Abstract：
:2-deoxy-2-[18F] fluoro-D-glucose (18FDG) was developed in 1976 in a collaboration between scientists at the National Institutes of Health, the University of Pennsylvania, and Brookhaven National Laboratory. It was developed for the specific purpose of mapping brain glucose metabolism in living humans, thereby serving as a tool in the basic human neurosciences. With 18FDG it was possible for the first time to measure regional glucose metabolism in the living human brain. Around the same time, the use of 18FDG for studies of myocardial metabolism and as a tracer for tumor metabolism were reported. After the first synthesis of 18FDG via an electrophilic fluorination with 18F gas (produced via the 20Ne(d,alpha)18F reaction), small volume enriched water targets were developed that made it possible to produce large quantities of [18F]fluoride ion via the high-yield 18(p,n)18F reaction. This was followed by a major milestone, the development of a nucleophilic fluorination method that produced 18FDG in very high yield. These advances and the remarkable properties of 18FDG have largely overcome the limitations of the 110-minute half-life of 18F so that 18FDG is now available to most regions of the United States from a number of central production sites. This avoids the need for an on-site cyclotron and chemistry laboratory and has opened up the use of 18FDG to institutions that have a positron emission tomography (PET) scanner (or other imaging device) but no cyclotron or chemistry infrastructure. Currently, 18FDG is used by many hospitals as an off the shelf radiopharmaceutical for clinical diagnosis in heart disease, seizure disorders, and oncology, the area of most rapid growth. However, it remains an important tool in human neuroscience and in drug research and development.
journal_name
Semin Nucl Medjournal_title
Seminars in nuclear medicineauthors
Fowler JS,Ido Tdoi
10.1053/snuc.2002.29270subject
Has Abstractpub_date
2002-01-01 00:00:00pages
6-12issue
1eissn
0001-2998issn
1558-4623pii
S0001-2998(02)80036-8journal_volume
32pub_type
杂志文章,评审abstract：:While 99mTc sulfur colloid imaging, because of its availability and convenience, remains the initial procedure of choice for spleen imaging, selective spleen scanning with damaged 99mTc-labeled RBCs can provide additional information in some cases. These cases include overlapping left hepatic lobe and suspected spleni...
journal_title：Seminars in nuclear medicine
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journal_title：Seminars in nuclear medicine
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 历史文章,杂志文章
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章
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journal_title：Seminars in nuclear medicine
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journal_title：Seminars in nuclear medicine
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journal_title：Seminars in nuclear medicine
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journal_title：Seminars in nuclear medicine
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journal_title：Seminars in nuclear medicine
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更新日期：1989-04-01 00:00:00
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journal_title：Seminars in nuclear medicine
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
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journal_title：Seminars in nuclear medicine
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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更新日期：2011-01-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
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更新日期：2008-07-01 00:00:00
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journal_title：Seminars in nuclear medicine
pub_type： 杂志文章,评审
doi：10.1016/s0001-2998(99)80014-2
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