Radiolabeling of antigens: procedures and assessment of properties.

abstract：:The advantage of immunoscintigraphy over autologous leukocyte techniques in the imaging of infection is the simplicity of its use compared with techniques that require the isolation of autologous white blood cells. The advantage over 99mTc- or 111In-labeled nonspecific human immunoglobulin is the excellent target-to-b...

journal_title：Seminars in nuclear medicine

authors： Becker W,Goldenberg DM,Wolf F

更新日期：1994-04-01 00:00:00

abstract：:Due to the increasing life expectancy, the diagnosis of malignancy and treatment of elderly patients is becoming more common. Prostate cancer is particularly frequent in this setting. Many different approaches are now available, but some of them imply significant risks or collateral effects. In those patients an accur...

journal_title：Seminars in nuclear medicine

authors： Castellucci P,Nanni C,Ambrosini V

更新日期：2018-11-01 00:00:00

abstract：:We describe our all-digital, filmless, department of nuclear medicine, which has been fully operational for 3 years. The approach to the design and implementation of a nuclear medicine picture archiving and communication system (PACS) is discussed, as well as enhancements found to be necessary or desirable during our ...

journal_title：Seminars in nuclear medicine

authors： Cohen AM,Parker JA,Donohoe K,Jansons D,Kolodny GM

更新日期：1990-07-01 00:00:00

abstract：:The concept of brain death has gained importance in the past few decades to prevent futile attempts to sustain ventilation and blood circulation when the brain has lost all function and to procure beneficial tissues or life-saving organs for transplantation. However, differences remain among professional societies and...

journal_title：Seminars in nuclear medicine

authors： Sinha P,Conrad GR

更新日期：2012-01-01 00:00:00

abstract：:Evaluation of ventricular performance is essential in the diagnosis and long-term management of patients with heart disease. This can be most easily performed clinically using simple tools. When more definitive objective assessment of cardiac function is indicated, the equilibrium gated blood pool study provides relia...

journal_title：Seminars in nuclear medicine

authors： Strauss HW,McKusick KA,Boucher CA,Bingham JB,Pohost GM

更新日期：1979-10-01 00:00:00

abstract：:Breast cancer is the most common cause of bone metastases in women. Imaging studies are useful to identify bone involvement and associated complications, for follow-up of disease spread and for the assessment of response to therapy. Bone scintigraphy with (99m)technetium-labeled diphosphonates is most widely used, due...

journal_title：Seminars in nuclear medicine

authors： Ben-Haim S,Israel O

更新日期：2009-11-01 00:00:00

abstract：:The radionuclide bone scan is one of the most commonly performed pediatric nuclear medicine procedures. Bone scintigraphy is used as the diagnostic procedure of choice for diagnosis of bone and soft-tissue infection and can aid in the diagnosis of occult trauma without radiographic findings. There is a complimentary r...

journal_title：Seminars in nuclear medicine

authors： Nadel HR

更新日期：2007-09-01 00:00:00

abstract：:In epilepsy, a detailed history, blood chemistry, routine electroencephalography, and brain MRI are important for the diagnosis of seizure type or epilepsy syndrome for the decision of appropriate drug treatment. Although antiepileptic drugs are mostly successful for controlling epileptic seizures, 20%-30% patients ar...

journal_title：Seminars in nuclear medicine

authors： Ergün EL,Saygi S,Yalnizoglu D,Oguz KK,Erbas B

更新日期：2016-07-01 00:00:00

abstract：:Autonomic innervation plays an important role in proper functioning of the cardiovascular system. Altered cardiac sympathetic function is present in a variety of diseases, and can be assessed with radionuclide imaging using sympathetic neurotransmitter analogues. The most studied adrenergic radiotracer is cardiac 123I...

journal_title：Seminars in nuclear medicine

authors： Wan N,Travin MI

更新日期：2020-07-01 00:00:00

abstract：:The convenience of (18)F-fluoride imaging is undeniable both because of its favorable tracer and because of its technical characteristics, including high image quality and short examination times leading to increased patient comfort. Depending on the activity administered, the radiation dose to patients is about compa...

