PET/CT Imaging in Soft Tissue Infection and Inflammation-An Update.

Abstract:

:Nuclear medicine procedures, including Ga-67 and labeled leucocyte SPECT/CT as well as PET/CT using 18F-FDG and recently Ga-68 tracers, have found extensive applications in the assessment of infectious and inflammatory processes in general and in soft tissues in particular. Recent published data focus on summarizing the available imaging information with the purpose of providing the referring clinicians with optimized evidence based results. Guidelines and/or recommendations of clinical societies have incorporated nuclear medicine tests (using both labeled leucocytes and FDG) in their suggested work-up for evaluation of infective endocarditis and in certain patients with suspected vascular graft infections. Joint guidelines of the European and American nuclear medicine societies include fever of unknown origin, sarcoidosis, and vasculitis among the major clinical indications that will benefit from nuclear medicine procedures, specifically from FDG PET/CT. Limitations and pitfalls for the use of radiotracers in assessment of infection and inflammation can be related to patient conditions (eg, diabetes mellitus), or to the biodistribution of a specific radiopharmaceutical. Limited presently available data on the use of functional and/or metabolic monitoring of response to infectious and inflammatory processes to treatment and with respect to the effect of drugs such as antibiotics and glucocorticoids on the imaging patterns of these patients need further confirmation.

journal_name

Semin Nucl Med

authors

Arnon-Sheleg E,Israel O,Keidar Z

doi

10.1053/j.semnuclmed.2019.07.005

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

35-49

issue

1

eissn

0001-2998

issn

1558-4623

pii

S0001-2998(19)30078-9

journal_volume

50

pub_type

杂志文章,评审
  • Gallium and other agents in diseases of the lung.

    abstract::The use of gallium for pulmonary diseases is hampered by its relative lack of specificity, typical 1- to 3-day delay between injection and imaging time, and suboptimal imaging characteristics. Other nuclear and nonnuclear imaging modalities, such as (18)F-fluorodeoxyglucose positron emission tomography (PET) and high-...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/snuc.2002.124178

    authors: Schuster DM,Alazraki N

    更新日期:2002-07-01 00:00:00

  • Quantitative imaging of neuroreceptors in the living human brain.

    abstract::Positron emission tomography (PET) makes it possible for the first time to examine in living humans the chemistry of the brain, which relates the structures of the brain to the functions of the mind. PET scans make it possible to assess the state of neurotransmitter receptors, such as the dopamine, serotonin, muscarin...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章

    doi:10.1016/s0001-2998(86)80004-6

    authors: Wagner HN Jr

    更新日期:1986-01-01 00:00:00

  • PET/CT in Lymphoma: Current Overview and Future Directions.

    abstract::Over the past several decades, PET has emerged as critical to accurate staging and restaging of lymphomas. Nonetheless, a number of critical issues regarding its optimal use remain. Whereas risk-adapted strategies appear to improve the outcome of patients with Hodgkin lymphoma, results are less convincing in non-Hodgk...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2017.09.007

    authors: Cheson BD

    更新日期:2018-01-01 00:00:00

  • Myocardial infarct imaging with technetium-labeled complexes.

    abstract::Detection of acute myocardial infarction as an area of increased activity has intrigued investigators for some time. Initial attempts with 203Hg-chlormerodrin and 203Hg-fluorescein analogues were successful in man. More recently, however, successful imaging of the acute myocardial infarct has been achieved with severa...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(77)80005-6

    authors: Holman BL,Davis MA,Hanson RN

    更新日期:1977-01-01 00:00:00

  • FLT: measuring tumor cell proliferation in vivo with positron emission tomography and 3'-deoxy-3'-[18F]fluorothymidine.

    abstract::Positron emission tomography (PET) using the radiotracer 3'-deoxy-3'-[(18)F]fluorothymidine (FLT) can image cellular proliferation in human cancers in vivo. FLT uptake has been shown to correlate with pathology-based proliferation measurements, including the Ki-67 score, in a variety of human cancers. Unlike pathology...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2007.08.001

    authors: Salskov A,Tammisetti VS,Grierson J,Vesselle H

    更新日期:2007-11-01 00:00:00

  • Radioimmunotherapy for Prostate Cancer--Current Status and Future Possibilities.

