Abstract:
:According to SEER Cancer Statistics Review there are around 165,000 new prostate cancer cases estimated in 2018 accounting for 9.5% of all newly diagnosed cancers. Accurate staging of primary prostate cancer is important for therapy selection (local vs systemic). Recent developments in molecular imaging may significantly impact staging procedures and management. Accordingly, this article addresses the current clinical standard, discusses the areas of unmet clinical need for imaging and then summarizes the most commonlyused molecular imaging probes. Finally, the authors dare an outlook to the short-term future role of molecular imaging in primary staging of prostate cancer.
journal_name
Semin Nucl Medjournal_title
Seminars in nuclear medicineauthors
Pomykala KL,Farolfi A,Hadaschik B,Fendler WP,Herrmann Kdoi
10.1053/j.semnuclmed.2019.02.004subject
Has Abstractpub_date
2019-07-01 00:00:00pages
271-279issue
4eissn
0001-2998issn
1558-4623pii
S0001-2998(19)30022-4journal_volume
49pub_type
杂志文章,评审abstract::In the past, T3 suppression testing was often required to confirm the presence of autonomous thyroid function in patients with borderline clinical and laboratory findings suggestive of hyperthyroidism or in euthyroid patients with the stigmata of Graves' disease. Similarly, TSH stimulation testing was used to document...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
doi:10.1016/s0001-2998(81)80043-8
更新日期:1981-04-01 00:00:00
abstract::The use of cholescintigraphy to diagnose acute cholecystitis, biliary obstruction, and biliary leakage dates back to the late 1970s. Today, despite the many advances in imaging instrumentation, radiopharmaceuticals, and methodology over these years, cholescintigraphy still plays an important role in confirming or excl...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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abstract::Epilepsy is the most common serious brain disorder in children, occurring in all parts of the world and within every stratum of the population. Through its effects, it exerts a significant physical, psychological, economic, and social toll on children and their caregivers. Historically, the surgical treatment of epile...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2012.06.005
更新日期:2012-11-01 00:00:00
abstract::In the early 1970s, when Seminars in Nuclear Medicine started publication, little was known about the quality of reporting in biomedical journals. Senior scholars were invited to become scientific editors of journals based on their research credibility and stature. Their knowledge of journalology (publication science)...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2018.11.009
更新日期:2019-03-01 00:00:00
abstract::Radionuclide renal studies are particularly well suited to pediatrics as renal problems in children usually are part of a dynamic process which requires serial assessment. The absence of side-effects and the low radiation dose has added to their popularity in pediatrics. A number of different renal parameters can be e...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
doi:10.1016/s0001-2998(82)80015-9
更新日期:1982-10-01 00:00:00
abstract::The practice of nuclear medicine in children is well established for imaging practically all physiologic systems but particularly in the fields of oncology, neurology, urology, and orthopedics. Pediatric nuclear medicine yields images of physiologic and molecular processes that can provide essential diagnostic informa...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2016.10.006
更新日期:2017-03-01 00:00:00
abstract::The American Board of Nuclear Medicine gave its first certifying examination in 1972 to 1,096 candidates. It was established with the support of the Society of Nuclear Medicine amid considerable conflict involving the American Board of Radiology, the American Board of Internal Medicine, and the American Board of Patho...
journal_title:Seminars in nuclear medicine
pub_type: 历史文章,杂志文章
doi:10.1016/s0001-2998(96)80024-9
更新日期:1996-07-01 00:00:00
abstract::Suspecting and diagnosing venous thrombosis and pulmonary embolism remain major clinical problems. For a variety of reasons, including the patient's pre-existing cardiac and pulmonary status and the release of humoral mediators, pulmonary emboli evoke varied responses in different patients. Symptoms and signs of pulmo...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(05)80131-x
更新日期:1991-10-01 00:00:00
abstract::Blood cell labeling with 99mTc has progressed through various developmental phases. In the case of red cell labeling, the science seems to have matured sufficiently, although minor refinements in the procedures will no doubt continue to be made. During the last 3 to 5 years, there has been a resurgence of interest in ...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(05)80175-8
更新日期:1990-01-01 00:00:00
abstract::Nuclear dacryocystography is simple, relatively harmless method of evaluating patients suspected of having abnormalities of the nasolacrimal drainage system. A group of normal saline containing approximately 100 muCi of 99mTc-pertechnetate is placed on the conjunctiva near the lateral canthus, and serial scintigrams a...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
doi:10.1016/s0001-2998(81)80022-0
更新日期:1981-10-01 00:00:00
abstract::Heart failure presents a significant problem in industrialized countries, with a high prevalence, morbidity, and mortality, where it is most frequently caused by coronary artery disease. Revascularization in patients with symptomatic heart failure has been associated with improved cardiovascular outcomes. Predictors o...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2014.07.003
更新日期:2014-09-01 00:00:00
abstract::Although planar radionuclide techniques provide accurate, noninvasive measurements of myocardial perfusion and function that are of proven clinical value in the evaluation of the cardiac patient, they are limited by poor object contrast and superimposition of surrounding structures. Due to incomplete angular sampling ...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(87)80034-x
更新日期:1987-07-01 00:00:00
abstract::Positron emission tomography (PET) of local cerebral glucose utilization is highly sensitive in detecting epileptogenic regions that correspond to electrographic localization in patients with epilepsy. In medically refractory temporal lobe epilepsy for which surgical resection of the epileptogenic zone is a therapeuti...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(05)80119-9