journal_title：Seminars in nuclear medicine

authors： Fischer DR

更新日期：2013-11-01 00:00:00

abstract：:The evaluation of primary brain tumor is challenging. Neuroimaging plays a significant role. At diagnosis, imaging is needed to establish a differential diagnosis, provide prognostic information, as well as direct biopsy. After the initial treatment, imaging is needed to distinguish recurrent disease from treatment-re...

journal_title：Seminars in nuclear medicine

authors： Chen W,Silverman DH

更新日期：2008-07-01 00:00:00

abstract：:Recent advances in the efficient production of high purity radioiodine (123I) and new efficient radiolabeling techniques have allowed the development of new classes of cardiovascular radiopharmaceuticals. These include 123I-labeled fatty acids to assess myocardial metabolism, 123I-metaiodobenzylguanidine (MIBG) for my...

journal_title：Seminars in nuclear medicine

authors： Kulkarni PV,Corbett JR

更新日期：1990-04-01 00:00:00

abstract：:Recently, the lung has received increasing attention as a metabolic organ. In this role, the lung modulates the composition of the arterial blood by several mechanisms: removing active substances from the plasma, releasing substances into the plasma, temporarily holding substances from circulation, and activating or i...

journal_title：Seminars in nuclear medicine

authors： Touya JJ,Rahimian J,Corbus HF,Grubbs DE,Savala KM,Glass EC,Bennett LR

更新日期：1986-10-01 00:00:00

abstract：:Sickling of erythrocytes in patients with S-hemoglobin causes marrow and bone infarction. The former can be demonstrated as a lack of 99mTc-sulfur colloid uptake on marrow imaging examination. These defects may resolve or persist long after the acute episode. If the bone is involved in the acute episode, imaging withi...

journal_title：Seminars in nuclear medicine

authors： Lutzker LG,Alavi A

更新日期：1976-01-01 00:00:00

abstract：:The radionuclide (99m)Tc-MDP bone scan is one of the most commonly performed nuclear medicine studies and helps in the diagnosis of different pathologies relating to the musculoskeletal system. With its increasing utility in clinical practice, it becomes more important to be aware of various limitations of this imagin...

journal_title：Seminars in nuclear medicine

authors： Agrawal K,Marafi F,Gnanasegaran G,Van der Wall H,Fogelman I

更新日期：2015-09-01 00:00:00

abstract：:There is little information in the literature concerning the role of bone scanning in benign bone neoplasms except for sporadic reports. Since the advent of 99mTc-polyphosphate, bone imaging has proven feasible and useful in locating the cause of bone pain, such as in osteoid osteomas, which are not always radiologica...

journal_title：Seminars in nuclear medicine

authors： Gilday DL,Ash JM

更新日期：1976-01-01 00:00:00

abstract：:Positron emission tomography (PET) of local cerebral glucose utilization is highly sensitive in detecting epileptogenic regions that correspond to electrographic localization in patients with epilepsy. In medically refractory temporal lobe epilepsy for which surgical resection of the epileptogenic zone is a therapeuti...

journal_title：Seminars in nuclear medicine

authors： Chugani HT

更新日期：1992-10-01 00:00:00

abstract：:The short range and high linear energy transfer of α-particles offer the potential for efficient tumor killing while sparing normal bystander cells. Hematologic malignancies are ideally suited to targeted α-particle therapy (TAT) due to easy accessibility of malignant cells in blood, bone marrow, lymph nodes, and sple...

journal_title：Seminars in nuclear medicine

authors： Jurcic JG

更新日期：2020-03-01 00:00:00

abstract：:Positron emission tomography (PET)/computed tomography (CT) is a rapidly expanding imaging modality, thanks to the availability of compact medical cyclotrons and automated chemistry synthesis modules for the production of PET radiopharmaceuticals. Despite the availability of many radiotracers, [(18)F]fluorodeoxyglucos...

journal_title：Seminars in nuclear medicine

authors： Vallabhajosula S,Solnes L,Vallabhajosula B

更新日期：2011-07-01 00:00:00

abstract：:Ventilation/Perfusion (V/Q) positron emission tomography computed tomography (PET/CT) is now possible by substituting Technetium-99m (99mTc) with Gallium-68 (68Ga), using the same carrier molecules as conventional V/Q imaging. Ventilation imaging can be performed with 68Ga-carbon nanoparticles using the same synthesis...