    abstract::Prostate cancer (PCa) is one of the most common cancers in men and is the second leading cause of cancer-related deaths in the USA. In the United States, it is the second most frequently diagnosed cancer after skin cancer, and in Europe it is number one. According to the American Cancer Society, approximately 221,000 ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2015.10.005

    authors: Evans-Axelsson S,Timmermand OV,Bjartell A,Strand SE,Elgqvist J

    更新日期:2016-03-01 00:00:00

  • Vital dyes in sentinel node localization.

    abstract::Vital blue dyes were used to show the feasibility and accuracy of intraoperative lymphatic mapping of the sentinel node (SN) in patients with melanoma, breast cancer, and other solid tumors. Surgeons who have successfully completed an adequate number of cases of intraoperative mapping and sentinel lymph node dissectio...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(00)80058-6

    authors: Bostick PJ,Giuliano AE

    更新日期:2000-01-01 00:00:00

  • Improvement of scintigrams by computer processing.

    abstract::Computer processing can improve the quality of scintigrams in several ways. It can increase the accuracy with which the image approximates the activity distribution by reversing degradation. It can selectively enhance normal or abnormal structures of interest. It can optimize the use of the display system presenting t...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章

    doi:10.1016/s0001-2998(78)80036-1

    authors: Pizer SM,Todd-Pokropek AE

    更新日期:1978-04-01 00:00:00

  • PET/MRI in Infection and Inflammation.

    abstract::Hybrid positron emission tomography/magnetic resonance imaging (PET/MR) systems are now more and more available for clinical use. PET/MR combines the unique features of MR including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as we...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2018.02.003

    authors: Sollini M,Berchiolli R,Kirienko M,Rossi A,Glaudemans AWJM,Slart R,Erba PA

    更新日期:2018-05-01 00:00:00

  • Positron emission tomography in lung cancer.

    abstract::Carcinoma of the lung is one of the most frequent malignancies and a major cause of mortality. The use of positron emission tomography (PET) has been extensively investigated in patients with carcinoma of the lung and has established clinical utility and cost-effectiveness in characterization of solitary pulmonary nod...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/snuc.2002.126059

    authors: Shon IH,O'doherty MJ,Maisey MN

    更新日期:2002-10-01 00:00:00

  • The use of monoclonal antibodies and antibody fragments in the imaging of infectious lesions.

    abstract::The advantage of immunoscintigraphy over autologous leukocyte techniques in the imaging of infection is the simplicity of its use compared with techniques that require the isolation of autologous white blood cells. The advantage over 99mTc- or 111In-labeled nonspecific human immunoglobulin is the excellent target-to-b...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章

    doi:10.1016/s0001-2998(05)80228-4

    authors: Becker W,Goldenberg DM,Wolf F

    更新日期:1994-04-01 00:00:00

  • SPECT-PET in Epilepsy and Clinical Approach in Evaluation.

    abstract::In epilepsy, a detailed history, blood chemistry, routine electroencephalography, and brain MRI are important for the diagnosis of seizure type or epilepsy syndrome for the decision of appropriate drug treatment. Although antiepileptic drugs are mostly successful for controlling epileptic seizures, 20%-30% patients ar...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2016.01.003

    authors: Ergün EL,Saygi S,Yalnizoglu D,Oguz KK,Erbas B

    更新日期:2016-07-01 00:00:00

  • Current status of immunoscintigraphy in the detection of thrombosis and thromboembolism.

    abstract::This review describes the use of monoclonal antibodies (MoAbs) for immunoscintigraphic detection of thrombosis and thromboembolism. Two major groups of MoAbs have been tested: Antibodies directed against platelets and antibodies directed against fibrin. Several antiplatelet antibodies have been developed that are dire...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(89)80015-7

    authors: Koblik PD,De Nardo GL,Berger HJ

    更新日期:1989-07-01 00:00:00

  • Biliary Leak in the Postsurgical Abdomen: A Primer to HIDA Scan Interpretation.

