging.

    abstract::Mammographic screening of women age 40 and older can reduce breast cancer deaths by at least 30% to 40%. However, not all cancers are detected by mammography. Although a new supplementary modality for screening could, in theory, fill in this detection gap, such utilization must be based on rigorous demonstration of it...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Feig SA

    更新日期:1999-01-01 00:00:00

  • Blood cell labeling with 99mTc: progress and perspectives.

    abstract::Blood cell labeling with 99mTc has progressed through various developmental phases. In the case of red cell labeling, the science seems to have matured sufficiently, although minor refinements in the procedures will no doubt continue to be made. During the last 3 to 5 years, there has been a resurgence of interest in ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Srivastava SC,Straub RF

    更新日期:1990-01-01 00:00:00

  • Cardiac Imaging With 123I-meta-iodobenzylguanidine and Analogous PET Tracers: Current Status and Future Perspectives.

    abstract::Autonomic innervation plays an important role in proper functioning of the cardiovascular system. Altered cardiac sympathetic function is present in a variety of diseases, and can be assessed with radionuclide imaging using sympathetic neurotransmitter analogues. The most studied adrenergic radiotracer is cardiac 123I...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Wan N,Travin MI

    更新日期:2020-07-01 00:00:00

  • PET/CT Imaging in Soft Tissue Infection and Inflammation-An Update.

    abstract::Nuclear medicine procedures, including Ga-67 and labeled leucocyte SPECT/CT as well as PET/CT using 18F-FDG and recently Ga-68 tracers, have found extensive applications in the assessment of infectious and inflammatory processes in general and in soft tissues in particular. Recent published data focus on summarizing t...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Arnon-Sheleg E,Israel O,Keidar Z

    更新日期:2020-01-01 00:00:00

  • Logistics of radioimmunotherapy with yttrium 90 ibritumomab tiuxetan (Zevalin).

    abstract::Radioimmunotherapy is a promising new therapeutic option for the treatment of B-cell non-Hodgkin's lymphoma. Several monoclonal antibody and radionuclide conjugates, including I-131 tositumomab and Y-90 ibritumomab, have been investigated in clinical trials. Yttrium 90 ibritumomab tiuxetan (Zevalin; Biogen Idec Inc, C...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Zimmer AM

    更新日期:2004-01-01 00:00:00

  • Holmium-166 Microsphere Radioembolization of Hepatic Malignancies.

    abstract::Holmium microspheres have recently become available in the European market as the third type of microspheres for radioembolization of unresectable liver malignancies. Holmium microspheres come with a dedicated administration system, and since these microspheres contain holmium-166 (166Ho) instead of yttrium-90, unique...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Reinders MTM,Smits MLJ,van Roekel C,Braat AJAT

    更新日期:2019-05-01 00:00:00

  • Aβ-amyloid and Tau Imaging in Dementia.

    abstract::The introduction of in vivo imaging of Aβ-amyloid (Αβ) pathology more than a decade ago, transformed the assessment of Alzheimer disease (AD) allowing the evaluation of Aβ deposition over time by providing highly accurate, reliable, and reproducible quantitative statements of regional or global Aβ burden in the brain ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Villemagne VL,Doré V,Bourgeat P,Burnham SC,Laws S,Salvado O,Masters CL,Rowe CC

    更新日期:2017-01-01 00:00:00

  • Update on Quantitative Imaging for Predicting and Assessing Response in Oncology.

    abstract::Molecular imaging has revolutionized clinical oncology by imaging-specific facets of cancer biology. Through noninvasive measurements of tumor physiology, targeted radiotracers can serve as biomarkers for disease characterization, prognosis, response assessment, and predicting long-term response/survival. In turn, the...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Gillman JA,Pantel AR,Mankoff DA,Edmonds CE

    更新日期:2020-11-01 00:00:00

  • Recombinant thyrotropin versus thyroid hormone withdrawal in evaluating patients with thyroid carcinoma.

    abstract::Patients with previously treated thyroid carcinoma require lifelong monitoring for recurrent disease. Two diagnostic tests that play a central role in follow-up of these patients--radioiodine whole body scanning and serum thyroglobulin measurement--are most accurate during thyroid-stimulating hormone (TSH) stimulation...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Ladenson PW