更新日期:1992-10-01 00:00:00
abstract::New software methods that incorporate iterative reconstruction, resolution recovery, and noise compensation now provide the ability to maintain or improve myocardial perfusion SPECT image quality with conventional sodium iodide cameras. Despite lower image counting statistics associated with significantly decreased in...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2014.04.001
更新日期:2014-07-01 00:00:00
abstract::This review describes general concepts with regard to radiopharmaceuticals for diagnostic or therapeutic applications that help to understand the specific challenges encountered during the design, (radio)synthesis, in vitro and in vivo evaluation and clinical translation of novel radiopharmaceuticals. The design of a ...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2019.07.001
更新日期:2019-09-01 00:00:00
abstract::Bone metastases are associated with increased morbidity and poor prognosis in castration-resistant prostate cancer. Since 2010, 5 systemic therapies for metastatic castration-resistant prostate cancer have been approved by the US Food and Drug Administration based on an improvement in overall survival, offering altern...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2014.07.006
更新日期:2015-01-01 00:00:00
abstract::The basic principles of the use of radiation dosimetry in nuclear medicine are reviewed. The basic structure of the main mathematical equations are given and formal dosimetry systems are discussed. An extensive overview of the history and current status of anthropomorphic models (phantoms) is given. The sources and ma...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2014.03.008
更新日期:2014-05-01 00:00:00
abstract::Prostate cancer (PCa) is one of the most common cancers in men and is the second leading cause of cancer-related deaths in the USA. In the United States, it is the second most frequently diagnosed cancer after skin cancer, and in Europe it is number one. According to the American Cancer Society, approximately 221,000 ...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2015.10.005
更新日期:2016-03-01 00:00:00
abstract::Sickling of erythrocytes in patients with S-hemoglobin causes marrow and bone infarction. The former can be demonstrated as a lack of 99mTc-sulfur colloid uptake on marrow imaging examination. These defects may resolve or persist long after the acute episode. If the bone is involved in the acute episode, imaging withi...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(76)80038-4
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abstract::Nuclear medicine imaging techniques continue to play a unique role in the evaluation of hepatic masses. Although many useful radiodiagnostic agents are available, the predominant nuclear medicine study used to evaluate hepatic masses in this decade is technetium-labeled red blood cell "blood-pool" scintigraphy. Hepati...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
doi:10.1016/s0001-2998(96)80012-2
更新日期:1996-01-01 00:00:00
abstract::Rhenium-186 (tin)hydroxyethylidene diphosphonate (HEDP) is a new radiopharmaceutical that localizes in skeletal metastases in patients with advanced cancer. A single intravenous administration of approximately 34 mCi (1,258 MBq) resulted in significant improvement in pain in 33 of 43 evaluable patients (77%) following...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(05)80155-2
更新日期:1992-01-01 00:00:00
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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abstract::This review describes the use of monoclonal antibodies (MoAbs) for immunoscintigraphic detection of thrombosis and thromboembolism. Two major groups of MoAbs have been tested: Antibodies directed against platelets and antibodies directed against fibrin. Several antiplatelet antibodies have been developed that are dire...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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abstract::Although electronic imaging was performed in the early 1950s in nuclear medicine, it was the introduction of computed tomography in 1972 that caused a revolution in medical imaging in that it marked the beginning of the inevitable transformation to digital imaging. This transformation is now more or less complete. Whi...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2018.11.010
更新日期:2019-03-01 00:00:00
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1053/j.semnuclmed.2010.02.001
更新日期:2010-07-01 00:00:00
abstract::Positron emission tomography (PET) scanning has been a powerful research tool since its inception. Changes in the marketplace that have allowed PET to move into the clinical environment include the commercial availability of appropriate radiopharmaceuticals, reimbursement of procedures by insurance companies, and incr...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
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更新日期:2000-10-01 00:00:00
abstract::Computer tomography (CT) is a radiological imaging method which yields transverse tomographic images reflecting with high accuracy the spatial distribution of x-ray attenuation in the part examined. The contrast resolution achieved by CT permits the visualization of soft tissue structure heretofore invisible with conv...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章
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journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
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abstract::The increasing use of automated blood chemistry screens for serum calcium levels along with improved methods in measuring parathyroid hormone (PTH) levels have made the diagnosis of parathyroid disease a common clinical problem. Parathyroid adenomas account for the majority of primary hyperparathyroidism with diffuse ...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(85)80024-6
更新日期:1985-04-01 00:00:00
abstract::Monoclonal antibody (MoAb) imaging has contributed greatly to the diagnosis and staging of both colorectal and ovarian cancers, and recently has been tested in patients with prostate cancer. Anatomic imaging modalities such as computed tomography, ultrasound, and magnetic resonance imaging have deficiencies in imaging...
journal_title:Seminars in nuclear medicine
pub_type: 杂志文章,评审
doi:10.1016/s0001-2998(05)80019-4
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