    abstract::Postsurgical bile leaks can be associated with significant morbidity and even mortality, if not identified and treated at an early phase. Hepatobiliary iminodiacetic acid (HIDA) scan is an important test for detection of bile leaks in the postoperative abdomen. However, the lack of anatomical details on planar images ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2017.06.002

    authors: Matesan M,Bermo M,Cruite I,Shih CH,Elojeimy S,Behnia F,Lewis D,Vesselle H

    更新日期:2017-11-01 00:00:00

  • PET Assessment of Cardiac Allograft Vasculopathy.

    abstract::Heart transplantation is an effective and life-saving therapy for patients with end-stage heart disease. Cardiac allograft vasculopathy (CAV) is a frequent complication after heart transplantation and a leading cause of graft failure and death. The diffuse involvement of the coronary macro- and microvasculature in CAV...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2020.12.010

    authors: Chih S,Wiefels CC,Beanlands RSB

    更新日期:2021-01-19 00:00:00

  • Is There Use for FDG-PET in Prostate Cancer?

    abstract::The use of positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in prostate cancer depends on the phase of the disease along the natural history of this prevalent malignancy in men. Incidental high FDG uptake in the prostate gland, although rare, should prompt further investigation with at least a meas...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2016.07.004

    authors: Jadvar H

    更新日期:2016-11-01 00:00:00

  • Transition from planar to SPECT V/Q scintigraphy: rationale, practicalities, and challenges.

    abstract::Compared with planar imaging, ventilation/perfusion scintigraphy performed with single-photon emission computed tomography (SPECT) has a greater sensitivity and specificity, greater accuracy, improved reproducibility, and a lower number of inconclusive reports in the detection of pulmonary embolism. Despite these impr...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2010.07.004

    authors: Roach PJ,Bailey DL,Schembri GP,Thomas PA

    更新日期:2010-11-01 00:00:00

  • Infection control in the Department of Nuclear Medicine.

    abstract::Concern about the spread of infections in the hospital setting has prompted regulatory agencies to mandate infection control standards. Each hospital department is required to have written policies and procedures which describe measures to prevent and control the spread of nosocomial infections (hospital acquired infe...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章

    doi:10.1016/s0001-2998(88)80043-6

    authors: Adams A,Egan A

    更新日期:1988-10-01 00:00:00

  • Cardiovascular applications: current status of immunoscintigraphy in the detection of myocardial necrosis using antimyosin (R11D10) and deep venous thrombosis using antifibrin (T2G1s).

    abstract::The remarkable progress in immunologic techniques in the development of monoclonal antibodies offers the potential for powerful new tools for the detection of cardiovascular disorders, such as acute myocardial necrosis and acute deep venous thrombosis, in an accurate, safe, and noninvasive manner. Historically the use...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(05)80094-7

    authors: Manspeaker P,Weisman HF,Schaible TF

    更新日期:1993-04-01 00:00:00

  • Age-related structural and metabolic changes in the pelvic reproductive end organs.

    abstract::In this work, we provide preliminary data and a review of the literature regarding normal structural and functional changes that occur in the aging uterus, ovary, testicle, and prostate gland. It is expected that such knowledge will help physicians to distinguish physiologic changes from pathologic changes at an early...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章

    doi:10.1053/j.semnuclmed.2007.01.004

    authors: Well D,Yang H,Houseni M,Iruvuri S,Alzeair S,Sansovini M,Wintering N,Alavi A,Torigian DA

    更新日期:2007-05-01 00:00:00

  • The economics of creating a positron emission tomography center.

    abstract::Positron emission tomography (PET) scanning has been a powerful research tool since its inception. Changes in the marketplace that have allowed PET to move into the clinical environment include the commercial availability of appropriate radiopharmaceuticals, reimbursement of procedures by insurance companies, and incr...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章

    doi:10.1053/snuc.2000.9544

    authors: Lissak RJ

    更新日期:2000-10-01 00:00:00

  • Gallium-67 citrate imaging studies of the lung.

    abstract::In spite of localization of gallium in the lungs in a large variety of inflammatory pulmonary diseases, the chest radiograph is and will continue to be the principal diagnostic tool for evaluation of pulmonary inflammatory disease. The 67Ga-citrate scan, however, serves as a study complementary to chest radiography be...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(80)80007-9

    authors: Bekerman C,Hoffer PB,Bitran JD,Gupta RG

    更新日期:1980-07-01 00:00:00

  • Evaluation of myocardial perfusion and function by single photon emission computed tomography.