    更新日期:2000-04-01 00:00:00

  • Infection control in the Department of Nuclear Medicine.

    abstract::Concern about the spread of infections in the hospital setting has prompted regulatory agencies to mandate infection control standards. Each hospital department is required to have written policies and procedures which describe measures to prevent and control the spread of nosocomial infections (hospital acquired infe...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章


    authors: Adams A,Egan A

    更新日期:1988-10-01 00:00:00

  • Methods of Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III).

    abstract::In this work, the methods of the Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III) are described in detail. PIOPED III is a multicenter collaborative investigation sponsored by the National Heart, Lung and Blood Institute. The purpose is to determine the accuracy of gadolinium-enhanced magneti...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,多中心研究,评审


    authors: Stein PD,Gottschalk A,Sostman HD,Chenevert TL,Fowler SE,Goodman LR,Hales CA,Hull RD,Kanal E,Leeper KV Jr,Nadich DP,Sak DJ,Tapson VF,Wakefield TW,Weg JG,Woodard PK

    更新日期:2008-11-01 00:00:00

  • Radionuclide imaging of parathyroid tumors: historical perspectives and newer techniques.

    abstract::The increasing use of automated blood chemistry screens for serum calcium levels along with improved methods in measuring parathyroid hormone (PTH) levels have made the diagnosis of parathyroid disease a common clinical problem. Parathyroid adenomas account for the majority of primary hyperparathyroidism with diffuse ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Winzelberg GG,Hydovitz JD

    更新日期:1985-04-01 00:00:00

  • Clinical studies with spleen-specific radiolabeled agents.

    abstract::While 99mTc sulfur colloid imaging, because of its availability and convenience, remains the initial procedure of choice for spleen imaging, selective spleen scanning with damaged 99mTc-labeled RBCs can provide additional information in some cases. These cases include overlapping left hepatic lobe and suspected spleni...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Armas RR

    更新日期:1985-07-01 00:00:00

  • Emergence of "Big Data" and Its Potential and Current Limitations in Medical Imaging.

    abstract::Although electronic imaging was performed in the early 1950s in nuclear medicine, it was the introduction of computed tomography in 1972 that caused a revolution in medical imaging in that it marked the beginning of the inevitable transformation to digital imaging. This transformation is now more or less complete. Whi...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Yaffe MJ

    更新日期:2019-03-01 00:00:00

  • Thyroid suppression and stimulation testing: The place of scanning in the evaluation of nodular thyroid disease.

    abstract::In the past, T3 suppression testing was often required to confirm the presence of autonomous thyroid function in patients with borderline clinical and laboratory findings suggestive of hyperthyroidism or in euthyroid patients with the stigmata of Graves' disease. Similarly, TSH stimulation testing was used to document...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章


    authors: Hurley JR,Becker DV

    更新日期:1981-04-01 00:00:00

  • Pathophysiologic considerations and clinicopathological correlates of technetium-99m stannous pyrophosphate myocardial scintigraphy.

    abstract::99mTc-PYP myocardial scintigrams represent a means to detect and localize acute myocardial necrosis. These scintigrams are expected to be abnormal with acute myocardial infarcts of at least 3 grams in weight if serial imaging is utilized and proper attention to technique is provided. Any etiology of myocardial necrosi...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Willerson JT,Parkey RW,Bonte FJ,Lewis SE,Corbett J,Buja LM

    更新日期:1980-01-01 00:00:00

  • Complimentary roles of cardiac ultrasound and cardiovascular nuclear medicine.

    abstract::This review is directed at the clinically useful highlights of ultrasound and radionuclide testing in adults with coronary and valvular heart disease, intracardiac shunts, and hypertrophic and congestive cardiomyopathies. As a clinical toto, the radionuclide procedures are currently more useful than ultrasound examina...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章


    authors: Horowitz SF,Goldsmith SJ,Meller J,Patterson RE,Teichholz LE

    更新日期:1980-01-01 00:00:00

  • Transplanted kidney function evaluation.

    abstract::The best option for the treatment of end-stage renal disease is kidney transplantation. Prompt diagnosis and management of early posttransplantation complications is of utmost importance for graft survival. Biochemical markers, allograft biopsies, and imaging modalities are used for the timely recognition and manageme...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Aktaş A