journal_title：Seminars in nuclear medicine

authors： Le Roux PY,Hicks RJ,Siva S,Hofman MS

更新日期：2019-01-01 00:00:00

abstract：:Postsurgical bile leaks can be associated with significant morbidity and even mortality, if not identified and treated at an early phase. Hepatobiliary iminodiacetic acid (HIDA) scan is an important test for detection of bile leaks in the postoperative abdomen. However, the lack of anatomical details on planar images ...

journal_title：Seminars in nuclear medicine

authors： Matesan M,Bermo M,Cruite I,Shih CH,Elojeimy S,Behnia F,Lewis D,Vesselle H

更新日期：2017-11-01 00:00:00

abstract：:This review, examines the indications for and limitations of gallium-67 (67Ga) scanning in the evaluation of patients infected with human immunodeficiency virus (HIV). The imaging protocol, as well as the normal biodistribution of 67Ga and its normal variants are discussed. The diagnostic significance of the different...

journal_title：Seminars in nuclear medicine

authors： Bekerman C,Bitran J

更新日期：1988-10-01 00:00:00

abstract：:There seems little doubt that the ability to prepare antibodies with a unique specificity for surface tumor antigens will have a tremendous usefulness in the diagnostic and therapeutics of cancer. This usefulness will be wide-ranged when the antibodies are labeled with radioisotopes as tools for screening for primary ...

journal_title：Seminars in nuclear medicine

authors： Spar IL

更新日期：1976-10-01 00:00:00

abstract：:When serious infections are suspected, patients are often treated empirically with broad-spectrum antibiotics while awaiting results that provide information on the bacterial class and species causing the infection, as well as drug susceptibilities. For deep-seated infections, these traditional diagnostic techniques o...

journal_title：Seminars in nuclear medicine

authors： Ordonez AA,Jain SK

更新日期：2018-03-01 00:00:00

abstract：:Blood cell labeling with 99mTc has progressed through various developmental phases. In the case of red cell labeling, the science seems to have matured sufficiently, although minor refinements in the procedures will no doubt continue to be made. During the last 3 to 5 years, there has been a resurgence of interest in ...

journal_title：Seminars in nuclear medicine

authors： Srivastava SC,Straub RF

更新日期：1990-01-01 00:00:00

abstract：:Most of the components of the thrombotic and fibrinolytic systems have at some time been evaluated as a means of carrying a radiolabel specifically to thrombi, although very few have been promising enough to emerge from investigational status to routine clinical use. New approaches are being explored, including improv...

journal_title：Seminars in nuclear medicine

authors： Knight LC

更新日期：1990-01-01 00:00:00

abstract：:Positron emission tomography (PET) scanning has been a powerful research tool since its inception. Changes in the marketplace that have allowed PET to move into the clinical environment include the commercial availability of appropriate radiopharmaceuticals, reimbursement of procedures by insurance companies, and incr...

journal_title：Seminars in nuclear medicine

authors： Lissak RJ

更新日期：2000-10-01 00:00:00

abstract：:FDG-PET/CT has an established role in the initial staging of locally advanced cervical cancers, particularly in evaluation of nodal disease and distant metastases. It is common practice to perform FDG-PET/CT 3 months postcompletion of chemoradiotherapy as it can predict outcome and be used to tailor management, includ...

journal_title：Seminars in nuclear medicine

authors： Gandy N,Arshad MA,Park WE,Rockall AG,Barwick TD

更新日期：2019-11-01 00:00:00

abstract：:The basic principles of the use of radiation dosimetry in nuclear medicine are reviewed. The basic structure of the main mathematical equations are given and formal dosimetry systems are discussed. An extensive overview of the history and current status of anthropomorphic models (phantoms) is given. The sources and ma...

journal_title：Seminars in nuclear medicine

authors： Stabin M,Xu XG

更新日期：2014-05-01 00:00:00

abstract：:The advent of simultaneous PET/MRI brought a large amount of possibilities in research and clinical applications into hybrid imaging. Unlike in PET/CT protocols, the MR component provides an almost unlimited number of pulse sequences and possibilities of different protocols in PET/MRI. Nevertheless, there is an impera...

journal_title：Seminars in nuclear medicine

authors： Barbosa Fde G,von Schulthess G,Veit-Haibach P

更新日期：2015-07-01 00:00:00