    abstract::Although planar radionuclide techniques provide accurate, noninvasive measurements of myocardial perfusion and function that are of proven clinical value in the evaluation of the cardiac patient, they are limited by poor object contrast and superimposition of surrounding structures. Due to incomplete angular sampling ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(87)80034-x

    authors: Cerqueira MD,Harp GD,Ritchie JL

    更新日期:1987-07-01 00:00:00

  • Newer methods of labeling diagnostic agents with Tc-99m.

    abstract::The past several years have seen marked advances in technetium/rhenium chemistry applicable to the preparation of new 99mTc-labeled radiopharmaceuticals. This article focuses on recent developments in technetium chemistry, including the preparation of "3 + 1" complexes, the preparation and use of (99mTc[CO]3)+ complex...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/snuc.2001.26182

    authors: Mease RC,Lambert C

    更新日期:2001-10-01 00:00:00

  • A history of the American Board of Nuclear Medicine.

    abstract::The American Board of Nuclear Medicine gave its first certifying examination in 1972 to 1,096 candidates. It was established with the support of the Society of Nuclear Medicine amid considerable conflict involving the American Board of Radiology, the American Board of Internal Medicine, and the American Board of Patho...

    journal_title:Seminars in nuclear medicine

    pub_type: 历史文章,杂志文章

    doi:10.1016/s0001-2998(96)80024-9

    authors: Ross JF

    更新日期:1996-07-01 00:00:00

  • Aβ-amyloid and Tau Imaging in Dementia.

    abstract::The introduction of in vivo imaging of Aβ-amyloid (Αβ) pathology more than a decade ago, transformed the assessment of Alzheimer disease (AD) allowing the evaluation of Aβ deposition over time by providing highly accurate, reliable, and reproducible quantitative statements of regional or global Aβ burden in the brain ...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2016.09.006

    authors: Villemagne VL,Doré V,Bourgeat P,Burnham SC,Laws S,Salvado O,Masters CL,Rowe CC

    更新日期:2017-01-01 00:00:00

  • Neurochemical imaging of dementias.

    abstract::Neurochemical imaging is one of the most established "molecular" imaging techniques. There have been tremendous efforts expended to develop radioligands specific to each neurochemical system. Investigational applications of neurochemical imaging in dementing disorders are extensive. Cholinergic, dopaminergic, and sero...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2003.09.008

    authors: Minoshima S,Frey KA,Cross DJ,Kuhl DE

    更新日期:2004-01-01 00:00:00

  • Update on Quantitative Imaging for Predicting and Assessing Response in Oncology.

    abstract::Molecular imaging has revolutionized clinical oncology by imaging-specific facets of cancer biology. Through noninvasive measurements of tumor physiology, targeted radiotracers can serve as biomarkers for disease characterization, prognosis, response assessment, and predicting long-term response/survival. In turn, the...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2020.07.002

    authors: Gillman JA,Pantel AR,Mankoff DA,Edmonds CE

    更新日期:2020-11-01 00:00:00

  • An overview of the contribution of regional cerebral blood flow studies in cerebrovascular disease: is there a role for single photon emission computed tomography?

    abstract::Regional cerebral blood flow (rCBF) findings and their application to cerebrovascular disease are reviewed. Although the coupling of cerebral blood flow and metabolism are best studied with positron emission tomography, single-photon emission computed tomography measurements of rCBF can contribute to patient managemen...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0001-2998(05)80236-3

    authors: Hellman RS,Tikofsky RS

    更新日期:1990-10-01 00:00:00

  • Transplanted kidney function evaluation.

    abstract::The best option for the treatment of end-stage renal disease is kidney transplantation. Prompt diagnosis and management of early posttransplantation complications is of utmost importance for graft survival. Biochemical markers, allograft biopsies, and imaging modalities are used for the timely recognition and manageme...

    journal_title:Seminars in nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1053/j.semnuclmed.2013.10.005

    authors: Aktaş A

    更新日期:2014-03-01 00:00:00