    更新日期:2014-03-01 00:00:00

  • Thematic planning: the role of the International Atomic Energy Agency in promoting education, medical research, and technology transfer among nuclear medicine communities of developing countries.

    abstract::One of the major mechanisms of implementing the International Atomic Energy Agency's (IAEA) programs in nuclear medicine has been through coordinated research projects (CRPs). In recent years, the IAEA has initiated a new type of CRP, called Doctoral CRP, in an attempt to further improve the effectiveness of its progr...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章


    authors: Padhy AK,Dondi M

    更新日期:2008-03-01 00:00:00

  • Nuclear medicine and diabetic foot infections.

    abstract::Up to 25% of the diabetic population is at risk for developing a pedal ulcer. These ulcers serve as a portal of entry for osteomyelitis and overlie more than 90% of diabetic pedal osteomyelitis cases. The diagnosis of osteomyelitis often is overlooked, and imaging studies are an essential part of the evaluation. The m...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Palestro CJ,Love C

    更新日期:2009-01-01 00:00:00

  • Correlative imaging with monoclonal antibodies in colorectal, ovarian, and prostate cancer.

    abstract::Monoclonal antibody (MoAb) imaging has contributed greatly to the diagnosis and staging of both colorectal and ovarian cancers, and recently has been tested in patients with prostate cancer. Anatomic imaging modalities such as computed tomography, ultrasound, and magnetic resonance imaging have deficiencies in imaging...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Neal CE,Meis LC

    更新日期:1994-10-01 00:00:00

  • Radiolabeling of antigens: procedures and assessment of properties.

    abstract::The role of labeled tracers in radioimmunoassay procedures (RIA) and the advantages of the iodine-labeled antigens over 14C or tritium-labeled antigens are discussed. Different methods of labeling with iodine isotopes are presented. The ease with which microgram amounts of hormonal proteins are tagged, achieving high...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章


    authors: Chervu LR,Murty DR

    更新日期:1975-04-01 00:00:00

  • Imaging for Target Delineation in Head and Neck Cancer Radiotherapy.

    abstract::The definition of tumor involved volumes in patients with head and neck cancer poses great challenges with the increasing use of highly conformal radiotherapy techniques eg, volumetric modulated arc therapy and intensity modulated proton therapy. The risk of underdosing the tumor might increase unless great care is ta...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Jensen K,Al-Farra G,Dejanovic D,Eriksen JG,Loft A,Hansen CR,Pameijer FA,Zukauskaite R,Grau C

    更新日期:2021-01-01 00:00:00

  • Upper extremity radionuclide bone imaging: the wrist and hand.

    abstract::Bone scintigraphy of the hands and wrists represents an important adjunct imaging technique that complements plain film radiographic examination. The use of the three-phase bone scan provides clinical information not only regarding osseous uptake but the blood flow and extravascular distribution of the radiotracer as ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Vande Streek P,Carretta RF,Weiland FL,Shelton DK

    更新日期:1998-01-01 00:00:00

  • Basic principles in the radiation dosimetry of nuclear medicine.

    abstract::The basic principles of the use of radiation dosimetry in nuclear medicine are reviewed. The basic structure of the main mathematical equations are given and formal dosimetry systems are discussed. An extensive overview of the history and current status of anthropomorphic models (phantoms) is given. The sources and ma...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Stabin M,Xu XG

    更新日期:2014-05-01 00:00:00

  • Trials and tribulations: oncological antibody imaging comes to the fore.

    abstract::At the present time, there are three radiolabeled antibodies that have been approved by the US Food and Drug Administration (FDA) for imaging of cancer, a fourth commercially sponsored product recommended for approval (as of 10/29/96, cap romab pendetide (ProstaScint; Cytogen Corp., Princeton, NJ) was upgraded from re...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Zuckier LS,DeNardo GL

    更新日期:1997-01-01 00:00:00

  • Musculoskeletal imaging using fluoride PET.

    abstract::The convenience of (18)F-fluoride imaging is undeniable both because of its favorable tracer and because of its technical characteristics, including high image quality and short examination times leading to increased patient comfort. Depending on the activity administered, the radiation dose to patients is about compa...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审


    authors: Fischer DR

    更新日期:2013-11-01 00:00:00